ATE426599T1 - Thiazolylpiperidin derivate als mtp inhibitoren - Google Patents
Thiazolylpiperidin derivate als mtp inhibitorenInfo
- Publication number
- ATE426599T1 ATE426599T1 AT04735742T AT04735742T ATE426599T1 AT E426599 T1 ATE426599 T1 AT E426599T1 AT 04735742 T AT04735742 T AT 04735742T AT 04735742 T AT04735742 T AT 04735742T AT E426599 T1 ATE426599 T1 AT E426599T1
- Authority
- AT
- Austria
- Prior art keywords
- mtp inhibitors
- thiazolylpiperidine derivatives
- thiazolylpiperidine
- derivatives
- mtp
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0307670A FR2856685B1 (fr) | 2003-06-25 | 2003-06-25 | Derives de thiazolylpiperidine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE426599T1 true ATE426599T1 (de) | 2009-04-15 |
Family
ID=33515396
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04735742T ATE426599T1 (de) | 2003-06-25 | 2004-06-02 | Thiazolylpiperidin derivate als mtp inhibitoren |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7674803B2 (de) |
| EP (1) | EP1636218B1 (de) |
| JP (1) | JP4629666B2 (de) |
| KR (1) | KR20060024812A (de) |
| CN (1) | CN1809560A (de) |
| AR (1) | AR044909A1 (de) |
| AT (1) | ATE426599T1 (de) |
| AU (1) | AU2004253649B2 (de) |
| BR (1) | BRPI0411721A (de) |
| CA (1) | CA2531011C (de) |
| DE (1) | DE602004020223D1 (de) |
| ES (1) | ES2323463T3 (de) |
| FR (1) | FR2856685B1 (de) |
| MX (1) | MXPA05013521A (de) |
| RU (1) | RU2006101890A (de) |
| TW (1) | TW200518751A (de) |
| WO (1) | WO2005003128A1 (de) |
| ZA (1) | ZA200600690B (de) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2865733B1 (fr) * | 2004-02-04 | 2007-10-12 | Merck Sante Sas | Derives de thiazolylimidazole, leurs procedes de preparation, les compositions pharmaceutiques qui les contiennent et leurs applications en medecine |
| NZ553734A (en) | 2004-09-20 | 2011-01-28 | 4Sc Ag | Novel thiazole derivatives as NF-kappaB inhibitors |
| EP1637529A1 (de) * | 2004-09-20 | 2006-03-22 | 4Sc Ag | Neue Piperidin-4-yl-Thiazol-Carboxamid-Analog als Inhibitoren für die Vermehrung von T-Zellen und ihre Verwendung |
| US7601745B2 (en) | 2004-09-27 | 2009-10-13 | 4Sc Ag | Heterocyclic NF-kB inhibitors |
| US20100267717A1 (en) * | 2005-07-29 | 2010-10-21 | 4Sc Ag | Novel Heterocyclic NF-kB Inhibitors |
| MY179032A (en) | 2004-10-25 | 2020-10-26 | Cancer Research Tech Ltd | Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors |
| TW200738701A (en) | 2005-07-26 | 2007-10-16 | Du Pont | Fungicidal carboxamides |
| JP2009502816A (ja) * | 2005-07-29 | 2009-01-29 | ４エスツェー アクチェンゲゼルシャフト | 新規ヘテロ環状ＮＦ−κＢ阻害剤 |
| WO2007020213A2 (en) * | 2005-08-18 | 2007-02-22 | F. Hoffmann-La Roche Ag | Thiazolyl piperidine derivatives useful as h3 receptor modulators |
| EP1832586A1 (de) * | 2006-03-10 | 2007-09-12 | Oridis Biomed Forschungs- und Entwicklungs GmbH | Thiazolpiperidinderivate zur Behandlung von Erkrankungen der Leber und des Pankreas |
