AR012436A1 - 4-AMINOPIRIDE [2,3-D] PIRIMIDINE 5,7-DISSTITUTED COMPOUNDS, PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS THEM, THE USE OF THE SAME FOR LAMANUFACTURE OF MEDICINES, A PROCEDURE FOR THEIR PREPARATION. - Google Patents
4-AMINOPIRIDE [2,3-D] PIRIMIDINE 5,7-DISSTITUTED COMPOUNDS, PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS THEM, THE USE OF THE SAME FOR LAMANUFACTURE OF MEDICINES, A PROCEDURE FOR THEIR PREPARATION.Info
- Publication number
- AR012436A1 AR012436A1 ARP980101733A ARP980101733A AR012436A1 AR 012436 A1 AR012436 A1 AR 012436A1 AR P980101733 A ARP980101733 A AR P980101733A AR P980101733 A ARP980101733 A AR P980101733A AR 012436 A1 AR012436 A1 AR 012436A1
- Authority
- AR
- Argentina
- Prior art keywords
- heterocyclic
- arylalkyl
- heteroaryl
- alkyl
- aryl
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Uso de compuestos de 4-aminopirido[2,3-D]pirimidina 5,7-disustituidos para la fabricacion de medicamentos utiles para inhibir adenosina quinasa mediantela administracion de un compuesto, o de una sal o amida del mismo, farmacéuticamenteaceptable, que tiene la formula I donde R1 y R2 estánindependientemente seleccionados de H, alquilo inferior, alcoxi C1-6 alquilo, arilalquilo C1-6, -C(O)alquilo C1-6, -C(O)arilo, -C(O)heterocíclico o puedenestar unidos conjuntamente con el nitrogeno al cual están adheridos para formar un anillo de 5-7 miembros que contiene opcionalmente 1-2 heteroátomosadicionales seleccionados de O, N, o S; R3 está seleccionado del grupo que consiste en alquilo inferior, alquenilo inferior, alquinilo inferior,cicloalquilo, arilo, arilalquilo, heteroarilo, un grupo heterocíclico, heteroarilalquilo o heterocicloalquilo donde los grupos heteroarilo yheterocíclicos están directamente o indirectamente ligados por un carbono del anillo; R4 está seleccionado del grupo que consiste en alquilo inferior,alquenilo inferior, alquinilo inferior, cicloalquilo, arilo, arilalquilo, heteroarilo, un grupo heterocíclico, heteroarilalquilo o heterocicloalquilo; yuna línea de trazos indica que está opcionalmente presente un doble enlace con la condicion de mantener las valencias apropiadas, in vitro o a un mamífero;compuesto de 4-aminopirido [2,3-D] pirimidina 5,7-disustituidos, composicion farmacéutica que los comprende, el uso de losmismos para la manufactura demedicamentos, un procedimiento para su preparacion.Use of 5,7-disubstituted 4-aminopyrido [2,3-D] pyrimidine compounds for the manufacture of medicaments useful to inhibit adenosine kinase by administering a compound, or a pharmaceutically acceptable salt or amide thereof having the Formula I where R1 and R2 are independently selected from H, lower alkyl, C1-6 alkoxy alkyl, arylalkyl C1-6, -C (O) C1-6 alkyl, -C (O) aryl, -C (O) heterocyclic or may be co-attached with the nitrogen to which they are attached to form a 5-7 membered ring optionally containing 1-2 additional heteroatoms selected from O, N, or S; R3 is selected from the group consisting of lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, aryl, arylalkyl, heteroaryl, a heterocyclic, heteroarylalkyl, or heterocycloalkyl group where the heteroaryl and heterocyclic groups are directly or indirectly linked by one ring carbon; R4 is selected from the group consisting of lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, aryl, arylalkyl, heteroaryl, a heterocyclic, heteroarylalkyl, or heterocycloalkyl group; and a dashed line indicates that a double bond is optionally present with the condition of maintaining the appropriate valencies, in vitro or to a mammal; 5,7-disubstituted 4-aminopyrido [2,3-D] pyrimidine, pharmaceutical composition than the includes the use of the same for the manufacture of medicines, a procedure for their preparation.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83821697A | 1997-04-16 | 1997-04-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR012436A1 true AR012436A1 (en) | 2000-10-18 |
Family
ID=25276561
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980101733A AR012436A1 (en) | 1997-04-16 | 1998-04-15 | 4-AMINOPIRIDE [2,3-D] PIRIMIDINE 5,7-DISSTITUTED COMPOUNDS, PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS THEM, THE USE OF THE SAME FOR LAMANUFACTURE OF MEDICINES, A PROCEDURE FOR THEIR PREPARATION. |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0989986A1 (en) |
| JP (1) | JP2001520655A (en) |
| KR (1) | KR20010006509A (en) |
| CN (1) | CN1252070A (en) |
| AR (1) | AR012436A1 (en) |
| AU (1) | AU7108398A (en) |
| BG (1) | BG103842A (en) |
| BR (1) | BR9809055A (en) |
| CA (1) | CA2286909A1 (en) |
| CO (1) | CO4940446A1 (en) |
