The study aim was to investigate the effect of three different morphine doses added to levobupiva... more The study aim was to investigate the effect of three different morphine doses added to levobupivacaine 0.125% for caudal analgesia after circumcision surgery in children, particularly in relation to the frequency of postoperative vomiting within the first 24 hours following surgery. Two hundred and forty patients aged 5 to 12 years undergoing circumcision were included in the study. Following induction, caudal 0.125% levobupivacaine 0.5 ml/kg was given after adding 7.5, 10 or 15 μg/kg morphine. The postoperative incidence of vomiting was 5%, 12.5% and 17.5% in the groups 7.5, 10 and 15 μg/kg morphine, respectively ( P=0.012, 7.5 versus 15 μg/kg groups). Five percent of the 7.5 μg/kg group and none of the patients in the other groups required paracetamol within the first 12 hours, and there was a significantly greater need for rescue paracetamol over the 24 hours in the 7.5 group versus the 15 μg/kg group ( P=0.013). Postoperative analgesic durations were long and did not differ betw...
The purpose of this research is to present a sample study analyzing data gathered from an educati... more The purpose of this research is to present a sample study analyzing data gathered from an educational study using data mining techniques appropriate for processing these data. In order to achieve this aim, a "Computer Self-efficiency Scale" used in educational sciences was selected and this scale was applied in a study group. Data was analyzed using descriptive statistics (ttest and analysis of variance), and the data mining techniques of decision tree, dependency networks and clustering. The descriptive statistics used were calculated not using common statistical software packages, but by running a program written in Delphi 2009 programming language on Microsoft SQL Server 2008. Microsoft SQL Server 2008 was directly used for the data mining techniques of dependency networks and clustering. Some of the findings of the research, which cannot be obtained by common statistical techniques but can be obtained by data mining methods, were as follows: "those who think they are competent with computer terms and concepts believe they have a special talent in using computers" ; "those who believe they have a special talent in using computers feel as if the computer is part of their body", and "students who have been using computers for more than six years believe they have a special talent in using computers".
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, Jan 16, 2015
Tonsillectomy surgery is associated with severe postoperative pain that usually requires analgesi... more Tonsillectomy surgery is associated with severe postoperative pain that usually requires analgesics including opioids. Pain control is still a big problem after tonsillectomy surgery. We aimed to evaluate the efficacy of preemptive analgesia using montelukast for pediatric post-tonsillectomy pain management. This is the first-time use of montelukast in post-tonsillectomy pain. Double-blind, controlled-randomized study. University teaching and research hospital. A total of 60 children, aged 5 to 15 years, American Society of Anesthesiologist class I-II, scheduled for elective tonsillectomy were enrolled in this clinical trial study. The patients were randomized into 2 groups: the montelukast group (group M, n = 30) and control group (group C, n = 30). Group M recieved an oral montelukast tablet and group C recieved placebo at 2400pm on the morning before surgery. Post-tonsillectomy pain was evaluated with the Wong-Baker FACES Scale during the 24 hours after surgery. Patients' int...
International forum of allergy & rhinology, Jan 9, 2015
In this prospective, multicenter, randomized, controlled, double-blind study, we investigated the... more In this prospective, multicenter, randomized, controlled, double-blind study, we investigated the impact of a mobile patient engagement application on health outcomes and quality of life in allergic rhinitis (AR) and asthma patients. In total, 327 patients with diagnoses of persistent AR or mild-to-severe persistent asthma were randomized into 2 intervention groups and 2 control groups upon their admission at outpatient clinics. The intervention groups (POPET-AR and POPET-Asthma) received a mobile phone application ("physician on call patient engagement trial" [POPET]), enabling them to communicate with their physician, and record their health status and medication compliance. The AR groups completed the Rhinitis Quality of Life Questionnaire (RQLQ) at initiation and at the first month of the study. The asthma groups completed the Asthma Control Test (ACT) at initiation and at the third month of the study. The POPET-AR group showed better clinical improvement than the cont...
We investigated the efficacy of intravenous (IV) preemptive paracetamol on postoperative total fe... more We investigated the efficacy of intravenous (IV) preemptive paracetamol on postoperative total fentanyl consumption and fentanyl-related side effects in patients undergoing open nephrectomy. A total of 60 patients scheduled for elective open nephrectomy under general anesthesia were included. All patients received Patient-controlled IV analgesia with fentanyl postoperatively. Patients were randomly allocated into three equal groups: The fentanyl group received 100 mL of IV normal saline as a placebo, with the first dose ending 30 min before intubation. In paracetamol group, IV 1 g paracetamol was given to the patients 30 min after extubation with repeated doses every 6 h totally 4 times a day. In preemptive paracetamol group, patients received IV 1 g paracetamol every 6 h, with the first dose ending 30 min before intubation. Postoperative cumulative fentanyl consumption for 24 h was significantly higher in the fentanyl group (1009 ± 139.361 μg) than those of paracetamol (752.25 ± 11...
Türk Kardiyoloji Derneği arşivi : Türk Kardiyoloji Derneğinin yayın organıdır, 2013
We aimed to investigate the efficacy and safety of a belt mechanism (anjiobelt), which we develop... more We aimed to investigate the efficacy and safety of a belt mechanism (anjiobelt), which we developed recently and patented, which allows mobility after coronary operations and the application of adjustable pressure to the femoral artery. Between October 2012 and April 2013, 189 consecutive patients undergoing percutaneous coronary intervention electively or due to acute coronary syndrome were enrolled. There were 96 patients in the sandbag group and 93 patients in anjiobelt group. Manual compression was applied to the femoral artery until reaching primary homeostasis. Then, a 4-5 kilogram sandbag or anjiobelt was placed. Mobilization was allowed in case of need in the anjiobelt group. Twenty-four hours after the procedure, superficial bruising in the femoral region, hematoma, pseudo-aneurysm, and arteriovenous fistula, as femoral artery complications, were noted using Doppler ultrasound. Hematoma occurred more frequently in the sandbag group. Hematoma of <1 cm developed in 52 pati...