| EP1834954A1 (de) * | 2006-03-15 | 2007-09-19 | 4Sc Ag | Thiazole als NF-kB Hemmer (Proteasom-Hemmer) |
| MX2008011696A (es) * | 2006-03-15 | 2008-11-12 | 4Sc Ag | Inhibidores de nf-kb heterociclicos novedosos. |
| WO2007115805A2 (en) * | 2006-04-05 | 2007-10-18 | European Molecular Biology Laboratory (Embl) | Aurora kinase inhibitors |
| CA2649043C (en) | 2006-04-19 | 2013-09-17 | Astellas Pharma Inc. | Azolecarboxamide derivative |
| EP3421471B1 (de) | 2006-04-25 | 2021-05-26 | Astex Therapeutics Limited | Purin- und deazapurinderivate als pharmazeutische verbindungen |
| WO2008013622A2 (en) * | 2006-07-27 | 2008-01-31 | E. I. Du Pont De Nemours And Company | Fungicidal azocyclic amides |
| US9090604B2 (en) | 2006-07-27 | 2015-07-28 | E I Du Pont De Nemours And Company | Fungicidal azocyclic amides |
| AU2007314342B2 (en) * | 2006-10-31 | 2013-02-21 | Merck Sharp & Dohme Corp. | Anilinopiperazine Derivatives and methods of use thereof |
| MX2009004791A (es) * | 2006-10-31 | 2009-08-19 | Schering Corp | Derivados de anilinopiperazina t metodos de uso de los mismos. |
| JP5498168B2 (ja) * | 2006-12-01 | 2014-05-21 | ブリストル−マイヤーズ スクイブ カンパニー | アテローム性動脈硬化および循環器疾患の治療のためのｃｅｔｐ阻害剤としてのｎ−（（３−ベンジル）−２，２−（ビス−フェニル）−プロパン−１−アミン誘導体 |
| PE20081559A1 (es) | 2007-01-12 | 2008-11-20 | Merck & Co Inc | DERIVADOS DE ESPIROCROMANONA SUSTITUIDOS COMO INHIBIDORES DE ACETIL CoA CARBOXILASA |
| CN101622245B (zh) * | 2007-01-25 | 2014-09-10 | 纳幕尔杜邦公司 | 杀真菌酰胺 |
| DE102007047735A1 (de) | 2007-10-05 | 2009-04-09 | Merck Patent Gmbh | Thiazolderivate |
| CN101861321B (zh) | 2007-10-11 | 2013-02-06 | 阿斯利康(瑞典)有限公司 | 作为蛋白激酶b抑制剂的吡咯并[2,3-d]嘧啶衍生物 |
| TWI428091B (zh) | 2007-10-23 | 2014-03-01 | Du Pont | 殺真菌劑混合物 |
| AU2008314922B2 (en) | 2007-10-24 | 2013-08-29 | Astellas Pharma Inc. | Azolecarboxamide compound or salt thereof |
| JP5230035B2 (ja) * | 2007-10-29 | 2013-07-10 | メルク・シャープ・アンド・ドーム・コーポレーション | プロテインキナーゼ阻害剤としてのチアゾール誘導体 |
| WO2009094445A2 (en) | 2008-01-25 | 2009-07-30 | E. I. Du Pont De Nemours And Company | Fungicidal hetercyclic compounds |
| BRPI0910837B1 (pt) | 2008-04-30 | 2017-03-07 | Bayer Cropscience Ag | ésteres e tioésteres tiazol-4-carboxílicos, seus usos, e método e composição para controlar fungos fitopatogênicos prejudiciais |
| BRPI0920767B1 (pt) * | 2008-10-01 | 2018-07-17 | Bayer Intellectual Property Gmbh | tiazóis substituídos por heterociclila como agentes protetores de cultura, seus usos e seus processos de preparação, composições e seu processo de preparação, e método para combate a fungos nocivos fitopatogênicos |
| MX2011005598A (es) | 2008-12-02 | 2011-06-16 | Du Pont | Compuestos heterociclicos fungicidas. |
| EP2404902A1 (de) * | 2009-03-05 | 2012-01-11 | Shionogi&Co., Ltd. | Piperidin- und pyrrolidinderivate mit npy-y5-rezeptorantagonismus |
| EP2272846A1 (de) * | 2009-06-23 | 2011-01-12 | Bayer CropScience AG | Thiazolylpiperidin Derivate als Fungizide |
