BE2017C055I2 - - Google Patents
Download PDFInfo
- Publication number
- BE2017C055I2 BE2017C055I2 BE2017C055C BE2017C055C BE2017C055I2 BE 2017C055 I2 BE2017C055 I2 BE 2017C055I2 BE 2017C055 C BE2017C055 C BE 2017C055C BE 2017C055 C BE2017C055 C BE 2017C055C BE 2017C055 I2 BE2017C055 I2 BE 2017C055I2
- Authority
- BE
- Belgium
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1217—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Neisseriaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2405—Glucanases
- C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
- C12N9/2411—Amylases
- C12N9/2414—Alpha-amylase (3.2.1.1.)
- C12N9/2417—Alpha-amylase (3.2.1.1.) from microbiological source
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2465—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1) acting on alpha-galactose-glycoside bonds, e.g. alpha-galactosidase (3.2.1.22)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2468—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1) acting on beta-galactose-glycoside bonds, e.g. carrageenases (3.2.1.83; 3.2.1.157); beta-agarase (3.2.1.81)
- C12N9/2471—Beta-galactosidase (3.2.1.23), i.e. exo-(1-->4)-beta-D-galactanase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6087—Polysaccharides; Lipopolysaccharides [LPS]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
- G01N2333/22—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Neisseriaceae (F), e.g. Acinetobacter
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/825—Bacteria
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Mycology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32810101P | 2001-10-11 | 2001-10-11 | |
US40693402P | 2002-08-30 | 2002-08-30 | |
EP02804818.9A EP1442047B1 (en) | 2001-10-11 | 2002-10-11 | Novel immunogenic compositions for the prevention and treatment of meningococcal disease |
Publications (1)
Publication Number | Publication Date |
---|---|
BE2017C055I2 true BE2017C055I2 (en) | 2022-02-01 |
Family
ID=27668840
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BE2017C055C BE2017C055I2 (en) | 2001-10-11 | 2017-11-23 | |
BE2017C056C BE2017C056I2 (en) | 2001-10-11 | 2017-11-23 | |
BE2017C057C BE2017C057I2 (en) | 2001-10-11 | 2017-11-23 |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BE2017C056C BE2017C056I2 (en) | 2001-10-11 | 2017-11-23 | |
BE2017C057C BE2017C057I2 (en) | 2001-10-11 | 2017-11-23 |
Country Status (19)
Country | Link |
---|---|
US (13) | US8101194B2 (en) |
EP (14) | EP2332961B1 (en) |
JP (6) | JP2005515771A (en) |
KR (4) | KR20100121699A (en) |
CN (4) | CN1578785B (en) |
AU (3) | AU2009213040C1 (en) |
BE (3) | BE2017C055I2 (en) |
BR (1) | BRPI0212999B8 (en) |
CA (5) | CA2463476C (en) |
DK (10) | DK2343308T3 (en) |
ES (14) | ES2549764T3 (en) |
FR (4) | FR15C0056I2 (en) |
HK (2) | HK1178429A1 (en) |
IL (5) | IL161052A0 (en) |
LU (4) | LU92786I2 (en) |
MX (3) | MX339524B (en) |
NL (3) | NL300897I2 (en) |
PT (10) | PT2341063E (en) |
WO (1) | WO2003063766A2 (en) |
Families Citing this family (76)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR9910089A (en) | 1998-05-01 | 2004-06-08 | Chiron Corp | Compositions and antigens of neisseria meningitidis |
WO2000071725A2 (en) | 1999-05-19 | 2000-11-30 | Chiron S.P.A. | Combination neisserial compositions |
AU784203B2 (en) | 1999-10-29 | 2006-02-23 | Glaxosmithkline Biologicals S.A. | Neisserial antigenic peptides |
DK1248647T3 (en) | 2000-01-17 | 2010-09-27 | Novartis Vaccines & Diagnostic | Outer membrane vesicle (OMV) vaccine comprising N. meningitidis serogroup B outer membrane proteins |
RU2299906C2 (en) | 2000-02-28 | 2007-05-27 | Новартис Вэксинс Энд Диагностикс С.Р.Л. | Heterologous expression of neisseria proteins |
GB0118249D0 (en) | 2001-07-26 | 2001-09-19 | Chiron Spa | Histidine vaccines |
GB0121591D0 (en) | 2001-09-06 | 2001-10-24 | Chiron Spa | Hybrid and tandem expression of neisserial proteins |
MX339524B (en) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Novel immunogenic compositions for the prevention and treatment of meningococcal disease. |
PT2353608T (en) | 2002-10-11 | 2020-03-11 | Novartis Vaccines And Diagnostics S R L | Polypeptide-vaccines for broad protection against hypervirulent meningococcal lineages |
GB0227346D0 (en) * | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
US10272147B2 (en) | 2003-01-30 | 2019-04-30 | Glaxosmithkline Biologicals S.A. | Injectable vaccines against multiple meningococcal serogroups |
KR20060019515A (en) * | 2003-04-16 | 2006-03-03 | 와이어쓰 홀딩스 코포레이션 | Novel immunogenic compositions for the prevention and treatment of meningococcal disease |
PT1961426E (en) | 2003-10-02 | 2011-06-28 | Novartis Vaccines & Diagnostic | Combined meningitis vaccines |
GB0408977D0 (en) | 2004-04-22 | 2004-05-26 | Chiron Srl | Immunising against meningococcal serogroup Y using proteins |
GB0419408D0 (en) | 2004-09-01 | 2004-10-06 | Chiron Srl | 741 chimeric polypeptides |
EP2425856A1 (en) | 2005-04-08 | 2012-03-07 | Wyeth LLC | Multivalent pneumococcal polysaccharide-protein conjugate composition |
US7709001B2 (en) | 2005-04-08 | 2010-05-04 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
ATE536884T1 (en) | 2005-06-27 | 2011-12-15 | Glaxosmithkline Biolog Sa | IMMUNOGENIC COMPOSITION |
GB0524066D0 (en) * | 2005-11-25 | 2006-01-04 | Chiron Srl | 741 ii |
AU2013201318B2 (en) * | 2005-11-25 | 2015-11-19 | Glaxosmithkline Biologicals Sa | Chimeric, hybrid and tandem polypeptides of meningococcal NMB 1870 |
TW200806315A (en) | 2006-04-26 | 2008-02-01 | Wyeth Corp | Novel formulations which stabilize and inhibit precipitation of immunogenic compositions |
AU2016204760A1 (en) * | 2006-04-26 | 2016-07-28 | Wyeth Llc | Novel formulations which stabilize and inhibit precipitation of immunogenic compositions |
AU2014268186C1 (en) * | 2006-04-26 | 2017-12-07 | Wyeth Llc | Novel formulations which stabilize and inhibit precipitation of immunogenic compositions |
SG174013A1 (en) | 2006-07-27 | 2011-09-29 | Wyeth Corp | High-cell density fed-batch fermentation process for producing recombinant protein |
AR064642A1 (en) | 2006-12-22 | 2009-04-15 | Wyeth Corp | POLINUCLEOTIDE VECTOR THAT INCLUDES IT RECOMBINATING CELL THAT UNDERSTANDS THE VECTOR POLYPEPTIDE, ANTIBODY, COMPOSITION THAT UNDERSTANDS THE POLINUCLEOTIDE, VECTOR, RECOMBINATING CELL POLYPEPTIDE OR ANTIBODY, USE OF THE COMPOSITION AND A COMPOSITION AND A METHOD |
GB0700562D0 (en) | 2007-01-11 | 2007-02-21 | Novartis Vaccines & Diagnostic | Modified Saccharides |
US9579372B2 (en) | 2008-02-21 | 2017-02-28 | Glaxosmithkline Biologicals Sa | Meningococcal fHBP polypeptides |