Türk Kardiyoloji Derneği arşivi : Türk Kardiyoloji Derneğinin yayın organıdır, 2011
Percutaneous closure of secundum atrial septal defects (ASD) has become an important alternative ... more Percutaneous closure of secundum atrial septal defects (ASD) has become an important alternative treatment to surgery. We evaluated our clinical experience with, and short-term results of transcatheter closure of ASDs with the Amplatzer septal occluder in adult patients. The study included 52 patients (36 women, 16 men; mean age 33±14 years; range 14 to 69 years) who underwent transcatheter ASD closure with the Amplatzer occluder device. The mean ASD diameter measured by transesophageal echocardiography was 19.5±5.7 mm and the mean device diameter was 24.5±5.7 mm. All the patients were assessed clinically and echocardiographically one month after the procedure. Transcatheter ASD closure was successfully performed in 48 patients (92.3%) and failed in four patients (7.7%). Echocardiographic controls showed significant decreases in tricuspid regurgitation, right ventricular dilatation, and pulmonary artery pressure (p=0.003, p=0.026, and p=0.0001, respectively). Functional capacity of ...
International Journal of Information and Education Technology, 2015
Due to the digital world explosion and its appearance in everyday life, predicting numeric action... more Due to the digital world explosion and its appearance in everyday life, predicting numeric actions became necessary in machine learning. However, due to growth of interest in understanding how problems can be solved, simple prediction algorithms are more helpful than the difficult statistical approaches. Covering algorithm can be used to accomplish difficult problems using simple rules or trees. One family called RULES was found to be very interesting with appealing properties. It is one of the most flexible and simplest families with high learning rate. Nevertheless, even though RULES is actively improving but it is surprisingly neglected, especially with numerical datasets. Thus, the purpose of this paper is to extend the literature and investigate the problems of continuous classes in RULES and other inductive learning families. A theoretical analysis is conducted to show the effect of numerical actions and how it is still an open research area. An empirical evaluation is also provided to prove how RULES family can be used as the base of further improvement. Accordingly, this paper can be used as a reference by researchers to know what research area is still not covered and need further refinement in inductive learning.
Türk Kardiyoloji Derneği arşivi : Türk Kardiyoloji Derneğinin yayın organıdır, 2008
We investigated factors associated with prolonged prehospital delay in patients with acute myocar... more We investigated factors associated with prolonged prehospital delay in patients with acute myocardial infarction (AMI). A total of 439 patients (351 males, 88 females; mean age 57+/-12 years) with ST-elevation AMI were interviewed within 48 hours of hospitalization. Patients were pain-free and hemodynamically stable at the time of interview. Data were collected on the time from the onset of chest pain to hospital admission and on sociodemographic and clinical characteristics. The patients were evaluated in two groups according to the place to which the first presentation was made, i.e., a local clinic/small hospital (clinic group: n=209, 47.6%) or our tertiary fully equipped cardiovascular center (hospital group: n=230, 52.4%). The median and mean delay times were 70 min and 185.2+/-334.8 min, respectively. Of the study group, 136 patients (31%) arrived within 60 minutes after the onset of symptoms. The median delay time was significantly longer in the clinic group (120 min vs 60 mi...
Background: Our aim is to compare the hemodynamic effects of combined psoas compartment-sciatic n... more Background: Our aim is to compare the hemodynamic effects of combined psoas compartment-sciatic nerve block (PCSNB) with continuous spinal anaesthesia (CSA) in elderly high-risk patients undergoing hip replacement surgery. Methods: Seventy patients over the age of 60 with ASA III or IV physical status were randomly allocated to two groups: In the PCSNB group, ultrasound-guided psoas compartment block was performed with modified Winnie technique using 30 mL of 0.25% bupivacaine with 1:200.000 epinephrine (5 μgr/mL) and iliac crest block was performed using the same local anaesthetic solution (5 mL). All patients in the PCSNB group needed continuing infusion of propofol (2 mg/kg/h) during operation. In the CSA group, CSA was performed in the L 3-L 4 interspaced with the patient in lateral decubitus position using 2.5 mg of isobaric bupivacaine 0.5%. When sensory block was not reached to the level of T 12 within 10 minutes in the CSA group, additional 2.5 mg of isobaric bupivacaine 0.5% was administered through the catheter at 5-min intervals by limiting the total dose of 15 mg until a T 12 level of the sensory block was achieved. Results: The PCSNB group had significantly higher mean arterial blood pressure values at the beginning of surgery and at 5 th , 10 th and 20 th minutes of surgery compared to the CSA group (P =0.038, P =0.029, P =0.012, P =0.009 respectively). There were no significant differences between groups in terms of heart rate and peripheral oxygen saturation values during surgery and the postoperative period (P >0.05). Arterial hypotension required ephedrine was observed in 13 patients in the CSA and 4 patients in the PCSNB group (P =0.012). Conclusions: CSA and PCSNB produce satisfactory quality of anaesthesia in elderly high-risk patients with fewer hemodynamic changes in PCSNB cases compared with CSA cases.