| NZ597562A (en) * | 2009-08-12 | 2013-10-25 | Syngenta Participations Ag | Microbiocidal heterocycles |
| WO2011051243A1 (en) | 2009-10-29 | 2011-05-05 | Bayer Cropscience Ag | Active compound combinations |
| WO2011051244A1 (de) | 2009-10-30 | 2011-05-05 | Bayer Cropscience Ag | Heteroarylpiperidin und -piperazin derivate |
| BR112012016923A2 (pt) * | 2009-12-22 | 2015-09-01 | Syngenta Participations Ag | Derivados de pirazol |
| BR112012027762B1 (pt) * | 2010-04-28 | 2018-06-05 | Bayer Intellectual Property Gmbh | Derivados de cetoheteroarilpiperidina e - piperazina como fungicidas |
| CA2812526A1 (en) | 2010-05-06 | 2011-11-10 | Vertex Pharmaceuticals Incorporated | Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels |
| US8815775B2 (en) * | 2010-05-18 | 2014-08-26 | Bayer Cropscience Ag | Bis(difluoromethyl)pyrazoles as fungicides |
| CN104987330B (zh) * | 2011-02-01 | 2019-04-05 | 拜耳知识产权有限责任公司 | 作为杀真菌剂的杂芳基哌啶和杂芳基哌嗪衍生物 |
| DK2670752T3 (en) | 2011-02-02 | 2016-07-04 | Vertex Pharma | PYRROLOPYRAZINE SPIROCYCLIC PIPERIDINAMIDE AS ION CHANNEL MODULATORS |
| US20130317064A1 (en) * | 2011-02-10 | 2013-11-28 | Syngenta Participations Ag | Microbiocidal pyrazole derivatives |
| US10385070B2 (en) | 2011-02-18 | 2019-08-20 | Vertex Pharmaceuticals Incorporated | Chroman-spirocyclic piperidine amides as modulators of ion channels |
| MX347982B (es) | 2011-03-14 | 2017-05-22 | Vertex Pharma | Morfolina-piperidina espirociclica-amidas como moduladores de canales ionicos. |
| LT2694056T (lt) | 2011-04-01 | 2019-12-10 | Astrazeneca Ab | Terapinis gydymas |
| HRP20191982T4 (hr) | 2011-11-30 | 2023-01-06 | Astrazeneca Ab | Kombinacijsko liječenje raka |
| AU2013204533B2 (en) | 2012-04-17 | 2017-02-02 | Astrazeneca Ab | Crystalline forms |
| WO2015018027A1 (en) * | 2013-08-08 | 2015-02-12 | Merck Sharp & Dohme Corp. | Thiazole orexin receptor antagonists |
| WO2016086357A1 (en) | 2014-12-02 | 2016-06-09 | Merck Sharp & Dohme Corp. | Methyl oxazole orexin receptor antagonists |
| EP3573619A4 (de) * | 2017-01-27 | 2020-10-28 | SignalRX Pharmaceuticals, Inc. | Thienopyranone und furanopyranone als kinase-, bromodomänen- und checkpoint-inhibitoren |
| EP3615087B1 (de) * | 2017-04-28 | 2023-09-06 | Texas Children's Hospital | Zielgerichtete nanopartikel |
| CN111196805A (zh) * | 2018-11-17 | 2020-05-26 | 曲阜德禄生物科技有限公司 | 哌啶基噻唑甲酰胺类化合物合成方法与用途 |
| AU2021270664B2 (en) * | 2020-05-12 | 2024-05-30 | Beijing Greatway Pharmaceutical Technology Co., Ltd. | Compound for adjusting activity of NMDA receptor, and pharmaceutical composition and use thereof |
| WO2024155864A1 (en) * | 2023-01-20 | 2024-07-25 | Allianthera (Suzhou) Biopharmaceutical Co., Ltd. | Sprk1 inhibitors and methods of use |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2229617A1 (en) * | 1995-10-20 | 1997-05-01 | Dr. Karl Thomae Gmbh | 5-membered heterocycles, medicaments containing these compounds, their use and processes for their preparation |
