ATE168989T1 - Nmda antagonisten - Google Patents

Nmda antagonisten

Info

Publication number
ATE168989T1
ATE168989T1 AT94110261T AT94110261T ATE168989T1 AT E168989 T1 ATE168989 T1 AT E168989T1 AT 94110261 T AT94110261 T AT 94110261T AT 94110261 T AT94110261 T AT 94110261T AT E168989 T1 ATE168989 T1 AT E168989T1
Authority
AT
Austria
Prior art keywords
halo
formula
nmda antagonists
epilepsy
anxiety
Prior art date
Application number
AT94110261T
Other languages
English (en)
Inventor
Michael G Palfreyman
Francesco G Salituro
Ian A Mcdonald
Robert Schwarcz
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Application granted granted Critical
Publication of ATE168989T1 publication Critical patent/ATE168989T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Anesthesiology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AT94110261T 1991-02-28 1992-02-24 Nmda antagonisten ATE168989T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US66267091A 1991-02-28 1991-02-28

Publications (1)

Publication Number Publication Date
ATE168989T1 true ATE168989T1 (de) 1998-08-15

Family

ID=24658685

Family Applications (2)

Application Number Title Priority Date Filing Date
AT94110261T ATE168989T1 (de) 1991-02-28 1992-02-24 Nmda antagonisten
AT92103066T ATE116969T1 (de) 1991-02-28 1992-02-24 Nmda-antagonisten.

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT92103066T ATE116969T1 (de) 1991-02-28 1992-02-24 Nmda-antagonisten.

Country Status (15)

Country Link
EP (2) EP0501378B1 (de)
JP (1) JP3168566B2 (de)
KR (2) KR100237264B1 (de)
AT (2) ATE168989T1 (de)
AU (2) AU643365B2 (de)
CA (1) CA2061836C (de)
DE (2) DE69201141T2 (de)
DK (2) DK0624569T3 (de)
ES (2) ES2069921T3 (de)
FI (1) FI920880A (de)
GR (1) GR3015130T3 (de)
HU (1) HU213214B (de)
IE (2) IE65728B1 (de)
NO (1) NO178727C (de)
NZ (1) NZ241718A (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU660717B2 (en) * 1991-09-09 1995-07-06 Warner-Lambert Company Pharmaceutical preparation containing an uricosuric and an excitatory amino acid antagonist
US5318985A (en) * 1991-12-20 1994-06-07 Merrell Dow Pharmaceuticals Inc. Potentiation of NMDA antagonists
IT1265101B1 (it) * 1993-07-23 1996-10-30 Erba Carlo Spa Derivati dell'acido 2-ammino-4-fenil-4-osso butirrico
US5519055A (en) * 1993-08-06 1996-05-21 University Of Maryland At Baltimore Substituted kynurenines and process for their preparation
US5786508A (en) * 1994-07-15 1998-07-28 Pharmacia & Upjohn S.P.A. Substituted kynurenines and process for their preparation
GB9521486D0 (en) * 1995-10-20 1995-12-20 Pharmacia Spa Fluoro-substituted benzoylpropionic acid derivatives
SE9901237D0 (sv) * 1999-04-06 1999-04-06 Astra Ab Novel use
EP1964835A1 (de) 2007-02-28 2008-09-03 Centre National de la Recherche Scientifique Derivate von Psammaplin A, Verfahren zu ihrer Synthese und ihre Verwendung für die Vorbeugung oder Behandlung von Krebs
KR101308507B1 (ko) * 2011-07-07 2013-09-17 (주)비알뷰티플레볼루션 트립토판을 함유하는 여드름 치료제 및 피지분비 억제제, 및 이를 포함하는 광역학적 치료용 키트
US20180305298A1 (en) * 2015-10-16 2018-10-25 Auspex Pharmaceuticals, Inc. Deuterated chlorokynurenines for the treatment of neuropsychiatric disorders
EP3427729A1 (de) * 2017-07-13 2019-01-16 Paris Sciences et Lettres - Quartier Latin Probenecid zur behandlung von epileptischen erkrankungen, störungen oder zuständen
US11427530B2 (en) 2018-02-09 2022-08-30 Vistagen Therapeutics, Inc. Synthesis of 4-chlorokynurenines and intermediates

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1179866B (it) * 1984-12-12 1987-09-16 Rotta Research Lab Derivati del triptofano farmaceuticamente attivi e composizioni farmaceutiche che li contengono
IT1206078B (it) * 1987-06-03 1989-04-14 Polifarma Spa Procedimento per la produzione di acido 3-indolpiruvico e suoi derivati loro uso farmaceutico
IT1237472B (it) * 1989-10-04 1993-06-07 Polifarma Spa Derivati di acido 3-indolpiruvico, loro procedimento di produzione ed impiego terapeutico.
DE19502075A1 (de) * 1995-01-24 1996-07-25 Grohe Armaturen Friedrich Auslaufarmatur mit Befestigungseinrichtung

Also Published As

Publication number Publication date
DE69201141D1 (de) 1995-02-23
CA2061836C (en) 2006-05-02
CA2061836A1 (en) 1992-08-29
NZ241718A (en) 1994-07-26
AU1114492A (en) 1992-09-03
AU656278B2 (en) 1995-01-27
ATE116969T1 (de) 1995-01-15
GR3015130T3 (en) 1995-05-31
HUT67033A (en) 1995-01-30
EP0501378A1 (de) 1992-09-02
IE65728B1 (en) 1995-11-15
FI920880A (fi) 1992-08-29
EP0624569A1 (de) 1994-11-17
DE69226447T2 (de) 1999-04-22
NO920784L (no) 1992-08-31
DE69201141T2 (de) 1995-05-11
JP3168566B2 (ja) 2001-05-21
EP0624569B1 (de) 1998-07-29
EP0501378B1 (de) 1995-01-11
AU4497593A (en) 1993-11-18
IE920631A1 (en) 1992-09-09
AU643365B2 (en) 1993-11-11
KR100237264B1 (ko) 2000-02-01
KR920016418A (ko) 1992-09-24
DE69226447D1 (de) 1998-09-03
JPH0586027A (ja) 1993-04-06
HU9200658D0 (en) 1992-05-28
NO920784D0 (no) 1992-02-27
DK0501378T3 (da) 1995-03-20
DK0624569T3 (da) 1998-10-26
NO178727B (no) 1996-02-12
FI920880A0 (fi) 1992-02-27
HU213214B (en) 1997-03-28
KR100261933B1 (ko) 2000-07-15
ES2069921T3 (es) 1995-05-16
ES2122098T3 (es) 1998-12-16
NO178727C (no) 1996-05-22
IE80774B1 (en) 1999-02-10

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