AR017807A1 - COMPUESTOS CON ACTIVIDAD SELECTIVA EN LOS SUBTIPOS DE RECEPTOR ADRENÉRGICO ALFA 2B o ALFA 2B Y ALFA 2C Y SUS USOS EN LA MANUFACTURA DE UN MEDICAMENTO - Google Patents

COMPUESTOS CON ACTIVIDAD SELECTIVA EN LOS SUBTIPOS DE RECEPTOR ADRENÉRGICO ALFA 2B o ALFA 2B Y ALFA 2C Y SUS USOS EN LA MANUFACTURA DE UN MEDICAMENTO

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Publication number
AR017807A1
AR017807A1 ARP980106173A ARP980106173A AR017807A1 AR 017807 A1 AR017807 A1 AR 017807A1 AR P980106173 A ARP980106173 A AR P980106173A AR P980106173 A ARP980106173 A AR P980106173A AR 017807 A1 AR017807 A1 AR 017807A1
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Argentina
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alfa
atom
attached
lower alkyl
integer
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ARP980106173A
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Allergan Sales Inc
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    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/06—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
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    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

Compuestos que presentan actividad adrenérgetica, que son agonistas selectivos con preferencia por uno o los dos subtipos de receptores adrenoreceptoresalfa2B y alfa2C antes que para el subtipo de receptor adrenoreceptor alfa2; el compuesto activose selecciona del grupo formado por compuestos que poseen laformula (I), donde las líneas punteadas representan enlaces optativos siempre que dos dobles enlaces no compartan un átomo de C en comun; R es H o alquiloinferior; X es S o C(H)R1, donde R1es H o alquilo inferior, pero R1 está ausente cuando el enlace entre X y el anillo representado por la formula (II) es unenlace doble; Y es O, N, S, (CR1 2)y, donde y es un numero entero de 1 a 3, -CH=CH o -Y1CH2-, donde Y1 es O, N o S; x es unnumero entero de 1 o dos donde elvalor de x es 1 cuando R2, R3 o R4 está unido a un átomo de C no saturado y el valor de x es 2 cuando R2, R3 o R4, está unido a un átomo de C saturado; R2 esH, alquilo inferior, halogeno, hidroxi o alcoxi inferior, ocuando está unido a un átomo de C saturado, R2 puede ser oxo; R3 y R4 son, cada uno, H, alquiloinferior, hidroxi, alcoxi inferior o fenilo, o bien juntos, son -(C(R2)x)z-, -Y1(C(R2)x)z-, -(C(R2)x)-, -(C(R2)x)Y1-(C(R2)x)-(C(R2)x)y-Y1-(C(R1)x)-Y1-(C(R2)x)dond e z es un numero entero de 3 a 5; z es un numero entero de 2 a 4 y x e y son como se definio antes, y además cualquiera de los extremos de estos gruposdivalentes se puede unir a R3 o R4 para formar una estructura de formula (III) en elanillo condens ada y los anillos formados pueden ser totalmenteinsaturados, parcialmente insaturados o totalmente saturados, siempre que el carbono del anillo no tenga más de 4 valencias, el nitrogeno no más de tres y O yS no más de dos e incluyendolas sales acept ables para uso farmacéutico del mismo; y son de utilidad en el tratamiento de espasticidad muscular, incluyendomiccion hiperactiva, diarrea, síndromes de abstinencia, dolor inclusive dolor neuropático, enfermedadesneurodegenerativas, memoria y defic ientes deconocimiento, psicosis incluyendo trastornos maníacos y ansiedad, hipertension e insuficiencia cardíaca congestiva y congestion nasal sin efectos secundarios
ARP980106173A 1997-12-04 1998-12-04 COMPUESTOS CON ACTIVIDAD SELECTIVA EN LOS SUBTIPOS DE RECEPTOR ADRENÉRGICO ALFA 2B o ALFA 2B Y ALFA 2C Y SUS USOS EN LA MANUFACTURA DE UN MEDICAMENTO AR017807A1 (es)

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US98534797A 1997-12-04 1997-12-04

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AR017807A1 true AR017807A1 (es) 2001-10-24

