From 1cfd3489bb40925193ea5ff257f7afe64cd2ba42 Mon Sep 17 00:00:00 2001 From: Zak King Date: Mon, 15 Jul 2019 14:14:17 -0700 Subject: [PATCH] upgrade notebook tutorial to 1.7.1 --- docs/escher-python.ipynb | 34 +++++++++++++++++----------------- 1 file changed, 17 insertions(+), 17 deletions(-) diff --git a/docs/escher-python.ipynb b/docs/escher-python.ipynb index c9d9bf72..d3abe69a 100644 --- a/docs/escher-python.ipynb +++ b/docs/escher-python.ipynb @@ -779,7 +779,7 @@ "state": { "1267e6baf32d4c9fa7e1e85ef57adf52": { "model_module": "escher", - "model_module_version": "1.7.0-beta.19", + "model_module_version": "1.7.1", "model_name": "EscherMapModel", "state": { "_loaded_map_json": "[{\"map_name\":\"iJO1366.Central metabolism\",\"map_id\":\"c50080dc494c0686982966090cefc2de\",\"map_description\":\"Central metabolism (iJO1366)\\nLast Modified Mon Oct 12 2015 17:39:00 GMT-0700 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C18:2)\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"cdpdag_hs_18_1_18_2_c\"\n]\n}\n},\n{\n\"id\":\"cdpdag_hs_18_2_16_0_c\",\n\"name\":\"CDP diacylglycerol (homo sapiens, C18:2, C16:0)\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"cdpdag_hs_18_2_16_0_c\"\n]\n}\n},\n{\n\"id\":\"cdpdag_hs_18_2_18_1_c\",\n\"name\":\"CDP diacylglycerol (homo sapiens, C18:2, C18:1)\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"cdpdag_hs_18_2_18_1_c\"\n]\n}\n},\n{\n\"id\":\"cdpea_c\",\n\"name\":\"CDPethanolamine C11H19N4O11P2\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"cdpea_c\"\n]\n}\n},\n{\n\"id\":\"chol_c\",\n\"name\":\"Choline C5H14NO\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"chol_c\"\n]\n}\n},\n{\n\"id\":\"cholp_c\",\n\"name\":\"Choline phosphate 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C18:2)\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"dag_hs_16_0_18_2_c\"\n]\n}\n},\n{\n\"id\":\"dag_hs_18_1_18_1_c\",\n\"name\":\"Diacylglycerol (homo sapiens, C18:1, C18:1)\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"dag_hs_18_1_18_1_c\"\n]\n}\n},\n{\n\"id\":\"dag_hs_18_1_18_2_c\",\n\"name\":\"Diacylglycerol (homo sapiens, C18:1, C18:2)\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"dag_hs_18_1_18_2_c\"\n]\n}\n},\n{\n\"id\":\"dag_hs_18_2_16_0_c\",\n\"name\":\"Diacylglycerol (homo sapiens, C18:2, C16:0)\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"dag_hs_18_2_16_0_c\"\n]\n}\n},\n{\n\"id\":\"dag_hs_18_2_18_1_c\",\n\"name\":\"Diacylglycerol (homo sapiens, C18:2, C18:1)\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"dag_hs_18_2_18_1_c\"\n]\n}\n},\n{\n\"id\":\"dhap_c\",\n\"name\":\"Dihydroxyacetone 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4-phosphate\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"e4p_c\"\n]\n}\n},\n{\n\"id\":\"etha_c\",\n\"name\":\"Ethanolamine\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"etha_c\"\n]\n}\n},\n{\n\"id\":\"ethamp_c\",\n\"name\":\"Ethanolamine phosphate C2H7NO4P\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"ethamp_c\"\n]\n}\n},\n{\n\"id\":\"f26bp_c\",\n\"name\":\"D Fructose 2 6 bisphosphate C6H10O12P2\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"f26bp_c\"\n]\n}\n},\n{\n\"id\":\"f6p_c\",\n\"name\":\"D-Fructose 6-phosphate\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"f6p_c\"\n]\n}\n},\n{\n\"id\":\"fad_c\",\n\"name\":\"Flavin adenine dinucleotide oxidized\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"fad_c\"\n]\n}\n},\n{\n\"id\":\"fdp_c\",\n\"name\":\"D-Fructose 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6-phosphate\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"gam6p_c\"\n]\n}\n},\n{\n\"id\":\"gdp_c\",\n\"name\":\"GDP 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3-phosphate\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"glyc3p_c\"\n]\n}\n},\n{\n\"id\":\"gmp_c\",\n\"name\":\"GMP C10H12N5O8P\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"gmp_c\"\n]\n}\n},\n{\n\"id\":\"gsn_c\",\n\"name\":\"Guanosine\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"gsn_c\"\n]\n}\n},\n{\n\"id\":\"gthox_c\",\n\"name\":\"Oxidized glutathione\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"gthox_c\"\n]\n}\n},\n{\n\"id\":\"gthrd_c\",\n\"name\":\"Reduced glutathione\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"gthrd_c\"\n]\n}\n},\n{\n\"id\":\"gtp_c\",\n\"name\":\"GTP C10H12N5O14P3\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"gtp_c\"\n]\n}\n},\n{\n\"id\":\"gua_c\",\n\"name\":\"Guanine\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"gua_c\"\n]\n}\n},\n{\n\"id\":\"guln__L_c\",\n\"name\":\"L-gulonate\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"guln_c\"\n]\n}\n},\n{\n\"id\":\"h_c\",\n\"name\":\"H+\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"h_c\"\n]\n}\n},\n{\n\"id\":\"h2o_c\",\n\"name\":\"H2O H2O\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"h2o_c\"\n]\n}\n},\n{\n\"id\":\"h2o2_c\",\n\"name\":\"Hydrogen peroxide\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"h2o2_c\"\n]\n}\n},\n{\n\"id\":\"hco3_c\",\n\"name\":\"Bicarbonate\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"hco3_c\"\n]\n}\n},\n{\n\"id\":\"hcys__L_c\",\n\"name\":\"L-Homocysteine\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"hcys_DASH_L_c\"\n]\n}\n},\n{\n\"id\":\"hdca_c\",\n\"name\":\"Hexadecanoate (n-C16:0)\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"hdca_c\"\n]\n}\n},\n{\n\"id\":\"hmbil_c\",\n\"name\":\"Hydroxymethylbilane\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"hmbil_c\"\n]\n}\n},\n{\n\"id\":\"hxan_c\",\n\"name\":\"Hypoxanthine\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"hxan_c\"\n]\n}\n},\n{\n\"id\":\"icit_c\",\n\"name\":\"Isocitrate\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"icit_c\"\n]\n}\n},\n{\n\"id\":\"imp_c\",\n\"name\":\"IMP 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B4(1-)\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"leuktrB4_c\"\n]\n}\n},\n{\n\"id\":\"lgt__S_c\",\n\"name\":\"(R)-S-Lactoylglutathione\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"lgt_DASH_S_c\"\n]\n}\n},\n{\n\"id\":\"lnlc_c\",\n\"name\":\"Linoleic acid (all cis C18:2) n-6\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"lnlc_c\"\n]\n}\n},\n{\n\"id\":\"lnlccoa_c\",\n\"name\":\"Linoleic coenzyme A\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"lnlccoa_c\"\n]\n}\n},\n{\n\"id\":\"lnlccrn_c\",\n\"name\":\"Linoleyl carnitine\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"lnlccrn_c\"\n]\n}\n},\n{\n\"id\":\"lpchol_hs_16_0_c\",\n\"name\":\"Lysophosphatidylcholine (homo sapiens, C16:0) cytosol\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"lpchol_hs_16_0_c\"\n]\n}\n},\n{\n\"id\":\"lpchol_hs_18_1_c\",\n\"name\":\"Lysophosphatidylcholine (homo sapiens, C18:1)\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"lpchol_hs_18_1_c\"\n]\n}\n},\n{\n\"id\":\"lpchol_hs_18_2_c\",\n\"name\":\"Lysophosphatidylcholine (homo sapiens, C18:2)\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"lpchol_hs_18_2_c\"\n]\n}\n},\n{\n\"id\":\"mal__L_c\",\n\"name\":\"L-Malate\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"mal_DASH_L_c\"\n]\n}\n},\n{\n\"id\":\"man_c\",\n\"name\":\"D-Mannose\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"man_c\"\n]\n}\n},\n{\n\"id\":\"man1p_c\",\n\"name\":\"D-Mannose 1-phosphate\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"man1p_c\"\n]\n}\n},\n{\n\"id\":\"man6p_c\",\n\"name\":\"D-Mannose 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1,4-bisphosphate\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"mi14p_c\"\n]\n}\n},\n{\n\"id\":\"mi1p__D_c\",\n\"name\":\"1D-myo-Inositol 1-phosphate\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"mi1p_DASH_D_c\"\n]\n}\n},\n{\n\"id\":\"mthgxl_c\",\n\"name\":\"Methylglyoxal\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"mthgxl_c\"\n]\n}\n},\n{\n\"id\":\"na1_c\",\n\"name\":\"Sodium\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"na1_c\"\n]\n}\n},\n{\n\"id\":\"nac_c\",\n\"name\":\"Nicotinate\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"nac_c\"\n]\n}\n},\n{\n\"id\":\"nad_c\",\n\"name\":\"Nicotinamide adenine dinucleotide\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"nad_c\"\n]\n}\n},\n{\n\"id\":\"nadh_c\",\n\"name\":\"Nicotinamide adenine dinucleotide - reduced\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"nadh_c\"\n]\n}\n},\n{\n\"id\":\"nadp_c\",\n\"name\":\"Nicotinamide adenine dinucleotide phosphate\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"nadp_c\"\n]\n}\n},\n{\n\"id\":\"nadph_c\",\n\"name\":\"Nicotinamide adenine dinucleotide phosphate - reduced\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"nadph_c\"\n]\n}\n},\n{\n\"id\":\"ncam_c\",\n\"name\":\"Nicotinamide\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"ncam_c\"\n]\n}\n},\n{\n\"id\":\"nh4_c\",\n\"name\":\"Ammonium\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"nh4_c\"\n]\n}\n},\n{\n\"id\":\"nicrns_c\",\n\"name\":\"Nicotinate D-ribonucleoside\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"nicrns_c\"\n]\n}\n},\n{\n\"id\":\"nicrnt_c\",\n\"name\":\"Nicotinate 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(n-C18:1CoA)\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"odecoa_c\"\n]\n}\n},\n{\n\"id\":\"odecrn_c\",\n\"name\":\"Octadecenoyl carnitine\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"odecrn_c\"\n]\n}\n},\n{\n\"id\":\"orn_c\",\n\"name\":\"Ornithine\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"orn_c\"\n]\n}\n},\n{\n\"id\":\"orot_c\",\n\"name\":\"Orotate C5H3N2O4\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"orot_c\"\n]\n}\n},\n{\n\"id\":\"orot5p_c\",\n\"name\":\"Orotidine 5'-phosphate\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"orot5p_c\"\n]\n}\n},\n{\n\"id\":\"pa_hs_16_0_16_0_c\",\n\"name\":\"Phosphatidic acid (homo sapiens, C16:0, C16:0)\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"pa_hs_16_0_16_0_c\"\n]\n}\n},\n{\n\"id\":\"pa_hs_16_0_18_1_c\",\n\"name\":\"Phosphatidic acid (homo sapiens, C16:0, C18:1)\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"pa_hs_16_0_18_1_c\"\n]\n}\n},\n{\n\"id\":\"pa_hs_16_0_18_2_c\",\n\"name\":\"Phosphatidic acid (homo sapiens, C16:0, C18:2)\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"pa_hs_16_0_18_2_c\"\n]\n}\n},\n{\n\"id\":\"pa_hs_18_1_18_1_c\",\n\"name\":\"Phosphatidic acid (homo sapiens, C18:1, C18:1)\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"pa_hs_18_1_18_1_c\"\n]\n}\n},\n{\n\"id\":\"pa_hs_18_1_18_2_c\",\n\"name\":\"Phosphatidic acid (homo sapiens, C18:1, C18:2)\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"pa_hs_18_1_18_2_c\"\n]\n}\n},\n{\n\"id\":\"pa_hs_18_2_16_0_c\",\n\"name\":\"Phosphatidic acid (homo sapiens, C18:2, C16:0)\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"pa_hs_18_2_16_0_c\"\n]\n}\n},\n{\n\"id\":\"pa_hs_18_2_18_1_c\",\n\"name\":\"Phosphatidic acid (homo sapiens, C18:2, C18:1)\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"pa_hs_18_2_18_1_c\"\n]\n}\n},\n{\n\"id\":\"pail45p_hs_16_0_16_0_c\",\n\"name\":\"Phosphatidylinositol 4,5-bisphosphate (homo sapiens, C16:0, C16:0)\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"pail45p_hs_16_0_16_0_c\"\n]\n}\n},\n{\n\"id\":\"pail45p_hs_16_0_18_1_c\",\n\"name\":\"Phosphatidylinositol 4,5-bisphosphate (homo sapiens, C16:0, C18:1)\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"pail45p_hs_16_0_18_1_c\"\n]\n}\n},\n{\n\"id\":\"pail45p_hs_16_0_18_2_c\",\n\"name\":\"Phosphatidylinositol 4,5-bisphosphate (homo sapiens, C16:0, C18:2)\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"pail45p_hs_16_0_18_2_c\"\n]\n}\n},\n{\n\"id\":\"pail45p_hs_18_1_18_1_c\",\n\"name\":\"Phosphatidylinositol 4,5-bisphosphate (homo sapiens, C18:1, C18:1)\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"pail45p_hs_18_1_18_1_c\"\n]\n}\n},\n{\n\"id\":\"pail45p_hs_18_1_18_2_c\",\n\"name\":\"Phosphatidylinositol 4,5-bisphosphate (homo sapiens, C18:1, C18:2)\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"pail45p_hs_18_1_18_2_c\"\n]\n}\n},\n{\n\"id\":\"pail45p_hs_18_2_16_0_c\",\n\"name\":\"Phosphatidylinositol 4,5-bisphosphate (homo sapiens, C18:2, C16:0)\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"pail45p_hs_18_2_16_0_c\"\n]\n}\n},\n{\n\"id\":\"pail45p_hs_18_2_18_1_c\",\n\"name\":\"Phosphatidylinositol 4,5-bisphosphate (homo sapiens, C18:2, C18:1)\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"pail45p_hs_18_2_18_1_c\"\n]\n}\n},\n{\n\"id\":\"pail4p_hs_16_0_16_0_c\",\n\"name\":\"1-Phosphatidyl-1D-myo-inositol 4-phosphate (homo sapiens, C16:0, C16:0)\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"pail4p_hs_16_0_16_0_c\"\n]\n}\n},\n{\n\"id\":\"pail4p_hs_16_0_18_1_c\",\n\"name\":\"1-Phosphatidyl-1D-myo-inositol 4-phosphate (homo sapiens, C16:0, C18:1)\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"pail4p_hs_16_0_18_1_c\"\n]\n}\n},\n{\n\"id\":\"pail4p_hs_16_0_18_2_c\",\n\"name\":\"1-Phosphatidyl-1D-myo-inositol 4-phosphate (homo sapiens, C16:0, C18:2)\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"pail4p_hs_16_0_18_2_c\"\n]\n}\n},\n{\n\"id\":\"pail4p_hs_18_1_18_1_c\",\n\"name\":\"1-Phosphatidyl-1D-myo-inositol 4-phosphate (homo sapiens, C18:1, C18:1)\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"pail4p_hs_18_1_18_1_c\"\n]\n}\n},\n{\n\"id\":\"pail4p_hs_18_1_18_2_c\",\n\"name\":\"1-Phosphatidyl-1D-myo-inositol 4-phosphate (homo sapiens, C18:1, C18:2)\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"pail4p_hs_18_1_18_2_c\"\n]\n}\n},\n{\n\"id\":\"pail4p_hs_18_2_16_0_c\",\n\"name\":\"1-Phosphatidyl-1D-myo-inositol 4-phosphate (homo sapiens, C18:2, C16:0)\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"pail4p_hs_18_2_16_0_c\"\n]\n}\n},\n{\n\"id\":\"pail4p_hs_18_2_18_1_c\",\n\"name\":\"1-Phosphatidyl-1D-myo-inositol 4-phosphate (homo sapiens, C18:2, C18:1)\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"pail4p_hs_18_2_18_1_c\"\n]\n}\n},\n{\n\"id\":\"pail_hs_16_0_16_0_c\",\n\"name\":\"Phosphatidylinositol (homo sapiens, C16:0, C16:0)\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"pail_hs_16_0_16_0_c\"\n]\n}\n},\n{\n\"id\":\"pail_hs_16_0_18_1_c\",\n\"name\":\"Phosphatidylinositol (homo sapiens, C16:0, C18:1)\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"pail_hs_16_0_18_1_c\"\n]\n}\n},\n{\n\"id\":\"pail_hs_16_0_18_2_c\",\n\"name\":\"Phosphatidylinositol (homo sapiens, C16:0, C18:2)\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"pail_hs_16_0_18_2_c\"\n]\n}\n},\n{\n\"id\":\"pail_hs_18_1_18_1_c\",\n\"name\":\"Phosphatidylinositol (homo sapiens, C18:1, C18:1)\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"pail_hs_18_1_18_1_c\"\n]\n}\n},\n{\n\"id\":\"pail_hs_18_1_18_2_c\",\n\"name\":\"Phosphatidylinositol (homo sapiens, C18:1, C18:2)\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"pail_hs_18_1_18_2_c\"\n]\n}\n},\n{\n\"id\":\"pail_hs_18_2_16_0_c\",\n\"name\":\"Phosphatidylinositol (homo sapiens, C18:2, C16:0)\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"pail_hs_18_2_16_0_c\"\n]\n}\n},\n{\n\"id\":\"pail_hs_18_2_18_1_c\",\n\"name\":\"Phosphatidylinositol (homo sapiens, C18:2, C18:1)\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"pail_hs_18_2_18_1_c\"\n]\n}\n},\n{\n\"id\":\"pchol_hs_16_0_16_0_c\",\n\"name\":\"Phosphatidylcholine (homo sapiens, C16:0, C16:0)\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"pchol_hs_16_0_16_0_c\"\n]\n}\n},\n{\n\"id\":\"pchol_hs_16_0_18_1_c\",\n\"name\":\"Phosphatidylcholine (homo sapiens, C16:0, C18:1) cytosol\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"pchol_hs_16_0_18_1_c\"\n]\n}\n},\n{\n\"id\":\"pchol_hs_16_0_18_2_c\",\n\"name\":\"Phosphatidylcholine (homo sapiens, C16:0, C18:2)\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"pchol_hs_16_0_18_2_c\"\n]\n}\n},\n{\n\"id\":\"pchol_hs_18_1_18_1_c\",\n\"name\":\"Phosphatidylcholine (homo sapiens, C18:1, C18:1)\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"pchol_hs_18_1_18_1_c\"\n]\n}\n},\n{\n\"id\":\"pchol_hs_18_1_18_2_c\",\n\"name\":\"Phosphatidylcholine (homo sapiens, C18:1, C18:2)\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"pchol_hs_18_1_18_2_c\"\n]\n}\n},\n{\n\"id\":\"pchol_hs_18_2_16_0_c\",\n\"name\":\"Phosphatidylcholine (homo sapiens, C18:2, C16:0)\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"pchol_hs_18_2_16_0_c\"\n]\n}\n},\n{\n\"id\":\"pchol_hs_18_2_18_1_c\",\n\"name\":\"Phosphatidylcholine (homo sapiens, C18:2, C18:1)\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"pchol_hs_18_2_18_1_c\"\n]\n}\n},\n{\n\"id\":\"pdx5p_c\",\n\"name\":\"Pyridoxine 5'-phosphate\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"pdx5p_c\"\n]\n}\n},\n{\n\"id\":\"pe_hs_16_0_16_0_c\",\n\"name\":\"Phosphatidylethanolamine (homo sapiens, C16:0, C16:0)\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"pe_hs_16_0_16_0_c\"\n]\n}\n},\n{\n\"id\":\"pe_hs_16_0_18_1_c\",\n\"name\":\"Phosphatidylethanolamine (homo sapiens, C16:0, C18:1)\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"pe_hs_16_0_18_1_c\"\n]\n}\n},\n{\n\"id\":\"pe_hs_16_0_18_2_c\",\n\"name\":\"Phosphatidylethanolamine (homo sapiens, C16:0, C18:2)\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"pe_hs_16_0_18_2_c\"\n]\n}\n},\n{\n\"id\":\"pe_hs_18_1_18_1_c\",\n\"name\":\"Phosphatidylethanolamine (homo sapiens, C18:1, C18:1)\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"pe_hs_18_1_18_1_c\"\n]\n}\n},\n{\n\"id\":\"pe_hs_18_1_18_2_c\",\n\"name\":\"Phosphatidylethanolamine (homo sapiens, C18:1, C18:2)\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"pe_hs_18_1_18_2_c\"\n]\n}\n},\n{\n\"id\":\"pe_hs_18_2_16_0_c\",\n\"name\":\"Phosphatidylethanolamine (homo sapiens, C18:2, C16:0)\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"pe_hs_18_2_16_0_c\"\n]\n}\n},\n{\n\"id\":\"pe_hs_18_2_18_1_c\",\n\"name\":\"Phosphatidylethanolamine (homo sapiens, C18:2, C18:1)\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"pe_hs_18_2_18_1_c\"\n]\n}\n},\n{\n\"id\":\"pep_c\",\n\"name\":\"Phosphoenolpyruvate\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"pep_c\"\n]\n}\n},\n{\n\"id\":\"phe__L_c\",\n\"name\":\"L-Phenylalanine\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"phe_DASH_L_c\"\n]\n}\n},\n{\n\"id\":\"pheme_c\",\n\"name\":\"Protoheme C34H30FeN4O4\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"pheme_c\"\n]\n}\n},\n{\n\"id\":\"phpyr_c\",\n\"name\":\"Phenylpyruvate\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"phpyr_c\"\n]\n}\n},\n{\n\"id\":\"pi_c\",\n\"name\":\"Phosphate\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"pi_c\"\n]\n}\n},\n{\n\"id\":\"pmtcoa_c\",\n\"name\":\"Palmitoyl-CoA (n-C16:0CoA)\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"pmtcoa_c\"\n]\n}\n},\n{\n\"id\":\"pmtcrn_c\",\n\"name\":\"L-Palmitoylcarnitine\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"pmtcrn_c\"\n]\n}\n},\n{\n\"id\":\"ppbng_c\",\n\"name\":\"Porphobilinogen\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"ppbng_c\"\n]\n}\n},\n{\n\"id\":\"ppi_c\",\n\"name\":\"Diphosphate\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"ppi_c\"\n]\n}\n},\n{\n\"id\":\"ppp9_c\",\n\"name\":\"Protoporphyrin\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"ppp9_c\"\n]\n}\n},\n{\n\"id\":\"pppg9_c\",\n\"name\":\"Protoporphyrinogen IX\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"pppg9_c\"\n]\n}\n},\n{\n\"id\":\"prpp_c\",\n\"name\":\"5-Phospho-alpha-D-ribose 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C11H15N2O5\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"rnam_c\"\n]\n}\n},\n{\n\"id\":\"ru5p__D_c\",\n\"name\":\"D-Ribulose 5-phosphate\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"ru5p_DASH_D_c\"\n]\n}\n},\n{\n\"id\":\"s7p_c\",\n\"name\":\"Sedoheptulose 7-phosphate\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"s7p_c\"\n]\n}\n},\n{\n\"id\":\"sbt__D_c\",\n\"name\":\"D-Sorbitol\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"sbt_DASH_D_c\"\n]\n}\n},\n{\n\"id\":\"spmd_c\",\n\"name\":\"Spermidine\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"spmd_c\"\n]\n}\n},\n{\n\"id\":\"sprm_c\",\n\"name\":\"Spermine C10H30N4\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"sprm_c\"\n]\n}\n},\n{\n\"id\":\"thm_c\",\n\"name\":\"Thiamin\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"thm_c\"\n]\n}\n},\n{\n\"id\":\"thmmp_c\",\n\"name\":\"Thiamin 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CH4N2O\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"urea_c\"\n]\n}\n},\n{\n\"id\":\"uri_c\",\n\"name\":\"Uridine\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"uri_c\"\n]\n}\n},\n{\n\"id\":\"utp_c\",\n\"name\":\"UTP C9H11N2O15P3\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"utp_c\"\n]\n}\n},\n{\n\"id\":\"xmp_c\",\n\"name\":\"Xanthosine 5'-phosphate\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"xmp_c\"\n]\n}\n},\n{\n\"id\":\"xu5p__D_c\",\n\"name\":\"D-Xylulose 5-phosphate\",\n\"compartment\":\"c\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"xu5p_DASH_D_c\"\n]\n}\n},\n{\n\"id\":\"xylt_c\",\n\"name\":\"Xylitol 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GMP\",\n\"compartment\":\"e\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"35cgmp_e\"\n]\n}\n},\n{\n\"id\":\"3moxtyr_e\",\n\"name\":\"3-Methoxytyramine\",\n\"compartment\":\"e\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"3moxtyr_e\"\n]\n}\n},\n{\n\"id\":\"4pyrdx_e\",\n\"name\":\"4-Pyridoxate\",\n\"compartment\":\"e\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"4pyrdx_e\"\n]\n}\n},\n{\n\"id\":\"5aop_e\",\n\"name\":\"5-Amino-4-oxopentanoate\",\n\"compartment\":\"e\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"5aop_e\"\n]\n}\n},\n{\n\"id\":\"ac_e\",\n\"name\":\"Acetate\",\n\"compartment\":\"e\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"ac_e\"\n]\n}\n},\n{\n\"id\":\"acald_e\",\n\"name\":\"Acetaldehyde\",\n\"compartment\":\"e\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"acald_e\"\n]\n}\n},\n{\n\"id\":\"acnam_e\",\n\"name\":\"N-Acetylneuraminate\",\n\"compartment\":\"e\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"acnam_e\"\n]\n}\n},\n{\n\"id\":\"ade_e\",\n\"name\":\"Adenine\",\n\"compartment\":\"e\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"ade_e\"\n]\n}\n},\n{\n\"id\":\"adn_e\",\n\"name\":\"Adenosine\",\n\"compartment\":\"e\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"adn_e\"\n]\n}\n},\n{\n\"id\":\"adrnl_e\",\n\"name\":\"Adrenaline\",\n\"compartment\":\"e\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"adrnl_e\"\n]\n}\n},\n{\n\"id\":\"ala__L_e\",\n\"name\":\"L-Alanine\",\n\"compartment\":\"e\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"ala_DASH_L_e\"\n]\n}\n},\n{\n\"id\":\"arg__L_e\",\n\"name\":\"L-Arginine\",\n\"compartment\":\"e\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"arg_DASH_L_e\"\n]\n}\n},\n{\n\"id\":\"ascb__L_e\",\n\"name\":\"L-Ascorbate\",\n\"compartment\":\"e\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"ascb_DASH_L_e\"\n]\n}\n},\n{\n\"id\":\"bilglcur_e\",\n\"name\":\"Bilirubin monoglucuronide\",\n\"compartment\":\"e\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"bilglcur_e\"\n]\n}\n},\n{\n\"id\":\"ca2_e\",\n\"name\":\"Calcium\",\n\"compartment\":\"e\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"ca2_e\"\n]\n}\n},\n{\n\"id\":\"camp_e\",\n\"name\":\"CAMP C10H11N5O6P\",\n\"compartment\":\"e\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"camp_e\"\n]\n}\n},\n{\n\"id\":\"chol_e\",\n\"name\":\"Choline C5H14NO\",\n\"compartment\":\"e\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"chol_e\"\n]\n}\n},\n{\n\"id\":\"cl_e\",\n\"name\":\"Chloride\",\n\"compartment\":\"e\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"cl_e\"\n]\n}\n},\n{\n\"id\":\"co_e\",\n\"name\":\"Carbon monoxide\",\n\"compartment\":\"e\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"co_e\"\n]\n}\n},\n{\n\"id\":\"co2_e\",\n\"name\":\"CO2 CO2\",\n\"compartment\":\"e\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"co2_e\"\n]\n}\n},\n{\n\"id\":\"cys__L_e\",\n\"name\":\"L-Cysteine\",\n\"compartment\":\"e\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"cys_DASH_L_e\"\n]\n}\n},\n{\n\"id\":\"dhdascb_e\",\n\"name\":\"Dehydroascorbate\",\n\"compartment\":\"e\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"dhdascb_e\"\n]\n}\n},\n{\n\"id\":\"dopa_e\",\n\"name\":\"Dopamine\",\n\"compartment\":\"e\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"dopa_e\"\n]\n}\n},\n{\n\"id\":\"etha_e\",\n\"name\":\"Ethanolamine\",\n\"compartment\":\"e\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"etha_e\"\n]\n}\n},\n{\n\"id\":\"fe2_e\",\n\"name\":\"Fe2+ 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exchange\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"EX_thm_LPAREN_e_RPAREN_\"\n]\n},\n\"annotation\":{\n\"SBO\":\"SBO:0000627\"\n}\n},\n{\n\"id\":\"EX_thmmp_e\",\n\"name\":\"Thiamin monophosphate exchange\",\n\"metabolites\":{\n\"thmmp_e\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":6e-05,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Extracellular exchange\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"EX_thmmp_LPAREN_e_RPAREN_\"\n]\n},\n\"annotation\":{\n\"SBO\":\"SBO:0000627\"\n}\n},\n{\n\"id\":\"EX_urea_e\",\n\"name\":\"Urea exchange\",\n\"metabolites\":{\n\"urea_e\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":0.1152,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Extracellular exchange\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"EX_urea_LPAREN_e_RPAREN_\"\n]\n},\n\"annotation\":{\n\"SBO\":\"SBO:0000627\"\n}\n},\n{\n\"id\":\"EX_uri_e\",\n\"name\":\"Uridine 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band(c)\",\n\"metabolites\":{\n\"band_c\":-1.0\n},\n\"lower_bound\":-10.0,\n\"upper_bound\":10.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Intracellular source/sink\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"sink_band_LPAREN_c_RPAREN_\"\n]\n}\n},\n{\n\"id\":\"SK_bandmt_c\",\n\"name\":\"Demand for Band Membrane Protein (Methylated, Universal, Erythrocyte -> 2.1,3,4.1)\",\n\"metabolites\":{\n\"bandmt_c\":-1.0\n},\n\"lower_bound\":-10.0,\n\"upper_bound\":10.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Intracellular source/sink\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"sink_bandmt_LPAREN_c_RPAREN_\"\n]\n}\n},\n{\n\"id\":\"SK_for_c\",\n\"name\":\"Sink for(c)\",\n\"metabolites\":{\n\"for_c\":-1.0\n},\n\"lower_bound\":-10.0,\n\"upper_bound\":10.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Intracellular source/sink\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"sink_for_LPAREN_c_RPAREN_\"\n]\n}\n},\n{\n\"id\":\"SK_mi1345p_c\",\n\"name\":\"Demand for 1D-Myo-Inositol 1,3,4,5-Tetrakisphosphate\",\n\"metabolites\":{\n\"mi1345p_c\":-1.0\n},\n\"lower_bound\":-10.0,\n\"upper_bound\":10.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Intracellular source/sink\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"sink_mi1345p_LPAREN_c_RPAREN_\"\n]\n}\n},\n{\n\"id\":\"SK_mi134p_c\",\n\"name\":\"Demand for 1D-Myo-Inositol 1,3,4-Trisphosphate\",\n\"metabolites\":{\n\"mi134p_c\":-1.0\n},\n\"lower_bound\":-10.0,\n\"upper_bound\":10.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Intracellular source/sink\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"sink_mi134p_LPAREN_c_RPAREN_\"\n]\n}\n},\n{\n\"id\":\"SK_mi145p_c\",\n\"name\":\"Demand for 1D-Myo-Inositol 1,4,5-Trisphosphate\",\n\"metabolites\":{\n\"mi145p_c\":-1.0\n},\n\"lower_bound\":-10.0,\n\"upper_bound\":10.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Intracellular source/sink\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"sink_mi145p_LPAREN_c_RPAREN_\"\n]\n}\n},\n{\n\"id\":\"SK_mi14p_c\",\n\"name\":\"Demand for (1R,2R,3R,4R,5R,6S)-2,3,5,6-Tetrahydroxy-4-(Phosphonatooxy)Cyclohexyl Phosphate\",\n\"metabolites\":{\n\"mi14p_c\":-1.0\n},\n\"lower_bound\":-10.0,\n\"upper_bound\":10.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Intracellular source/sink\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"sink_mi14p_LPAREN_c_RPAREN_\"\n]\n}\n},\n{\n\"id\":\"SK_pchol_hs_16_0_16_0_c\",\n\"name\":\"Sink pchol hs 16 0 16 0(c)\",\n\"metabolites\":{\n\"pchol_hs_16_0_16_0_c\":-1.0\n},\n\"lower_bound\":-10.0,\n\"upper_bound\":10.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Intracellular source/sink\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"sink_pchol_hs_16_0_16_0_LPAREN_c_RPAREN_\"\n]\n}\n},\n{\n\"id\":\"SK_pchol_hs_16_0_18_1_c\",\n\"name\":\"Sink pchol hs 16 0 18 1(c)\",\n\"metabolites\":{\n\"pchol_hs_16_0_18_1_c\":-1.0\n},\n\"lower_bound\":-10.0,\n\"upper_bound\":10.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Intracellular source/sink\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"sink_pchol_hs_16_0_18_1_LPAREN_c_RPAREN_\"\n]\n}\n},\n{\n\"id\":\"SK_pchol_hs_16_0_18_2_c\",\n\"name\":\"Sink pchol hs 16 0 18 2(c)\",\n\"metabolites\":{\n\"pchol_hs_16_0_18_2_c\":-1.0\n},\n\"lower_bound\":-10.0,\n\"upper_bound\":10.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Intracellular source/sink\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"sink_pchol_hs_16_0_18_2_LPAREN_c_RPAREN_\"\n]\n}\n},\n{\n\"id\":\"SK_pchol_hs_18_1_18_1_c\",\n\"name\":\"Sink pchol hs 18 1 18 1(c)\",\n\"metabolites\":{\n\"pchol_hs_18_1_18_1_c\":-1.0\n},\n\"lower_bound\":-10.0,\n\"upper_bound\":10.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Intracellular source/sink\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"sink_pchol_hs_18_1_18_1_LPAREN_c_RPAREN_\"\n]\n}\n},\n{\n\"id\":\"SK_pchol_hs_18_1_18_2_c\",\n\"name\":\"Sink pchol hs 18 1 18 2(c)\",\n\"metabolites\":{\n\"pchol_hs_18_1_18_2_c\":-1.0\n},\n\"lower_bound\":-10.0,\n\"upper_bound\":10.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Intracellular source/sink\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"sink_pchol_hs_18_1_18_2_LPAREN_c_RPAREN_\"\n]\n}\n},\n{\n\"id\":\"SK_pchol_hs_18_2_16_0_c\",\n\"name\":\"Sink pchol hs 18 2 16 0(c)\",\n\"metabolites\":{\n\"pchol_hs_18_2_16_0_c\":-1.0\n},\n\"lower_bound\":-10.0,\n\"upper_bound\":10.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Intracellular source/sink\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"sink_pchol_hs_18_2_16_0_LPAREN_c_RPAREN_\"\n]\n}\n},\n{\n\"id\":\"SK_pchol_hs_18_2_18_1_c\",\n\"name\":\"Sink pchol hs 18 2 18 1(c)\",\n\"metabolites\":{\n\"pchol_hs_18_2_18_1_c\":-1.0\n},\n\"lower_bound\":-10.0,\n\"upper_bound\":10.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Intracellular source/sink\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"sink_pchol_hs_18_2_18_1_LPAREN_c_RPAREN_\"\n]\n}\n},\n{\n\"id\":\"SK_pe_hs_16_0_16_0_c\",\n\"name\":\"Sink pe hs 16 0 16 0(c)\",\n\"metabolites\":{\n\"pe_hs_16_0_16_0_c\":-1.0\n},\n\"lower_bound\":-10.0,\n\"upper_bound\":10.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Intracellular source/sink\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"sink_pe_hs_16_0_16_0_LPAREN_c_RPAREN_\"\n]\n}\n},\n{\n\"id\":\"SK_pe_hs_16_0_18_1_c\",\n\"name\":\"Sink pe hs 16 0 18 1(c)\",\n\"metabolites\":{\n\"pe_hs_16_0_18_1_c\":-1.0\n},\n\"lower_bound\":-10.0,\n\"upper_bound\":10.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Intracellular source/sink\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"sink_pe_hs_16_0_18_1_LPAREN_c_RPAREN_\"\n]\n}\n},\n{\n\"id\":\"SK_pe_hs_16_0_18_2_c\",\n\"name\":\"Sink pe hs 16 0 18 2(c)\",\n\"metabolites\":{\n\"pe_hs_16_0_18_2_c\":-1.0\n},\n\"lower_bound\":-10.0,\n\"upper_bound\":10.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Intracellular source/sink\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"sink_pe_hs_16_0_18_2_LPAREN_c_RPAREN_\"\n]\n}\n},\n{\n\"id\":\"SK_pe_hs_18_1_18_1_c\",\n\"name\":\"Sink pe hs 18 1 18 1(c)\",\n\"metabolites\":{\n\"pe_hs_18_1_18_1_c\":-1.0\n},\n\"lower_bound\":-10.0,\n\"upper_bound\":10.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Intracellular source/sink\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"sink_pe_hs_18_1_18_1_LPAREN_c_RPAREN_\"\n]\n}\n},\n{\n\"id\":\"SK_pe_hs_18_1_18_2_c\",\n\"name\":\"Sink pe hs 18 1 18 2(c)\",\n\"metabolites\":{\n\"pe_hs_18_1_18_2_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Intracellular source/sink\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"sink_pe_hs_18_1_18_2_LPAREN_c_RPAREN_\"\n]\n}\n},\n{\n\"id\":\"SK_pe_hs_18_2_16_0_c\",\n\"name\":\"Sink pe hs 18 2 16 0(c)\",\n\"metabolites\":{\n\"pe_hs_18_2_16_0_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Intracellular source/sink\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"sink_pe_hs_18_2_16_0_LPAREN_c_RPAREN_\"\n]\n}\n},\n{\n\"id\":\"SK_pe_hs_18_2_18_1_c\",\n\"name\":\"Sink pe hs 18 2 18 1(c)\",\n\"metabolites\":{\n\"pe_hs_18_2_18_1_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Intracellular source/sink\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"sink_pe_hs_18_2_18_1_LPAREN_c_RPAREN_\"\n]\n}\n},\n{\n\"id\":\"UNK3\",\n\"name\":\"2-keto-4-methylthiobutyrate transamination\",\n\"metabolites\":{\n\"2kmb_c\":-1.0,\n\"akg_c\":1.0,\n\"glu__L_c\":-1.0,\n\"met__L_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Tat_AT1\",\n\"subsystem\":\"Methionine Salvage\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"2KMBTA\"\n]\n}\n},\n{\n\"id\":\"3MOXTYRESSte\",\n\"name\":\"3-Methoxytyramine secretion via secretory vesicle (ATP driven)\",\n\"metabolites\":{\n\"3moxtyr_c\":-3.0,\n\"3moxtyr_e\":3.0,\n\"adp_c\":2.0,\n\"atp_c\":-2.0,\n\"h2o_c\":-2.0,\n\"h_c\":2.0,\n\"pi_c\":2.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"3MOXTYRESSte\"\n]\n}\n},\n{\n\"id\":\"4PYRDX\",\n\"name\":\"4-Pyridoxal secretion\",\n\"metabolites\":{\n\"4pyrdx_c\":-1.0,\n\"4pyrdx_e\":1.0,\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"4PYRDX\"\n]\n}\n},\n{\n\"id\":\"5AOPt2\",\n\"name\":\"5 Aminolevulinate transport in via proton symport\",\n\"metabolites\":{\n\"5aop_c\":1.0,\n\"5aop_e\":-1.0,\n\"h_c\":1.0,\n\"h_e\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"5AOPt2\"\n]\n}\n},\n{\n\"id\":\"ACALDt\",\n\"name\":\"Acetaldehyde reversible transport\",\n\"metabolites\":{\n\"acald_c\":1.0,\n\"acald_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Transport, 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(pyruvate-phosphorylating)\",\n\"metabolites\":{\n\"acmanap_c\":-1.0,\n\"acnamp_c\":1.0,\n\"h2o_c\":-1.0,\n\"pep_c\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Nans_AT1\",\n\"subsystem\":\"Aminosugar Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"ACNAM9PL\"\n]\n}\n},\n{\n\"id\":\"ACNAMPH\",\n\"name\":\"N-Acetylneuraminate 9-phosphate phosphohydrolase\",\n\"metabolites\":{\n\"acnam_c\":1.0,\n\"acnamp_c\":-1.0,\n\"h2o_c\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Nanp_AT1\",\n\"subsystem\":\"Aminosugar Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"ACNAMPH\"\n]\n}\n},\n{\n\"id\":\"ACNAMt2\",\n\"name\":\"N-acetylneuraminate proton symport\",\n\"metabolites\":{\n\"acnam_c\":1.0,\n\"acnam_e\":-1.0,\n\"h_c\":1.0,\n\"h_e\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Transport, 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symport\",\n\"metabolites\":{\n\"ac_c\":1.0,\n\"ac_e\":-1.0,\n\"h_c\":1.0,\n\"h_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"ACt2r\"\n]\n}\n},\n{\n\"id\":\"ADA\",\n\"name\":\"Adenosine deaminase\",\n\"metabolites\":{\n\"adn_c\":-1.0,\n\"h2o_c\":-1.0,\n\"h_c\":-1.0,\n\"ins_c\":1.0,\n\"nh4_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Ada_AT1\",\n\"subsystem\":\"Purine Catabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"ADA\"\n]\n}\n},\n{\n\"id\":\"ADEt\",\n\"name\":\"Adenine transport via diffusion\",\n\"metabolites\":{\n\"ade_c\":1.0,\n\"ade_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Slc29a2_1_e\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"ADEt\"\n]\n}\n},\n{\n\"id\":\"ADK1\",\n\"name\":\"Adenylate kinase\",\n\"metabolites\":{\n\"adp_c\":2.0,\n\"amp_c\":-1.0,\n\"atp_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Ak1_AT1\",\n\"subsystem\":\"Nucleotides\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"ADK1\"\n]\n}\n},\n{\n\"id\":\"ADMDC\",\n\"name\":\"Adenosylmethionine decarboxylase\",\n\"metabolites\":{\n\"amet_c\":-1.0,\n\"ametam_c\":1.0,\n\"co2_c\":1.0,\n\"h_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Amd1_AT1\",\n\"subsystem\":\"Arginine and Proline Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"ADMDC\"\n]\n}\n},\n{\n\"id\":\"ADNCYC\",\n\"name\":\"Adenylate cyclase\",\n\"metabolites\":{\n\"atp_c\":-1.0,\n\"camp_c\":1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Adcy6_AT2 or Adcy6_AT1 or Adcy5_AT1 or Adcy4_AT1 or Adcy7_AT1 or Adcy2_AT1 or Adcy3_AT1 or Adcy1_AT1 or Adcy8_AT1 or Adcy9_AT1\",\n\"subsystem\":\"Nucleotides\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"ADNCYC\"\n]\n}\n},\n{\n\"id\":\"ADNK1\",\n\"name\":\"Adenosine kinase\",\n\"metabolites\":{\n\"adn_c\":-1.0,\n\"adp_c\":1.0,\n\"amp_c\":1.0,\n\"atp_c\":-1.0,\n\"h_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Adk_AT2 or Adk_AT1\",\n\"subsystem\":\"Nucleotides\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"ADNK1\"\n]\n}\n},\n{\n\"id\":\"ADNt\",\n\"name\":\"Adenosine facilated transport in cytosol\",\n\"metabolites\":{\n\"adn_c\":1.0,\n\"adn_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Slc29a1_1_e\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"ADNt\"\n]\n}\n},\n{\n\"id\":\"ADPT\",\n\"name\":\"Adenine phosphoribosyltransferase\",\n\"metabolites\":{\n\"ade_c\":-1.0,\n\"amp_c\":1.0,\n\"ppi_c\":1.0,\n\"prpp_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"AprT_AT1\",\n\"subsystem\":\"Salvage Pathway\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"ADPT\"\n]\n}\n},\n{\n\"id\":\"ADRNLtu\",\n\"name\":\"Adrenaline (epinephrine) transport, uniport\",\n\"metabolites\":{\n\"adrnl_c\":1.0,\n\"adrnl_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"ADRNLtu\"\n]\n}\n},\n{\n\"id\":\"AGDC\",\n\"name\":\"N-acetylglucosamine-6-phosphate deacetylase\",\n\"metabolites\":{\n\"ac_c\":1.0,\n\"acgam6p_c\":-1.0,\n\"gam6p_c\":1.0,\n\"h2o_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Cgi_14_AT1\",\n\"subsystem\":\"Aminosugar Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"AGDC\"\n]\n}\n},\n{\n\"id\":\"AGPAT1_16_0_16_1\",\n\"name\":\"1-acylglycerol-3-phosphate O-acyltransferase 1 (C16:0, C16:0)\",\n\"metabolites\":{\n\"alpa_hs_16_0_c\":-1.0,\n\"coa_c\":1.0,\n\"pa_hs_16_0_16_0_c\":1.0,\n\"pmtcoa_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Agpat3_AT2 or Agpat5_AT1 or Agpat3_AT1 or Agpat6_AT1 or Agpat1_AT1 or Agpat2_AT1 or Agpat4_AT1\",\n\"subsystem\":\"Diacylglycerol Synthesis\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"AGPAT1_16_0_16_0\"\n]\n}\n},\n{\n\"id\":\"AGPAT1_16_0_18_3\",\n\"name\":\"1-acylglycerol-3-phosphate O-acyltransferase 1 (C16:0, C18:1)\",\n\"metabolites\":{\n\"alpa_hs_16_0_c\":-1.0,\n\"coa_c\":1.0,\n\"odecoa_c\":-1.0,\n\"pa_hs_16_0_18_1_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Agpat3_AT2 or Agpat5_AT1 or Agpat3_AT1 or Agpat6_AT1 or Agpat1_AT1 or Agpat2_AT1 or Agpat4_AT1\",\n\"subsystem\":\"Diacylglycerol Synthesis\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"AGPAT1_16_0_18_1\"\n]\n}\n},\n{\n\"id\":\"AGPAT1_16_0_18_4\",\n\"name\":\"1-acylglycerol-3-phosphate O-acyltransferase 1 (C16:0, C18:2)\",\n\"metabolites\":{\n\"alpa_hs_16_0_c\":-1.0,\n\"coa_c\":1.0,\n\"lnlccoa_c\":-1.0,\n\"pa_hs_16_0_18_2_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Agpat3_AT2 or Agpat5_AT1 or Agpat3_AT1 or Agpat6_AT1 or Agpat1_AT1 or Agpat2_AT1 or Agpat4_AT1\",\n\"subsystem\":\"Diacylglycerol Synthesis\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"AGPAT1_16_0_18_2\"\n]\n}\n},\n{\n\"id\":\"AGPAT1_18_1_18_3\",\n\"name\":\"1-acylglycerol-3-phosphate O-acyltransferase 1 (C18:1,C18:1)\",\n\"metabolites\":{\n\"alpa_hs_18_1_c\":-1.0,\n\"coa_c\":1.0,\n\"odecoa_c\":-1.0,\n\"pa_hs_18_1_18_1_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Agpat3_AT2 or Agpat5_AT1 or Agpat3_AT1 or Agpat6_AT1 or Agpat1_AT1 or Agpat2_AT1 or Agpat4_AT1\",\n\"subsystem\":\"Diacylglycerol Synthesis\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"AGPAT1_18_1_18_1\"\n]\n}\n},\n{\n\"id\":\"AGPAT1_18_1_18_4\",\n\"name\":\"1-acylglycerol-3-phosphate O-acyltransferase 1 (C18:1,C18:2)\",\n\"metabolites\":{\n\"alpa_hs_18_1_c\":-1.0,\n\"coa_c\":1.0,\n\"lnlccoa_c\":-1.0,\n\"pa_hs_18_1_18_2_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Agpat3_AT2 or Agpat5_AT1 or Agpat3_AT1 or Agpat6_AT1 or Agpat1_AT1 or Agpat2_AT1 or Agpat4_AT1\",\n\"subsystem\":\"Diacylglycerol Synthesis\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"AGPAT1_18_1_18_2\"\n]\n}\n},\n{\n\"id\":\"AGPAT1_18_2_16_0\",\n\"name\":\"1-acylglycerol-3-phosphate O-acyltransferase 1 (C18:2,C16:0)\",\n\"metabolites\":{\n\"alpa_hs_18_2_c\":-1.0,\n\"coa_c\":1.0,\n\"pa_hs_18_2_16_0_c\":1.0,\n\"pmtcoa_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Agpat3_AT2 or Agpat5_AT1 or Agpat3_AT1 or Agpat6_AT1 or Agpat1_AT1 or Agpat2_AT1 or Agpat4_AT1\",\n\"subsystem\":\"Diacylglycerol Synthesis\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"AGPAT1_18_2_16_0\"\n]\n}\n},\n{\n\"id\":\"AGPAT1_18_2_18_1\",\n\"name\":\"1-acylglycerol-3-phosphate O-acyltransferase 1 (C18:2,C18:1)\",\n\"metabolites\":{\n\"alpa_hs_18_2_c\":-1.0,\n\"coa_c\":1.0,\n\"odecoa_c\":-1.0,\n\"pa_hs_18_2_18_1_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Agpat3_AT2 or Agpat5_AT1 or Agpat3_AT1 or Agpat6_AT1 or Agpat1_AT1 or Agpat2_AT1 or Agpat4_AT1\",\n\"subsystem\":\"Diacylglycerol Synthesis\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"AGPAT1_18_2_18_1\"\n]\n}\n},\n{\n\"id\":\"AHCi\",\n\"name\":\"Adenosylhomocysteinase\",\n\"metabolites\":{\n\"adn_c\":1.0,\n\"ahcys_c\":-1.0,\n\"h2o_c\":-1.0,\n\"hcys__L_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Ahcy_AT1\",\n\"subsystem\":\"Methionine Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"AHC\"\n]\n}\n},\n{\n\"id\":\"ALAt4\",\n\"name\":\"Alanine-Sodium symporter\",\n\"metabolites\":{\n\"ala__L_c\":1.0,\n\"ala__L_e\":-1.0,\n\"na1_c\":1.0,\n\"na1_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Slc7a3_AT1 or Slc38a4_AT1 or Slc38a1_AT1 or Slc7a1_AT1 or Slc6a14_AT1 or Slc38a2_AT1 or Slc7a2_AT1\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"ALAt4\"\n]\n}\n},\n{\n\"id\":\"ALDD2x\",\n\"name\":\"Aldehyde dehydrogenase (acetaldehyde, NAD)\",\n\"metabolites\":{\n\"ac_c\":1.0,\n\"acald_c\":-1.0,\n\"h2o_c\":-1.0,\n\"h_c\":2.0,\n\"nad_c\":-1.0,\n\"nadh_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Aldh1a2_AT2 or Aldh3a1_AT1 or Aldh9a1_AT1 or Aldh1a1_AT1\",\n\"subsystem\":\"Glycolysis/Gluconeogenesis\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"ALDD2x\"\n]\n}\n},\n{\n\"id\":\"AMANK\",\n\"name\":\"N-acetyl-D-mannosamine kinase\",\n\"metabolites\":{\n\"acmana_c\":-1.0,\n\"acmanap_c\":1.0,\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"h_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Nagk_AT1\",\n\"subsystem\":\"Aminosugar Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"AMANK\"\n]\n}\n},\n{\n\"id\":\"AMPDA\",\n\"name\":\"Adenosine monophosphate deaminase\",\n\"metabolites\":{\n\"amp_c\":-1.0,\n\"h2o_c\":-1.0,\n\"h_c\":-1.0,\n\"imp_c\":1.0,\n\"nh4_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"AmpD3_AT1\",\n\"subsystem\":\"Nucleotides\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"AMPDA\"\n]\n}\n},\n{\n\"id\":\"AP4AH1\",\n\"name\":\"Ap4A hydrolase, asymmetrically\",\n\"metabolites\":{\n\"amp_c\":1.0,\n\"ap4a_c\":-1.0,\n\"atp_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":2.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"NudT2_AT2 or NudT2_AT1 or NudT2_AT3\",\n\"subsystem\":\"Nucleotides\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"AP4AH1\"\n]\n}\n},\n{\n\"id\":\"ARD\",\n\"name\":\"1;2-dihydroxy-3-keto-5-methylthiopentene dioxygenase\",\n\"metabolites\":{\n\"2kmb_c\":1.0,\n\"dhmtp_c\":-1.0,\n\"for_c\":1.0,\n\"h_c\":2.0,\n\"o2_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"55256\",\n\"subsystem\":\"Methionine Salvage\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"ARD1_hs\"\n]\n}\n},\n{\n\"id\":\"ARGN\",\n\"name\":\"Arginase\",\n\"metabolites\":{\n\"arg__L_c\":-1.0,\n\"h2o_c\":-1.0,\n\"orn_c\":1.0,\n\"urea_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Arg1_AT1\",\n\"subsystem\":\"Urea cycle/amino group metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"ARGN\"\n]\n}\n},\n{\n\"id\":\"ARGt5r\",\n\"name\":\"ARGtiDF\",\n\"metabolites\":{\n\"arg__L_c\":1.0,\n\"arg__L_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"ARGt5r\"\n]\n}\n},\n{\n\"id\":\"ENOPH\",\n\"name\":\"Enolase-phosphatase E1\",\n\"metabolites\":{\n\"dhmtp_c\":1.0,\n\"dkmpp_c\":-1.0,\n\"h2o_c\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"58478\",\n\"subsystem\":\"Methionine Salvage\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"ARS_hs\"\n]\n}\n},\n{\n\"id\":\"ASCBt\",\n\"name\":\"L-ascorbate transport via facilitated diffusion\",\n\"metabolites\":{\n\"ascb__L_c\":1.0,\n\"ascb__L_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"ASCBt\"\n]\n}\n},\n{\n\"id\":\"BANDMT\",\n\"name\":\"Band membrane protein-methyltransferase\",\n\"metabolites\":{\n\"ahcys_c\":1.0,\n\"amet_c\":-1.0,\n\"band_c\":-1.0,\n\"bandmt_c\":1.0,\n\"h_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Methionine Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"BANDMT\"\n]\n}\n},\n{\n\"id\":\"BILGLCURt\",\n\"name\":\"Bilirubin monoglucuronide transport via bicarbonate countertransport\",\n\"metabolites\":{\n\"bilglcur_c\":1.0,\n\"bilglcur_e\":-1.0,\n\"hco3_c\":-1.0,\n\"hco3_e\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Slco1b3_AT1 or Slco1b1_AT1\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"BILGLCURt\"\n]\n}\n},\n{\n\"id\":\"BILIRBU\",\n\"name\":\"Bilirubin UDP-glucuronosyltransferase\",\n\"metabolites\":{\n\"bilglcur_c\":1.0,\n\"bilirub_c\":-1.0,\n\"h_c\":-2.0,\n\"udp_c\":1.0,\n\"udpglcur_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Ugt1A1_AT1 or Ugt1A4_AT1\",\n\"subsystem\":\"Heme Degradation\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"BILIRBU\"\n]\n}\n},\n{\n\"id\":\"BILIRED\",\n\"name\":\"Nad(p)h biliverdin reductase\",\n\"metabolites\":{\n\"bilirub_c\":1.0,\n\"biliverd_c\":-1.0,\n\"h_c\":-1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Blvra_AT1\",\n\"subsystem\":\"Heme Degradation\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"BILIRED\"\n]\n}\n},\n{\n\"id\":\"C160CPT1\",\n\"name\":\"Carnitine O-palmitoyltransferase\",\n\"metabolites\":{\n\"coa_c\":1.0,\n\"crn_c\":-1.0,\n\"pmtcoa_c\":-1.0,\n\"pmtcrn_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Cpt1a_AT1\",\n\"subsystem\":\"Carnitine shuttle\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"C160CPT1\"\n]\n}\n},\n{\n\"id\":\"C160CPT2rbc\",\n\"name\":\"C160 reverse\",\n\"metabolites\":{\n\"coa_c\":-1.0,\n\"crn_c\":1.0,\n\"pmtcoa_c\":1.0,\n\"pmtcrn_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Cpt2_AT1\",\n\"subsystem\":\"Carnitine shuttle\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"C160CPT2rbc\"\n]\n}\n},\n{\n\"id\":\"C181CPT1\",\n\"name\":\"Carnitine octadecenoyl transferase\",\n\"metabolites\":{\n\"coa_c\":1.0,\n\"crn_c\":-1.0,\n\"odecoa_c\":-1.0,\n\"odecrn_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Cpt1a_AT1\",\n\"subsystem\":\"Carnitine shuttle\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"C181CPT1\"\n]\n}\n},\n{\n\"id\":\"C181CPT2rbc\",\n\"name\":\"Carnitine octadecenoyl transferase\",\n\"metabolites\":{\n\"coa_c\":-1.0,\n\"crn_c\":1.0,\n\"odecoa_c\":1.0,\n\"odecrn_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Cpt2_AT1\",\n\"subsystem\":\"Carnitine shuttle\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"C181CPT2rbc\"\n]\n}\n},\n{\n\"id\":\"CA2t\",\n\"name\":\"Calcium (Ca+2) transport via diffusion (extracellular to periplasm)\",\n\"metabolites\":{\n\"ca2_c\":1.0,\n\"ca2_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"CA2t\"\n]\n}\n},\n{\n\"id\":\"CAATPS\",\n\"name\":\"CAATPS\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"ca2_c\":-2.0,\n\"ca2_e\":2.0,\n\"h2o_c\":-1.0,\n\"h_e\":1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Atp2b1_AT1 or Atp2b4_AT1\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"CAATPS\"\n]\n}\n},\n{\n\"id\":\"CAMPt\",\n\"name\":\"CAMP transport (ATP-dependent)\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"camp_c\":-1.0,\n\"camp_e\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Abcc4_1_e\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"CAMPt\"\n]\n}\n},\n{\n\"id\":\"CAT\",\n\"name\":\"Catalase\",\n\"metabolites\":{\n\"h2o2_c\":-2.0,\n\"h2o_c\":2.0,\n\"o2_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Cat_AT1\",\n\"subsystem\":\"ROS Detoxification\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"CAT\"\n]\n}\n},\n{\n\"id\":\"CDIPTr_16_0_16_0\",\n\"name\":\"Phosphatidylinositol synthase (Homo sapiens, C16:0, C16:0)\",\n\"metabolites\":{\n\"cdpdag_hs_16_0_16_0_c\":-1.0,\n\"cmp_c\":1.0,\n\"h_c\":1.0,\n\"inost_c\":-1.0,\n\"pail_hs_16_0_16_0_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Cdipt_AT2 or Cdipt_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"CDIPTr_16_0_16_0\"\n]\n}\n},\n{\n\"id\":\"CDIPTr_16_0_18_1\",\n\"name\":\"Phosphatidylinositol synthase (Homo sapiens, C16:0, C18:1)\",\n\"metabolites\":{\n\"cdpdag_hs_16_0_18_1_c\":-1.0,\n\"cmp_c\":1.0,\n\"h_c\":1.0,\n\"inost_c\":-1.0,\n\"pail_hs_16_0_18_1_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Cdipt_AT2 or Cdipt_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"CDIPTr_16_0_18_1\"\n]\n}\n},\n{\n\"id\":\"CDIPTr_16_0_18_2\",\n\"name\":\"Phosphatidylinositol synthase (Homo sapiens, C16:0, C18:2)\",\n\"metabolites\":{\n\"cdpdag_hs_16_0_18_2_c\":-1.0,\n\"cmp_c\":1.0,\n\"h_c\":1.0,\n\"inost_c\":-1.0,\n\"pail_hs_16_0_18_2_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Cdipt_AT2 or Cdipt_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"CDIPTr_16_0_18_2\"\n]\n}\n},\n{\n\"id\":\"CDIPTr_18_1_18_1\",\n\"name\":\"Phosphatidylinositol synthase (Homo sapiens, C18:1,C18:1)\",\n\"metabolites\":{\n\"cdpdag_hs_18_1_18_1_c\":-1.0,\n\"cmp_c\":1.0,\n\"h_c\":1.0,\n\"inost_c\":-1.0,\n\"pail_hs_18_1_18_1_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Cdipt_AT2 or Cdipt_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"CDIPTr_18_1_18_1\"\n]\n}\n},\n{\n\"id\":\"CDIPTr_18_1_18_2\",\n\"name\":\"Phosphatidylinositol synthase (Homo sapiens, C18:1,C18:2)\",\n\"metabolites\":{\n\"cdpdag_hs_18_1_18_2_c\":-1.0,\n\"cmp_c\":1.0,\n\"h_c\":1.0,\n\"inost_c\":-1.0,\n\"pail_hs_18_1_18_2_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Cdipt_AT2 or Cdipt_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"CDIPTr_18_1_18_2\"\n]\n}\n},\n{\n\"id\":\"CDIPTr_18_2_16_0\",\n\"name\":\"Phosphatidylinositol synthase (Homo sapiens, C18:2,C16:0)\",\n\"metabolites\":{\n\"cdpdag_hs_18_2_16_0_c\":-1.0,\n\"cmp_c\":1.0,\n\"h_c\":1.0,\n\"inost_c\":-1.0,\n\"pail_hs_18_2_16_0_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Cdipt_AT2 or Cdipt_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"CDIPTr_18_2_16_0\"\n]\n}\n},\n{\n\"id\":\"CDIPTr_18_2_18_1\",\n\"name\":\"Phosphatidylinositol synthase (Homo sapiens, C18:2,C18:1)\",\n\"metabolites\":{\n\"cdpdag_hs_18_2_18_1_c\":-1.0,\n\"cmp_c\":1.0,\n\"h_c\":1.0,\n\"inost_c\":-1.0,\n\"pail_hs_18_2_18_1_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Cdipt_AT2 or Cdipt_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"CDIPTr_18_2_18_1\"\n]\n}\n},\n{\n\"id\":\"CDS_16_0_16_0\",\n\"name\":\"Phosphatidate cytidylyltransferase (C16:0, C16:0)\",\n\"metabolites\":{\n\"cdpdag_hs_16_0_16_0_c\":1.0,\n\"ctp_c\":-1.0,\n\"h_c\":-1.0,\n\"pa_hs_16_0_16_0_c\":-1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Cds1_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"CDS_16_0_16_0\"\n]\n}\n},\n{\n\"id\":\"CDS_16_0_18_1\",\n\"name\":\"Phosphatidate cytidylyltransferase (C16:0, C18:1)\",\n\"metabolites\":{\n\"cdpdag_hs_16_0_18_1_c\":1.0,\n\"ctp_c\":-1.0,\n\"h_c\":-1.0,\n\"pa_hs_16_0_18_1_c\":-1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Cds1_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"CDS_16_0_18_1\"\n]\n}\n},\n{\n\"id\":\"CDS_16_0_18_2\",\n\"name\":\"Phosphatidate cytidylyltransferase (C16:0, C18:2)\",\n\"metabolites\":{\n\"cdpdag_hs_16_0_18_2_c\":1.0,\n\"ctp_c\":-1.0,\n\"h_c\":-1.0,\n\"pa_hs_16_0_18_2_c\":-1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Cds1_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"CDS_16_0_18_2\"\n]\n}\n},\n{\n\"id\":\"CDS_18_1_18_1\",\n\"name\":\"Phosphatidate cytidylyltransferase (C18:1,C18:1)\",\n\"metabolites\":{\n\"cdpdag_hs_18_1_18_1_c\":1.0,\n\"ctp_c\":-1.0,\n\"h_c\":-1.0,\n\"pa_hs_18_1_18_1_c\":-1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Cds1_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"CDS_18_1_18_1\"\n]\n}\n},\n{\n\"id\":\"CDS_18_1_18_2\",\n\"name\":\"Phosphatidate cytidylyltransferase (C18:1,C18:2)\",\n\"metabolites\":{\n\"cdpdag_hs_18_1_18_2_c\":1.0,\n\"ctp_c\":-1.0,\n\"h_c\":-1.0,\n\"pa_hs_18_1_18_2_c\":-1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Cds1_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"CDS_18_1_18_2\"\n]\n}\n},\n{\n\"id\":\"CDS_18_2_16_0\",\n\"name\":\"Phosphatidate cytidylyltransferase (C18:2,C16:0)\",\n\"metabolites\":{\n\"cdpdag_hs_18_2_16_0_c\":1.0,\n\"ctp_c\":-1.0,\n\"h_c\":-1.0,\n\"pa_hs_18_2_16_0_c\":-1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Cds1_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"CDS_18_2_16_0\"\n]\n}\n},\n{\n\"id\":\"CDS_18_2_18_1\",\n\"name\":\"Phosphatidate cytidylyltransferase (C18:2,C18:1)\",\n\"metabolites\":{\n\"cdpdag_hs_18_2_18_1_c\":1.0,\n\"ctp_c\":-1.0,\n\"h_c\":-1.0,\n\"pa_hs_18_2_18_1_c\":-1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Cds1_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"CDS_18_2_18_1\"\n]\n}\n},\n{\n\"id\":\"CEPTC_16_0_16_0\",\n\"name\":\"Choline phosphotransferase (C16:0, C16:0)\",\n\"metabolites\":{\n\"cdpchol_c\":-1.0,\n\"cmp_c\":1.0,\n\"dag_hs_16_0_16_0_c\":-1.0,\n\"h_c\":1.0,\n\"pchol_hs_16_0_16_0_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"10390 or Chpt1_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"CEPTC_16_0_16_0\"\n]\n}\n},\n{\n\"id\":\"CEPTC_16_0_18_1\",\n\"name\":\"Choline phosphotransferase (C16:0, C18:1)\",\n\"metabolites\":{\n\"cdpchol_c\":-1.0,\n\"cmp_c\":1.0,\n\"dag_hs_16_0_18_1_c\":-1.0,\n\"h_c\":1.0,\n\"pchol_hs_16_0_18_1_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"10390 or Chpt1_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"CEPTC_16_0_18_1\"\n]\n}\n},\n{\n\"id\":\"CEPTC_16_0_18_2\",\n\"name\":\"Choline phosphotransferase (C16:0, C18:2)\",\n\"metabolites\":{\n\"cdpchol_c\":-1.0,\n\"cmp_c\":1.0,\n\"dag_hs_16_0_18_2_c\":-1.0,\n\"h_c\":1.0,\n\"pchol_hs_16_0_18_2_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"10390 or Chpt1_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"CEPTC_16_0_18_2\"\n]\n}\n},\n{\n\"id\":\"CEPTC_18_1_18_1\",\n\"name\":\"Choline phosphotransferase (C18:1, C18:1)\",\n\"metabolites\":{\n\"cdpchol_c\":-1.0,\n\"cmp_c\":1.0,\n\"dag_hs_18_1_18_1_c\":-1.0,\n\"h_c\":1.0,\n\"pchol_hs_18_1_18_1_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"10390 or Chpt1_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"CEPTC_18_1_18_1\"\n]\n}\n},\n{\n\"id\":\"CEPTC_18_1_18_2\",\n\"name\":\"Choline phosphotransferase (C18:1, C18:2)\",\n\"metabolites\":{\n\"cdpchol_c\":-1.0,\n\"cmp_c\":1.0,\n\"dag_hs_18_1_18_2_c\":-1.0,\n\"h_c\":1.0,\n\"pchol_hs_18_1_18_2_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"10390 or Chpt1_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"CEPTC_18_1_18_2\"\n]\n}\n},\n{\n\"id\":\"CEPTC_18_2_16_0\",\n\"name\":\"Choline phosphotransferase (C18:2, C16:0)\",\n\"metabolites\":{\n\"cdpchol_c\":-1.0,\n\"cmp_c\":1.0,\n\"dag_hs_18_2_16_0_c\":-1.0,\n\"h_c\":1.0,\n\"pchol_hs_18_2_16_0_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"10390 or Chpt1_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"CEPTC_18_2_16_0\"\n]\n}\n},\n{\n\"id\":\"CEPTC_18_2_18_1\",\n\"name\":\"Choline phosphotransferase (C18:2, C18:1)\",\n\"metabolites\":{\n\"cdpchol_c\":-1.0,\n\"cmp_c\":1.0,\n\"dag_hs_18_2_18_1_c\":-1.0,\n\"h_c\":1.0,\n\"pchol_hs_18_2_18_1_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"10390 or Chpt1_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"CEPTC_18_2_18_1\"\n]\n}\n},\n{\n\"id\":\"CEPTE_16_0_16_0\",\n\"name\":\"Ethanolamine phosphotransferase (C16:0,C16:0)\",\n\"metabolites\":{\n\"cdpea_c\":-1.0,\n\"cmp_c\":1.0,\n\"dag_hs_16_0_16_0_c\":-1.0,\n\"h_c\":1.0,\n\"pe_hs_16_0_16_0_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"10390\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"CEPTE_16_0_16_0\"\n]\n}\n},\n{\n\"id\":\"CEPTE_16_0_18_1\",\n\"name\":\"Ethanolamine phosphotransferase (C16:0,C18:1)\",\n\"metabolites\":{\n\"cdpea_c\":-1.0,\n\"cmp_c\":1.0,\n\"dag_hs_16_0_18_1_c\":-1.0,\n\"h_c\":1.0,\n\"pe_hs_16_0_18_1_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"10390\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"CEPTE_16_0_18_1\"\n]\n}\n},\n{\n\"id\":\"CEPTE_16_0_18_2\",\n\"name\":\"Ethanolamine phosphotransferase (C16:0,C18:2)\",\n\"metabolites\":{\n\"cdpea_c\":-1.0,\n\"cmp_c\":1.0,\n\"dag_hs_16_0_18_2_c\":-1.0,\n\"h_c\":1.0,\n\"pe_hs_16_0_18_2_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"10390\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"CEPTE_16_0_18_2\"\n]\n}\n},\n{\n\"id\":\"CEPTE_18_1_18_1\",\n\"name\":\"Ethanolamine phosphotransferase (C18:1,C18:1)\",\n\"metabolites\":{\n\"cdpea_c\":-1.0,\n\"cmp_c\":1.0,\n\"dag_hs_18_1_18_1_c\":-1.0,\n\"h_c\":1.0,\n\"pe_hs_18_1_18_1_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"10390\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"CEPTE_18_1_18_1\"\n]\n}\n},\n{\n\"id\":\"CEPTE_18_1_18_2\",\n\"name\":\"Ethanolamine phosphotransferase (C18:1,C18:2)\",\n\"metabolites\":{\n\"cdpea_c\":-1.0,\n\"cmp_c\":1.0,\n\"dag_hs_18_1_18_2_c\":-1.0,\n\"h_c\":1.0,\n\"pe_hs_18_1_18_2_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"10390\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"CEPTE_18_1_18_2\"\n]\n}\n},\n{\n\"id\":\"CEPTE_18_2_16_0\",\n\"name\":\"Ethanolamine phosphotransferase (C18:2,C16:0)\",\n\"metabolites\":{\n\"cdpea_c\":-1.0,\n\"cmp_c\":1.0,\n\"dag_hs_18_2_16_0_c\":-1.0,\n\"h_c\":1.0,\n\"pe_hs_18_2_16_0_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"10390\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"CEPTE_18_2_16_0\"\n]\n}\n},\n{\n\"id\":\"CEPTE_18_2_18_1\",\n\"name\":\"Ethanolamine phosphotransferase (C18:2,C18:1)\",\n\"metabolites\":{\n\"cdpea_c\":-1.0,\n\"cmp_c\":1.0,\n\"dag_hs_18_2_18_1_c\":-1.0,\n\"h_c\":1.0,\n\"pe_hs_18_2_18_1_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"10390\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"CEPTE_18_2_18_1\"\n]\n}\n},\n{\n\"id\":\"CGMPt\",\n\"name\":\"CGMP transport (ATP-dependent)\",\n\"metabolites\":{\n\"35cgmp_c\":-1.0,\n\"35cgmp_e\":1.0,\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Abcc4_1_e\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"CGMPt\"\n]\n}\n},\n{\n\"id\":\"CHLP\",\n\"name\":\"Choline phosphate phosphatase\",\n\"metabolites\":{\n\"chol_c\":1.0,\n\"cholp_c\":-1.0,\n\"h2o_c\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Phospho1_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"CHLP\"\n]\n}\n},\n{\n\"id\":\"CHLPCTD\",\n\"name\":\"Choline phosphate cytididyltransferase\",\n\"metabolites\":{\n\"cdpchol_c\":1.0,\n\"cholp_c\":-1.0,\n\"ctp_c\":-1.0,\n\"h_c\":-1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Pcyt1a_AT1 or Pcyt1b_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"CHLPCTD\"\n]\n}\n},\n{\n\"id\":\"CHOLK\",\n\"name\":\"Choline kinase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"chol_c\":-1.0,\n\"cholp_c\":1.0,\n\"h_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Chkl_AT2 or Chkl_AT1 or Chk_AT2 or Chk_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"CHOLK\"\n]\n}\n},\n{\n\"id\":\"CHOLt4\",\n\"name\":\"Choline, sodium cotransport\",\n\"metabolites\":{\n\"chol_c\":1.0,\n\"chol_e\":-1.0,\n\"na1_c\":1.0,\n\"na1_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Slc5a7_AT1\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"CHOLt4\"\n]\n}\n},\n{\n\"id\":\"CO2t\",\n\"name\":\"CO2 transporter via diffusion\",\n\"metabolites\":{\n\"co2_c\":1.0,\n\"co2_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"CO2t\"\n]\n}\n},\n{\n\"id\":\"COt\",\n\"name\":\"CO transporter via diffusion\",\n\"metabolites\":{\n\"co_c\":-1.0,\n\"co_e\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"COt\"\n]\n}\n},\n{\n\"id\":\"CPPPGO\",\n\"name\":\"Coproporphyrinogen oxidase (O2 required)\",\n\"metabolites\":{\n\"co2_c\":2.0,\n\"cpppg3_c\":-1.0,\n\"h2o_c\":2.0,\n\"h_c\":-2.0,\n\"o2_c\":-1.0,\n\"pppg9_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Cpox_AT1\",\n\"subsystem\":\"Heme Biosynthesis\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"CPPPGO\"\n]\n}\n},\n{\n\"id\":\"CYStec\",\n\"name\":\"L-cysteine transport via diffusion (extracellular to cytosol)\",\n\"metabolites\":{\n\"cys__L_c\":1.0,\n\"cys__L_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Slc43a2_AT1\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"CYStec\"\n]\n}\n},\n{\n\"id\":\"CYTK1\",\n\"name\":\"Cytidylate kinase (CMP)\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"cdp_c\":1.0,\n\"cmp_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"UmpK_AT1\",\n\"subsystem\":\"Nucleotides\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"CYTK1\"\n]\n}\n},\n{\n\"id\":\"D_LACt2\",\n\"name\":\"D lactate transport via proton symport\",\n\"metabolites\":{\n\"h_c\":1.0,\n\"h_e\":-1.0,\n\"lac__D_c\":1.0,\n\"lac__D_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Slc16a1_AT1\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"D_DASH_LACt2\"\n]\n}\n},\n{\n\"id\":\"DAGK_hs_16_0_16_0\",\n\"name\":\"Diacylglycerol phosphate kinase (homo sapiens, C16:0, C16:0)\",\n\"metabolites\":{\n\"adp_c\":-1.0,\n\"atp_c\":1.0,\n\"dag_hs_16_0_16_0_c\":1.0,\n\"h_c\":-1.0,\n\"pa_hs_16_0_16_0_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Dgkb_AT2 or Dgkz_AT3 or Dgkz_AT1 or Dgkb_AT1 or Dgkb_AT1 or Dgkd_AT2 or Dgkz_AT2 or Dgkd_AT1 or Dgka_AT1 or Dgkq_AT1 or Dgkh_AT2 or Dgki_AT1 or Dgkh_AT1 or Dgkg_AT1 or Dgke_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"DAGK_hs_16_0_16_0\"\n]\n}\n},\n{\n\"id\":\"DAGK_hs_16_0_18_1\",\n\"name\":\"Diacylglycerol phosphate kinase (homo sapiens, C16:0, C18:1)\",\n\"metabolites\":{\n\"adp_c\":-1.0,\n\"atp_c\":1.0,\n\"dag_hs_16_0_18_1_c\":1.0,\n\"h_c\":-1.0,\n\"pa_hs_16_0_18_1_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Dgkb_AT2 or Dgkz_AT3 or Dgkz_AT1 or Dgkb_AT1 or Dgkb_AT1 or Dgkd_AT2 or Dgkz_AT2 or Dgkd_AT1 or Dgka_AT1 or Dgkq_AT1 or Dgkh_AT2 or Dgki_AT1 or Dgkh_AT1 or Dgkg_AT1 or Dgke_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"DAGK_hs_16_0_18_1\"\n]\n}\n},\n{\n\"id\":\"DAGK_hs_16_0_18_2\",\n\"name\":\"Diacylglycerol phosphate kinase (homo sapiens, C16:0, C18:2)\",\n\"metabolites\":{\n\"adp_c\":-1.0,\n\"atp_c\":1.0,\n\"dag_hs_16_0_18_2_c\":1.0,\n\"h_c\":-1.0,\n\"pa_hs_16_0_18_2_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Dgkb_AT2 or Dgkz_AT3 or Dgkz_AT1 or Dgkb_AT1 or Dgkb_AT1 or Dgkd_AT2 or Dgkz_AT2 or Dgkd_AT1 or Dgka_AT1 or Dgkq_AT1 or Dgkh_AT2 or Dgki_AT1 or Dgkh_AT1 or Dgkg_AT1 or Dgke_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"DAGK_hs_16_0_18_2\"\n]\n}\n},\n{\n\"id\":\"DAGK_hs_18_1_18_1\",\n\"name\":\"Diacylglycerol phosphate kinase (homo sapiens, C18:1,C18:1)\",\n\"metabolites\":{\n\"adp_c\":-1.0,\n\"atp_c\":1.0,\n\"dag_hs_18_1_18_1_c\":1.0,\n\"h_c\":-1.0,\n\"pa_hs_18_1_18_1_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Dgkb_AT2 or Dgkz_AT3 or Dgkz_AT1 or Dgkb_AT1 or Dgkb_AT1 or Dgkd_AT2 or Dgkz_AT2 or Dgkd_AT1 or Dgka_AT1 or Dgkq_AT1 or Dgkh_AT2 or Dgki_AT1 or Dgkh_AT1 or Dgkg_AT1 or Dgke_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"DAGK_hs_18_1_18_1\"\n]\n}\n},\n{\n\"id\":\"DAGK_hs_18_1_18_2\",\n\"name\":\"Diacylglycerol phosphate kinase (homo sapiens, C18:1,C18:2)\",\n\"metabolites\":{\n\"adp_c\":-1.0,\n\"atp_c\":1.0,\n\"dag_hs_18_1_18_2_c\":1.0,\n\"h_c\":-1.0,\n\"pa_hs_18_1_18_2_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Dgkb_AT2 or Dgkz_AT3 or Dgkz_AT1 or Dgkb_AT1 or Dgkb_AT1 or Dgkd_AT2 or Dgkz_AT2 or Dgkd_AT1 or Dgka_AT1 or Dgkq_AT1 or Dgkh_AT2 or Dgki_AT1 or Dgkh_AT1 or Dgkg_AT1 or Dgke_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"DAGK_hs_18_1_18_2\"\n]\n}\n},\n{\n\"id\":\"DAGK_hs_18_2_16_0\",\n\"name\":\"Diacylglycerol phosphate kinase (homo sapiens, C18:2,C16:0)\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"dag_hs_18_2_16_0_c\":-1.0,\n\"h_c\":1.0,\n\"pa_hs_18_2_16_0_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Dgkb_AT2 or Dgkz_AT3 or Dgkz_AT1 or Dgkb_AT1 or Dgkb_AT1 or Dgkd_AT2 or Dgkz_AT2 or Dgkd_AT1 or Dgka_AT1 or Dgkq_AT1 or Dgkh_AT2 or Dgki_AT1 or Dgkh_AT1 or Dgkg_AT1 or Dgke_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"DAGK_hs_18_2_16_0\"\n]\n}\n},\n{\n\"id\":\"DAGK_hs_18_2_18_1\",\n\"name\":\"Diacylglycerol phosphate kinase (homo sapiens, C18:2,C18:1)\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"dag_hs_18_2_18_1_c\":-1.0,\n\"h_c\":1.0,\n\"pa_hs_18_2_18_1_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Dgkb_AT2 or Dgkz_AT3 or Dgkz_AT1 or Dgkb_AT1 or Dgkb_AT1 or Dgkd_AT2 or Dgkz_AT2 or Dgkd_AT1 or Dgka_AT1 or Dgkq_AT1 or Dgkh_AT2 or Dgki_AT1 or Dgkh_AT1 or Dgkg_AT1 or Dgke_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"DAGK_hs_18_2_18_1\"\n]\n}\n},\n{\n\"id\":\"DGULND\",\n\"name\":\"Dehydro-L-gulonate decarboxylase\",\n\"metabolites\":{\n\"3dhguln_c\":-1.0,\n\"co2_c\":1.0,\n\"h_c\":-1.0,\n\"xylu__L_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Pentose and Glucuronate Interconversions\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"DGULND\"\n]\n}\n},\n{\n\"id\":\"DHAAt1r\",\n\"name\":\"Dehydroascorbate transport (uniport)\",\n\"metabolites\":{\n\"dhdascb_c\":1.0,\n\"dhdascb_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Slc2a1_1_e\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"DHAAt1r\"\n]\n}\n},\n{\n\"id\":\"DM_nadh\",\n\"name\":\"Demand NADH\",\n\"metabolites\":{\n\"h_c\":1.0,\n\"nad_c\":1.0,\n\"nadh_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"'\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"DM_nadh\"\n]\n}\n},\n{\n\"id\":\"DOPAMT\",\n\"name\":\"Dopamine:amet O-methyltransferase\",\n\"metabolites\":{\n\"3moxtyr_c\":1.0,\n\"ahcys_c\":1.0,\n\"amet_c\":-1.0,\n\"dopa_c\":-1.0,\n\"h_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Comt_AT1 or Comt_AT2\",\n\"subsystem\":\"Tyrosine metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"DOPAMT\"\n]\n}\n},\n{\n\"id\":\"DOPAtu\",\n\"name\":\"Dopamine uniport\",\n\"metabolites\":{\n\"dopa_c\":1.0,\n\"dopa_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Slc22a2_AT1 or Slc22a2_AT2 or Slc22a3_AT1\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"DOPAtu\"\n]\n}\n},\n{\n\"id\":\"DPGM\",\n\"name\":\"Diphosphoglyceromutase\",\n\"metabolites\":{\n\"13dpg_c\":-1.0,\n\"23dpg_c\":1.0,\n\"h_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Bpgm_AT2 or Bpgm_AT1\",\n\"subsystem\":\"Glycolysis/Gluconeogenesis\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"DPGM\"\n]\n}\n},\n{\n\"id\":\"DPGase\",\n\"name\":\"Diphosphoglycerate phosphatase\",\n\"metabolites\":{\n\"23dpg_c\":-1.0,\n\"3pg_c\":1.0,\n\"h2o_c\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Bpgm_AT2 or Bpgm_AT1\",\n\"subsystem\":\"Glycolysis/Gluconeogenesis\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"DPGase\"\n]\n}\n},\n{\n\"id\":\"ENO\",\n\"name\":\"Enolase\",\n\"metabolites\":{\n\"2pg_c\":-1.0,\n\"h2o_c\":1.0,\n\"pep_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Eno1_AT1\",\n\"subsystem\":\"Glycolysis/Gluconeogenesis\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"ENO\"\n]\n}\n},\n{\n\"id\":\"ETHAK\",\n\"name\":\"Ethanolamine kinase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"etha_c\":-1.0,\n\"ethamp_c\":1.0,\n\"h_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"55224 or 55500 or Chk_AT1 or Chk_AT2\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"ETHAK\"\n]\n}\n},\n{\n\"id\":\"ETHAt\",\n\"name\":\"Ethanolamine transport via diffusion extracellular \",\n\"metabolites\":{\n\"etha_c\":1.0,\n\"etha_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"ETHAt\"\n]\n}\n},\n{\n\"id\":\"ETHP\",\n\"name\":\"Ethanolamine phosphate phosphatase\",\n\"metabolites\":{\n\"etha_c\":1.0,\n\"ethamp_c\":-1.0,\n\"h2o_c\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Phospho1_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"ETHP\"\n]\n}\n},\n{\n\"id\":\"FACOAL160\",\n\"name\":\"Fatty acid CoA ligase hexadecanoate \",\n\"metabolites\":{\n\"amp_c\":1.0,\n\"atp_c\":-1.0,\n\"coa_c\":-1.0,\n\"hdca_c\":-1.0,\n\"pmtcoa_c\":1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Acsl1_AT1\",\n\"subsystem\":\"Fatty acid activation\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"FACOAL160\"\n]\n}\n},\n{\n\"id\":\"FACOAL181\",\n\"name\":\"Fatty acid CoA ligase octadecenoate \",\n\"metabolites\":{\n\"amp_c\":1.0,\n\"atp_c\":-1.0,\n\"coa_c\":-1.0,\n\"ocdcea_c\":-1.0,\n\"odecoa_c\":1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Acsl1_AT1\",\n\"subsystem\":\"Fatty acid activation\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"FACOAL181\"\n]\n}\n},\n{\n\"id\":\"FACOAL1821\",\n\"name\":\"Linoleic acid:CoA ligase (AMP-forming)\",\n\"metabolites\":{\n\"amp_c\":1.0,\n\"atp_c\":-1.0,\n\"coa_c\":-1.0,\n\"lnlc_c\":-1.0,\n\"lnlccoa_c\":1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Acsl1_AT1\",\n\"subsystem\":\"Fatty acid activation\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"FACOAL1821\"\n]\n}\n},\n{\n\"id\":\"FADDP\",\n\"name\":\"FAD diphosphatase\",\n\"metabolites\":{\n\"amp_c\":1.0,\n\"fad_c\":-1.0,\n\"fmn_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":2.