Turkish Journal of Anesthesia and Reanimation, 2015
Elderly patients have increased risk for perioperative mortality and morbidity due to additional ... more Elderly patients have increased risk for perioperative mortality and morbidity due to additional comorbidities, such as cardiac diseases. Regional anaesthesia techniques are usually preferred in high-risk patients due to some advantages, such as the maintenance of cardiovascular stability and early postoperative mobilisation. This case presents the anaesthetic approach in a 55-year-old male patient with low ejection fraction that underwent hip fracture surgery. In this present case, continuous spinal anaesthesia with low-dose hyperbaric bupivacaine provided safe and effective anaesthesia during surgery with minimal haemodynamic changes and adequate analgesia during the first 24 hours after surgery.
This study investigated the effect of metyrosine against ketamine-induced cardiotoxicity in rats ... more This study investigated the effect of metyrosine against ketamine-induced cardiotoxicity in rats and compared the results with the effect of metoprolol. In this study, rats were divided into groups A, B and C. In group A, we investigated the effects of a single dose of metyrosine (150 mg/kg) and metoprolol (20 mg/kg) on single dose ketamine (60 mg/kg)-induced cardiotoxicity. In group B, we investigated the effect of metyrosine and metoprolol, which were given together with ketamine for 30 days. In group C, we investigated the effect of metyrosine and metoprolol given 15 days before ketamine and 30 days together with ketamine on ketamine cardiotoxicity. By the end of this process, we evaluated the effects of the levels of oxidant-antioxidant parameters such as MDA, MPO, 8-OHGua, tGSH, and SOD in addition to CK-MB and TP I on cardiotoxicity in rat heart tissue. The experimental results show that metyrosine prevented ketamine cardiotoxicity in groups A, B and C and metoprolol prevented it in only group C.
This study investigated the association between fear of childbirth (FOC) and women’s knowledge ab... more This study investigated the association between fear of childbirth (FOC) and women’s knowledge about painless childbirth methods. The study was performed on 900 multiparous women within the last month of pregnancy. Data was obtained through a questionnaire including the Wijma Delivery Expectancy/Experience Questionnaire (W-DEQ) Turkish form A. FOC was defined as W-DEQ sum score ≥85. Women were questioned about their knowledge about painless childbirth and the most important source of this knowledge. Group 1 consists of participants with knowledge about painless childbirth. Group 2 consists of participants without knowledge about painless childbirth. Five hundred and twenty-four women (58.2%) had knowledge while 376 women (41.7%) had no knowledge about painless childbirth. Mean W-DEQ scores in group 1 (68.46±12.53) were found to be lower than group 2 (71.35±12.28) (P=0.001). FOC was associated with increased maternal request for elective caesarean section (OR 4.22, 95% CI 2.91–6.11)....
Turkish Journal of Anesthesia and Reanimation, 2014
Objective: The technique of anaesthesia in caesarean sections is selected according to the patien... more Objective: The technique of anaesthesia in caesarean sections is selected according to the patient's clinical presentation, experience of the anaesthesist and the patient's wishes. The purpose of this study was to evaluate the anaesthesia methods employed in our clinic in the last decade (2003-2012). Methods: Records of caesarean operations performed between 2003-2012 in the Anaesthesia department of Atatürk University Medical Faculty and stored in the hospital computer system were examined. The annual distribution of methods of anaesthesia in operations was analysed. Results: During 2003-2012, 9049 caesarean operations were performed in our clinic. General anaesthesia was used in 45% of operations and regional anaesthesia in 54%. Whereas the rate of regional anaesthesia in 2003 was 34%, this increased to 69% in 2012. The most commonly used method of regional anaesthesia was spinal anaesthesia (34%) in 2003, and spinal anaesthesia (41%) and combined spinal-epidural anaesthesia (27%) in 2012. Conclusion: The most commonly used anaesthesia technique for caesarean operations in our clinic between 2003-2012 was spinal anaesthesia. The most widely used regional anaesthetic method in our clinic was spinal anaesthesia. A significant increase in the use of the combined spinal-epidural anaesthetic technique occurred in the last two years of the study period.
Multimedia Information security becomes a important part for the organization's intangible assets... more Multimedia Information security becomes a important part for the organization's intangible assets. Level of confidence and stakeholder trusted are performance indicator as successes organization, it is imperative for organizations to use Information Security Management System (ISMS) to effectively manage their multimedia information assets. The main objective of this paper is to Provide a novel practical framework approach to the development of ISMS, Called by the I-SolFramework, implemented in multimedia information security architecture (MISA), it divides a problem into six object domains or six layers, namely organization, stakeholders, tool & technology, policy, knowledge, and culture. In addition, this framework also introduced novelty algorithm and mathematic models as measurement and assessment tools of MISA parameters.
ABSTRACT Due to the rapid growth of computer technologies and the extensive changes in human need... more ABSTRACT Due to the rapid growth of computer technologies and the extensive changes in human needs, expertise and digital information were used to induce general conclusions. Such conclusions can be used to deal with future activates and make the life of humans easier. One active filed of machine learning that was developed for this purpose is inductive learning, and several families have emerged from this field. Specifically, RULES family was discovered as covering algorithm that directly induces good and general conclusions in the shape of simple rules. However, it was found that RULES suffer from two major deficiencies. It needs to tradeoff between time and accuracy when inducing the best rule and it did not appropriately handle incomplete data. As a result, this paper will present a new RULES algorithm, which takes advantage of previous versions of RULES family in addition to other advance methods of machine learning, specifically Transfer learning. Moreover, multi-modeling is also merged to transfer the knowledge of a different classification model and further improve the original algorithm. At the end, an empirical test is applied to compare the proposed algorithm with different single-model algorithms to prove that using the past knowledge of other agents in different domains improves specialization accuracy, whether the data is complete or incomplete.
