AR063165A1 - Derivados de acido boronico como inhibidores de amidihidrolasa de acidos grasos. composiciones farmaceuticas. - Google Patents
Derivados de acido boronico como inhibidores de amidihidrolasa de acidos grasos. composiciones farmaceuticas.Info
- Publication number
- AR063165A1 AR063165A1 ARP070104441A ARP070104441A AR063165A1 AR 063165 A1 AR063165 A1 AR 063165A1 AR P070104441 A ARP070104441 A AR P070104441A AR P070104441 A ARP070104441 A AR P070104441A AR 063165 A1 AR063165 A1 AR 063165A1
- Authority
- AR
- Argentina
- Prior art keywords
- optionally substituted
- ring
- group
- optionally
- aliphatic
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 150000001642 boronic acid derivatives Chemical class 0.000 title 1
- 235000014113 dietary fatty acids Nutrition 0.000 title 1
- 229930195729 fatty acid Natural products 0.000 title 1
- 239000000194 fatty acid Substances 0.000 title 1
- 150000004665 fatty acids Chemical class 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 8
- 125000003118 aryl group Chemical group 0.000 abstract 6
- 125000005842 heteroatom Chemical group 0.000 abstract 4
- 229910052757 nitrogen Inorganic materials 0.000 abstract 4
- 229910052760 oxygen Inorganic materials 0.000 abstract 4
- 229910052717 sulfur Inorganic materials 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 102100027297 Fatty acid 2-hydroxylase Human genes 0.000 abstract 2
- 101000937693 Homo sapiens Fatty acid 2-hydroxylase Proteins 0.000 abstract 2
- 101000918494 Homo sapiens Fatty-acid amide hydrolase 1 Proteins 0.000 abstract 2
- 125000002619 bicyclic group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
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- A—HUMAN NECESSITIES
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- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/05—Cyclic compounds having at least one ring containing boron but no carbon in the ring
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Abstract
La presente también provee métodos para tratar afecciones asociadas con una actividad excesiva de FAAH al administrar una cantidad terapéuticamente efectiva de un compuesto provisto de las formulas (1), (2) o (3) o una de sus composiciones farmacéuticas, a un paciente que lo necesita. De forma adicional, la presente provee métodos para inhibir FAAH en un paciente al administrar una cantidad terapéuticamente efectiva de un compuesto de las formulas (1), (2) o (3) o una de sus composiciones farmacéuticas, a un paciente que lo necesita. Reivindicacion 1: Una composicion farmacéuticamente aceptable que comprende un compuesto de la formula 1, o una de sus formas farmacéuticamente aceptables y un excipiente farmacéuticamente aceptable; en donde: (i) Z1 es -OR y Z2 es -OR, un grupo alifático C1-6 opcionalmente sustituido, alifático C1-6, arilo C6-12 o heteroarilo C6-12; (ii) Z1 y Z2 tomados juntos forman un anillo de 5 a 8 miembros que tiene al menos un átomo de O directamente unido a B, en donde el anillo está formado por átomos de carbono y opcionalmente uno o varios heteroátomos adicionales seleccionados, de modo independiente, del grupo que consiste en N, S y O; o (iii) Z1 es -OH u -OR y Z2 y el anillo A tomados juntos forman un anillo de 5 a 7 miembros opcionalmente sustituido, en donde el anillo está formado por átomos de carbono y opcionalmente uno o varios heteroátomos adicionales seleccionados, de modo independiente, del grupo que consiste en N, S y O; cada R es hidrogeno o un grupo alifático C1-6 opcionalmente sustituido, alifático C1-6, arilo C6-12 o heteroarilo C6-12; L1 es un enlace covalente o un resto alquileno C1-6 o alquenileno C2-6 lineal o ramificado opcionalmente sustituido; el anillo A es un sistema de anillos monocíclicos C5-8, bicíclicos C6-10 o tricíclicos C10-16 saturados, parcialmente insaturados o aromáticos opcionalmente sustituido que opcionalmente contiene uno o varios heteroátomos seleccionados, de modo independiente, del grupo que consiste en N, S y O; X es un enlace covalente o una cadena hidrocarbonada C1-6 bivalente, en donde uno, dos o tres unidades de metileno de X están opcionalmente reemplazados con -O-, -N=N-, -NR-, -(C=NR')-, -S-, -C(=O)-, -S(=O)-, -S(=O)2- o un resto fenileno opcionalmente sustituido; cada R es hidrogeno, -C(O)R, un grupo protector amino apropiado o un grupo alifático C1-6 opcionalmente sustituido, alifático C1-6, arilo C6-1 o heteroarilo C6-12, RA es (i) H, halogeno, -OR, -CF3, -CN, -NO2, -NC, -SO2R, -SOR, -C(O)R, -CO2R, -C(O)N(R)2, -CHO, -N3, -N2R o N(Rd)2; o (ii) el anillo B que tiene la formula: (2) en donde el anillo B es un sistema de anillos monocíclicos C5-8, bicíclicos C6-10 o tricíclicos C10- 16 saturados, parcialmente insaturados o aromáticos opcionalmente sustituido que opcionalmente contiene uno o varios heteroátomos seleccionados, de modo independiente, del grupo que consiste en N, S y O; cada aparicion de R1 es, de modo independiente, halogeno, -OR, -CF3, -CN, -NO2, -NC, -SO2R, -SOR, -C(O)R, -CO2R, -C(O)N(R)2, -CHO, -N3, -N2R o N(Rd)2, -B(OH2) o un grupo alifático C1-8 opcionalmente sustituido; cada instancia de R2 es, de modo independiente, halogeno, -OR, -CF3, - CN, -NO2, -NC, -SO2R, -SOR, -C(O)R, -CO2R, -C(O)N(R)2, -N3, -N2R, -N(R)2, un grupo alifático C1-8 o arilo C6-12 opcionalmente sustituido; y cada instancia de n y m es, de modo independiente, un numero entero de 0 a 10, inclusive.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85052006P | 2006-10-10 | 2006-10-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR063165A1 true AR063165A1 (es) | 2008-12-30 |
Family
ID=39323893
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070104441A AR063165A1 (es) | 2006-10-10 | 2007-10-09 | Derivados de acido boronico como inhibidores de amidihidrolasa de acidos grasos. composiciones farmaceuticas. |
Country Status (27)
| Country | Link |
|---|---|
| US (6) | US7947663B2 (es) |
| EP (4) | EP2399585A1 (es) |
| JP (2) | JP5641600B2 (es) |
| KR (2) | KR20150038363A (es) |
| CN (2) | CN101563089A (es) |
| AR (1) | AR063165A1 (es) |
| AT (1) | ATE524188T1 (es) |
| AU (1) | AU2007322268B2 (es) |
| BR (1) | BRPI0719218A2 (es) |
| CA (1) | CA2666224C (es) |
| CL (1) | CL2007002910A1 (es) |
| DK (1) | DK2073816T3 (es) |
| ES (1) | ES2373697T3 (es) |
| HK (1) | HK1137137A1 (es) |
| IL (2) | IL197932A (es) |
| JO (1) | JO3598B1 (es) |
| MX (1) | MX2009003727A (es) |
| NO (1) | NO342439B1 (es) |
| NZ (1) | NZ576851A (es) |
| PE (1) | PE20081172A1 (es) |
| PH (1) | PH12012500765A1 (es) |
| PT (1) | PT2073816E (es) |
| RU (1) | RU2492174C2 (es) |
| SG (3) | SG10201908757TA (es) |
| TW (1) | TWI451870B (es) |
| UA (1) | UA101601C2 (es) |
| WO (1) | WO2008063300A2 (es) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3598B1 (ar) | 2006-10-10 | 2020-07-05 | Infinity Discovery Inc | الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني |
| CA2663984C (en) | 2006-10-18 | 2012-02-21 | Pfizer Products Inc. | Biaryl ether urea compounds |
| AR072249A1 (es) * | 2008-04-09 | 2010-08-18 | Infinity Pharmaceuticals Inc | Inhibidores de amida hidrolasa de acido graso. usos. metodos. |
| US9353082B2 (en) * | 2008-12-24 | 2016-05-31 | Bial—Portela & Ca, S.A. | Pharmaceutical compounds |
| US20100222381A1 (en) | 2009-02-27 | 2010-09-02 | Hariprasad Vankayalapati | Cyclopentathiophene/cyclohexathiophene DNA methyltransferase inhibitors |
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