AR054102A1 - Derivados de fenil-piperazina-metanona. procesos de obtencion y composiciones farmaceuticas - Google Patents
Derivados de fenil-piperazina-metanona. procesos de obtencion y composiciones farmaceuticasInfo
- Publication number
- AR054102A1 AR054102A1 ARP050105107A ARP050105107A AR054102A1 AR 054102 A1 AR054102 A1 AR 054102A1 AR P050105107 A ARP050105107 A AR P050105107A AR P050105107 A ARP050105107 A AR P050105107A AR 054102 A1 AR054102 A1 AR 054102A1
- Authority
- AR
- Argentina
- Prior art keywords
- lower alkyl
- halogen
- obtaining
- processes
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Procesos de obtencion de dichos compuestos y composiciones farmacéuticas que los comprenden. Reivindicacion 1: Compuestos de la formula general (1), en la que: R1 es el grupo de formulas (2) a (5); R2 es un heterociclo no aromático o es OR' o N(R'')2; R' es alquilo inferior, alquilo inferior sustituido por halogeno o -(CH2)n-cicloalquilo; R'' es alquilo inferior; R3 es NO2, CN o SO2R'; R4 es hidrogeno, hidroxi, halogeno, NO2, alquilo inferior, alquilo inferior sustituido por halogeno, alcoxi inferior SO2R' o C(O)OR''; R5/R6/R7 son hidrogeno, halogeno, alquilo inferior o alquilo inferior sustituido por halogeno; X1/X1' son CH o N, con la condicion de que X1/X1' no sean simultáneamente CH; X2 es O, S, NH o N(alquilo inferior); n es 0, 1 o 2; y a sales de adicion de ácido farmacéuticamente activas.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04106440 | 2004-12-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR054102A1 true AR054102A1 (es) | 2007-06-06 |
Family
ID=36061356
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050105107A AR054102A1 (es) | 2004-12-09 | 2005-12-07 | Derivados de fenil-piperazina-metanona. procesos de obtencion y composiciones farmaceuticas |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US7241761B2 (es) |
| EP (1) | EP1828154B1 (es) |
| JP (1) | JP4762250B2 (es) |
| KR (1) | KR100880093B1 (es) |
| CN (1) | CN101072762B (es) |
| AR (1) | AR054102A1 (es) |
| AT (1) | ATE430142T1 (es) |
| AU (1) | AU2005313581B2 (es) |
| BR (1) | BRPI0518608A2 (es) |
| CA (1) | CA2589192C (es) |
| DE (1) | DE602005014274D1 (es) |
| DK (1) | DK1828154T3 (es) |
| ES (1) | ES2324232T3 (es) |
| HK (1) | HK1114841A1 (es) |
| HR (1) | HRP20090264T1 (es) |
| IL (1) | IL183594A (es) |
| MX (1) | MX2007006429A (es) |
| MY (1) | MY141969A (es) |
| NO (1) | NO20072643L (es) |
| NZ (1) | NZ555290A (es) |
| PL (1) | PL1828154T3 (es) |
| PT (1) | PT1828154E (es) |
| RU (1) | RU2395502C2 (es) |
| SI (1) | SI1828154T1 (es) |
| TW (1) | TWI304064B (es) |
| WO (1) | WO2006061135A1 (es) |
| ZA (1) | ZA200705027B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7485637B2 (en) * | 2005-01-04 | 2009-02-03 | Hoffmann-La Roche Inc. | Benzoyl-tetrahydropiperidine derivatives |
| AU2008223915B2 (en) | 2007-03-05 | 2013-05-02 | F. Hoffmann-La Roche Ag | Process for the synthesis of GLYT-1 inhibitors |
| AU2011261375B2 (en) * | 2010-06-04 | 2016-09-22 | Albany Molecular Research, Inc. | Glycine transporter-1 inhibitors, methods of making them, and uses thereof |