ABSTRACT In today&#39;s world of excessive development in technologies, sustainability and ad... more ABSTRACT In today&#39;s world of excessive development in technologies, sustainability and adaptability of computer applications is a challenge, and future prediction became significant. Therefore, strong artificial intelligence (AI) became important and, thus, statistical machine learning (ML) methods were applied to serve it. These methods are very difficult to understand, and they predict the future without showing how. However, understanding of how machines make their decision is also important, especially in information system domain. Consequently, incremental covering algorithms (CA) can be used to produce simple rules to make difficult decisions. Nevertheless, even though using simple CA as the base of strong AI agent would be a novel idea but doing so with themethods available in CA is not possible. It was found that having to accurately update the discovered rules based on new information in CA is a challenge and needs extra attention. In specific, incomplete data with missing classes is inappropriately considered, whereby the speed and data size was also a concern, and future none existing classes were neglected. Consequently, this paper will introduce a novel algorithm called RULES-IT, in order to solve the problems of incremental CA and introduce it into strong AI. This algorithm is the first incremental algorithm in its family, and CA as a whole, that transfer rules of different domains to improve the performance, generalize the induction, take advantage of past experience in different domain, and make the learner more intelligent. It is also the first to introduce intelligent aspects into incremental CA, including consciousness, subjective emotions, awareness, and adjustment. Furthermore, all decisions made can be understood due to the simple representation of repository as rules. Finally, RULES-IT performance will be benchmarked with six different methods and compared with its predecessors to see the effect of transferring rules in the learning process, and to prove how RULES-IT actually solved the shortcoming of current incremental CA in addition to its improvement in the total performance.
Background/Aims: To investigate the importance of antioxidant activity in infertility caused by c... more Background/Aims: To investigate the importance of antioxidant activity in infertility caused by cisplatin in rats. Methods: Rats in cisplatin control (CG), Vitamin E + cisplatin (ECG), Vitamin C + cisplatin (CCG), Hippophae rhamnoides extract (HRE) + cisplatin (HRECG), and thiamine pyrophosphate (TPP) + cisplatin (TPPCG) groups were injected intraperitoneally (ip) with (100 mg/kg) Vitamin E, Vitamin C, HRE, and TPP, respectively. One hour later, ip cisplatin was administered (5 mg/kg), and then antioxidant medications were continued for 10 days. Cisplatin + Vitamin E (CEG-1), cisplatin + Vitamin C (CCG-1), cisplatin + HRE (CHREG-1), and cisplatin + TPP (TPPCG-1) rats received cisplatin (5 mg/kg, ip) and were kept for 10 days. At the end of that period, rats received antioxidant medications for 10 days. (n = 12, for each group). Six rats from each group were sacrificed. Ovaries were removed to measure malondialdehyde, total glutathione, glutathione S-transferase, and glutathione redu...
Background. Postoperative nausea and vomiting (PONV) is one of common complications in patients u... more Background. Postoperative nausea and vomiting (PONV) is one of common complications in patients undergoing laparoscopic cholecystectomy (LC). Aim of this study was to compare the efficacy of subhypnotic (1 mg/kg/h) infusion of propofol with dexamethasone on PONV in patients undergoing LC.Methods. A total of 120 patients were included in this randomized, double-blind, placebo-controlled study. Patients were randomly assigned to 3 groups; patients of group dexamethasone (group D) were administrated 8 mg dexamethasone before induction of anesthesia, patients of group propofol (group P) were infused to subhypnotic (1 mg/kg/h) propofol during operation and patients of group control (group C) were applied infusion of 10% intralipid. The incidence of PONV and needs for rescue analgesic and antiemetic were recorded in the first 24 h postoperatively.Results. In the 0–24 h, the incidence of PONV was significantly lower in the group D and group P compared with the group C (37.5%, 40%, and 72.5...
Object We present the efficacy of shockwave lithotripsy (SWL) therapy administered with sedoanalg... more Object We present the efficacy of shockwave lithotripsy (SWL) therapy administered with sedoanalgesia in infants with kidney stones. Materials and methods We enrolled 102 patients aged 5-24 months who had kidney stones and received SWL therapy under sedoanalgesia using a Siemens Lithostar Modularis device. Patient and stone characteristics, therapy parameters, pain score, complications, discharge time, and follow-ups were registered and evaluated. Pain score was assessed using a Neonatal Infant Pain Score (NIPS). Postanesthetic discharge scoring system (PADSS) was used for the assessments of postprocedural discharge procedure. Results Mean age of the patients was 17.2 ± 6.3 months (5-24 months). Mean stone size was 7.9 ± 3.3 mm (5-23 mm). The most common concomitant metabolic disorders were hypercalciuria and hypocitraturia. The stone-free rates of the infants were 70.6, 87.3, and 99.1 % after the first, second, and third sessions of SWL therapy, respectively. The mean NIPS scores procedure during, and at 1 h after SWL procedure were determined as 0.24 ± 0.45 and 0.34 ± 0.47, respectively. There was no statistically significant difference between two pain score values (P = 0.114). The mean discharge time of patients after the SWL procedure were 108.6 ± 27.9 min. Forty-two patients (41.1 %) were followed up. The follow-up period varied between 8 and 48 months (mean 19.5 months); none of those patients showed evidence of diabetes mellitus, hypertension, or renal function impairment. Conclusions SWL therapy under sedoanalgesia is a safe and efficient treatment modality that can be administered with low complication rates and high stone-free rates in the treatment of renal stones in infants.