AU2009329193A1 (en) | 2008-12-17 | 2011-07-14 | Novartis Ag | Meningococcal vaccines including hemoglobin receptor |
CA2756522C (en) | 2009-03-24 | 2018-06-26 | Novartis Ag | Adjuvanting meningococcal factor h binding protein |
CN102438649A (en) * | 2009-03-24 | 2012-05-02 | 诺华有限公司 | Meningococcal factor H binding proteins and pneumococcal binding saccharides |
EP2443250B8 (en) | 2009-06-16 | 2016-09-21 | GlaxoSmithKline Biologicals SA | High-throughput complement-mediated antibody-dependent and opsonic bactericidal assays |
EP2470204B1 (en) | 2009-08-27 | 2015-12-16 | GlaxoSmithKline Biologicals SA | Hybrid polypeptides including meningococcal fhbp sequences |
CA2772103A1 (en) | 2009-08-27 | 2011-03-03 | Novartis Ag | Adjuvant comprising aluminium, oligonucleotide and polycation |
AU2010302344A1 (en) | 2009-09-30 | 2012-04-26 | Novartis Ag | Expression of meningococcal fhbp polypeptides |
WO2011051893A1 (en) | 2009-10-27 | 2011-05-05 | Novartis Ag | Modified meningococcal fhbp polypeptides |
ES2910199T3 (en) | 2010-03-30 | 2022-05-11 | Childrens Hospital & Res Center At Oakland | Factor H-binding proteins (fHbp) with altered properties and methods of using them |
KR101609032B1 (en) | 2010-06-04 | 2016-04-04 | 와이어쓰 엘엘씨 | Streptococcus pneumoniae vaccine formulations |
CA2803239A1 (en) * | 2010-06-25 | 2011-12-29 | Novartis Ag | Combinations of meningococcal factor h binding proteins |
HRP20240965T1 (en) | 2010-08-23 | 2024-10-25 | Wyeth Llc | Stable formulations of neisseria meningitidis rlp2086 antigens |
PE20140173A1 (en) | 2010-09-10 | 2014-02-20 | Wyeth Llc | NON-LIPIDED VARIANTS OF NEISSERIA MENINGITIDIS ANTIGENS ORF2086 |
EP2613805B1 (en) | 2010-09-10 | 2019-10-23 | GlaxoSmithKline Biologicals SA | Meningococcus overexpressing nada and/or nhba and outer membrane vesicles derived therefrom |
GB201015132D0 (en) * | 2010-09-10 | 2010-10-27 | Univ Bristol | Vaccine composition |
CN103533954B (en) | 2011-03-02 | 2015-09-09 | 诺华股份有限公司 | Contain compared with the antigen of low dosage and/or the combined vaccine of adjuvant |
EP2707009A1 (en) | 2011-05-12 | 2014-03-19 | Novartis AG | Antipyretics to enhance tolerability of vesicle-based vaccines |
BR112014016223A8 (en) | 2011-12-29 | 2017-07-04 | Novartis Ag | adjuvant combinations of meningococcal h-factor binding proteins |
EP2809785B1 (en) | 2012-02-02 | 2017-11-01 | GlaxoSmithKline Biologicals SA | Promoters for increased protein expression in meningococcus |
CN104159603A (en) | 2012-03-08 | 2014-11-19 | 诺华股份有限公司 | Combination vaccines with tlr4 agonists |
ES2750366T3 (en) | 2012-03-08 | 2020-03-25 | Glaxosmithkline Biologicals Sa | In vitro potency assay for protein-based meningococcal vaccines |
SG10201602558UA (en) | 2012-03-09 | 2016-05-30 | Pfizer | Neisseria meningitidis compositions and methods thereof |
SA115360586B1 (en) | 2012-03-09 | 2017-04-12 | فايزر انك | Neisseria meningitidis compositions and methods thereof |
MX357538B (en) | 2012-06-14 | 2018-07-13 | Novartis Ag | Vaccines for serogroup x meningococcus. |
CN104736563A (en) | 2012-07-27 | 2015-06-24 | 国家健康与医学研究院 | Cd147 as receptor for pilus-mediated adhesion of meningococci to vascular endothelia |
RU2015106930A (en) | 2012-09-06 | 2016-10-20 | Новартис Аг | COMBINED VACCINES WITH THE MENINGOCOCC SEROGRAPH B AND K / D / S |
US9802987B2 (en) | 2013-03-08 | 2017-10-31 | Pfizer Inc. | Immunogenic fusion polypeptides |
CN105431167A (en) | 2013-08-02 | 2016-03-23 | 奥克兰儿童医院及研究中心 | Non-naturally occurring factor h binding proteins (FHBP) and methods of use thereof |
WO2015033251A2 (en) * | 2013-09-08 | 2015-03-12 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
SI3110442T1 (en) | 2014-02-28 | 2021-01-29 | Glaxosmithkline Biologicals S.A. | Modified meningococcal fhbp polypeptides |
RU2714248C2 (en) | 2014-07-23 | 2020-02-13 | Чилдрен'З Хоспитал Энд Рисёрч Сентер Эт Окленд | Versions of factor n-binding protein and methods of use thereof |
US11031102B2 (en) | 2014-11-17 | 2021-06-08 | Alexion Pharmaceuticals, Inc. | Risk evaluation and management strategy involving patient follow-ups relating to the use or discontinuation of a complement inhibitor |
MX2017010705A (en) | 2015-02-19 | 2017-12-04 | Pfizer | Neisseria meningitidis compositions and methods thereof. |
EP3263695A1 (en) | 2016-06-29 | 2018-01-03 | GlaxoSmithKline Biologicals SA | Immunogenic compositions |
CN106434720A (en) * | 2016-08-03 | 2017-02-22 | 中国医学科学院医学生物学研究所 | Method for improving expression of neisseria meningitidis fHBP |
JP7104027B2 (en) | 2016-09-02 | 2022-07-20 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | Vaccine against gonorrhea |
CN118236477A (en) | 2016-09-02 | 2024-06-25 | 赛诺菲巴斯德股份有限公司 | Neisseria meningitidis vaccine |
US10738338B2 (en) | 2016-10-18 | 2020-08-11 | The Research Foundation for the State University | Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate |
SG11201906519RA (en) | 2017-01-31 | 2019-08-27 | Pfizer | Neisseria meningitidis compositions and methods thereof |
CN111316161B (en) * | 2017-09-28 | 2021-11-23 | 富士胶片株式会社 | Imaging device, information acquisition method, and information acquisition program |
JP6911136B2 (en) | 2017-09-28 | 2021-07-28 | 富士フイルム株式会社 | Imaging device, information acquisition method and information acquisition program |
TWI687696B (en) * | 2019-06-26 | 2020-03-11 | 國立中興大學 | Method for establishing feedback type hidden Markov model identifier and method for establishing identification system based on the identifier |
CN114681601A (en) * | 2020-12-31 | 2022-07-01 | 基础治疗有限公司 | Neisseria meningitidis vaccines and uses thereof |
IL305313A (en) | 2021-02-19 | 2023-10-01 | Sanofi Pasteur | Meningococcal b recombinant vaccine |
GB202115077D0 (en) | 2021-10-21 | 2021-12-08 | Glaxosmithkline Biologicals Sa | Assay |
WO2023138914A1 (en) | 2022-01-24 | 2023-07-27 | Koninklijke Philips N.V. | Pulse wave velocity determination using co-registration between intravascular data and extraluminal image, and associated systems, devices, and methods |
GB202208089D0 (en) | 2022-06-01 | 2022-07-13 | Glaxosmithkline Biologicals Sa | Immunogenic composition |
GB202208093D0 (en) | 2022-06-01 | 2022-07-13 | Glaxosmithkline Biologicals Sa | Immunogenic composition |
TW202423477A (en) | 2022-08-03 | 2024-06-16 | 美商賽諾菲巴斯德公司 | Adjuvanted immunogenic composition against neisseria meningitidis b |
Family Cites Families (248)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT280356B (en) | 1968-03-06 | 1970-04-10 | Telefonbau & Normalzeit Gmbh | Circuit arrangement for controlling the capacitor of a demodulator of a time division multiplex system used for the intermediate storage of the time value of a signal |
