MeSH Browser

MeSH Heading: DNA Damage
Tree Number(s): G05.200
Unique ID: D004249
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D004249
Annotation: do not use /‌drug eff & /‌rad eff for DNA damage induced by drugs or radiation; do not confuse with DNA FRAGMENTATION: see note there
Scope Note: Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.
Entry Term(s): DNA Injury; DNA Lesion; DNA Lesions; Genotoxic Stress; Injury, DNA; Stress, Genotoxic
NLM Classification #: QU 510
Previous Indexing: DNA (1966-1986); DNA Repair (1971-1986); DNA Replication (1968-1986)
See Also: Mutation
Public MeSH Note: 87
History Note: 87
Date Established: 1987/01/01
Date of Entry: 1986/06/19
Revision Date: 2023/05/26

Allowable Qualifiers: drug effects (DE)

ethics (ES)

genetics (GE)

immunology (IM)

physiology (PH)

radiation effects (RE)

Concept UI: M0006649
Scope Note: Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.
Terms: DNA Damage Preferred Term
Term UI T012897
Date01/01/1999
LexicalTag ACX
ThesaurusID NLM (1987); Injury, DNA
Term UI T012898
Date06/19/1986
LexicalTag NON
ThesaurusID UNK (19XX); DNA Injury
Term UI T012899
Date06/19/1986
LexicalTag NON
ThesaurusID UNK (19XX); DNA Lesion
Term UI T001134461
Date03/03/2023
LexicalTag NON
ThesaurusID NLM (2024); DNA Lesions
Term UI T001134462
Date03/03/2023
LexicalTag NON
ThesaurusID NLM (2024)

DNA Damage MeSH Descriptor Data 2024