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EP (2) EP1036065B1 (es)
JP (3) JP4783502B2 (es)
KR (1) KR100544787B1 (es)
CN (1) CN1284066A (es)
AR (1) AR017807A1 (es)
AT (1) ATE266643T1 (es)
AU (1) AU744798B2 (es)
BR (1) BR9813381A (es)
CA (1) CA2312334A1 (es)
DE (1) DE69823868T2 (es)
DK (1) DK1036065T3 (es)
ES (1) ES2216339T3 (es)
HU (1) HUP0004557A3 (es)
IL (2) IL136388A0 (es)
NO (2) NO317292B1 (es)
NZ (1) NZ504667A (es)
PL (1) PL341009A1 (es)
PT (1) PT1036065E (es)
RU (1) RU2235092C2 (es)
SK (1) SK8542000A3 (es)
TW (1) TW577878B (es)
WO (1) WO1999028300A1 (es)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6841684B2 (en) * 1997-12-04 2005-01-11 Allergan, Inc. Imidiazoles having reduced side effects
NZ504667A (en) * 1997-12-04 2003-03-28 Allergan Sales Inc Substituted imidazole derivatives having agonist-like activity at alpha 2B or 2B/2C adrenergic receptors
AU2002254265B2 (en) * 1997-12-04 2008-05-15 Allergan, Inc. Imidiazole derivatives and their use as agonists selective at alpha 2B or 2B/2C adrenergic receptors
TWI283669B (en) * 1999-06-10 2007-07-11 Allergan Inc Compounds and method of treatment having agonist-like activity selective at alpha 2B or 2B/2C adrenergic receptors
US6388090B2 (en) 2000-01-14 2002-05-14 Orion Corporation Imidazole derivatives
FI20000073A0 (fi) * 2000-01-14 2000-01-14 Orion Yhtymae Oy Uusia imidatsolijohdannaisia
US6294553B1 (en) * 2000-02-15 2001-09-25 Allergan Sales, Inc. Method for treating ocular pain
US6593324B2 (en) 2000-03-01 2003-07-15 Orion Corporation Dervatives of quinoline as alpha-2 antagonists
JP2006036636A (ja) * 2000-11-22 2006-02-09 Nippon Shinyaku Co Ltd 消化管機能障害治療剤及びスクリーニング方法
WO2003082866A1 (en) 2002-04-03 2003-10-09 Orion Corporation Polycyclic compounds as potent alpha2-adrenoceptor antagonists
AU2003235310A1 (en) * 2002-04-22 2003-11-03 Takeda Chemical Industries, Ltd. Novel screening method
US7276522B2 (en) 2002-05-21 2007-10-02 Allergan, Inc. 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones, 4-(substituted cycloalkenylmethyl) imidazol-2-ones and related compounds
US7323485B2 (en) 2002-05-21 2008-01-29 Allergan, Inc. 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones and 4-(substituted cycloalkenylmethyl) imidazol-2-ones and related compounds
US7345065B2 (en) 2002-05-21 2008-03-18 Allergan, Inc. Methods and compositions for alleviating pain
US7358269B2 (en) 2002-05-21 2008-04-15 Allergan, Inc. 2-((2-Thioxo-2,3-dihydro-1H-imidazol-4-yl)methyl)-3,4-dihydronapthalen-1(2H)-one
US7091232B2 (en) 2002-05-21 2006-08-15 Allergan, Inc. 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones and 4-(substituted cycloalkenylmethyl) imidazol-2-ones and related compounds
DE60327335D1 (de) * 2002-10-08 2009-06-04 Allergan Inc Alpha 2b oder 2b/2c adrenozeptor-agonisten zur behandlung von morbus alzheimer und morbus parkinson
ATE380551T1 (de) * 2002-10-08 2007-12-15 Allergan Inc Verwendung von brimonidine zur behandlung von dementia und morbus parkinson
EP1796664B1 (en) 2004-09-20 2013-11-27 Janssen Pharmaceutica NV Novel tetracyclic heteroatom containing derivatives useful as sex steroid hormone receptor modulators
CA2580777A1 (en) 2004-09-20 2006-03-30 Janssen Pharmaceutica N.V. Novel tetracyclic heteroatom containing derivatives useful as sex steroid hormone receptor modulators
WO2006036507A1 (en) 2004-09-24 2006-04-06 Allergan, Inc. 4-(heteroaryl-methyl and substituted heteroaryl-methyl)-imidazole-2-thiones acting as alpha2 adrenergic agonists
MX2007003094A (es) 2004-09-24 2007-06-07 Allergan Inc 4-(metilo ciclico condensado)-imidazol-2-tionas como agonistas alfa2 adrenergicos.
BRPI0516217A (pt) * 2004-09-28 2008-08-26 Allergan Inc compostos de 4-benzil-1,3-diidro-imidazol-2-tionas não-substituìdos e substituìdos que atuam como agonistas especìficos ou seletivos alfa2-adrenérgicos e métodos de utilização dos mesmos
US7390829B2 (en) 2005-06-29 2008-06-24 Allergan, Inc. Alpha-2 adrenergic agonists
CA2620173A1 (en) 2005-08-25 2007-03-01 Schering Corporation Alpha2c adrenoreceptor agonists
US7700592B2 (en) 2005-08-25 2010-04-20 Schering Corporation α2C adrenoreceptor agonists
US7592362B2 (en) 2006-01-19 2009-09-22 Pfizer Limited Substituted imidazoles
CN101374832B (zh) * 2006-01-27 2013-03-06 弗·哈夫曼-拉罗切有限公司 4-咪唑衍生物用于cns病症的用途
AU2007242859A1 (en) * 2006-04-20 2007-11-01 Janssen Pharmaceutica N.V. Substituted pyrazinone derivatives for use as a medicine
JP2009537602A (ja) * 2006-05-22 2009-10-29 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 薬剤として用いるための置換ピラジノン誘導体