US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
US4554101A (en) | 1981-01-09 | 1985-11-19 | New York Blood Center, Inc. | Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity |
CH660375A5 (en) | 1983-02-08 | 1987-04-15 | Sclavo Spa | PROCEDURE FOR THE PRODUCTION OF PROPHINES RELATED TO DIPHTERIC TOXIN. |
EP0138854B1 (en) | 1983-03-08 | 1992-11-04 | Chiron Mimotopes Pty. Ltd. | Antigenically active amino acid sequences |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4650764A (en) | 1983-04-12 | 1987-03-17 | Wisconsin Alumni Research Foundation | Helper cell |
US4668829A (en) * | 1984-07-18 | 1987-05-26 | University Patents, Inc. | Ferroelectric smectic liquid crystals |
JPS6147500A (en) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | Chimera monoclonal antibody and its preparation |
EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
GB8424757D0 (en) | 1984-10-01 | 1984-11-07 | Pasteur Institut | Retroviral vector |
SE8405493D0 (en) | 1984-11-01 | 1984-11-01 | Bror Morein | IMMUNOGENT COMPLEX AND KITCHEN FOR PREPARING IT AND USING IT AS IMMUNOSTIMENTING AGENTS |
FR2573436B1 (en) | 1984-11-20 | 1989-02-17 | Pasteur Institut | RECOMBINANT DNA COMPRISING A NUCLEOTIDE SEQUENCE ENCODING A DETERMINED POLYPEPTIDE UNDER THE CONTROL OF AN ADENOVIRUS PROMOTER, VECTORS CONTAINING THIS RECOMBINANT DNA, EUKARYOT CELLS TRANSFORMED BY THIS RECOMBINANT DNA, THE CONSTITUTION OF VACCINES |
JPS61134325A (en) | 1984-12-04 | 1986-06-21 | Teijin Ltd | Expression of hybrid antibody gene |
US4797368A (en) | 1985-03-15 | 1989-01-10 | The United States Of America As Represented By The Department Of Health And Human Services | Adeno-associated virus as eukaryotic expression vector |
US4666829A (en) | 1985-05-15 | 1987-05-19 | University Of California | Polypeptide marker for Alzheimer's disease and its use for diagnosis |
WO1987001130A1 (en) | 1985-08-15 | 1987-02-26 | Stauffer Chemical Company | Tryptophan producing microorganism |
US5078996A (en) | 1985-08-16 | 1992-01-07 | Immunex Corporation | Activation of macrophage tumoricidal activity by granulocyte-macrophage colony stimulating factor |
US5139941A (en) | 1985-10-31 | 1992-08-18 | University Of Florida Research Foundation, Inc. | AAV transduction vectors |
WO1987002671A1 (en) | 1985-11-01 | 1987-05-07 | International Genetic Engineering, Inc. | Modular assembly of antibody genes, antibodies prepared thereby and use |
US4861719A (en) | 1986-04-25 | 1989-08-29 | Fred Hutchinson Cancer Research Center | DNA constructs for retrovirus packaging cell lines |
US5514581A (en) * | 1986-11-04 | 1996-05-07 | Protein Polymer Technologies, Inc. | Functional recombinantly prepared synthetic protein polymer |
US4980289A (en) | 1987-04-27 | 1990-12-25 | Wisconsin Alumni Research Foundation | Promoter deficient retroviral vector |
US5057540A (en) | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
RU2023448C1 (en) | 1987-07-30 | 1994-11-30 | Сентро Насьональ Де Биопрепарадос | Method for manufacturing vaccine against various pathogenic serotypes of group b neisser's meningitis |
JPH01144977A (en) | 1987-11-30 | 1989-06-07 | Agency Of Ind Science & Technol | Novel recombinant plasmid ptpgif2 |
WO1989007150A1 (en) | 1988-02-05 | 1989-08-10 | The Trustees Of Columbia University In The City Of | Retroviral packaging cell lines and processes of using same |
US4912094B1 (en) | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
WO1990002806A1 (en) | 1988-09-01 | 1990-03-22 | Whitehead Institute For Biomedical Research | Recombinant retroviruses with amphotropic and ecotropic host ranges |
US7118757B1 (en) * | 1988-12-19 | 2006-10-10 | Wyeth Holdings Corporation | Meningococcal class 1 outer-membrane protein vaccine |
US5124263A (en) | 1989-01-12 | 1992-06-23 | Wisconsin Alumni Research Foundation | Recombination resistant retroviral helper cell and products produced thereby |
EP0462210B1 (en) * | 1989-03-09 | 1994-09-07 | Praxis Biologics, Inc. | Vaccines for nontypable haemophilus influenzae |
US5354844A (en) | 1989-03-16 | 1994-10-11 | Boehringer Ingelheim International Gmbh | Protein-polycation conjugates |
US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
CA2017507C (en) | 1989-05-25 | 1996-11-12 | Gary Van Nest | Adjuvant formulation comprising a submicron oil droplet emulsion |
US5399346A (en) | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
US5585362A (en) | 1989-08-22 | 1996-12-17 | The Regents Of The University Of Michigan | Adenovirus vectors for gene therapy |
CA2039921A1 (en) | 1990-04-16 | 1991-10-17 | Xandra O. Breakefield | Transfer and expression of gene sequences into central nervous system cells using herpes simplex virus mutants with deletions in genes for viral replication |
US5264618A (en) | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
WO1991018088A1 (en) | 1990-05-23 | 1991-11-28 | The United States Of America, Represented By The Secretary, United States Department Of Commerce | Adeno-associated virus (aav)-based eucaryotic vectors |
EP0467714A1 (en) | 1990-07-19 | 1992-01-22 | Merck & Co. Inc. | The class II protein of the outer membrane of neisseria meningitidis |
JPH0453645U (en) * | 1990-09-12 | 1992-05-07 | ||
DK0550553T3 (en) | 1990-09-25 | 2000-10-23 | Cantab Pharma Res | Viral defective vaccine made from a trans-complementing cell line |
US5173414A (en) | 1990-10-30 | 1992-12-22 | Applied Immune Sciences, Inc. | Production of recombinant adeno-associated virus vectors |
IL101715A (en) | 1991-05-02 | 2005-06-19 | Amgen Inc | Recombinant dna-derived cholera toxin subunit analogs |
WO1993007897A1 (en) | 1991-10-21 | 1993-04-29 | Medimmune, Inc. | Bacterial expression vectors containing dna encoding secretion signals of lipoproteins |
US5252479A (en) | 1991-11-08 | 1993-10-12 | Research Corporation Technologies, Inc. | Safe vector for gene therapy |
IT1253009B (en) | 1991-12-31 | 1995-07-10 | Sclavo Ricerca S R L | DETOXIFIED IMMUNOGENIC MUTANTS OF COLERIC TOXIN AND TOXIN LT, THEIR PREPARATION AND USE FOR THE PREPARATION OF VACCINES |
WO1993015115A1 (en) * | 1992-01-24 | 1993-08-05 | Cornell Research Foundation, Inc. | E. coli dna polymerase iii holoenzyme and subunits |
EP0905253A3 (en) | 1992-12-03 | 2000-11-02 | Genzyme Corporation | Adenoviral vector deleted of all E4-ORF except ORF6 |
DE69434079T2 (en) | 1993-03-05 | 2005-02-24 | Wyeth Holdings Corp. | Plasmid for the production of CRM protein and diphtheria toxin |
JPH08507784A (en) | 1993-03-19 | 1996-08-20 | キャンタブ ファーマシューティカルズ リサーチ リミティド | Virus vaccine |
DK0624376T3 (en) | 1993-05-13 | 2000-07-24 | American Cyanamid Co | Preparation and use of LOS-depleted outer membrane proteins of gram-negative cocci |
FR2705361B1 (en) | 1993-05-18 | 1995-08-04 | Centre Nat Rech Scient | Viral vectors and use in gene therapy. |
FR2705686B1 (en) | 1993-05-28 | 1995-08-18 | Transgene Sa | New defective adenoviruses and corresponding complementation lines. |
JP4190028B2 (en) | 1993-07-13 | 2008-12-03 | アベンテイス・フアルマ・ソシエテ・アノニム | Defective recombinant adenovirus vector and use in gene therapy |
US5439808A (en) * | 1993-07-23 | 1995-08-08 | North American Vaccine, Inc. | Method for the high level expression, purification and refolding of the outer membrane group B porin proteins from Neisseria meningitidis |
AU7477394A (en) | 1993-07-30 | 1995-03-27 | University Of Medicine And Dentistry Of New Jersey | Efficient gene transfer into primary lymphocytes |
FR2708622B1 (en) | 1993-08-02 | 1997-04-18 | Raymond Hamers | Recombinant vector containing a sequence of a structural lipoprotein gene for the expression of nucleotide sequences. |
US5550213A (en) * | 1993-12-27 | 1996-08-27 | Rutgers, The State University Of New Jersey | Inhibitors of urokinase plasminogen activator |
FR2714830B1 (en) | 1994-01-10 | 1996-03-22 | Rhone Poulenc Rorer Sa | Composition containing nucleic acids, preparation and uses. |
FR2715847B1 (en) | 1994-02-08 | 1996-04-12 | Rhone Poulenc Rorer Sa | Composition containing nucleic acids, preparation and uses. |
FI98045C (en) | 1994-02-21 | 1997-04-10 | Arto Remes | Device for incontinence treatment |
FR2716459B1 (en) | 1994-02-22 | 1996-05-10 | Univ Paris Curie | Host-vector system usable in gene therapy. |
WO1995026411A2 (en) | 1994-03-25 | 1995-10-05 | The Uab Research Foundation | Composition and methods for creating syngeneic recombinant virus-producing cells |
US5739118A (en) | 1994-04-01 | 1998-04-14 | Apollon, Inc. | Compositions and methods for delivery of genetic material |
JPH10501963A (en) | 1994-04-15 | 1998-02-24 | ターゲテッド ジェネティクス コーポレイション | Gene delivery fusion protein |
US5571515A (en) | 1994-04-18 | 1996-11-05 | The Wistar Institute Of Anatomy & Biology | Compositions and methods for use of IL-12 as an adjuvant |
ATE173634T1 (en) * | 1994-04-20 | 1998-12-15 | Us Army | VACCINE AGAINST GRAM-NEGATIVE BACTERIAL INFECTIONS |
US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
US5565204A (en) | 1994-08-24 | 1996-10-15 | American Cyanamid Company | Pneumococcal polysaccharide-recombinant pneumolysin conjugate vaccines for immunization against pneumococcal infections |
US5837533A (en) | 1994-09-28 | 1998-11-17 | American Home Products Corporation | Complexes comprising a nucleic acid bound to a cationic polyamine having an endosome disruption agent |
GB9422096D0 (en) | 1994-11-02 | 1994-12-21 | Biocine Spa | Combined meningitis vaccine |
FR2727679B1 (en) | 1994-12-05 | 1997-01-03 | Rhone Poulenc Rorer Sa | NEW TRANSFECTION AGENTS AND THEIR PHARMACEUTICAL APPLICATIONS |
BE1008978A5 (en) | 1994-12-27 | 1996-10-01 | Solvay | Adjuvants for vaccines. |
IL116816A (en) | 1995-01-20 | 2003-05-29 | Rhone Poulenc Rorer Sa | Cell for the production of a defective recombinant adenovirus or an adeno-associated virus and the various uses thereof |
FR2730637B1 (en) | 1995-02-17 | 1997-03-28 | Rhone Poulenc Rorer Sa | PHARMACEUTICAL COMPOSITION CONTAINING NUCLEIC ACIDS, AND USES THEREOF |
IL117483A (en) | 1995-03-17 | 2008-03-20 | Bernard Brodeur | Proteinase k resistant surface protein of neisseria meningitidis |
AU6043396A (en) | 1995-06-05 | 1996-12-24 | University Of Alabama At Birmingham Research Foundation, The | Composition and methods for creating syngeneic recombinant v irus-producing cells |
EP1741718A3 (en) * | 1995-06-07 | 2007-03-28 | Sanofi Pasteur Inc. | Expression of lipoproteins |
FR2741358B1 (en) | 1995-11-17 | 1998-01-02 | Centre Nat Rech Scient | PRODUCTION OF RETROVIRAL VECTORS VIA DNA VIRUS-BASED VIRAL VECTORS |
CU22559A1 (en) * | 1996-01-17 | 1999-05-03 | Ct Ingenieria Genetica Biotech | EXPRESSION SYSTEM OF HETEROLOGICAL ANTIGENS IN E. COLI AS FUSION PROTEINS |
US6355255B1 (en) | 1998-12-07 | 2002-03-12 | Regents Of The University Of Minnesota | Streptococcal C5a peptidase vaccine |
US5846547A (en) | 1996-01-22 | 1998-12-08 | Regents Of The University Of Minnesota | Streptococcal C5a peptidase vaccine |
ATE252602T1 (en) | 1996-08-27 | 2003-11-15 | Chiron Corp | MENINGOCOCCUS B-EPITOPE MONOCLONAL ANTIBODIES AND THEIR USE FOR PREPARING VACCINE COMPOSITIONS |
CA2264735C (en) | 1996-08-27 | 2008-01-29 | Chiron Corporation | Neisseria meningitidis serogroup b glycoconjugates and methods of using the same |
US6472518B1 (en) | 1996-10-24 | 2002-10-29 | Centers For Disease Control And Prevention, As Represented By The Secretary, Department Of Health And Human Services | Invasion associated genes from Neisseria meningitidis serogroup B |
GB9622159D0 (en) | 1996-10-24 | 1996-12-18 | Solvay Sociutu Anonyme | Polyanionic polymers as adjuvants for mucosal immunization |
GB9622660D0 (en) | 1996-10-31 | 1997-01-08 | Biocine Spa | Immunogenic detoxified mutant toxin |
US6113918A (en) | 1997-05-08 | 2000-09-05 | Ribi Immunochem Research, Inc. | Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors |
DE19723095C2 (en) | 1997-06-02 | 2001-08-23 | Siemens Ag | Image reconstruction method for a computer tomograph |
AU8730798A (en) | 1997-06-30 | 1999-01-25 | Aventis Pharma S.A. | Device for optimized electrotransfer of nucleic acid vectors to tissues in vivo |
PL337584A1 (en) | 1997-06-30 | 2000-08-28 | Rhone Poulenc Rorer Sa | Improved method of transferring nucleic acid to eucariotic cells of multiple-cell organisms and connection enabling accomplishment of this method |
CZ299473B6 (en) | 1997-06-30 | 2008-08-06 | Rhone-Poulenc Rorer S. A. | Nucleic acid and electric field as associated product for transfer of nucleic acid into cells of adversely stripped musculature |
WO1999003501A1 (en) * | 1997-07-17 | 1999-01-28 | North American Vaccine, Inc. | Immunogenic conjugates comprising a group b meningococcal porin and an h. influenzae polysaccharide |
JPH1144977A (en) | 1997-07-25 | 1999-02-16 | Copyer Co Ltd | Image forming device |
US6030619A (en) | 1997-08-27 | 2000-02-29 | Chiron Corporation | Molecular mimetics of meningococcal B epitopes |
KR20010023451A (en) * | 1997-08-29 | 2001-03-26 | 그래햄 이. 테일러 | Homogeneous filled polymer composite |
ATE476508T1 (en) | 1997-11-06 | 2010-08-15 | Novartis Vaccines & Diagnostic | NEISSERIAL ANTIGENS |
TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
BR9906927A (en) | 1998-01-14 | 2001-11-20 | Chiron Spa | Neisseria meningitidis proteins |
DK1053329T3 (en) * | 1998-02-03 | 2010-01-25 | Ct Disease Contr & Prevention | Recombinant lipidized PsaA protein, methods of preparation and use |
GB9806456D0 (en) | 1998-03-25 | 1998-05-27 | Smithkline Beecham Biolog | Vaccine composition |
GB9808734D0 (en) | 1998-04-23 | 1998-06-24 | Smithkline Beecham Biolog | Novel compounds |
GB9808932D0 (en) | 1998-04-27 | 1998-06-24 | Chiron Spa | Polyepitope carrier protein |
BR9910089A (en) | 1998-05-01 | 2004-06-08 | Chiron Corp | Compositions and antigens of neisseria meningitidis |
US8007815B1 (en) | 1998-05-29 | 2011-08-30 | Novartis Ag | Combination meningitidis B/C vaccines |
CA2344740C (en) | 1998-09-30 | 2011-11-22 | American Cyanamid Company | Mutant cholera holotoxin as an adjuvant |
ATE274353T1 (en) * | 1998-09-30 | 2004-09-15 | Us Army | USE OF PURIFIED INVAPLEX AS A VACCINE FOR GRAM NEGATIVE BACTERIA |
MXPA01003557A (en) | 1998-10-09 | 2004-04-05 | Chiron Corp | Neisseria genomic sequences and methods of their use. |
US6660843B1 (en) * | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
US6281337B1 (en) | 1998-11-12 | 2001-08-28 | Schering Corporation | Methods for conversion of protein isoforms |
JP2004537954A (en) | 1999-01-15 | 2004-12-24 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | Neisseria meningitidis polypeptide BASB052 |
AU2292800A (en) | 1999-01-22 | 2000-08-07 | Smithkline Beecham Biologicals (Sa) | Neisseria meningitidis antigenic polypeptides, corresponding polynucleotides andprotective antibodies |
GB9902084D0 (en) * | 1999-01-29 | 1999-03-24 | Smithkline Beecham Biolog | Novel compounds |
AU764138B2 (en) | 1999-02-05 | 2003-08-14 | Merck Sharp & Dohme Corp. | Human papilloma virus vaccine formulations |
ES2228454T3 (en) | 1999-02-26 | 2005-04-16 | Chiron S.R.L. | IMPROVEMENT OF THE BACTERIAL ACTIVITY OF NEISSERIA ANTIGENS WITH OLIGONUCLEOTIDES CONTAINING MOTIVES CG. |
US6245568B1 (en) | 1999-03-26 | 2001-06-12 | Merck & Co., Inc. | Human papilloma virus vaccine with disassembled and reassembled virus-like particles |
US7115730B1 (en) | 1999-04-27 | 2006-10-03 | Chiron Srl | Immunogenic detoxified mutant E. coli LT-A-toxin |
EP1605061A1 (en) | 1999-04-30 | 2005-12-14 | Chiron Corporation | Neisseria genomic sequences and methods of their use |
EP1228217B1 (en) | 1999-04-30 | 2012-11-21 | Novartis Vaccines and Diagnostics S.r.l. | Conserved neisserial antigens |
WO2000071725A2 (en) * | 1999-05-19 | 2000-11-30 | Chiron S.P.A. | Combination neisserial compositions |
GB9911683D0 (en) | 1999-05-19 | 1999-07-21 | Chiron Spa | Antigenic peptides |
GB9916529D0 (en) | 1999-07-14 | 1999-09-15 | Chiron Spa | Antigenic peptides |
GB9918319D0 (en) * | 1999-08-03 | 1999-10-06 | Smithkline Beecham Biolog | Vaccine composition |
US7384640B1 (en) | 1999-09-30 | 2008-06-10 | Wyeth Holdings Corporation | Mutant cholera holotoxin as an adjuvant |
AU784203B2 (en) | 1999-10-29 | 2006-02-23 | Glaxosmithkline Biologicals S.A. | Neisserial antigenic peptides |
ATE460484T1 (en) | 1999-11-29 | 2010-03-15 | Novartis Vaccines & Diagnostic | 85 KDA ANTIGEN OF NEISSERIA |
GB9928196D0 (en) * | 1999-11-29 | 2000-01-26 | Chiron Spa | Combinations of B, C and other antigens |
DE60039450D1 (en) | 1999-12-02 | 2008-08-21 | Novartis Vaccines & Diagnostic | COMPOSITIONS AND METHODS FOR STABILIZING BIOLOGICAL MOLECULES AFTER LYOPHILIZATION |
DK1248647T3 (en) * | 2000-01-17 | 2010-09-27 | Novartis Vaccines & Diagnostic | Outer membrane vesicle (OMV) vaccine comprising N. meningitidis serogroup B outer membrane proteins |
RU2299906C2 (en) | 2000-02-28 | 2007-05-27 | Новартис Вэксинс Энд Диагностикс С.Р.Л. | Heterologous expression of neisseria proteins |
AU2001281812B2 (en) | 2000-06-08 | 2005-04-07 | Valneva Austria Gmbh | Immunostimulatory oligodeoxynucleotides |
AT410635B (en) | 2000-10-18 | 2003-06-25 | Cistem Biotechnologies Gmbh | VACCINE COMPOSITION |
AP1897A (en) | 2001-01-23 | 2008-10-10 | Aventis Pasteur | Multivalent Meningococcal polysaccharide-Protein Conjugate Vaccine. |
GB0103424D0 (en) | 2001-02-12 | 2001-03-28 | Chiron Spa | Gonococcus proteins |
EP1373314A2 (en) | 2001-03-30 | 2004-01-02 | Geneprot, Inc. | Human arginine-rich protein-related compositions |
WO2002083710A2 (en) | 2001-04-13 | 2002-10-24 | Wyeth Holdings Corporation | Removal of bacterial endotoxin in a protein solution by immobilized metal affinity chromatography |
AU2002252638A1 (en) | 2001-04-17 | 2002-10-28 | Children's Hospital Oakland Research Institute | Molecular mimetics of meningococcal b epitopes which elicit functionally active antibodies |
MXPA03011135A (en) | 2001-06-07 | 2004-09-08 | Wyeth Corp | Mutant forms of cholera holotoxin as an adjuvant. |
AU2002346249B2 (en) | 2001-06-07 | 2007-03-15 | The Regents Of The University Of Colorado | Mutant Forms of Cholera Holotoxin as an Adjuvant |
GB0115176D0 (en) | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
AU2002330681C1 (en) | 2001-07-26 | 2015-04-02 | Glaxosmithkline Biologicals S.A. | Vaccines comprising aluminium adjuvants and histidine |
GB0121591D0 (en) | 2001-09-06 | 2001-10-24 | Chiron Spa | Hybrid and tandem expression of neisserial proteins |
US20070020622A1 (en) | 2001-09-14 | 2007-01-25 | Invitrogen Corporation | DNA Polymerases and mutants thereof |
MX339524B (en) * | 2001-10-11 | 2016-05-30 | Wyeth Corp | Novel immunogenic compositions for the prevention and treatment of meningococcal disease. |
GB0129007D0 (en) | 2001-12-04 | 2002-01-23 | Chiron Spa | Adjuvanted antigenic meningococcal compositions |
ES2318117T3 (en) | 2002-03-26 | 2009-05-01 | Novartis Vaccines And Diagnostics S.R.L. | MODIFIED SALADS THAT HAVE IMPROVED STABILITY IN WATER. |
GB0302218D0 (en) | 2003-01-30 | 2003-03-05 | Chiron Sri | Vaccine formulation & Mucosal delivery |
DE60328481D1 (en) | 2002-05-14 | 2009-09-03 | Novartis Vaccines & Diagnostic | SLEEP-CAPACITIVE VACCINE CONTAINING THE ADJUVANZ CHITOSAN AND MENIGOKOKKENANTIGENE |
MXPA04011248A (en) | 2002-05-14 | 2005-02-17 | Chiron Srl | Mucosal combination vaccines for bacterial meningitis. |
GB0220198D0 (en) | 2002-08-30 | 2002-10-09 | Chiron Spa | Modified saccharides,conjugates thereof and their manufacture |
GB0220194D0 (en) | 2002-08-30 | 2002-10-09 | Chiron Spa | Improved vesicles |
US7785608B2 (en) * | 2002-08-30 | 2010-08-31 | Wyeth Holdings Corporation | Immunogenic compositions for the prevention and treatment of meningococcal disease |
PT2353608T (en) | 2002-10-11 | 2020-03-11 | Novartis Vaccines And Diagnostics S R L | Polypeptide-vaccines for broad protection against hypervirulent meningococcal lineages |
EP1562982B1 (en) | 2002-11-15 | 2010-05-05 | Novartis Vaccines and Diagnostics S.r.l. | Unexpected surface proteins in neisseria meningitidis |
GB0227346D0 (en) | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
CA2512917A1 (en) * | 2003-01-15 | 2004-08-05 | Wyeth Holdings Corporation | Methods for increasing neisseria protein expression |
US10272147B2 (en) | 2003-01-30 | 2019-04-30 | Glaxosmithkline Biologicals S.A. | Injectable vaccines against multiple meningococcal serogroups |
CA2519511A1 (en) | 2003-03-17 | 2004-09-30 | Wyeth Holdings Corporation | Mutant cholera holotoxin as an adjuvant and an antigen carrier protein |
KR20060019515A (en) | 2003-04-16 | 2006-03-03 | 와이어쓰 홀딩스 코포레이션 | Novel immunogenic compositions for the prevention and treatment of meningococcal disease |
JP5557415B2 (en) | 2003-06-02 | 2014-07-23 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | Immunogenic compositions based on microparticles containing adsorbed toxoid and polysaccharide-containing antigens |
EP2364725A3 (en) | 2003-06-23 | 2012-05-09 | Sanofi Pasteur Inc. | Immunization method against neisseria meningitidis serogroups a and c |
GB0316560D0 (en) | 2003-07-15 | 2003-08-20 | Chiron Srl | Vesicle filtration |
GB0323103D0 (en) | 2003-10-02 | 2003-11-05 | Chiron Srl | De-acetylated saccharides |
PT1961426E (en) | 2003-10-02 | 2011-06-28 | Novartis Vaccines & Diagnostic | Combined meningitis vaccines |
EP1699482A2 (en) | 2003-12-30 | 2006-09-13 | Wyeth | Formulations of hydrophobic proteins in an immunogenic composition having improved tolerability |
GB0406013D0 (en) | 2004-03-17 | 2004-04-21 | Chiron Srl | Analysis of saccharide vaccines without interference |
GB0408978D0 (en) | 2004-04-22 | 2004-05-26 | Chiron Srl | Meningococcal fermentation for preparing conjugate vaccines |
GB0408977D0 (en) | 2004-04-22 | 2004-05-26 | Chiron Srl | Immunising against meningococcal serogroup Y using proteins |
GB0500787D0 (en) | 2005-01-14 | 2005-02-23 | Chiron Srl | Integration of meningococcal conjugate vaccination |
GB0409745D0 (en) | 2004-04-30 | 2004-06-09 | Chiron Srl | Compositions including unconjugated carrier proteins |
PL1740217T3 (en) | 2004-04-30 | 2012-03-30 | Novartis Ag | Meningococcal conjugate vaccination |
GB0410220D0 (en) | 2004-05-07 | 2004-06-09 | Kirkham Lea Ann | Mutant pneumolysin proteins |
GB0411387D0 (en) | 2004-05-21 | 2004-06-23 | Chiron Srl | Analysis of saccharide length |
GB0413868D0 (en) | 2004-06-21 | 2004-07-21 | Chiron Srl | Dimensional anlaysis of saccharide conjugates |
ATE493437T1 (en) | 2004-07-23 | 2011-01-15 | Novartis Vaccines & Diagnostic | POLYPEPTIDES FOR OLIGOMERIZATION OF ANTIGENS |
GB0419408D0 (en) | 2004-09-01 | 2004-10-06 | Chiron Srl | 741 chimeric polypeptides |
GB0419846D0 (en) | 2004-09-07 | 2004-10-13 | Chiron Srl | Vaccine adjuvants for saccharides |
GB0424092D0 (en) | 2004-10-29 | 2004-12-01 | Chiron Srl | Immunogenic bacterial vesicles with outer membrane proteins |
GB0428394D0 (en) | 2004-12-24 | 2005-02-02 | Chiron Srl | Saccharide conjugate vaccines |
NZ555937A (en) | 2005-01-27 | 2009-05-31 | Childrens Hosp & Res Ct Oak | GNA1870-based vesicle vaccines for broad spectrum protection against diseases caused by Neisseria meningitidis |
US20070014842A1 (en) | 2005-03-07 | 2007-01-18 | Denis Martin | Pharmaceutical liposomal compositions |
MX2007013881A (en) | 2005-05-06 | 2008-10-22 | Novartis Vaccines & Diagnostic | Immunogens for meningitidis-a vaccines. |
ATE536884T1 (en) | 2005-06-27 | 2011-12-15 | Glaxosmithkline Biolog Sa | IMMUNOGENIC COMPOSITION |
WO2007026249A2 (en) | 2005-09-01 | 2007-03-08 | Novartis Vaccines And Diagnostics Gmbh & Co Kg | Multiple vaccination including serogroup c meningococcus |
JP5047969B2 (en) | 2005-09-05 | 2012-10-10 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | Serum bactericidal assay for meningococcal specific antiserum |
GB0524066D0 (en) | 2005-11-25 | 2006-01-04 | Chiron Srl | 741 ii |
EP1940462A2 (en) | 2005-12-23 | 2008-07-09 | GlaxoSmithKline Biologicals S.A. | Conjugate vaccines |
EP2357001B1 (en) | 2006-03-22 | 2018-03-07 | GlaxoSmithKline Biologicals S.A. | Regimens for immunisation with meningococcal conjugates |
TW200806315A (en) | 2006-04-26 | 2008-02-01 | Wyeth Corp | Novel formulations which stabilize and inhibit precipitation of immunogenic compositions |
US20070253985A1 (en) | 2006-04-26 | 2007-11-01 | Wyeth | Novel processes for coating container means which inhibit precipitation of polysaccharide-protein conjugate formulations |
WO2007144316A2 (en) | 2006-06-12 | 2007-12-21 | Glaxosmithkline Biologicals Sa | Vaccine |
GB0612854D0 (en) | 2006-06-28 | 2006-08-09 | Novartis Ag | Saccharide analysis |
RU2450019C2 (en) | 2006-06-29 | 2012-05-10 | Новартис Аг | Neisseria meningitidis polypeptides |
SG174013A1 (en) | 2006-07-27 | 2011-09-29 | Wyeth Corp | High-cell density fed-batch fermentation process for producing recombinant protein |
AR064642A1 (en) * | 2006-12-22 | 2009-04-15 | Wyeth Corp | POLINUCLEOTIDE VECTOR THAT INCLUDES IT RECOMBINATING CELL THAT UNDERSTANDS THE VECTOR POLYPEPTIDE, ANTIBODY, COMPOSITION THAT UNDERSTANDS THE POLINUCLEOTIDE, VECTOR, RECOMBINATING CELL POLYPEPTIDE OR ANTIBODY, USE OF THE COMPOSITION AND A COMPOSITION AND A METHOD |
GB0700562D0 (en) | 2007-01-11 | 2007-02-21 | Novartis Vaccines & Diagnostic | Modified Saccharides |
BRPI0811979A2 (en) | 2007-06-04 | 2014-10-21 | Novartis Ag | FORMULATION FOR MENINGITIS VACCINES |
GB0713880D0 (en) | 2007-07-17 | 2007-08-29 | Novartis Ag | Conjugate purification |
GB0714963D0 (en) | 2007-08-01 | 2007-09-12 | Novartis Ag | Compositions comprising antigens |
WO2009038889A1 (en) * | 2007-08-02 | 2009-03-26 | Children's Hospital And Research Center At Oakland | Fhbp- and lpxl1-based vesicle vaccines for broad spectrum protection against diseases caused by neisseria meningitidis |
ATE553774T1 (en) | 2007-10-19 | 2012-05-15 | Novartis Ag | MENINGOCOCCAL VACCINE FORMULATIONS |
US9579372B2 (en) | 2008-02-21 | 2017-02-28 | Glaxosmithkline Biologicals Sa | Meningococcal fHBP polypeptides |
EP2589392B1 (en) | 2008-03-05 | 2016-11-30 | Sanofi Pasteur | Process for stabilizing an adjuvant containing vaccine composition |
CA2717870A1 (en) * | 2008-03-10 | 2009-09-17 | Children's Hospital & Research Center At Oakland | Chimeric factor h binding proteins (fhbp) containing a heterologous b domain and methods of use |
US20100035234A1 (en) | 2008-05-19 | 2010-02-11 | Novartis Ag | Vaccine assays |
US9387239B2 (en) | 2008-05-30 | 2016-07-12 | U.S. Army Medical Research And Materiel Command | Meningococcal multivalent native outer membrane vesicle vaccine, methods of making and use thereof |
US8476032B2 (en) | 2008-08-27 | 2013-07-02 | Children's Hospital & Research Center Oakland | Complement factor H-based assays for serum bactericidal activity against Neisseria meningitidis |
AU2009288095A1 (en) | 2008-09-03 | 2010-03-11 | Children's Hospital & Research Center At Oakland | Peptides presenting an epitope of a domain of factor H binding protein and methods of use |
IT1394288B1 (en) | 2008-09-12 | 2012-06-06 | Novartis Vaccines & Diagnostic | PROTEIN IMMUNOGENES THAT LINK THE FACTOR H. |
US9393304B2 (en) | 2008-10-29 | 2016-07-19 | Ablynx N.V. | Formulations of single domain antigen binding molecules |
GB0822634D0 (en) | 2008-12-11 | 2009-01-21 | Novartis Ag | Meningitis vaccines |
JP5410084B2 (en) * | 2008-12-15 | 2014-02-05 | 川上産業株式会社 | Packing box and box-shaped core |
AU2009329193A1 (en) | 2008-12-17 | 2011-07-14 | Novartis Ag | Meningococcal vaccines including hemoglobin receptor |
CN102438649A (en) | 2009-03-24 | 2012-05-02 | 诺华有限公司 | Meningococcal factor H binding proteins and pneumococcal binding saccharides |
CA2756522C (en) | 2009-03-24 | 2018-06-26 | Novartis Ag | Adjuvanting meningococcal factor h binding protein |
AU2010242905B2 (en) | 2009-04-30 | 2014-10-23 | Children's Hospital & Research Center At Oakland | Chimeric factor H binding proteins (fHbp) and methods of use |
US9365885B2 (en) | 2009-06-16 | 2016-06-14 | Puiying Annie Mak | High-throughput complement-mediated antibody-dependent and opsonic bactericidal assays |
EP2470204B1 (en) | 2009-08-27 | 2015-12-16 | GlaxoSmithKline Biologicals SA | Hybrid polypeptides including meningococcal fhbp sequences |
IT1395574B1 (en) | 2009-09-14 | 2012-10-16 | Guala Dispensing Spa | DISTRIBUTION DEVICE |
AU2010302344A1 (en) | 2009-09-30 | 2012-04-26 | Novartis Ag | Expression of meningococcal fhbp polypeptides |
GB0917647D0 (en) | 2009-10-08 | 2009-11-25 | Glaxosmithkline Biolog Sa | Expression system |
JP3158225U (en) * | 2009-10-22 | 2010-03-25 | 王 文燦 | Folding storage bag |
WO2011051893A1 (en) | 2009-10-27 | 2011-05-05 | Novartis Ag | Modified meningococcal fhbp polypeptides |
EP2519265B1 (en) | 2009-12-30 | 2018-11-14 | GlaxoSmithKline Biologicals SA | Polysaccharide immunogens conjugated to e. coli carrier proteins |
GB201003922D0 (en) | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Conjugation process |
JP2013521327A (en) | 2010-03-10 | 2013-06-10 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | Immunogenic composition |
WO2012020326A1 (en) | 2010-03-18 | 2012-02-16 | Novartis Ag | Adjuvanted vaccines for serogroup b meningococcus |
ES2910199T3 (en) | 2010-03-30 | 2022-05-11 | Childrens Hospital & Res Center At Oakland | Factor H-binding proteins (fHbp) with altered properties and methods of using them |
CA2803239A1 (en) | 2010-06-25 | 2011-12-29 | Novartis Ag | Combinations of meningococcal factor h binding proteins |
HRP20240965T1 (en) | 2010-08-23 | 2024-10-25 | Wyeth Llc | Stable formulations of neisseria meningitidis rlp2086 antigens |
ES2744471T3 (en) | 2010-09-04 | 2020-02-25 | Glaxosmithkline Biologicals Sa | Bactericidal antibody assays to assess immunogenesis and potency of meningococcal capsular saccharide vaccines |
US20120070457A1 (en) | 2010-09-10 | 2012-03-22 | J. Craig Venter Institute, Inc. | Polypeptides from neisseria meningitidis |
GB201015132D0 (en) | 2010-09-10 | 2010-10-27 | Univ Bristol | Vaccine composition |
PE20140173A1 (en) | 2010-09-10 | 2014-02-20 | Wyeth Llc | NON-LIPIDED VARIANTS OF NEISSERIA MENINGITIDIS ANTIGENS ORF2086 |
EP2613805B1 (en) | 2010-09-10 | 2019-10-23 | GlaxoSmithKline Biologicals SA | Meningococcus overexpressing nada and/or nhba and outer membrane vesicles derived therefrom |
GB201101665D0 (en) | 2011-01-31 | 2011-03-16 | Novartis Ag | Immunogenic compositions |
CN103533954B (en) | 2011-03-02 | 2015-09-09 | 诺华股份有限公司 | Contain compared with the antigen of low dosage and/or the combined vaccine of adjuvant |
WO2012134975A1 (en) | 2011-03-28 | 2012-10-04 | St. Jude Children's Research Hospital | Methods and compositions employing immunogenic fusion proteins |
SG10201602558UA (en) | 2012-03-09 | 2016-05-30 | Pfizer | Neisseria meningitidis compositions and methods thereof |
SA115360586B1 (en) | 2012-03-09 | 2017-04-12 | فايزر انك | Neisseria meningitidis compositions and methods thereof |
US9802987B2 (en) | 2013-03-08 | 2017-10-31 | Pfizer Inc. | Immunogenic fusion polypeptides |
US9965924B2 (en) | 2013-07-15 | 2018-05-08 | Ahmnon D. Moskowitz | Methods, systems, and apparatus for playing multi-zone 21 |
WO2015033251A2 (en) | 2013-09-08 | 2015-03-12 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
MX2017010705A (en) | 2015-02-19 | 2017-12-04 | Pfizer | Neisseria meningitidis compositions and methods thereof. |
SG11201906519RA (en) | 2017-01-31 | 2019-08-27 | Pfizer | Neisseria meningitidis compositions and methods thereof |
-
2001
- 2001-10-11 MX MX2012002655A patent/MX339524B/en unknown
-
2002
- 2002-10-11 ES ES10182324.3T patent/ES2549764T3/en not_active Expired - Lifetime
- 2002-10-11 CN CN028233301A patent/CN1578785B/en not_active Expired - Lifetime
- 2002-10-11 IL IL16105202A patent/IL161052A0/en active IP Right Grant
- 2002-10-11 MX MXPA04003356A patent/MXPA04003356A/en active IP Right Grant
- 2002-10-11 EP EP10182298.9A patent/EP2332961B1/en not_active Expired - Lifetime
- 2002-10-11 PT PT101823458T patent/PT2341063E/en unknown
- 2002-10-11 ES ES10182345.8T patent/ES2549765T3/en not_active Expired - Lifetime
- 2002-10-11 ES ES10182544.6T patent/ES2603532T3/en not_active Expired - Lifetime
- 2002-10-11 KR KR1020107022714A patent/KR20100121699A/en not_active Application Discontinuation
- 2002-10-11 DK DK10183020.6T patent/DK2343308T3/en active
- 2002-10-11 ES ES10182364.9T patent/ES2609039T3/en not_active Expired - Lifetime
- 2002-10-11 CA CA2463476A patent/CA2463476C/en not_active Expired - Lifetime
- 2002-10-11 PT PT101825909T patent/PT2348036E/en unknown
- 2002-10-11 EP EP10182487.8A patent/EP2371836B1/en not_active Expired - Lifetime
- 2002-10-11 DK DK10182345.8T patent/DK2341063T3/en active
- 2002-10-11 ES ES10182399.5T patent/ES2603531T3/en not_active Expired - Lifetime
- 2002-10-11 PT PT101826113T patent/PT2371838E/en unknown
- 2002-10-11 DK DK10182487.8T patent/DK2371836T3/en active
- 2002-10-11 DK DK10182590.9T patent/DK2348036T3/en active
