Papers by Mesut Sahin, PhD
One of the roadblocks in the field of neural prosthetics is the lack of microelectronic devices f... more One of the roadblocks in the field of neural prosthetics is the lack of microelectronic devices for neural stimulation that can last a lifetime in the central nervous system. Wireless multi-electrode arrays are being developed to improve the longevity of implants by eliminating the wire interconnects as well as the chronic tissue reactions due to the tethering forces generated by these wires. An area of research that has not been sufficiently investigated is a simple single-channel passive microstimulator that can collect the stimulus energy that is transmitted wirelessly through the tissue and immediately convert it into the stimulus pulse. For example, many neural prosthetic approaches to intraspinal microstimulation require only a few channels of stimulation. Wired spinal cord implants are not practical for human subjects because of the extensive flexions and rotations that the spinal cord experiences. Thus, intraspinal microstimulation may be a pioneering application that can benefit from submillimeter-size floating stimulators. Possible means of energizing such a floating microstimulator, such as optical, acoustic, and electromagnetic waves, are discussed.
BMC biomedical engineering, Mar 21, 2022
Background: Electrocorticography (ECoG) arrays are commonly used to record the brain activity bot... more Background: Electrocorticography (ECoG) arrays are commonly used to record the brain activity both in animal and human subjects. There is a lack of guidelines in the literature as to how the array geometry, particularly the via holes in the substrate, affects the recorded signals. A finite element (FE) model was developed to simulate the electric field generated by neurons located at different depths in the rat brain cortex and a micro ECoG array (μECoG) was placed on the pia surface for recording the neural signal. The array design chosen was a typical array of 8 × 8 circular (100 μm in diam.) contacts with 500 μm pitch. The size of the via holes between the recording contacts was varied to see the effect. Results: The results showed that recorded signal amplitudes were reduced if the substrate was smaller than about four times the depth of the neuron in the gray matter. The signal amplitude profiles had dips around the via holes and the amplitudes were also lower at the contact sites as compared to the design without the holes; an effect that increased with the hole size. Another noteworthy result is that the spatial selectivity of the multi-contact recordings could be improved or reduced by the selection of the via hole sizes, and the effect depended on the distance between the neuron pair targeted for selective recording and its depth. Conclusions: The results suggest that the via-hole size clearly affects the recorded neural signal amplitudes and it can be leveraged as a parameter to reduce the inter-channel correlation and thus maximize the information content of neural signals with μECoG arrays.
Elimination of wires connecting neural recording electrodes to external electronics is highly des... more Elimination of wires connecting neural recording electrodes to external electronics is highly desired, particularly in survival animal studies, due to neural damage and the device failures caused by these wires. In this study, an electroacoustic device for sensing and wireless transmission of neural signals to an external unit is proposed and results from a prototype are presented. In this method, the neural signals modulate the acoustic pulse amplitudes generated by a small piezoelectric element that is implanted at the recording site. The acoustics waves are detected wirelessly outside the nervous system by another piezoelectric transducer and the neural signals are extracted by amplitude demodulation. To test the prototype, a sinusoidal signal with 100μVpp amplitude was applied in phosphate buffered saline to simulated neural signals and the external transducer was placed 10mm away from the recording element. The results show that a sinusoidal signal of the given amplitude could be wirelessly sensed and reconstructed with a signal-to-noise ratio of 14dB.
Journal of Applied Physiology, Jul 1, 2019
The extrinsic tongue muscles are activated in coordination with pharyngeal muscles to dilate the ... more The extrinsic tongue muscles are activated in coordination with pharyngeal muscles to dilate the airways as needed during breathing. The genioglossus (GG) activity is known to be modulated by several reflexes evoked via the mechanoreceptors of the upper airways. The primary objective of this paper was to investigate the effectiveness of activating these reflex pathways using mechanical stimulation of the mandible or the submandibular muscles. In eight healthy subjects, 3-s long, 5-mm vertical mechanical vibrations were delivered at 8 and 12 Hz to the lower jaw in a seated position, while the GG EMG was recorded using a custom-made sublingual electrode, along with the activity of the masseter (MS) and mylohyoid (MH). All three muscle activities were significantly higher during stimulation compared with the baseline (P Ͻ 0.02), and the increase was larger at 12 Hz versus 8 Hz (P Ͻ 0.02). All three muscle responses had components that synchronized with the mechanical stimuli, but those of MS were much more strongly phase-locked to the vibrational cycle. In 10 healthy subjects, we also applied mechanical vibrations to the submandibular muscles at three different stimulation intensities, while subjects were lying in a supine position. The GG activity increased significantly above the baseline (P ϭ 0.026) in 9 out of 10 subjects, and the elevated activity persisted after termination of the stimulus for a few seconds. The results demonstrate that GG muscle responses can be evoked with mechanical vibrations applied to the lower jaw or the submandibular muscles in healthy subjects during wakefulness. NEW & NOTEWORTHY The evoked responses observed in the genioglossus (GG) activity during mechanical vibrations of the lower jaw or the submandibular muscles may lead to therapeutic applications for improving the patency of airways during sleep. The presence of these GG reflexes may also explain a mechanism by which the vibrations produced during snoring can help the airways stay open in individuals who may otherwise have obstructed airways in sleep.
