Mental health problems are common in the general population. The aim of this study was to investi... more Mental health problems are common in the general population. The aim of this study was to investigate differences in frequencies of self-reported psychiatric symptoms, harmful alcohol use and healthcare contacts, in an urban and a rural area in Sweden. Two samples of 10,441 (urban site) and 3538 (rural site) subjects, aged 20-64, responded to a questionnaire, covering demographic characteristics and self-report psychiatric instruments as well as contact with healthcare during the past 12 months. Psychiatric symptoms and symptoms of substance abuse were reported by 17% of the urban women compared with 13% of the rural women, and by 20% of the urban men compared with 15% of the rural men. This difference is mainly due to an uneven age distribution in the two populations and remains statistically significant only in the oldest age group (50-64 years). Symptoms of anxiety and depression occurred with similar frequencies in both samples. Harmful alcohol use was reported by 3.6% of the urban women, 1.5% of rural women, 11.8% of urban men and 8.6% of rural men. The urban sample had more often been in contact with medical services, 77% vs. 52%. Symptoms of anxiety and depression were equally common in the two samples. Harmful use of alcohol was more common in the urban sample, especially among women. Most obvious was the stronger inclination to seek help in the urban sample.
British Journal of Clinical Psychology, Apr 5, 2016
Mental ill-health has become a large health problem and it is important for caregivers to provide... more Mental ill-health has become a large health problem and it is important for caregivers to provide effective treatment alternatives. REGASSA is a randomized controlled study performed in primary care to study the effects of 12 weeks of Internet-based cognitive behaviour therapy (ICBT) and physical exercise (PE) compared with treatment as usual (TAU) in patients with mild-to-moderate mental ill-health. The present study aimed to examine the results of these treatment alternatives on psychological functioning, stress, and sleep disturbances. The study comprised 879 patients with mental ill-health taking part in the REGASSA study. Data were collected by Interactive Voice Response (IVR), a computerized, automated telephone technique. The treatments were compared at baseline, twice during treatment, at the end of treatment and at three follow-ups after treatment. Measures used were the Outcome Questionnaire-45, the short versions of the Perceived Stress Scale, and the Karolinska Sleep Questionnaire. Linear mixed models showed that the patients in ICBT and PE had better results than in TAU on psychological functioning and sleep disturbances, p < .001, with weak-to-moderate effect sizes. On stress there were no differences; all groups made improvements. Women had stronger effects than men. More patients recovered on psychological functioning (OQ-45) in ICBT and PE than in TAU. Internet-based cognitive behaviour therapy and PE proved to be effective treatment alternatives for patients with mild-to-moderate mental ill-health in improving psychological functioning, stress, and sleep disturbances and could be useful alternatives in primary care. Internet-based cognitive behaviour therapy and physical exercise proved to be effective treatment alternatives for mental ill-health patients in primary care. Automated techniques (Interactive Voice Response) could be useful for following treatment course in large groups of patients in the health care. It is important to use measures that capture different aspects of patients' health problems. The recruitment of participants was based on patients' interest and inclusion criteria which may have affect the generalizability.
Mental health problems are often underrecognized and undertreated. Knowledge of the characteristi... more Mental health problems are often underrecognized and undertreated. Knowledge of the characteristics associated with the pathway to having a need for mental health care by appropriate treatment (met need) can help to correct this deficit. This study used data from a population-based study to determine the characteristics of persons whose needs were meetable, who were aware of the need for mental health care, who requested care, and whose needs were met. A total of 10,443 randomly selected persons in Stockholm, Sweden, aged 20 to 64 years answered a survey that included questions about mental health problems. A subsample of 1,093 persons was then interviewed by psychiatrists, who determined whether the respondents had a psychiatric disorder according to DSM-IV criteria. The interview also assessed need for care, service use, and whether an evidence-based treatment was available for the mental health problem. Among the 1,093 persons interviewed 462 were found to have a mental health problem for which psychiatric treatment was available (meetable need for care). Among the 462 persons with a meetable need for care, 70 percent fulfilled the DSM-IV diagnostic criteria for having a psychiatric disorder; the rest had various symptoms, mostly depressive. Among the persons with a meetable need for care, 84 percent were aware of this need, 37 percent had requested care, and 17 percent had their needs met by evidence-based treatment. Persons whose needs were met tended to be female, have more education, and have good social support. Also, they were less likely to report that feelings of shame would prevent them from requesting psychiatric care. The characteristics associated with unmet need suggest that strategies that focus on specific groups (for example, males and persons with less education) could increase the percentage of persons whose needs are met.