| US9403815B2 (en) | 2010-06-24 | 2016-08-02 | The Regents Of The University Of California | Compounds and uses thereof in modulating levels of various amyloid beta peptide alloforms |
| FR2967674B1 (fr) * | 2010-11-23 | 2012-12-14 | Pf Medicament | Derives d'heteroarylsulfonamides, leur preparation et leur application en therapeutique humaine |
| RU2496495C2 (ru) * | 2011-12-05 | 2013-10-27 | Учреждение Российской академии медицинских наук Научно-исследовательский институт нормальной физиологии имени П.К. Анохина РАМН | ПРИМЕНЕНИЕ СЕЛЕКТИВНОГО АНТАГОНИСТА ГЛУТАМАТНЫХ РЕЦЕПТОРОВ Ro-256981 ДЛЯ НАПРАВЛЕННОГО ВЛИЯНИЯ НА КОГНИТИВНЫЕ ФУНКЦИИ |
| WO2014165263A1 (en) | 2013-03-12 | 2014-10-09 | The Regents Of The University Of California, A California Corporation | Gamma-secretase modulators |
| US10472346B2 (en) | 2014-10-31 | 2019-11-12 | The General Hospital Corporation | Potent gamma-secretase modulators |
| CN105712945B (zh) * | 2014-12-22 | 2020-12-01 | 上海翰森生物医药科技有限公司 | 2-取代氧基-5-甲砜基芳基哌嗪酰胺类似物及其制备方法和用途 |
| CN105712952B (zh) * | 2014-12-22 | 2021-03-26 | 上海翰森生物医药科技有限公司 | 2-取代氧基-5-甲砜基苯基哌嗪酰胺类似物及其制备方法和用途 |
| CA3023237A1 (en) * | 2016-05-17 | 2017-11-23 | The Regents Of The University Of California | Piperazinyl methanone naaa inhibitors |
| CN111116573B (zh) * | 2019-12-31 | 2021-08-06 | 中山大学 | 一种双通道下同时检测dna和rna的近红外荧光探针及其制备方法和应用 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2423847A1 (de) | 1973-05-28 | 1975-01-02 | Ciba Geigy Ag | Neue sulfamoylbenzoesaeureamide |
| DE2611705A1 (de) | 1976-03-18 | 1977-09-22 | Josef Dipl Chem Dr Rer N Klosa | N-5-(nitrofurfuryliden-)-1-amino- hydantoin enthaltende kristalloesungsmittel |
| IT1176613B (it) | 1984-08-14 | 1987-08-18 | Ravizza Spa | Derivati piperazinici farmacologicamente attivi e processo per la loro preparazione |
| RU2124511C1 (ru) | 1993-05-14 | 1999-01-10 | Фармасьютикал Ко., Лтд | Производные пиперазина |
| EP1059922A2 (en) * | 1998-03-06 | 2000-12-20 | Janssen Pharmaceutica N.V. | Glycine transport inhibitors |
| CN1291984A (zh) | 1998-03-06 | 2001-04-18 | 詹森药业有限公司 | 甘氨酸传输抑制剂 |
| WO2001081308A2 (en) * | 2000-04-20 | 2001-11-01 | Nps Allelix Corp. | Aminopiperidines for use as glyt-1 inhibitors |
| GB0021419D0 (en) | 2000-08-31 | 2000-10-18 | Oxford Glycosciences Uk Ltd | Compounds |
| AU2001290786A1 (en) * | 2000-09-14 | 2002-03-26 | Gliatech, Inc. | Nitrogen-containing compounds and their use as glycine transport inhibitors |
| DE60234453D1 (de) | 2001-07-02 | 2009-12-31 | High Point Pharmaceuticals Llc | Substituierte piperazin- und diazepanderivate zur verwendung als histamin h3 rezeptormodulatoren |
| DE60229646D1 (de) | 2001-07-17 | 2008-12-11 | Organon Nv | N- (1-dimethylaminocycloalkyl)methyl benzamid-derivate |
| WO2003035602A1 (fr) | 2001-10-25 | 2003-05-01 | Sankyo Company, Limited | Modulateurs lipidiques |
| BR0215202A (pt) * | 2001-12-20 | 2004-10-13 | Osi Pharm Inc | Compostos antagonistas seletivos a2b de pirimidina, sua sìntese e uso |
| WO2004037800A1 (en) | 2002-10-22 | 2004-05-06 | Glaxo Group Limited | Aryloxyalkylamine derivates as h3 receptor ligands |
| DE602004002567T2 (de) * | 2003-02-17 | 2007-05-31 | F. Hoffmann-La Roche Ag | Piperidinbenzolsulfonamidderivate |