Proceedings of SPIE, Sep 14, 1993
ABSTRACT
Journal of Biomedical Optics, May 13, 2017
Neural electrodes and associated electronics are powered either through percutaneous wires or tra... more Neural electrodes and associated electronics are powered either through percutaneous wires or transcutaneous powering schemes with energy harvesting devices implanted underneath the skin. For electrodes implanted in the spinal cord and the brain stem that experience large displacements, wireless powering may be an option to eliminate device failure by the breakage of wires and the tethering of forces on the electrodes. We tested the feasibility of using optically clear polydimethylsiloxane (PDMS) as a waveguide to collect the light in a subcutaneous location and deliver to deeper regions inside the body, thereby replacing brittle metal wires tethered to the electrodes with PDMS-based optical waveguides that can transmit energy without being attached to the targeted electrode. We determined the attenuation of light along the PDMS waveguides as 0.36 AE 0.03 dB∕cm and the transcutaneous light collection efficiency of cylindrical waveguides as 44% AE 11% by transmitting a laser beam through the thenar skin of human hands. We then implanted the waveguides in rats for a month to demonstrate the feasibility of optical transmission. The collection efficiency and longitudinal attenuation values reported here can help others design their own waveguides and make estimations of the waveguide cross-sectional area required to deliver sufficient power to a certain depth in tissue.
This study investigated the feasibility of chronically recording descending signals from the rat ... more This study investigated the feasibility of chronically recording descending signals from the rat spinal cord using microwire electrodes. Eight 25μm diameter Pt-Ir microwires were implanted in the dorsolateral rubrospinal tract (RST) bilaterally at the c5 level in each of the four adult Long Evans rats trained for food reach-to-grasp task. Signal stability was assessed by calculating the signal-to-noise ratio (SNR) and mean signal amplitude during the four week recording period. The results of ANOVA did not suggest significant difference between sessions for any of the electrodes, indicating stability. Immunohistology suggested minimal tissue response to these microwires during the four week implant period. The results of this study show that microwire electrodes can be used for short-term chronic recordings of signals from the descending motor tracts in experimental animals.
Many applications of neural stimulation demand a high current density from the electrodes used fo... more Many applications of neural stimulation demand a high current density from the electrodes used for stimulus delivery. New materials have been searched that can provide such large current and charge densities where the traditional noble metal and capacitor electrodes are inadequate. Titanium nitride, which has been used in cardiac pacemaker leads for many years, is one of these materials recently considered for neural stimulation. In this short report, we investigated the charge injection capacity of TiN electrodes for an extended range of cathodic voltages. The injected charge increased first slowly as a function of the electrode voltage, and then at a faster rate beyond −1.6 V. The maximum charge was 4.45 mC/cm 2 (n=6) for a cathodic voltage peak of −3.0 V and a bias voltage of −0.8 V. There was no evidence of bubble generation under microscopic observation. The unrecoverable charges remained under 7% of the total injected charge for the largest cathodic voltage tested. These large values of charge injection capacity and relatively small unrecoverable charges warrant further investigation of the charge injection mechanism in TiN interfaces at this extended range of electrode voltages.
IEEE Transactions on Neural Systems and Rehabilitation Engineering, Dec 1, 2005
A single-stage, low-noise preamplifier is designed using the concept of noise matching for record... more A single-stage, low-noise preamplifier is designed using the concept of noise matching for recordings of neural signal with cuff electrodes. The signal-to-noise ratio is approximately 1.6 times higher than that of a low-noise integrated amplifier (AMP-01) for a cuff impedance of 1.5 k. The bandwidth is 230 Hz-8.25 kHz (R =2 k), and the commonmode-rejection-ratio is 91.2 dB at 1 kHz.