International Journal of Social Psychiatry, Mar 1, 2010
Background: In epidemiological studies, analyses are needed to investigate the consequences of no... more Background: In epidemiological studies, analyses are needed to investigate the consequences of non-response. Aims: To analyse the consequences of attrition in the second wave of the population-based PART study, which was performed three years after the first wave. Methods: Potential determinants for non-participation obtained from population registers and the first wave were analyzed. The relationships between potential determinants and reduced well-being or depressive mood in the first wave questionnaire were investigated separately for participants and non-participants in the second wave. Samples of respondents to the second wave questionnaire with reduced or not reduced well-being were summoned for interview regarding determinants of distress and disorder. The occurrence of potential determinants was compared between participants and non-participants in both groups Results: Low income, low education, non-Nordic origin, not being married and previous psychiatric diagnosis were associated with lower participation rates. These variables were similarly related to depressive mood and low psychological well-being in the first wave among participants and non-participants in the second wave. Potential determinants were not or only weakly related to participation in the interview groups. Conclusion: Although the true prevalence of distress and disorder is underestimated, the true associations between potential determinants and the outcomes seem reasonably well reproduced.
Social Psychiatry and Psychiatric Epidemiology, Jun 1, 2005
The study had two objectives: (i) to analyse determinants of non-participation in a general popul... more The study had two objectives: (i) to analyse determinants of non-participation in a general population study of mental disorder in Stockholm, and (ii) to determine whether associations between mental disorder and some potential determinants were different among participants and non-participants in the study. The study was based on a questionnaire including potential risk factors for mental disorder and symptom scales. The study group was a random sample of the Stockholm County population aged 20-64 years (19,742 persons). Replies were obtained from 10,441 participants, i. e. the response rate was 53%. The symptom scales were used to identify a group with increased likelihood of mental disorder, screening-positive, and a group with low likelihood of mental disorder, screening-negative. Random samples of the screening-positive and screening-negative respondents were summoned for interview concerning psychiatric symptoms. The database of respondents and non-respondents was linked to several population registers. The participation was higher in females, among older persons, married persons, among persons with higher income and education and among those born in the Nordic countries. There seemed to be little further risk indicator based selection to interview participation. The associations between in-patient psychiatric care and register variables were strong and similar among participants and non-participants. The occurrence of mental disorders is likely to be underestimated in studies with this design and with substantial dropout rates. However, the study participants can most likely be a base for generalising risk indicators for, or social consequences of,mental disorder, to the general population.
Circadian rhythm disturbances overlap between psychotic disorders, e.g. schizophrenia, and major ... more Circadian rhythm disturbances overlap between psychotic disorders, e.g. schizophrenia, and major depression. We hypothesized that circadian gene variants previously associated with unipolar depression would be overrepresented also in patients with psychotic disorder. Six genetic polymorphisms in ARNTL, PER2 and CRY2 were genotyped in 566 schizophrenia spectrum disorder patients and 926 controls. The rs2290036-C variant of ARNTL was over-represented in psychosis patients, and the variants rs934945-G and rs10462023-G of PER2 were associated with a more severe psychotic disorder. The directions of these genetic associations were in line with those previously identified for depression.