The study aim was to investigate the effect of three different morphine doses added to levobupiva... more The study aim was to investigate the effect of three different morphine doses added to levobupivacaine 0.125% for caudal analgesia after circumcision surgery in children, particularly in relation to the frequency of postoperative vomiting within the first 24 hours following surgery. Two hundred and forty patients aged 5 to 12 years undergoing circumcision were included in the study. Following induction, caudal 0.125% levobupivacaine 0.5 ml/kg was given after adding 7.5, 10 or 15 μg/kg morphine. The postoperative incidence of vomiting was 5%, 12.5% and 17.5% in the groups 7.5, 10 and 15 μg/kg morphine, respectively ( P=0.012, 7.5 versus 15 μg/kg groups). Five percent of the 7.5 μg/kg group and none of the patients in the other groups required paracetamol within the first 12 hours, and there was a significantly greater need for rescue paracetamol over the 24 hours in the 7.5 group versus the 15 μg/kg group ( P=0.013). Postoperative analgesic durations were long and did not differ betw...
The purpose of this research is to present a sample study analyzing data gathered from an educati... more The purpose of this research is to present a sample study analyzing data gathered from an educational study using data mining techniques appropriate for processing these data. In order to achieve this aim, a "Computer Self-efficiency Scale" used in educational sciences was selected and this scale was applied in a study group. Data was analyzed using descriptive statistics (ttest and analysis of variance), and the data mining techniques of decision tree, dependency networks and clustering. The descriptive statistics used were calculated not using common statistical software packages, but by running a program written in Delphi 2009 programming language on Microsoft SQL Server 2008. Microsoft SQL Server 2008 was directly used for the data mining techniques of dependency networks and clustering. Some of the findings of the research, which cannot be obtained by common statistical techniques but can be obtained by data mining methods, were as follows: "those who think they are competent with computer terms and concepts believe they have a special talent in using computers" ; "those who believe they have a special talent in using computers feel as if the computer is part of their body", and "students who have been using computers for more than six years believe they have a special talent in using computers".
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, Jan 16, 2015
Tonsillectomy surgery is associated with severe postoperative pain that usually requires analgesi... more Tonsillectomy surgery is associated with severe postoperative pain that usually requires analgesics including opioids. Pain control is still a big problem after tonsillectomy surgery. We aimed to evaluate the efficacy of preemptive analgesia using montelukast for pediatric post-tonsillectomy pain management. This is the first-time use of montelukast in post-tonsillectomy pain. Double-blind, controlled-randomized study. University teaching and research hospital. A total of 60 children, aged 5 to 15 years, American Society of Anesthesiologist class I-II, scheduled for elective tonsillectomy were enrolled in this clinical trial study. The patients were randomized into 2 groups: the montelukast group (group M, n = 30) and control group (group C, n = 30). Group M recieved an oral montelukast tablet and group C recieved placebo at 2400pm on the morning before surgery. Post-tonsillectomy pain was evaluated with the Wong-Baker FACES Scale during the 24 hours after surgery. Patients' int...
International forum of allergy & rhinology, Jan 9, 2015
In this prospective, multicenter, randomized, controlled, double-blind study, we investigated the... more In this prospective, multicenter, randomized, controlled, double-blind study, we investigated the impact of a mobile patient engagement application on health outcomes and quality of life in allergic rhinitis (AR) and asthma patients. In total, 327 patients with diagnoses of persistent AR or mild-to-severe persistent asthma were randomized into 2 intervention groups and 2 control groups upon their admission at outpatient clinics. The intervention groups (POPET-AR and POPET-Asthma) received a mobile phone application ("physician on call patient engagement trial" [POPET]), enabling them to communicate with their physician, and record their health status and medication compliance. The AR groups completed the Rhinitis Quality of Life Questionnaire (RQLQ) at initiation and at the first month of the study. The asthma groups completed the Asthma Control Test (ACT) at initiation and at the third month of the study. The POPET-AR group showed better clinical improvement than the cont...
We investigated the efficacy of intravenous (IV) preemptive paracetamol on postoperative total fe... more We investigated the efficacy of intravenous (IV) preemptive paracetamol on postoperative total fentanyl consumption and fentanyl-related side effects in patients undergoing open nephrectomy. A total of 60 patients scheduled for elective open nephrectomy under general anesthesia were included. All patients received Patient-controlled IV analgesia with fentanyl postoperatively. Patients were randomly allocated into three equal groups: The fentanyl group received 100 mL of IV normal saline as a placebo, with the first dose ending 30 min before intubation. In paracetamol group, IV 1 g paracetamol was given to the patients 30 min after extubation with repeated doses every 6 h totally 4 times a day. In preemptive paracetamol group, patients received IV 1 g paracetamol every 6 h, with the first dose ending 30 min before intubation. Postoperative cumulative fentanyl consumption for 24 h was significantly higher in the fentanyl group (1009 ± 139.361 μg) than those of paracetamol (752.25 ± 11...
Türk Kardiyoloji Derneği arşivi : Türk Kardiyoloji Derneğinin yayın organıdır, 2013
We aimed to investigate the efficacy and safety of a belt mechanism (anjiobelt), which we develop... more We aimed to investigate the efficacy and safety of a belt mechanism (anjiobelt), which we developed recently and patented, which allows mobility after coronary operations and the application of adjustable pressure to the femoral artery. Between October 2012 and April 2013, 189 consecutive patients undergoing percutaneous coronary intervention electively or due to acute coronary syndrome were enrolled. There were 96 patients in the sandbag group and 93 patients in anjiobelt group. Manual compression was applied to the femoral artery until reaching primary homeostasis. Then, a 4-5 kilogram sandbag or anjiobelt was placed. Mobilization was allowed in case of need in the anjiobelt group. Twenty-four hours after the procedure, superficial bruising in the femoral region, hematoma, pseudo-aneurysm, and arteriovenous fistula, as femoral artery complications, were noted using Doppler ultrasound. Hematoma occurred more frequently in the sandbag group. Hematoma of <1 cm developed in 52 pati...