- 2002-10-11 DK DK10182324.3T patent/DK2351767T3/en active
- 2002-10-11 ES ES10182298.9T patent/ES2593360T3/en not_active Expired - Lifetime
- 2002-10-11 ES ES10182437.3T patent/ES2532639T3/en not_active Expired - Lifetime
- 2002-10-11 ES ES02804818.9T patent/ES2568895T3/en not_active Expired - Lifetime
- 2002-10-11 DK DK10182469.6T patent/DK2341062T3/en active
- 2002-10-11 EP EP10182611.3A patent/EP2371838B1/en not_active Expired - Lifetime
- 2002-10-11 PT PT171568884T patent/PT3199539T/en unknown
- 2002-10-11 KR KR1020047005313A patent/KR101068318B1/en active IP Right Review Request
- 2002-10-11 PT PT101822989T patent/PT2332961T/en unknown
- 2002-10-11 US US10/492,427 patent/US8101194B2/en active Active
- 2002-10-11 DK DK17156888.4T patent/DK3199539T3/en active
- 2002-10-11 EP EP17156888.4A patent/EP3199539B1/en not_active Expired - Lifetime
- 2002-10-11 CN CN201210211368.3A patent/CN102755631B/en not_active Expired - Lifetime
- 2002-10-11 EP EP10182469.6A patent/EP2341062B1/en not_active Expired - Lifetime
- 2002-10-11 EP EP10182364.9A patent/EP2348034B1/en not_active Expired - Lifetime
- 2002-10-11 CA CA2894296A patent/CA2894296C/en not_active Expired - Lifetime
- 2002-10-11 DK DK10182437.3T patent/DK2348035T3/en active
- 2002-10-11 ES ES10183020.6T patent/ES2532640T3/en not_active Expired - Lifetime
- 2002-10-11 EP EP10182590.9A patent/EP2348036B1/en not_active Expired - Lifetime
- 2002-10-11 EP EP02804818.9A patent/EP1442047B1/en not_active Expired - Lifetime
- 2002-10-11 KR KR1020117022199A patent/KR101215664B1/en active IP Right Grant
- 2002-10-11 PT PT101824373T patent/PT2348035E/en unknown
- 2002-10-11 ES ES10182611.3T patent/ES2562811T3/en not_active Expired - Lifetime
- 2002-10-11 EP EP10182324.3A patent/EP2351767B1/en not_active Expired - Lifetime
- 2002-10-11 ES ES10182469.6T patent/ES2625876T3/en not_active Expired - Lifetime
- 2002-10-11 ES ES10182590.9T patent/ES2561430T3/en not_active Expired - Lifetime
- 2002-10-11 CA CA2918207A patent/CA2918207C/en not_active Expired - Lifetime
- 2002-10-11 ES ES10182487.8T patent/ES2615206T3/en not_active Expired - Lifetime
- 2002-10-11 JP JP2003563462A patent/JP2005515771A/en active Pending
- 2002-10-11 BR BRPI0212999A patent/BRPI0212999B8/en not_active IP Right Cessation
- 2002-10-11 CA CA2849427A patent/CA2849427C/en not_active Expired - Lifetime
- 2002-10-11 PT PT101824878T patent/PT2371836T/en unknown
- 2002-10-11 PT PT101830206T patent/PT2343308E/en unknown
- 2002-10-11 CA CA2939781A patent/CA2939781C/en not_active Expired - Lifetime
- 2002-10-11 DK DK10182298.9T patent/DK2332961T3/en active
- 2002-10-11 EP EP10182544.6A patent/EP2371837B1/en not_active Expired - Lifetime
- 2002-10-11 EP EP20100182437 patent/EP2348035B1/en not_active Expired - Lifetime
- 2002-10-11 EP EP20100183020 patent/EP2343308B1/en not_active Expired - Lifetime
- 2002-10-11 PT PT101824696T patent/PT2341062T/en unknown
- 2002-10-11 PT PT101823243T patent/PT2351767E/en unknown
- 2002-10-11 CN CN201511028093.XA patent/CN105617372A/en active Pending
- 2002-10-11 WO PCT/US2002/032369 patent/WO2003063766A2/en active Application Filing
- 2002-10-11 CN CN201210209882.3A patent/CN102836426B/en not_active Expired - Lifetime
- 2002-10-11 KR KR1020107002131A patent/KR101099916B1/en active IP Right Grant
- 2002-10-11 EP EP10182345.8A patent/EP2341063B1/en not_active Expired - Lifetime
- 2002-10-11 EP EP10182399.5A patent/EP2366707B1/en not_active Expired - Lifetime
- 2002-10-11 ES ES17156888T patent/ES2781213T3/en not_active Expired - Lifetime
- 2002-10-11 DK DK10182611.3T patent/DK2371838T3/en active
-
2004
- 2004-03-24 IL IL161052A patent/IL161052A/en active Protection Beyond IP Right Term
-
2009
- 2009-03-20 US US12/408,286 patent/US9107873B2/en not_active Expired - Lifetime
- 2009-03-20 US US12/408,076 patent/US20120034261A1/en not_active Abandoned
- 2009-09-10 AU AU2009213040A patent/AU2009213040C1/en active Active
-
2010
- 2010-01-18 JP JP2010007996A patent/JP5404441B2/en not_active Expired - Lifetime
-
2011
- 2011-12-21 US US13/333,123 patent/US8563006B2/en not_active Expired - Lifetime
-
2012
- 2012-04-25 US US13/455,326 patent/US9623101B2/en not_active Expired - Lifetime
- 2012-04-25 US US13/455,268 patent/US9132182B2/en not_active Expired - Lifetime
- 2012-04-25 US US13/455,518 patent/US20120308595A1/en not_active Abandoned
- 2012-05-18 AU AU2012202916A patent/AU2012202916C1/en active Active
- 2012-10-11 MX MX2015018022A patent/MX349481B/en unknown
-
2013
- 2013-04-30 HK HK13105277.8A patent/HK1178429A1/en not_active IP Right Cessation
- 2013-05-21 HK HK13106021.5A patent/HK1178800A1/en not_active IP Right Cessation
- 2013-06-05 US US13/910,187 patent/US8563007B1/en not_active Expired - Lifetime
- 2013-07-31 JP JP2013158937A patent/JP5923070B2/en not_active Expired - Lifetime
-
2014
- 2014-07-08 IL IL233545A patent/IL233545A/en active IP Right Grant
-
2015
- 2015-03-05 US US14/639,543 patent/US9168293B2/en not_active Expired - Lifetime
- 2015-05-18 JP JP2015100931A patent/JP5976880B2/en not_active Expired - Lifetime
- 2015-07-29 LU LU92786C patent/LU92786I2/en unknown
- 2015-08-06 US US14/820,452 patent/US9757444B2/en not_active Expired - Lifetime
- 2015-08-10 FR FR15C0056C patent/FR15C0056I2/en active Active
-
2016
- 2016-03-02 JP JP2016040311A patent/JP5997400B2/en not_active Expired - Lifetime
- 2016-05-31 IL IL245955A patent/IL245955B/en active IP Right Grant
- 2016-05-31 IL IL245956A patent/IL245956B/en active IP Right Grant
- 2016-07-21 JP JP2016143674A patent/JP2017025061A/en not_active Withdrawn
-
2017
- 2017-02-27 US US15/443,618 patent/US10300122B2/en not_active Expired - Lifetime
- 2017-10-11 LU LU00041C patent/LUC00041I2/en unknown
- 2017-10-11 LU LU00042C patent/LUC00042I2/en unknown
- 2017-10-11 NL NL300897C patent/NL300897I2/en unknown
- 2017-10-11 NL NL300896C patent/NL300896I2/en unknown
- 2017-10-11 LU LU00040C patent/LUC00040I2/en unknown
- 2017-10-11 NL NL300899C patent/NL300899I2/en unknown
- 2017-11-10 FR FR17C1042C patent/FR17C1042I2/en active Active
- 2017-11-10 FR FR17C1043C patent/FR17C1043I2/en active Active
- 2017-11-10 FR FR17C1044C patent/FR17C1044I2/en active Active
- 2017-11-23 BE BE2017C055C patent/BE2017C055I2/fr unknown
- 2017-11-23 BE BE2017C056C patent/BE2017C056I2/fr unknown
- 2017-11-23 BE BE2017C057C patent/BE2017C057I2/fr unknown
-
2018
- 2018-05-22 AU AU2018203627A patent/AU2018203627A1/en not_active Withdrawn
-
2019
- 2019-02-07 US US16/270,067 patent/US20190151431A1/en not_active Abandoned
-
2020
- 2020-01-07 US US16/736,619 patent/US11116829B2/en not_active Expired - Lifetime