| HU (1) | HUP0001434A3 (en) |
| IL (1) | IL131618A0 (en) |
| NO (1) | NO995036D0 (en) |
| PL (1) | PL336304A1 (en) |
| SK (1) | SK141799A3 (en) |
| TR (1) | TR199902455T2 (en) |
| WO (1) | WO1998046605A1 (en) |
| ZA (1) | ZA983177B (en) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000023444A1 (en) * | 1998-10-21 | 2000-04-27 | Abbott Laboratories | 5,7-disubstituted-4-aminopyrido[2,3-d]pyrimidine compounds |
| WO2002064594A2 (en) | 2001-02-12 | 2002-08-22 | F. Hoffmann-La Roche Ag | 6-substituted pyrido-pyrimidines |
| WO2003062209A2 (en) | 2002-01-17 | 2003-07-31 | Neurogen Corporation | Substituted quinazolin-4-ylamine analogues as modulators of capsaicin |
| DE10335183A1 (en) * | 2003-07-30 | 2005-02-24 | Bayer Cropscience Ag | Fungicidal drug combinations |
| DE602006010564D1 (en) * | 2005-07-21 | 2009-12-31 | Hoffmann La Roche | PYRIDOÄ2,3-DÜPYRIMIDIN-2,4-DIAMINE COMPOUNDS AS PTPIB INHIBITORS |
| WO2007081517A2 (en) | 2005-12-21 | 2007-07-19 | Abbott Laboratories | Anti-viral compounds |
| JP2009521479A (en) * | 2005-12-21 | 2009-06-04 | アボット・ラボラトリーズ | Antiviral compounds |
| US8236950B2 (en) | 2006-12-20 | 2012-08-07 | Abbott Laboratories | Anti-viral compounds |
| JP5718053B2 (en) | 2007-08-27 | 2015-05-13 | ヘリコン・セラピューティクス・インコーポレーテッド | Therapeutic isoxazole compounds |
| TW200916469A (en) | 2007-08-31 | 2009-04-16 | Eisai R & Amp D Man Co Ltd | Multi-cyclic compounds |
| DE102007061764A1 (en) * | 2007-12-20 | 2009-06-25 | Bayer Healthcare Ag | Anellated cyanopyridines and their use |
| WO2010098487A1 (en) * | 2009-02-26 | 2010-09-02 | Eisai R&D Management Co., Ltd. | Nitrogen-containing fused heterocyclic compounds and their use as beta amyloid production inhibitors |
| US9550750B2 (en) | 2012-10-05 | 2017-01-24 | Merck Sharp & Dohme Corp. | Indoline compounds as aldosterone synthase inhibitors |
| EP3795563B1 (en) | 2016-03-31 | 2024-07-17 | Oncternal Therapeutics, Inc. | Indoline analogs and uses thereof |
| CN110256420B (en) * | 2019-05-07 | 2020-04-28 | 江西中医药大学 | Tetrahydropyridopyrimidine derivatives, their preparation and use |
| CN110283171A (en) * | 2019-07-17 | 2019-09-27 | 鼎泰(南京)临床医学研究有限公司 | Compound of the one kind containing Pyridopyrimidine -4- amine structure, pharmaceutical composition and its application |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5324731A (en) * | 1989-02-14 | 1994-06-28 | Amira, Inc. | Method of inhibiting transformation of cells in which purine metabolic enzyme activity is elevated |
| IL112249A (en) * | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
| US6143749A (en) * | 1995-06-07 | 2000-11-07 | Abbott Laboratories | Heterocyclic substituted cyclopentane compounds |
-
1998
- 1998-04-14 EP EP98918093A patent/EP0989986A1/en not_active Withdrawn
- 1998-04-14 CN CN98804151A patent/CN1252070A/en active Pending
- 1998-04-14 AU AU71083/98A patent/AU7108398A/en not_active Abandoned
- 1998-04-14 SK SK1417-99A patent/SK141799A3/en unknown
- 1998-04-14 CA CA002286909A patent/CA2286909A1/en not_active Abandoned
- 1998-04-14 IL IL13161898A patent/IL131618A0/en unknown
- 1998-04-14 JP JP54408898A patent/JP2001520655A/en active Pending
- 1998-04-14 KR KR1019997009599A patent/KR20010006509A/en not_active Application Discontinuation
- 1998-04-14 TR TR1999/02455T patent/TR199902455T2/en unknown
- 1998-04-14 BR BR9809055-0A patent/BR9809055A/en not_active Application Discontinuation
- 1998-04-14 PL PL98336304A patent/PL336304A1/en unknown
- 1998-04-14 HU HU0001434A patent/HUP0001434A3/en unknown
- 1998-04-14 WO PCT/US1998/007207 patent/WO1998046605A1/en not_active Application Discontinuation
- 1998-04-15 AR ARP980101733A patent/AR012436A1/en unknown
- 1998-04-15 ZA ZA983177A patent/ZA983177B/en unknown
- 1998-04-16 CO CO98020979A patent/CO4940446A1/en unknown
-
1999
- 1999-10-15 NO NO995036A patent/NO995036D0/en not_active Application Discontinuation
- 1999-10-29 BG BG103842A patent/BG103842A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| NO995036L (en) | 1999-10-15 |
| WO1998046605A1 (en) | 1998-10-22 |
| CN1252070A (en) | 2000-05-03 |
| CO4940446A1 (en) | 2000-07-24 |
| EP0989986A1 (en) | 2000-04-05 |
| TR199902455T2 (en) | 2000-01-21 |
| HUP0001434A3 (en) | 2001-01-29 |
| CA2286909A1 (en) | 1998-10-22 |
| BG103842A (en) | 2000-06-30 |
| JP2001520655A (en) | 2001-10-30 |
| BR9809055A (en) | 2000-08-08 |
| AU7108398A (en) | 1998-11-11 |
| HUP0001434A2 (en) | 2000-10-28 |
| ZA983177B (en) | 1999-01-22 |
| PL336304A1 (en) | 2000-06-19 |
| KR20010006509A (en) | 2001-01-26 |
| SK141799A3 (en) | 2000-08-14 |
| NO995036D0 (en) | 1999-10-15 |
| IL131618A0 (en) | 2001-01-28 |
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