Mental health problems are common in the general population. The aim of this study was to investi... more Mental health problems are common in the general population. The aim of this study was to investigate differences in frequencies of self-reported psychiatric symptoms, harmful alcohol use and healthcare contacts, in an urban and a rural area in Sweden. Two samples of 10,441 (urban site) and 3538 (rural site) subjects, aged 20-64, responded to a questionnaire, covering demographic characteristics and self-report psychiatric instruments as well as contact with healthcare during the past 12 months. Psychiatric symptoms and symptoms of substance abuse were reported by 17% of the urban women compared with 13% of the rural women, and by 20% of the urban men compared with 15% of the rural men. This difference is mainly due to an uneven age distribution in the two populations and remains statistically significant only in the oldest age group (50-64 years). Symptoms of anxiety and depression occurred with similar frequencies in both samples. Harmful alcohol use was reported by 3.6% of the urban women, 1.5% of rural women, 11.8% of urban men and 8.6% of rural men. The urban sample had more often been in contact with medical services, 77% vs. 52%. Symptoms of anxiety and depression were equally common in the two samples. Harmful use of alcohol was more common in the urban sample, especially among women. Most obvious was the stronger inclination to seek help in the urban sample.
British Journal of Clinical Psychology, Apr 5, 2016
Mental ill-health has become a large health problem and it is important for caregivers to provide... more Mental ill-health has become a large health problem and it is important for caregivers to provide effective treatment alternatives. REGASSA is a randomized controlled study performed in primary care to study the effects of 12 weeks of Internet-based cognitive behaviour therapy (ICBT) and physical exercise (PE) compared with treatment as usual (TAU) in patients with mild-to-moderate mental ill-health. The present study aimed to examine the results of these treatment alternatives on psychological functioning, stress, and sleep disturbances. The study comprised 879 patients with mental ill-health taking part in the REGASSA study. Data were collected by Interactive Voice Response (IVR), a computerized, automated telephone technique. The treatments were compared at baseline, twice during treatment, at the end of treatment and at three follow-ups after treatment. Measures used were the Outcome Questionnaire-45, the short versions of the Perceived Stress Scale, and the Karolinska Sleep Questionnaire. Linear mixed models showed that the patients in ICBT and PE had better results than in TAU on psychological functioning and sleep disturbances, p < .001, with weak-to-moderate effect sizes. On stress there were no differences; all groups made improvements. Women had stronger effects than men. More patients recovered on psychological functioning (OQ-45) in ICBT and PE than in TAU. Internet-based cognitive behaviour therapy and PE proved to be effective treatment alternatives for patients with mild-to-moderate mental ill-health in improving psychological functioning, stress, and sleep disturbances and could be useful alternatives in primary care. Internet-based cognitive behaviour therapy and physical exercise proved to be effective treatment alternatives for mental ill-health patients in primary care. Automated techniques (Interactive Voice Response) could be useful for following treatment course in large groups of patients in the health care. It is important to use measures that capture different aspects of patients' health problems. The recruitment of participants was based on patients' interest and inclusion criteria which may have affect the generalizability.
Mental health problems are often underrecognized and undertreated. Knowledge of the characteristi... more Mental health problems are often underrecognized and undertreated. Knowledge of the characteristics associated with the pathway to having a need for mental health care by appropriate treatment (met need) can help to correct this deficit. This study used data from a population-based study to determine the characteristics of persons whose needs were meetable, who were aware of the need for mental health care, who requested care, and whose needs were met. A total of 10,443 randomly selected persons in Stockholm, Sweden, aged 20 to 64 years answered a survey that included questions about mental health problems. A subsample of 1,093 persons was then interviewed by psychiatrists, who determined whether the respondents had a psychiatric disorder according to DSM-IV criteria. The interview also assessed need for care, service use, and whether an evidence-based treatment was available for the mental health problem. Among the 1,093 persons interviewed 462 were found to have a mental health problem for which psychiatric treatment was available (meetable need for care). Among the 462 persons with a meetable need for care, 70 percent fulfilled the DSM-IV diagnostic criteria for having a psychiatric disorder; the rest had various symptoms, mostly depressive. Among the persons with a meetable need for care, 84 percent were aware of this need, 37 percent had requested care, and 17 percent had their needs met by evidence-based treatment. Persons whose needs were met tended to be female, have more education, and have good social support. Also, they were less likely to report that feelings of shame would prevent them from requesting psychiatric care. The characteristics associated with unmet need suggest that strategies that focus on specific groups (for example, males and persons with less education) could increase the percentage of persons whose needs are met.