| US5965537A (en) * | 1997-03-10 | 1999-10-12 | Basf Aktiengesellschaft | Dolastatin 15 derivatives with carbonyl and heterocyclic functionalities at the C-terminus |
| JP2003529593A (ja) * | 2000-04-04 | 2003-10-07 | スミスクライン ビーチャム パブリック リミテッド カンパニー | 抗菌剤として用いるための２−ヒドロキシムチリンカルバメート誘導体 |
| FR2816940A1 (fr) | 2000-11-23 | 2002-05-24 | Lipha | Derives de 4-(biphenylcarbonylamino)-piperidine, compositions les contenant et leur utilisation |
| GB0129013D0 (en) * | 2001-12-04 | 2002-01-23 | Glaxo Group Ltd | Compounds |
| GB0230162D0 (en) * | 2002-12-24 | 2003-02-05 | Metris Therapeutics Ltd | Compounds useful in inhibiting angiogenesis |
-
2003
- 2003-06-25 FR FR0307670A patent/FR2856685B1/fr not_active Expired - Fee Related
-
2004
- 2004-06-02 JP JP2006515818A patent/JP4629666B2/ja not_active Expired - Fee Related
- 2004-06-02 WO PCT/EP2004/005931 patent/WO2005003128A1/en active Application Filing
- 2004-06-02 ES ES04735742T patent/ES2323463T3/es not_active Expired - Lifetime
- 2004-06-02 RU RU2006101890/04A patent/RU2006101890A/ru unknown
- 2004-06-02 CN CNA2004800157394A patent/CN1809560A/zh active Pending
- 2004-06-02 US US10/561,989 patent/US7674803B2/en not_active Expired - Fee Related
- 2004-06-02 AU AU2004253649A patent/AU2004253649B2/en not_active Ceased
- 2004-06-02 BR BRPI0411721-2A patent/BRPI0411721A/pt not_active IP Right Cessation
- 2004-06-02 KR KR1020057024663A patent/KR20060024812A/ko not_active Application Discontinuation
- 2004-06-02 EP EP04735742A patent/EP1636218B1/de not_active Expired - Lifetime
- 2004-06-02 AT AT04735742T patent/ATE426599T1/de not_active IP Right Cessation
- 2004-06-02 DE DE602004020223T patent/DE602004020223D1/de not_active Expired - Lifetime
- 2004-06-02 CA CA2531011A patent/CA2531011C/en not_active Expired - Fee Related
- 2004-06-02 MX MXPA05013521A patent/MXPA05013521A/es unknown
- 2004-06-21 TW TW093117985A patent/TW200518751A/zh unknown
- 2004-06-25 AR ARP040102230A patent/AR044909A1/es unknown
-
2006
- 2006-01-24 ZA ZA200600690A patent/ZA200600690B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2531011A1 (en) | 2005-01-13 |
| EP1636218A1 (de) | 2006-03-22 |
| EP1636218B1 (de) | 2009-03-25 |
| TW200518751A (en) | 2005-06-16 |
| AU2004253649A1 (en) | 2005-01-13 |
| ES2323463T3 (es) | 2009-07-16 |
| FR2856685A1 (fr) | 2004-12-31 |
| FR2856685B1 (fr) | 2005-09-23 |
| RU2006101890A (ru) | 2007-07-27 |
| CA2531011C (en) | 2012-10-09 |
| WO2005003128A1 (en) | 2005-01-13 |
| BRPI0411721A (pt) | 2006-05-23 |
| JP2007506651A (ja) | 2007-03-22 |
| MXPA05013521A (es) | 2006-03-09 |
| US7674803B2 (en) | 2010-03-09 |
| US20070054939A1 (en) | 2007-03-08 |
| AR044909A1 (es) | 2005-10-05 |
| AU2004253649B2 (en) | 2009-09-24 |
| JP4629666B2 (ja) | 2011-02-09 |
| ZA200600690B (en) | 2007-05-30 |
| CN1809560A (zh) | 2006-07-26 |
| DE602004020223D1 (de) | 2009-05-07 |
| KR20060024812A (ko) | 2006-03-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |