AU2002214325A1 - Process for producing carbapenem-type antibacterial - Google Patents

Process for producing carbapenem-type antibacterial

Info

Publication number
AU2002214325A1
AU2002214325A1 AU2002214325A AU1432502A AU2002214325A1 AU 2002214325 A1 AU2002214325 A1 AU 2002214325A1 AU 2002214325 A AU2002214325 A AU 2002214325A AU 1432502 A AU1432502 A AU 1432502A AU 2002214325 A1 AU2002214325 A1 AU 2002214325A1
Authority
AU
Australia
Prior art keywords
type antibacterial
carbapenem
producing carbapenem
salt
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002214325A
Inventor
Katsuhiko Fujimoto
Takashi Kasai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Publication of AU2002214325A1 publication Critical patent/AU2002214325A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C07D477/04—Preparation by forming the ring or condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C07D477/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

A process for the preparation of a carbapenem-type antibacterial agent of formula (4) having a 1-alkylpyrrolidine structure or a salt thereof, a useful synthetic intermediate of formula (1) or a salt thereof, and a process for the preparation thereof: <CHEM> Äwherein R<1> represents a C1-C3 alkyl group, R<2> and R<3> each independently represents a hydrogen atom or the likeÜ.
AU2002214325A 2000-11-20 2001-11-19 Process for producing carbapenem-type antibacterial Abandoned AU2002214325A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2000-352178 2000-11-20
JP2000352178 2000-11-20
PCT/JP2001/010096 WO2002040482A1 (en) 2000-11-20 2001-11-19 Process for producing carbapenem-type antibacterial

Publications (1)

Publication Number Publication Date
AU2002214325A1 true AU2002214325A1 (en) 2002-05-27

Family

ID=18825114

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002214325A Abandoned AU2002214325A1 (en) 2000-11-20 2001-11-19 Process for producing carbapenem-type antibacterial

Country Status (15)

Country Link
US (2) US7034150B2 (en)
EP (1) EP1338596B1 (en)
KR (1) KR100825243B1 (en)
CN (1) CN1247581C (en)
AT (1) ATE315568T1 (en)
AU (1) AU2002214325A1 (en)
CA (1) CA2429071A1 (en)
CY (1) CY1105598T1 (en)
DE (1) DE60116656T2 (en)
DK (1) DK1338596T3 (en)
ES (1) ES2256311T3 (en)
HK (1) HK1054745A1 (en)
PT (1) PT1338596E (en)
TW (1) TWI290925B (en)
WO (1) WO2002040482A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2602097A1 (en) * 2005-03-22 2006-09-28 Daiichi Sankyo Company, Limited Process for producing carbapenem derivatives having 1-alkylpyrrolidine structure
CN101328178B (en) * 2007-06-15 2010-10-13 山东轩竹医药科技有限公司 Penem derivates containing thiophen substituted sulfhydryl pyrrolidine
CN101357919B (en) * 2007-06-22 2011-06-15 山东轩竹医药科技有限公司 Penem derivative containing sulfhydryl formamide benzenesulfonyl pyrrolidine
CN101333219B (en) * 2007-06-26 2010-10-13 山东轩竹医药科技有限公司 Penem derivates with mercapto pyrrolidine formamide benzene alkyl heterocycle
CN101367812B (en) * 2007-06-28 2011-04-27 山东轩竹医药科技有限公司 Sulfhydryl pyrrolidine formamido cyclopentene acid substituted penem derivant
CN101343271B (en) * 2007-07-13 2011-01-12 山东轩竹医药科技有限公司 Penem derivant containing isoxazole alkyl ketone
WO2011068543A1 (en) * 2009-12-04 2011-06-09 Becton, Dickinson And Company Pen needle removal device for a drug delivery device
CN102002069A (en) * 2010-11-12 2011-04-06 上海巴迪生物医药科技有限公司 Preparation method of dicyclic intermediate for synthesizing carbapenem side chains and application thereof
EP2945929B1 (en) * 2013-01-15 2020-01-22 Merck Patent GmbH Acylguanidines for the treatment of osteoarthritis