Türk Kardiyoloji Derneği arşivi : Türk Kardiyoloji Derneğinin yayın organıdır, 2011
Percutaneous closure of secundum atrial septal defects (ASD) has become an important alternative ... more Percutaneous closure of secundum atrial septal defects (ASD) has become an important alternative treatment to surgery. We evaluated our clinical experience with, and short-term results of transcatheter closure of ASDs with the Amplatzer septal occluder in adult patients. The study included 52 patients (36 women, 16 men; mean age 33±14 years; range 14 to 69 years) who underwent transcatheter ASD closure with the Amplatzer occluder device. The mean ASD diameter measured by transesophageal echocardiography was 19.5±5.7 mm and the mean device diameter was 24.5±5.7 mm. All the patients were assessed clinically and echocardiographically one month after the procedure. Transcatheter ASD closure was successfully performed in 48 patients (92.3%) and failed in four patients (7.7%). Echocardiographic controls showed significant decreases in tricuspid regurgitation, right ventricular dilatation, and pulmonary artery pressure (p=0.003, p=0.026, and p=0.0001, respectively). Functional capacity of ...
International Journal of Information and Education Technology, 2015
Due to the digital world explosion and its appearance in everyday life, predicting numeric action... more Due to the digital world explosion and its appearance in everyday life, predicting numeric actions became necessary in machine learning. However, due to growth of interest in understanding how problems can be solved, simple prediction algorithms are more helpful than the difficult statistical approaches. Covering algorithm can be used to accomplish difficult problems using simple rules or trees. One family called RULES was found to be very interesting with appealing properties. It is one of the most flexible and simplest families with high learning rate. Nevertheless, even though RULES is actively improving but it is surprisingly neglected, especially with numerical datasets. Thus, the purpose of this paper is to extend the literature and investigate the problems of continuous classes in RULES and other inductive learning families. A theoretical analysis is conducted to show the effect of numerical actions and how it is still an open research area. An empirical evaluation is also provided to prove how RULES family can be used as the base of further improvement. Accordingly, this paper can be used as a reference by researchers to know what research area is still not covered and need further refinement in inductive learning.
Türk Kardiyoloji Derneği arşivi : Türk Kardiyoloji Derneğinin yayın organıdır, 2008
We investigated factors associated with prolonged prehospital delay in patients with acute myocar... more We investigated factors associated with prolonged prehospital delay in patients with acute myocardial infarction (AMI). A total of 439 patients (351 males, 88 females; mean age 57+/-12 years) with ST-elevation AMI were interviewed within 48 hours of hospitalization. Patients were pain-free and hemodynamically stable at the time of interview. Data were collected on the time from the onset of chest pain to hospital admission and on sociodemographic and clinical characteristics. The patients were evaluated in two groups according to the place to which the first presentation was made, i.e., a local clinic/small hospital (clinic group: n=209, 47.6%) or our tertiary fully equipped cardiovascular center (hospital group: n=230, 52.4%). The median and mean delay times were 70 min and 185.2+/-334.8 min, respectively. Of the study group, 136 patients (31%) arrived within 60 minutes after the onset of symptoms. The median delay time was significantly longer in the clinic group (120 min vs 60 mi...
Background: Our aim is to compare the hemodynamic effects of combined psoas compartment-sciatic n... more Background: Our aim is to compare the hemodynamic effects of combined psoas compartment-sciatic nerve block (PCSNB) with continuous spinal anaesthesia (CSA) in elderly high-risk patients undergoing hip replacement surgery. Methods: Seventy patients over the age of 60 with ASA III or IV physical status were randomly allocated to two groups: In the PCSNB group, ultrasound-guided psoas compartment block was performed with modified Winnie technique using 30 mL of 0.25% bupivacaine with 1:200.000 epinephrine (5 μgr/mL) and iliac crest block was performed using the same local anaesthetic solution (5 mL). All patients in the PCSNB group needed continuing infusion of propofol (2 mg/kg/h) during operation. In the CSA group, CSA was performed in the L 3-L 4 interspaced with the patient in lateral decubitus position using 2.5 mg of isobaric bupivacaine 0.5%. When sensory block was not reached to the level of T 12 within 10 minutes in the CSA group, additional 2.5 mg of isobaric bupivacaine 0.5% was administered through the catheter at 5-min intervals by limiting the total dose of 15 mg until a T 12 level of the sensory block was achieved. Results: The PCSNB group had significantly higher mean arterial blood pressure values at the beginning of surgery and at 5 th , 10 th and 20 th minutes of surgery compared to the CSA group (P =0.038, P =0.029, P =0.012, P =0.009 respectively). There were no significant differences between groups in terms of heart rate and peripheral oxygen saturation values during surgery and the postoperative period (P >0.05). Arterial hypotension required ephedrine was observed in 13 patients in the CSA and 4 patients in the PCSNB group (P =0.012). Conclusions: CSA and PCSNB produce satisfactory quality of anaesthesia in elderly high-risk patients with fewer hemodynamic changes in PCSNB cases compared with CSA cases.
