BR0115260A - Complexos de sn-38 com lipìdeos e seus usos no tratamento de doenças - Google Patents

Complexos de sn-38 com lipìdeos e seus usos no tratamento de doenças

Info

Publication number
BR0115260A
BR0115260A BR0115260-2A BR0115260A BR0115260A BR 0115260 A BR0115260 A BR 0115260A BR 0115260 A BR0115260 A BR 0115260A BR 0115260 A BR0115260 A BR 0115260A
Authority
BR
Brazil
Prior art keywords
complexes
lipid complexes
treating diseases
compositions
specifically
Prior art date
Application number
BR0115260-2A
Other languages
English (en)
Inventor
Imran Ahmad
Aquilur Rahman
Jia-Ai Zhang
Original Assignee
Neopharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neopharm Inc filed Critical Neopharm Inc
Publication of BR0115260A publication Critical patent/BR0115260A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"COMPLEXOS DE SN-38 COM LIPìDEOS E SEUS USOS NO TRATAMENTO DE DOENçAS". A presente invenção se refere a novas composições e processos para tratamento de doenças causadas por proliferação celular, especificamente, para tratamento de câncer em mamíferos e mais especificamente em seres humanos. As composições terapêuticas da presente invenção incluem complexos de lipídeo SNp-38, nos quais os complexos podem conter qualquer de uma variedade de lipídeos neutros ou carregados e, desejavelmente, cardiolipina. As composições são capazes de incorporar, eficazmente, SN-38 aos complexos e são capazes de solubilizar em concentrações relativamente altas de SN-38.
BR0115260-2A 2000-11-09 2001-11-09 Complexos de sn-38 com lipìdeos e seus usos no tratamento de doenças BR0115260A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24730600P 2000-11-09 2000-11-09
PCT/US2001/043325 WO2002058622A2 (en) 2000-11-09 2001-11-09 Sn-38 lipid complexes and methods of use

Publications (1)

Publication Number Publication Date
BR0115260A true BR0115260A (pt) 2005-08-16

Family

ID=22934406

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0115260-2A BR0115260A (pt) 2000-11-09 2001-11-09 Complexos de sn-38 com lipìdeos e seus usos no tratamento de doenças

Country Status (22)

Country Link
US (1) US7390502B2 (pt)
EP (1) EP1355634B8 (pt)
JP (1) JP4524071B2 (pt)
KR (1) KR100869824B1 (pt)
CN (1) CN1531424A (pt)
AT (1) ATE413164T1 (pt)
AU (1) AU2002246510B2 (pt)
BG (1) BG107862A (pt)
BR (1) BR0115260A (pt)
CA (1) CA2427467C (pt)
CZ (1) CZ20031515A3 (pt)
DE (1) DE60136490D1 (pt)
EA (1) EA006741B1 (pt)
HU (1) HUP0302352A3 (pt)
IL (1) IL155696A0 (pt)
MX (1) MXPA03004095A (pt)
NO (1) NO20032069L (pt)
NZ (1) NZ525552A (pt)
PL (1) PL363618A1 (pt)
SK (1) SK7092003A3 (pt)
WO (1) WO2002058622A2 (pt)
ZA (1) ZA200303432B (pt)

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AU2002246510A2 (en) 2002-08-06
MXPA03004095A (es) 2004-09-10
EP1355634B1 (en) 2008-11-05
NZ525552A (en) 2005-04-29
KR20030072352A (ko) 2003-09-13
CA2427467A1 (en) 2002-08-01
ATE413164T1 (de) 2008-11-15
WO2002058622A3 (en) 2003-08-28
EA200300550A1 (ru) 2004-06-24
EP1355634A4 (en) 2005-07-06
WO2002058622A2 (en) 2002-08-01
NO20032069L (no) 2003-07-02
SK7092003A3 (en) 2004-06-08
EA006741B1 (ru) 2006-04-28
NO20032069D0 (no) 2003-05-08
PL363618A1 (en) 2004-11-29
EP1355634B8 (en) 2009-03-04
IL155696A0 (en) 2003-11-23
AU2002246510B2 (en) 2007-09-20
BG107862A (bg) 2004-06-30
ZA200303432B (en) 2004-08-05
JP4524071B2 (ja) 2010-08-11
DE60136490D1 (de) 2008-12-18
CA2427467C (en) 2010-01-12
CN1531424A (zh) 2004-09-22
JP2004529086A (ja) 2004-09-24
EP1355634A2 (en) 2003-10-29
HUP0302352A3 (en) 2007-03-28
CZ20031515A3 (cs) 2003-09-17
KR100869824B1 (ko) 2008-11-21
US20030215492A1 (en) 2003-11-20
HUP0302352A2 (hu) 2003-11-28
US7390502B2 (en) 2008-06-24

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