AR039891A1 - Compuestos tiofen-amidinas, sus composiciones farmaceuticas y su uso para la preparacion de medicamentos para tratar enfermedades y trastornos mediados por c1s - Google Patents

Compuestos tiofen-amidinas, sus composiciones farmaceuticas y su uso para la preparacion de medicamentos para tratar enfermedades y trastornos mediados por c1s

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Publication number
AR039891A1
AR039891A1 ARP030101873A ARP030101873A AR039891A1 AR 039891 A1 AR039891 A1 AR 039891A1 AR P030101873 A ARP030101873 A AR P030101873A AR P030101873 A ARP030101873 A AR P030101873A AR 039891 A1 AR039891 A1 AR 039891A1
Authority
AR
Argentina
Prior art keywords
alkyl
phenyl
hydrogen
alkenyl
alkoxy
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Application number
ARP030101873A
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English (en)
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Dimensional Pharm Inc
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Publication date
Application filed by Dimensional Pharm Inc filed Critical Dimensional Pharm Inc
Publication of AR039891A1 publication Critical patent/AR039891A1/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
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    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
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    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
    • C07F9/655345—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring

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  • Health & Medical Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Diabetes (AREA)
  • Immunology (AREA)
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  • Hematology (AREA)
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  • Rheumatology (AREA)
  • Neurology (AREA)
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  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
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  • Cardiology (AREA)
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Abstract

Un compuesto tiofen-amidina de fórmula (1): o un solvato, hidrato o sal farmacéuticamente aceptable del mismo; en donde: Z es -S(O)- o -S(O2)-; R1 es alquilo C1-4, halo, amino, alquiltio C1-6, alqueniltio C2-6, alcoxi C1-6, trifluormetilo, metilsulfonilo, o benciltio; Ar es fenilo, naftilo, piridilo, imidazolilo, tiazolilo, furanilo, tienilo, benzotiazolilo, pirazolilo, pirimidinilo, bencimidazolilo, benzofuranilo, indolilo, benzotiofenilo o benzo[c]cromenilo, cualquiera de los cuales está opcionalmente sustituido; R2, R3 y R4 son independientemente hidrógeno, alquilo C1-4, arilo C6-10, hidroxialquilo C1-4, aminoalquilo C1-4, mono alquilamino(C1-4)alquilo(C2-6), di(C1-4)alquilamino(C2-6)alquilo, carboxi(C1-4)alquilo, ciano, amino, nitro, C1-4 alcoxi, o hidroxi o BCO2Rw, donde Rw es hidrógeno, hidroxi, C1-4 alcoxi, ciano, C1-4alcoxicarbonilo, C1-4 alquilo, C3-8 cicloalquilo, fenilo, bencilo, representado por las fórmulas (2) o (3): donde Rd y Re son independientemente hidrógeno, C1-6 alquilo, C2-6 alquenilo o fenilo, Rf es hidrógeno, C1-6 alquilo, C2-6 alquenilo, o fenilo, Rg es hidrógeno, C1-6 alquilo, C2-6 alquenilo o fenilo, y Rh es C6-10 ar(C1-4)alquilo o C1-6 alquilo; y R7 es hidrógeno, cloro, fluoro o amino. Composiciones farmacéuticas que los comprenden, el uso de dichos compuestos para la preparación de un medicamento para tratar los síntomas de un desorden agudo o crónico mediado por la ruta clásica de la cascada del complemento.
ARP030101873A 2002-05-28 2003-05-28 Compuestos tiofen-amidinas, sus composiciones farmaceuticas y su uso para la preparacion de medicamentos para tratar enfermedades y trastornos mediados por c1s AR039891A1 (es)

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AR039891A1 true AR039891A1 (es) 2005-03-09

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US (2) US7138530B2 (es)
EP (1) EP1549632A4 (es)
JP (1) JP2005538953A (es)
KR (1) KR20050009720A (es)
CN (1) CN100412073C (es)
AR (1) AR039891A1 (es)
AU (1) AU2003251384B2 (es)
BR (1) BR0311419A (es)
CA (1) CA2484822A1 (es)
CO (1) CO5640081A2 (es)
HK (1) HK1081187A1 (es)
HR (1) HRP20041220A2 (es)
IL (1) IL164890A0 (es)
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MY (1) MY137509A (es)
NO (1) NO20045403L (es)
NZ (1) NZ537346A (es)
PL (1) PL372246A1 (es)
RU (1) RU2359967C2 (es)
TW (1) TW200406395A (es)
UA (1) UA80131C2 (es)
WO (1) WO2003099805A1 (es)
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OA12622A (en) * 2001-06-11 2006-06-12 Shire Biochem Inc Thiophene derivatives as antiviral agents for flavivirus infection.
DE10162114A1 (de) * 2001-12-12 2003-06-26 Schering Ag Neue Amidin-Derivate und deren Verwendung in Arzneimitteln
AR039891A1 (es) 2002-05-28 2005-03-09 Dimensional Pharm Inc Compuestos tiofen-amidinas, sus composiciones farmaceuticas y su uso para la preparacion de medicamentos para tratar enfermedades y trastornos mediados por c1s
DE60332482D1 (de) 2002-12-10 2010-06-17 Virochem Pharma Inc Verbindungen und methoden zum behandeln oder vorbeugen von flavivirus infektionen
GB0305575D0 (en) * 2003-03-11 2003-04-16 Glaxo Group Ltd Novel compounds
US7482376B2 (en) * 2003-07-03 2009-01-27 3-Dimensional Pharmaceuticals, Inc. Conjugated complement cascade inhibitors
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