International Journal of Social Psychiatry, Mar 1, 2010
Background: In epidemiological studies, analyses are needed to investigate the consequences of no... more Background: In epidemiological studies, analyses are needed to investigate the consequences of non-response. Aims: To analyse the consequences of attrition in the second wave of the population-based PART study, which was performed three years after the first wave. Methods: Potential determinants for non-participation obtained from population registers and the first wave were analyzed. The relationships between potential determinants and reduced well-being or depressive mood in the first wave questionnaire were investigated separately for participants and non-participants in the second wave. Samples of respondents to the second wave questionnaire with reduced or not reduced well-being were summoned for interview regarding determinants of distress and disorder. The occurrence of potential determinants was compared between participants and non-participants in both groups Results: Low income, low education, non-Nordic origin, not being married and previous psychiatric diagnosis were associated with lower participation rates. These variables were similarly related to depressive mood and low psychological well-being in the first wave among participants and non-participants in the second wave. Potential determinants were not or only weakly related to participation in the interview groups. Conclusion: Although the true prevalence of distress and disorder is underestimated, the true associations between potential determinants and the outcomes seem reasonably well reproduced.
Social Psychiatry and Psychiatric Epidemiology, Jun 1, 2005
The study had two objectives: (i) to analyse determinants of non-participation in a general popul... more The study had two objectives: (i) to analyse determinants of non-participation in a general population study of mental disorder in Stockholm, and (ii) to determine whether associations between mental disorder and some potential determinants were different among participants and non-participants in the study. The study was based on a questionnaire including potential risk factors for mental disorder and symptom scales. The study group was a random sample of the Stockholm County population aged 20-64 years (19,742 persons). Replies were obtained from 10,441 participants, i. e. the response rate was 53%. The symptom scales were used to identify a group with increased likelihood of mental disorder, screening-positive, and a group with low likelihood of mental disorder, screening-negative. Random samples of the screening-positive and screening-negative respondents were summoned for interview concerning psychiatric symptoms. The database of respondents and non-respondents was linked to several population registers. The participation was higher in females, among older persons, married persons, among persons with higher income and education and among those born in the Nordic countries. There seemed to be little further risk indicator based selection to interview participation. The associations between in-patient psychiatric care and register variables were strong and similar among participants and non-participants. The occurrence of mental disorders is likely to be underestimated in studies with this design and with substantial dropout rates. However, the study participants can most likely be a base for generalising risk indicators for, or social consequences of,mental disorder, to the general population.
Circadian rhythm disturbances overlap between psychotic disorders, e.g. schizophrenia, and major ... more Circadian rhythm disturbances overlap between psychotic disorders, e.g. schizophrenia, and major depression. We hypothesized that circadian gene variants previously associated with unipolar depression would be overrepresented also in patients with psychotic disorder. Six genetic polymorphisms in ARNTL, PER2 and CRY2 were genotyped in 566 schizophrenia spectrum disorder patients and 926 controls. The rs2290036-C variant of ARNTL was over-represented in psychosis patients, and the variants rs934945-G and rs10462023-G of PER2 were associated with a more severe psychotic disorder. The directions of these genetic associations were in line with those previously identified for depression.
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Papers by Yvonne Forsell