Implantable microelectrode arrays (MEAs) usually have on-site electronics that need to be powered... more Implantable microelectrode arrays (MEAs) usually have on-site electronics that need to be powered, both in neural recording and stimulation applications. Interconnecting wires between implanted electrodes and the outside world constitute a major source of complications. Our solution to this tethering problem is to design a light waveguide that can collect the optical power transcutaneously and transmit it to the microelectrode array where it is to be converted to an electric current. A polydimethylsiloxane (PDMS)-based waveguide was fabricated and its attenuation was measured in vitro and found to be 0.36 dB/cm. The skin flap of the thenar web space in the hand was used to test the photon collection efficiency of the waveguide in diffuse light. The efficiency of the waveguide alone was 44±11% (mean±std), excluding the attenuation within the thenar skin, as measured in 13 subjects with different skin pigmentations. These preliminary results suggest that a PDMS waveguide may collect and deliver optical power with sufficient efficiencies to deep structures inside the body. Optical powering scheme can solve the tethering and breakage problems associated with metal wire connections.
Annals of Biomedical Engineering, Jun 1, 2004
Journal of Neural Engineering, Jan 21, 2015
Objective. Microelectrodes implanted in the central nervous system (CNS) often fail in long term ... more Objective. Microelectrodes implanted in the central nervous system (CNS) often fail in long term implants due to the immunological tissue response caused by tethering forces of the connecting wires. In addition to the tethering effect, there is a mechanical stress that occurs at the devicetissue interface simply because the microelectrode is a rigid body floating in soft tissue and it cannot reshape itself to comply with changes in the surrounding tissue. In the current study we evaluated the scar tissue formation to tetherless devices with two significantly different geometries in the rat brain and spinal cord in order to investigate the effects of device geometry. Approach. One of the implant geometries resembled the wireless, floating microstimulators that we are currently developing in our laboratory and the other was a (shank only) Michigan probe for comparison. Both electrodes were implanted into either the cervical spinal cord or the motor cortices, one on each side. Main results. The most pronounced astroglial and microglial reactions occurred within 20 μm from the device and decreased sharply at larger distances. Both cell types displayed the morphology of non-activated cells past the 100 μm perimeter. Even though the aspect ratios of the implants were different, the astroglial and microglial responses to both microelectrode types were very mild in the brain, stronger and yet limited in the spinal cord. Significance. These observations confirm previous reports and further suggest that tethering may be responsible for most of the tissue response in chronic implants and that the electrode size has a smaller contribution with floating electrodes. The electrode size may be playing primarily an amplifying role to the tethering forces in the brain whereas the size itself may induce chronic response in the spinal cord where the movement of surrounding tissues is more significant.
Encyclopedia of Computational Neuroscience
Characterization of neural activity recorded from the
Key Engineering Materials, 2017
Fibre Bragg Grating (FBG) sensors are frequently being used for Structural Health Monitoring (SHM... more Fibre Bragg Grating (FBG) sensors are frequently being used for Structural Health Monitoring (SHM) of aerospace structures. One of the most important advantages of using FBG sensors is that it is possible to embed them into composites. In this paper, manufacturing methods of composite specimens with embedded FBG sensors are given. To avoid stress concentrations at ingress/egress regions of fibre optic wires, PTFE (Teflon) tubes were used during manufacturing. Moreover, FBG connectors melt at high curing temperatures. Therefore, those connectors were cut and after manufacturing, these connectors were spliced back to the FBG sensors. Embedded FBG’s were then checked and the correct wavelength data were taken. All the sensors were observed as intact and ready for bending tests. Procedure for bending tests is also explained including applied loads, boundary conditions, test setup and the peripheral equipment. Results of bending tests show that the system is an appropriate one for SHM pu...
This study presents the design and analysis of a novel hybrid trailing edge control surface that ... more This study presents the design and analysis of a novel hybrid trailing edge control surface that is capable to perform both camber and decamber morphing. The design was conducted with CATIA V5-6R2012 package program. Structural analyses were performed with Finite Element Method by using ANSYS® Workbench™ v14.0 package program both in in-vacuo condition and under aerodynamic loading. The aerodynamic loads were calculated by Computational Fluid Dynamics analyses. The required aerodynamic mesh was generated by Pointwise® V17.2 R2 package program, and SU2 (Stanford University Unstructured) V3.2.1 open source software was used as flow solver. The results prove that the designed control surface is capable of performing both camber and decamber morphing both in in-vacuo condition and under aerodynamic loading.
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Papers by Mesut Sahin, PhD