Turkish Journal of Anesthesia and Reanimation, 2015
Elderly patients have increased risk for perioperative mortality and morbidity due to additional ... more Elderly patients have increased risk for perioperative mortality and morbidity due to additional comorbidities, such as cardiac diseases. Regional anaesthesia techniques are usually preferred in high-risk patients due to some advantages, such as the maintenance of cardiovascular stability and early postoperative mobilisation. This case presents the anaesthetic approach in a 55-year-old male patient with low ejection fraction that underwent hip fracture surgery. In this present case, continuous spinal anaesthesia with low-dose hyperbaric bupivacaine provided safe and effective anaesthesia during surgery with minimal haemodynamic changes and adequate analgesia during the first 24 hours after surgery.
This study investigated the effect of metyrosine against ketamine-induced cardiotoxicity in rats ... more This study investigated the effect of metyrosine against ketamine-induced cardiotoxicity in rats and compared the results with the effect of metoprolol. In this study, rats were divided into groups A, B and C. In group A, we investigated the effects of a single dose of metyrosine (150 mg/kg) and metoprolol (20 mg/kg) on single dose ketamine (60 mg/kg)-induced cardiotoxicity. In group B, we investigated the effect of metyrosine and metoprolol, which were given together with ketamine for 30 days. In group C, we investigated the effect of metyrosine and metoprolol given 15 days before ketamine and 30 days together with ketamine on ketamine cardiotoxicity. By the end of this process, we evaluated the effects of the levels of oxidant-antioxidant parameters such as MDA, MPO, 8-OHGua, tGSH, and SOD in addition to CK-MB and TP I on cardiotoxicity in rat heart tissue. The experimental results show that metyrosine prevented ketamine cardiotoxicity in groups A, B and C and metoprolol prevented it in only group C.
This study investigated the association between fear of childbirth (FOC) and women’s knowledge ab... more This study investigated the association between fear of childbirth (FOC) and women’s knowledge about painless childbirth methods. The study was performed on 900 multiparous women within the last month of pregnancy. Data was obtained through a questionnaire including the Wijma Delivery Expectancy/Experience Questionnaire (W-DEQ) Turkish form A. FOC was defined as W-DEQ sum score ≥85. Women were questioned about their knowledge about painless childbirth and the most important source of this knowledge. Group 1 consists of participants with knowledge about painless childbirth. Group 2 consists of participants without knowledge about painless childbirth. Five hundred and twenty-four women (58.2%) had knowledge while 376 women (41.7%) had no knowledge about painless childbirth. Mean W-DEQ scores in group 1 (68.46±12.53) were found to be lower than group 2 (71.35±12.28) (P=0.001). FOC was associated with increased maternal request for elective caesarean section (OR 4.22, 95% CI 2.91–6.11)....
Turkish Journal of Anesthesia and Reanimation, 2014
Objective: The technique of anaesthesia in caesarean sections is selected according to the patien... more Objective: The technique of anaesthesia in caesarean sections is selected according to the patient's clinical presentation, experience of the anaesthesist and the patient's wishes. The purpose of this study was to evaluate the anaesthesia methods employed in our clinic in the last decade (2003-2012). Methods: Records of caesarean operations performed between 2003-2012 in the Anaesthesia department of Atatürk University Medical Faculty and stored in the hospital computer system were examined. The annual distribution of methods of anaesthesia in operations was analysed. Results: During 2003-2012, 9049 caesarean operations were performed in our clinic. General anaesthesia was used in 45% of operations and regional anaesthesia in 54%. Whereas the rate of regional anaesthesia in 2003 was 34%, this increased to 69% in 2012. The most commonly used method of regional anaesthesia was spinal anaesthesia (34%) in 2003, and spinal anaesthesia (41%) and combined spinal-epidural anaesthesia (27%) in 2012. Conclusion: The most commonly used anaesthesia technique for caesarean operations in our clinic between 2003-2012 was spinal anaesthesia. The most widely used regional anaesthetic method in our clinic was spinal anaesthesia. A significant increase in the use of the combined spinal-epidural anaesthetic technique occurred in the last two years of the study period.
Multimedia Information security becomes a important part for the organization's intangible assets... more Multimedia Information security becomes a important part for the organization's intangible assets. Level of confidence and stakeholder trusted are performance indicator as successes organization, it is imperative for organizations to use Information Security Management System (ISMS) to effectively manage their multimedia information assets. The main objective of this paper is to Provide a novel practical framework approach to the development of ISMS, Called by the I-SolFramework, implemented in multimedia information security architecture (MISA), it divides a problem into six object domains or six layers, namely organization, stakeholders, tool & technology, policy, knowledge, and culture. In addition, this framework also introduced novelty algorithm and mathematic models as measurement and assessment tools of MISA parameters.
ABSTRACT Due to the rapid growth of computer technologies and the extensive changes in human need... more ABSTRACT Due to the rapid growth of computer technologies and the extensive changes in human needs, expertise and digital information were used to induce general conclusions. Such conclusions can be used to deal with future activates and make the life of humans easier. One active filed of machine learning that was developed for this purpose is inductive learning, and several families have emerged from this field. Specifically, RULES family was discovered as covering algorithm that directly induces good and general conclusions in the shape of simple rules. However, it was found that RULES suffer from two major deficiencies. It needs to tradeoff between time and accuracy when inducing the best rule and it did not appropriately handle incomplete data. As a result, this paper will present a new RULES algorithm, which takes advantage of previous versions of RULES family in addition to other advance methods of machine learning, specifically Transfer learning. Moreover, multi-modeling is also merged to transfer the knowledge of a different classification model and further improve the original algorithm. At the end, an empirical test is applied to compare the proposed algorithm with different single-model algorithms to prove that using the past knowledge of other agents in different domains improves specialization accuracy, whether the data is complete or incomplete.
ABSTRACT In today&#39;s world of excessive development in technologies, sustainability and ad... more ABSTRACT In today&#39;s world of excessive development in technologies, sustainability and adaptability of computer applications is a challenge, and future prediction became significant. Therefore, strong artificial intelligence (AI) became important and, thus, statistical machine learning (ML) methods were applied to serve it. These methods are very difficult to understand, and they predict the future without showing how. However, understanding of how machines make their decision is also important, especially in information system domain. Consequently, incremental covering algorithms (CA) can be used to produce simple rules to make difficult decisions. Nevertheless, even though using simple CA as the base of strong AI agent would be a novel idea but doing so with themethods available in CA is not possible. It was found that having to accurately update the discovered rules based on new information in CA is a challenge and needs extra attention. In specific, incomplete data with missing classes is inappropriately considered, whereby the speed and data size was also a concern, and future none existing classes were neglected. Consequently, this paper will introduce a novel algorithm called RULES-IT, in order to solve the problems of incremental CA and introduce it into strong AI. This algorithm is the first incremental algorithm in its family, and CA as a whole, that transfer rules of different domains to improve the performance, generalize the induction, take advantage of past experience in different domain, and make the learner more intelligent. It is also the first to introduce intelligent aspects into incremental CA, including consciousness, subjective emotions, awareness, and adjustment. Furthermore, all decisions made can be understood due to the simple representation of repository as rules. Finally, RULES-IT performance will be benchmarked with six different methods and compared with its predecessors to see the effect of transferring rules in the learning process, and to prove how RULES-IT actually solved the shortcoming of current incremental CA in addition to its improvement in the total performance.
Background/Aims: To investigate the importance of antioxidant activity in infertility caused by c... more Background/Aims: To investigate the importance of antioxidant activity in infertility caused by cisplatin in rats. Methods: Rats in cisplatin control (CG), Vitamin E + cisplatin (ECG), Vitamin C + cisplatin (CCG), Hippophae rhamnoides extract (HRE) + cisplatin (HRECG), and thiamine pyrophosphate (TPP) + cisplatin (TPPCG) groups were injected intraperitoneally (ip) with (100 mg/kg) Vitamin E, Vitamin C, HRE, and TPP, respectively. One hour later, ip cisplatin was administered (5 mg/kg), and then antioxidant medications were continued for 10 days. Cisplatin + Vitamin E (CEG-1), cisplatin + Vitamin C (CCG-1), cisplatin + HRE (CHREG-1), and cisplatin + TPP (TPPCG-1) rats received cisplatin (5 mg/kg, ip) and were kept for 10 days. At the end of that period, rats received antioxidant medications for 10 days. (n = 12, for each group). Six rats from each group were sacrificed. Ovaries were removed to measure malondialdehyde, total glutathione, glutathione S-transferase, and glutathione redu...
Background. Postoperative nausea and vomiting (PONV) is one of common complications in patients u... more Background. Postoperative nausea and vomiting (PONV) is one of common complications in patients undergoing laparoscopic cholecystectomy (LC). Aim of this study was to compare the efficacy of subhypnotic (1 mg/kg/h) infusion of propofol with dexamethasone on PONV in patients undergoing LC.Methods. A total of 120 patients were included in this randomized, double-blind, placebo-controlled study. Patients were randomly assigned to 3 groups; patients of group dexamethasone (group D) were administrated 8 mg dexamethasone before induction of anesthesia, patients of group propofol (group P) were infused to subhypnotic (1 mg/kg/h) propofol during operation and patients of group control (group C) were applied infusion of 10% intralipid. The incidence of PONV and needs for rescue analgesic and antiemetic were recorded in the first 24 h postoperatively.Results. In the 0–24 h, the incidence of PONV was significantly lower in the group D and group P compared with the group C (37.5%, 40%, and 72.5...
Object We present the efficacy of shockwave lithotripsy (SWL) therapy administered with sedoanalg... more Object We present the efficacy of shockwave lithotripsy (SWL) therapy administered with sedoanalgesia in infants with kidney stones. Materials and methods We enrolled 102 patients aged 5-24 months who had kidney stones and received SWL therapy under sedoanalgesia using a Siemens Lithostar Modularis device. Patient and stone characteristics, therapy parameters, pain score, complications, discharge time, and follow-ups were registered and evaluated. Pain score was assessed using a Neonatal Infant Pain Score (NIPS). Postanesthetic discharge scoring system (PADSS) was used for the assessments of postprocedural discharge procedure. Results Mean age of the patients was 17.2 ± 6.3 months (5-24 months). Mean stone size was 7.9 ± 3.3 mm (5-23 mm). The most common concomitant metabolic disorders were hypercalciuria and hypocitraturia. The stone-free rates of the infants were 70.6, 87.3, and 99.1 % after the first, second, and third sessions of SWL therapy, respectively. The mean NIPS scores procedure during, and at 1 h after SWL procedure were determined as 0.24 ± 0.45 and 0.34 ± 0.47, respectively. There was no statistically significant difference between two pain score values (P = 0.114). The mean discharge time of patients after the SWL procedure were 108.6 ± 27.9 min. Forty-two patients (41.1 %) were followed up. The follow-up period varied between 8 and 48 months (mean 19.5 months); none of those patients showed evidence of diabetes mellitus, hypertension, or renal function impairment. Conclusions SWL therapy under sedoanalgesia is a safe and efficient treatment modality that can be administered with low complication rates and high stone-free rates in the treatment of renal stones in infants.
Uploads
Papers by Emir Aksoy