| GB0314476D0 (en) * | 2003-06-20 | 2003-07-23 | Glaxo Group Ltd | Compounds |
| GB0314479D0 (en) * | 2003-06-20 | 2003-07-23 | Glaxo Group Ltd | Compounds |
| PL1656361T3 (pl) * | 2003-08-11 | 2008-06-30 | Hoffmann La Roche | Piperazyny z OR-podstawioną grupą fenylową i ich zastosowanie jako inhibitorów GlyT1 |
| KR100774621B1 (ko) | 2003-09-09 | 2007-11-14 | 에프. 호프만-라 로슈 아게 | 정신병 치료용의 글라이신 섭취 억제제로서의1-벤조일-피페라진 유도체 |
| RU2354653C2 (ru) * | 2003-09-09 | 2009-05-10 | Ф.Хоффманн-Ля Рош Аг | Производные 1-(2-аминобензол)пиперазина, используемые в качестве ингибиторов поглощения глицина и предназначенные для лечения психоза |
| FR2861073B1 (fr) * | 2003-10-17 | 2006-01-06 | Sanofi Synthelabo | Derives de n-[heteroaryl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique |
| GB0408777D0 (en) | 2004-04-20 | 2004-05-26 | Glaxo Group Ltd | Compounds |
| CN1946685A (zh) * | 2004-04-29 | 2007-04-11 | 默克公司 | 氮杂环丁烷甘氨酸转运蛋白抑制剂 |
| GB0505086D0 (en) * | 2005-03-11 | 2005-04-20 | Glaxo Group Ltd | Compounds |
-
2005
- 2005-12-01 AT AT05817965T patent/ATE430142T1/de active
- 2005-12-01 US US11/291,216 patent/US7241761B2/en not_active Expired - Fee Related
- 2005-12-01 WO PCT/EP2005/012833 patent/WO2006061135A1/en active Application Filing
- 2005-12-01 DE DE602005014274T patent/DE602005014274D1/de active Active
- 2005-12-01 JP JP2007544778A patent/JP4762250B2/ja not_active Expired - Fee Related
- 2005-12-01 DK DK05817965T patent/DK1828154T3/da active
- 2005-12-01 ES ES05817965T patent/ES2324232T3/es active Active
- 2005-12-01 SI SI200530699T patent/SI1828154T1/sl unknown
- 2005-12-01 CN CN2005800421620A patent/CN101072762B/zh not_active Expired - Fee Related
- 2005-12-01 PL PL05817965T patent/PL1828154T3/pl unknown
- 2005-12-01 RU RU2007120209/04A patent/RU2395502C2/ru not_active IP Right Cessation
- 2005-12-01 KR KR1020077015528A patent/KR100880093B1/ko not_active IP Right Cessation
- 2005-12-01 EP EP05817965A patent/EP1828154B1/en active Active
- 2005-12-01 NZ NZ555290A patent/NZ555290A/en not_active IP Right Cessation
- 2005-12-01 AU AU2005313581A patent/AU2005313581B2/en not_active Ceased
- 2005-12-01 MX MX2007006429A patent/MX2007006429A/es active IP Right Grant
- 2005-12-01 BR BRPI0518608-0A patent/BRPI0518608A2/pt active Search and Examination
- 2005-12-01 CA CA2589192A patent/CA2589192C/en not_active Expired - Fee Related
- 2005-12-01 PT PT05817965T patent/PT1828154E/pt unknown
- 2005-12-06 TW TW094143004A patent/TWI304064B/zh not_active IP Right Cessation
- 2005-12-07 AR ARP050105107A patent/AR054102A1/es not_active Application Discontinuation
- 2005-12-07 MY MYPI20055721A patent/MY141969A/en unknown
-
2007
- 2007-05-21 US US11/804,955 patent/US7429585B2/en not_active Expired - Fee Related
- 2007-05-24 NO NO20072643A patent/NO20072643L/no not_active Application Discontinuation
- 2007-05-31 IL IL183594A patent/IL183594A/en not_active IP Right Cessation
- 2007-06-04 ZA ZA200705027A patent/ZA200705027B/xx unknown
-
2008
- 2008-04-29 HK HK08104729.2A patent/HK1114841A1/xx not_active IP Right Cessation
-
2009
- 2009-05-12 HR HR20090264T patent/HRP20090264T1/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |