BR0116411A - Compostos de pirazol úteis como inibidores de proteìna cinase - Google Patents

Compostos de pirazol úteis como inibidores de proteìna cinase

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Publication number
BR0116411A
BR0116411A BR0116411-2A BR0116411A BR0116411A BR 0116411 A BR0116411 A BR 0116411A BR 0116411 A BR0116411 A BR 0116411A BR 0116411 A BR0116411 A BR 0116411A
Authority
BR
Brazil
Prior art keywords
protein kinase
kinase inhibitors
ring
pyrazole compounds
compounds useful
Prior art date
Application number
BR0116411-2A
Other languages
English (en)
Inventor
David Bebbington
Jean-Damien Charrier
Julian Golec
Andrew Miller
Ronald Knegtel
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of BR0116411A publication Critical patent/BR0116411A/pt

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Abstract

"COMPOSTOS DE PIRAZOL úTEIS COMO INIBIDORES DE PROTEìNA CINASE". Esta invenção descreve novos compostos de pirazol da fórmula IIIa: IIIa em que R^ 1^ é T-anel D, em que o Anel D é um anel monocíclico de 5-7 membros ou um anel bicíclico de 8-10 membros selecionado de arila, heteroarila, heterociclila ou carbociclila; R^ x^, R^ y^, R^ 2^ e R^ 2'^ são como descritos no relatório descritivo. Os compostos são úteis como inibidores de proteína cinase, especialmente como inibidores de Aurora-2 e GSK-3, para tratar doenças como câncer, diabetes e doença de Alzheimer.
BR0116411-2A 2000-12-21 2001-12-19 Compostos de pirazol úteis como inibidores de proteìna cinase BR0116411A (pt)

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