KR101176699B1 (ko) 2006-10-19 2012-08-23 에프. 호프만-라 로슈 아게 아미노메틸-4-이미다졸
KR101176700B1 (ko) 2006-11-02 2012-08-23 에프. 호프만-라 로슈 아게 미량 아민 결합된 수용체의 조절자로서 치환된 2-이미다졸
EP2084152A2 (en) * 2006-11-16 2009-08-05 F. Hoffmann-Roche AG Substituted 4-imidazoles
CN101190218B (zh) * 2006-11-20 2010-12-22 四川科瑞德制药有限公司 替扎尼定及其衍生物在制备抗焦虑症药物中的用途
MX2009005920A (es) 2006-12-13 2009-06-16 Hoffmann La Roche Nuevos 2-imidazoles como ligandos para receptores asociados con trazas de amina.
US20080146523A1 (en) 2006-12-18 2008-06-19 Guido Galley Imidazole derivatives
US7868020B2 (en) 2007-01-12 2011-01-11 Allergan, Inc. Quinolynylmethylimidizoles as therapeutic agents
WO2008086131A1 (en) 2007-01-12 2008-07-17 Allergan, Inc. Naphthylmethylimidizoles as therapeutic agents
WO2008088937A1 (en) * 2007-01-12 2008-07-24 Allergan, Inc. Quinolynylmethylimidizoles as therapeutic agents
RU2473545C2 (ru) 2007-02-02 2013-01-27 Ф.Хоффманн-Ля Рош Аг Новые 2-аминооксазолины в качестве лигандов taar1 для заболеваний цнс
CL2008000429A1 (es) 2007-02-13 2008-08-18 Schering Corp Compuestos derivados de heterociclos condensados; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar afecciones asociadas con los receptores alfa2c adrenergicos, tales como congestion asociada a rinitis, polipos, resfrio
BRPI0807961A2 (pt) 2007-02-13 2017-05-16 Pharmacopeia Llc agonista de alfa2c adrenorreceptor funcionalmente seletivos.
EP2398776A1 (en) 2007-02-13 2011-12-28 Schering Corporation Functionally selective alpha2c adrenoreceptor agonists
EP2121641B1 (en) 2007-02-15 2014-09-24 F. Hoffmann-La Roche AG 2-aminooxazolines as taar1 ligands
ES2390323T3 (es) * 2007-05-23 2012-11-08 Allergan, Inc. Compuestos terapéuticos de ((fenil)imidazolil)metilquinolinilo
CN101318020B (zh) * 2007-06-06 2011-09-28 四川科瑞德制药有限公司 抗焦虑或/和抗抑郁的药物组合物及用途
KR101150561B1 (ko) 2007-07-02 2012-06-08 에프. 호프만-라 로슈 아게 미량 아민 결합 수용체(ｔａａｒ)에 대한 양호한 친화도를 갖는 2-이미다졸린
MX2009013745A (es) 2007-07-03 2010-01-26 Hoffmann La Roche 4-imidazolinas y su uso como antidepresivos.
EP2175850B1 (en) * 2007-07-17 2017-01-11 Allergan, Inc. Treatment of anxiety
TWI457122B (zh) 2007-07-20 2014-10-21 Orion Corp 作為用於治療周邊和中央神經系統疾病之alpha2C拮抗劑的2,3－二氫苯並[1,4]戴奧辛－2－基甲基衍生物
JP2010534701A (ja) 2007-07-27 2010-11-11 エフ．ホフマン−ラ ロシュ アーゲー Ｔａａｒリガンドとしての２−アゼチジンメタンアミン及び２−ピロリジンメタンアミン
CN101784515A (zh) 2007-08-03 2010-07-21 弗·哈夫曼-拉罗切有限公司 作为taar1配体的吡啶甲酰胺和苯甲酰胺衍生物
WO2009020578A1 (en) * 2007-08-06 2009-02-12 Schering Corporation Alpha2c adrenoreceptor agonists
US7902247B2 (en) 2008-01-09 2011-03-08 Allergan, Inc. Substituted-aryl-2-phenylethyl-1H-imidazole compounds as subtype selective modulators of alpha 2B and/or alpha 2C adrenergic receptors
ES2421896T3 (es) * 2008-01-18 2013-09-06 Allergan Inc Compuestos de aril-(imidazol)-metil-fenilo sustituidos como moduladores selectivos de los subtipos de receptores adrenérgicos alfa 2B y/o alfa 2C
US8383818B2 (en) 2008-02-21 2013-02-26 Merck Sharp & Dohme Corp. Functionally selective alpha2C adrenoreceptor agonists
WO2009140138A1 (en) * 2008-05-13 2009-11-19 Allergan, Inc. Quinolynylmethylimidizoles as therapeutic agents
DE102008001932A1 (de) 2008-05-21 2009-11-26 Bayer Cropscience Ag Substiuierte Spiroisoxazoline
US8242153B2 (en) 2008-07-24 2012-08-14 Hoffmann-La Roche Inc. 4,5-dihydro-oxazol-2YL derivatives
EP2356106A1 (en) 2008-10-07 2011-08-17 Schering Corporation Biaryl spiroaminooxazoline analogues as alpha2c adrenergic receptor modulators
US8354441B2 (en) 2009-11-11 2013-01-15 Hoffmann-La Roche Inc. Oxazoline derivatives
US9452980B2 (en) 2009-12-22 2016-09-27 Hoffmann-La Roche Inc. Substituted benzamides
BR112013012112A2 (pt) * 2010-11-16 2016-09-27 Allergan Inc composições farmacêuticas compreendendo (3-(1-h-imidazol-4-il)etil)-2-metilfenil)metanol
US9073911B2 (en) 2011-06-09 2015-07-07 Hoffmann-La Roche Inc. Pyrazole derivatives
US9029370B2 (en) 2011-06-10 2015-05-12 Hoffmann-La Roche Inc. Substituted benzamide derivatives
EP2782569A1 (en) 2011-11-21 2014-10-01 Allergan, Inc. Pharmaceutical compositions comprising 4-[1-(2,3-dimethylphenyl)ethyl]-3h-imidazole derivatives for treating retinal diseases
AR090557A1 (es) * 2012-04-02 2014-11-19 Orion Corp DERIVADOS IMIDAZOLICOS AGONISTAS ADRENERGICOS a2
CN108713019B (zh) 2016-03-17 2021-06-15 豪夫迈·罗氏有限公司 具有作为taar的激动剂的活性的5-乙基-4-甲基-吡唑-3-甲酰胺衍生物
CN110240542B (zh) * 2019-06-24 2020-05-12 牡丹江医学院 一种选择性β1-肾上腺素受体抑制剂及其在制备心血管疾病药物中的用途
MX2024004756A (es) * 2021-10-20 2024-05-27 Assembly Biosciences Inc Proceso.

