Papers by marie korostelev
Journal of Cerebral Blood Flow and Metabolism, Jul 4, 2018
Le Pharmacien Hospitalier et Clinicien, Dec 1, 2017
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, Jul 4, 2018
Following middle cerebral artery (MCA) stroke, enhanced contralesional evoked responses have been... more Following middle cerebral artery (MCA) stroke, enhanced contralesional evoked responses have been consistently reported both in man and rodents as part of plastic processes thought to influence motor recovery. How early this marker of large-scale network reorganization develops has however been little addressed, yet has clinical relevance for rehabilitation strategies targeting plasticity. Previous work in mice has reported enhanced contralesional responses to unaffected-side forepaw stimulation as early as 45 min after MCA small branch occlusion. Using functional ultrasound imaging (fUSi) in anesthetized rats subjected to distal temporary MCA occlusion (MCAo), we assessed here (i) whether enhanced contralesional responses also occurred with unaffected-side whisker pad stimulation, and if so, how early after MCAo; and (ii) the time course of this abnormal response during occlusion and after reperfusion. We replicate in a more proximal MCA occlusion model the earlier findings of ultr...
Science signaling, Jan 19, 2016
The ability of the gut hormone ghrelin to promote positive energy balance is mediated by the grow... more The ability of the gut hormone ghrelin to promote positive energy balance is mediated by the growth hormone secretagogue receptor (GHSR). GHSR is a G protein-coupled receptor (GPCR) that is found centrally and peripherally and that can signal in a ligand-independent manner basally or when heterodimerized with other GPCRs. However, current Ghsr knockout models cannot dissect ghrelin-dependent and ghrelin-independent signaling, precluding assessment of the physiological importance of these signaling pathways. An animal model carrying a Ghsr mutation that preserves GHSR cell surface abundance, but selectively alters GHSR signaling, would be a useful tool to decipher GHSR signaling in vivo. We used rats with the Ghsr(Q343X) mutation (Ghsr(M/M)), which is predicted to delete the distal part of the GHSR carboxyl-terminal tail, a domain critical for the signal termination processes of receptor internalization and β-arrestin recruitment. In cells, the GHSR-Q343X mutant showed enhanced ligan...
La Revue de Médecine Interne, 2012
Résultats.-Cent soixante-sept cas de FM ont été rapportés au cours de cette période impliquant 10... more Résultats.-Cent soixante-sept cas de FM ont été rapportés au cours de cette période impliquant 108 médicaments différents. Sur la base du PRR, 22 médicaments étaient associés de faç on statistiquement significative à une FM. Les antibiotiques étaient les médicaments les plus fréquemment rapportés : amikacine (39,6, PRR), oxacilline (9,1), céfotaxime (5,5), ceftriaxone (5,4), rifampicine (4,0), vancomycine (4,0), ciprofloxacine (3,1), isoniazide (3,9), pristinamycine (3,1), et triméthoprime-sulfaméthoxazole (2,6). Le délai entre l'administration du médicament et le début de la fièvre était de 12,1 ± 27,9 jours. Le diagnostic de FM était posé et les médicaments suspects interrompus 18,0 ± 46,0 jours après l'apparition de la fièvre. Un rechallenge était réalisé dans 38,0 % des cas avec récidive de la FM dans tous les cas. Les FM ont donné lieu à des évènements potentiellement mortels dans 0,6 % des cas, à des hospitalisations ou des séjours prolongés à l'hôpital dans 26, 3 % des cas, et à une incapacité persistante dans 0,6 % des cas. L'évolution finale était favorable dans 96,9 % des cas. Conclusions.-La FM est un effet indésirable médicamenteux potentiellement grave et sous rapporté. Son diagnostic est difficile amenant à réaliser des explorations coûteuses et inutiles. Les médicaments les plus fréquemment impliqués étaient les antibiotiques.
Journal of Pharmaceutical and Biomedical Analysis, 2014
A sensitive and accurate liquid chromatography method with mass spectrometry detection was develo... more A sensitive and accurate liquid chromatography method with mass spectrometry detection was developed and validated for the quantification of dabigatran (Pradaxa ®) and rivaroxaban (Xarelto ®). 13 C 6-dabigatran and 13 C 6-rivaroxaban were used as the internal standard. A single-step protein precipitation was used for plasma sample preparation. This method was validated with respect to linearity, selectivity, inter-and intra-day precision and accuracy, limit of quantification and stability. The lower limit of quantification was 2.5 ng/mL for both drugs in plasma.
Le Pharmacien Hospitalier et Clinicien, 2013
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Papers by marie korostelev