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4491541A (en) * 1982-11-10 1985-01-01 Farmitalia Carlo Erba Peptides
US4958029A (en) * 1987-01-13 1990-09-18 Banyu Pharmaceutical Co., Ltd. Process for the production of isoindoline derivatives, novel intermediates and process for their production
GB8809736D0 (en) * 1988-04-25 1988-06-02 Fujisawa Pharmaceutical Co New cephem compounds & process for preparation thereof
JP3091297B2 (en) 1992-01-10 2000-09-25 住友製薬株式会社 Pyrrolidine derivative and method for producing the same
EP0882728B1 (en) 1995-12-21 2002-09-04 Sankyo Company Limited 1-methylcarbapenem derivatives
US5952338A (en) * 1996-07-05 1999-09-14 Takeda Chemical Industries, Ltd. Agent for prophylaxis and treatment of disturbance of visual function
JP2955276B2 (en) 1997-06-19 1999-10-04 三共株式会社 Antibacterial agent containing 1-methylcarbapenem derivative
CA2294342C (en) * 1997-07-09 2006-03-14 Merck & Co., Inc. Process for synthesizing carbapenem side chain intermediates
US6063931A (en) * 1997-07-09 2000-05-16 Merck & Co., Inc. Process for synthesizing carbapenem side chain intermediates
WO2004078195A1 (en) * 2003-03-07 2004-09-16 Ajinomoto Co., Inc. Agent for converting intestinal cell into insulin-producing cell and remedy for diabetes

Also Published As

Publication number Publication date
EP1338596A4 (en) 2004-08-04
US20060009508A1 (en) 2006-01-12
US20030225055A1 (en) 2003-12-04
CN1247581C (en) 2006-03-29
EP1338596B1 (en) 2006-01-11
KR20030097793A (en) 2003-12-31
US7034150B2 (en) 2006-04-25
EP1338596A1 (en) 2003-08-27
HK1054745A1 (en) 2003-12-12
ES2256311T3 (en) 2006-07-16
KR100825243B1 (en) 2008-04-25
DK1338596T3 (en) 2006-04-18
DE60116656T2 (en) 2006-09-21
CY1105598T1 (en) 2010-07-28
US7091363B2 (en) 2006-08-15
PT1338596E (en) 2006-05-31
DE60116656D1 (en) 2006-04-06
CN1486316A (en) 2004-03-31
CA2429071A1 (en) 2002-05-23
TWI290925B (en) 2007-12-11
WO2002040482A1 (en) 2002-05-23
ATE315568T1 (en) 2006-02-15

Similar Documents

Publication Publication Date Title
MY104627A (en) A 1-pyridylimidazole derivative and its production and use.
CA2445306A1 (en) Process for preparing 4&#34;-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives
AU2001277753A1 (en) Phosphonocephem compound
AU685116B2 (en) Azolylamine derivative
EP1380564A4 (en) Binaphtol derivative and process for producing the same
CA2231052A1 (en) Benzoxazepine compounds, their production and use as lipid lowering agents
AU9281198A (en) Benzofuran derivatives
AU2722095A (en) Novel pyrrolocarbazoles
HU912649D0 (en) New tricyclic compounds production threreof and anti-microbic preparatives
AU2002214325A1 (en) Process for producing carbapenem-type antibacterial
EP1134219A4 (en) Cycloalkyl-substituted aminomethylpyrrolidine derivatives
DE60223227D1 (en) BenzoÄbÄthiophenderivate and process for their preparation
MY130488A (en) Process for preparing 3,3&#39;,6,6&#39;-tetraalkyl-2,2&#39;-biphenols and 3,3&#39;,6,6&#39;-tetraalkyl-5,5&#39;-dihalo-2,2&#39;-biphenols
HU9601701D0 (en) Aromatic hydroxamic acid compounds, process for producing them and their use
IL162788A (en) Process for preparing a tripeptide and salt thereof
AU2003248059A1 (en) NOVEL Alpha-KETOAMIDE DERIVATIVE AND USE THEREOF
WO2002051822A3 (en) Isothiazolecarboxamides as microbicides
EP1148059A4 (en) Thiazolopyrimidine compounds, process for the preparation of the same and uses thereof
AU4628399A (en) Polyhydroalkylpyrazine derivatives and their preparation and medicines containing them
AU2001225466A1 (en) Pyrimidine derivatives having antitumor effect