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU85747A1 (fr) * 1985-01-28 1986-08-04 Continental Pharma Derives d'imidazole leur preparation et utilisation ainsi que les compositions pharmaceutiques contenant des derives
FI864570A0 (fi) * 1986-11-11 1986-11-11 Farmos Oy Terapeutiskt anvaendbar foerening.
US4882343A (en) * 1987-08-28 1989-11-21 G. D. Searle & Co. Biarylalkylimidazole derivatives as anti-depressants
JPH01242571A (ja) * 1988-03-22 1989-09-27 Mitsui Petrochem Ind Ltd イミダゾール誘導体の製造方法
GB8823980D0 (en) * 1988-10-13 1988-11-23 Glaxo Group Ltd Chemical compounds
DE69212164T2 (de) * 1991-12-18 1996-12-05 Schering Corp., Kenilworth, N.J. Imidolylalkyl-derivate substituiert mit einem stickstoffenthaltende-6 gliedrigen ring
WO1994007866A1 (en) * 1992-10-06 1994-04-14 Tokyo Tanabe Company Limited Aromatase inhibitor
JPH11505224A (ja) * 1995-05-12 1999-05-18 アラーガン 心臓血管系副作用を伴わないα▲下２▼アドレナリン作動剤として有用なアリール−イミダゾリンおよびアリール−イミダゾール
GB9520150D0 (en) * 1995-10-03 1995-12-06 Orion Yhtymae Oy New imidazole derivatives
US5750720A (en) * 1996-03-28 1998-05-12 Ortho Pharmaceutical Corporation 4- (thien-3-yl)methyl!-imidazole analgesics
US5621113A (en) * 1996-03-28 1997-04-15 Ortho Pharmaceutical Corporation 4-[(thien-2-yl)methyl]-imidazole analgesics
US6841684B2 (en) * 1997-12-04 2005-01-11 Allergan, Inc. Imidiazoles having reduced side effects
NZ504667A (en) * 1997-12-04 2003-03-28 Allergan Sales Inc Substituted imidazole derivatives having agonist-like activity at alpha 2B or 2B/2C adrenergic receptors

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