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"EnpP1_AT1\",\n\"subsystem\":\"Riboflavin Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"FADDP\"\n]\n}\n},\n{\n\"id\":\"FBA\",\n\"name\":\"Fructose-bisphosphate aldolase\",\n\"metabolites\":{\n\"dhap_c\":1.0,\n\"fdp_c\":-1.0,\n\"g3p_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Aldoc_AT1 or Aldoa_AT2 or Aldoa_AT1 or Aldoa_AT3\",\n\"subsystem\":\"Glycolysis/Gluconeogenesis\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"FBA\"\n]\n}\n},\n{\n\"id\":\"FBP26\",\n\"name\":\"Fructose 2 6 bisphosphate 2 phosphatase\",\n\"metabolites\":{\n\"f26bp_c\":-1.0,\n\"f6p_c\":1.0,\n\"h2o_c\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Pfkfb4_AT1 or Pfkfb1_AT1 or Pfkfb3_AT1 or Pfkfb2_AT1 or Fbp2_AT1 or Fbp1_AT1\",\n\"subsystem\":\"Fructose and Mannose Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"FBP26\"\n]\n}\n},\n{\n\"id\":\"FCLT\",\n\"name\":\"Ferrochelatase\",\n\"metabolites\":{\n\"fe2_c\":-1.0,\n\"h_c\":2.0,\n\"pheme_c\":1.0,\n\"ppp9_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Fech_AT1 or Fech_AT2\",\n\"subsystem\":\"Heme Biosynthesis\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"FCLT\"\n]\n}\n},\n{\n\"id\":\"FE2t\",\n\"name\":\"Iron II transport\",\n\"metabolites\":{\n\"fe2_c\":1.0,\n\"fe2_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"FE2t1\"\n]\n}\n},\n{\n\"id\":\"FMNAT\",\n\"name\":\"FMN adenylyltransferase\",\n\"metabolites\":{\n\"atp_c\":-1.0,\n\"fad_c\":1.0,\n\"fmn_c\":-1.0,\n\"h_c\":-1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"FadS_AT1 or FadS_AT2\",\n\"subsystem\":\"Riboflavin Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"FMNAT\"\n]\n}\n},\n{\n\"id\":\"FRUt1r\",\n\"name\":\"D-fructose transport in via uniport\",\n\"metabolites\":{\n\"fru_c\":1.0,\n\"fru_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Slc2a8_1_e or Slc2a7_1_e or Slc2a11_1_e or Slc2a2_1_e or Slc2a5_1_e\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"FRUt1r\"\n]\n}\n},\n{\n\"id\":\"FUM\",\n\"name\":\"Fumarase\",\n\"metabolites\":{\n\"fum_c\":-1.0,\n\"h2o_c\":-1.0,\n\"mal__L_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Fh_AT1\",\n\"subsystem\":\"Citric Acid Cycle\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"FUM\"\n]\n}\n},\n{\n\"id\":\"FUMtr\",\n\"name\":\"Fumarate transport via diffusion (reversible)\",\n\"metabolites\":{\n\"fum_c\":1.0,\n\"fum_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"FUMtr\"\n]\n}\n},\n{\n\"id\":\"G6PDA\",\n\"name\":\"Glucosamine-6-phosphate deaminase\",\n\"metabolites\":{\n\"f6p_c\":1.0,\n\"gam6p_c\":-1.0,\n\"h2o_c\":-1.0,\n\"nh4_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Gnpda1_AT1\",\n\"subsystem\":\"Aminosugar Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"G6PDA\"\n]\n}\n},\n{\n\"id\":\"G6PDH2r\",\n\"name\":\"Glucose 6-phosphate dehydrogenase\",\n\"metabolites\":{\n\"6pgl_c\":1.0,\n\"g6p_c\":-1.0,\n\"h_c\":1.0,\n\"nadp_c\":-1.0,\n\"nadph_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"G6pd_AT1\",\n\"subsystem\":\"Pentose Phosphate Pathway\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"G6PDH2r\"\n]\n}\n},\n{\n\"id\":\"GALKr\",\n\"name\":\"Galactokinase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"gal1p_c\":1.0,\n\"gal_c\":-1.0,\n\"h_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Galk1_AT1\",\n\"subsystem\":\"Galactose metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"GALK\"\n]\n}\n},\n{\n\"id\":\"GALOR\",\n\"name\":\"D-Galactose:NADP+ 1-oxidoreductase\",\n\"metabolites\":{\n\"gal_c\":-1.0,\n\"galt_c\":1.0,\n\"h_c\":-1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Akr1a1_AT2 or Akr1a1_AT1 or Akr1b1_AT1\",\n\"subsystem\":\"Galactose metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"GALOR\"\n]\n}\n},\n{\n\"id\":\"GALT\",\n\"name\":\"Galactose 1 phosphate uridylyltransferase\",\n\"metabolites\":{\n\"gal1p_c\":-1.0,\n\"h_c\":-1.0,\n\"ppi_c\":1.0,\n\"udpgal_c\":1.0,\n\"utp_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Galt_AT1 or Galt_AT3 or Galt_AT2\",\n\"subsystem\":\"Galactose metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"GALT\"\n]\n}\n},\n{\n\"id\":\"GALUi\",\n\"name\":\"UTP-glucose-1-phosphate uridylyltransferase (irreversible)\",\n\"metabolites\":{\n\"g1p_c\":-1.0,\n\"h_c\":-1.0,\n\"ppi_c\":1.0,\n\"udpg_c\":1.0,\n\"utp_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Ugp2_AT2 or Ugp2_AT1\",\n\"subsystem\":\"Galactose metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"GALU\"\n]\n}\n},\n{\n\"id\":\"GALt1r\",\n\"name\":\"Galactose transport (uniport)\",\n\"metabolites\":{\n\"gal_c\":1.0,\n\"gal_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Slc2a1_1_e or Slc2a3_1_e\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"GALt1r\"\n]\n}\n},\n{\n\"id\":\"GAMt1r\",\n\"name\":\"Glucosamine transport (uniport)\",\n\"metabolites\":{\n\"gam_c\":1.0,\n\"gam_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Slc2a4_1_e or Slc2a1_1_e\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"GAMt1r\"\n]\n}\n},\n{\n\"id\":\"GAPD\",\n\"name\":\"Glyceraldehyde-3-phosphate dehydrogenase\",\n\"metabolites\":{\n\"13dpg_c\":1.0,\n\"g3p_c\":-1.0,\n\"h_c\":1.0,\n\"nad_c\":-1.0,\n\"nadh_c\":1.0,\n\"pi_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Gapdh_AT1\",\n\"subsystem\":\"Glycolysis/Gluconeogenesis\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"GAPD\"\n]\n}\n},\n{\n\"id\":\"GGLUCT\",\n\"name\":\"Gamma-glutamylcyclotransferase\",\n\"metabolites\":{\n\"5oxpro_c\":1.0,\n\"ala__L_c\":1.0,\n\"gluala_e\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Gctg_AT1\",\n\"subsystem\":\"Glutathione Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"GGLUCT\"\n]\n}\n},\n{\n\"id\":\"GK1\",\n\"name\":\"Guanylate kinase (GMP:ATP)\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"gdp_c\":1.0,\n\"gmp_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Guk1_AT1\",\n\"subsystem\":\"Nucleotides\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"GK1\"\n]\n}\n},\n{\n\"id\":\"GLCt1\",\n\"name\":\"Glucose transport uniport \",\n\"metabolites\":{\n\"glc__D_c\":1.0,\n\"glc__D_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Slc2a3_1_e or Slc2a1_1_e or Slc2a4_1_e\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"GLCt1r\"\n]\n}\n},\n{\n\"id\":\"GLNS\",\n\"name\":\"Glutamine synthetase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"gln__L_c\":1.0,\n\"glu__L_c\":-1.0,\n\"h_c\":1.0,\n\"nh4_c\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Glul_AT1\",\n\"subsystem\":\"Glutamate metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"GLNS\"\n]\n}\n},\n{\n\"id\":\"GLNt4\",\n\"name\":\"L-glutamine reversible transport via sodium symport\",\n\"metabolites\":{\n\"gln__L_c\":1.0,\n\"gln__L_e\":-1.0,\n\"na1_c\":1.0,\n\"na1_e\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Slc38a4_AT1 or Slc38a1_AT1 or Slc6a14_AT1 or Slc38a2_AT1\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"GLNt4\"\n]\n}\n},\n{\n\"id\":\"GLUCYS\",\n\"name\":\"Gamma-glutamylcysteine synthetase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"cys__L_c\":-1.0,\n\"glu__L_c\":-1.0,\n\"glucys_c\":1.0,\n\"h_c\":1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Gclm_AT1 and Gclc_AT1\",\n\"subsystem\":\"Glutathione Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"GLUCYS\"\n]\n}\n},\n{\n\"id\":\"GLYCt\",\n\"name\":\"Glycerol transport via channel\",\n\"metabolites\":{\n\"glyc_c\":-1.0,\n\"glyc_e\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"GLYCt\"\n]\n}\n},\n{\n\"id\":\"GLYK\",\n\"name\":\"Glycerol kinase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"glyc3p_c\":1.0,\n\"glyc_c\":-1.0,\n\"h_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Gkp3_AT1 or Gk_AT1 or Gk_AT2 or Gk2_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"GLYK\"\n]\n}\n},\n{\n\"id\":\"GLYOX\",\n\"name\":\"Hydroxyacylglutathione hydrolase\",\n\"metabolites\":{\n\"gthrd_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"lac__D_c\":1.0,\n\"lgt__S_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Hagh_AT1\",\n\"subsystem\":\"Pyruvate Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"GLYOX\"\n]\n}\n},\n{\n\"id\":\"GLYt7_211_r\",\n\"name\":\"GLYt7 LPAREN 211 RPAREN r\",\n\"metabolites\":{\n\"cl_c\":1.0,\n\"cl_e\":-1.0,\n\"gly_c\":1.0,\n\"gly_e\":-1.0,\n\"na1_c\":2.0,\n\"na1_e\":-2.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Slc6a9_AT1 or Slc6a9_AT2\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"GLYt7_LPAREN_211_RPAREN_r\"\n]\n}\n},\n{\n\"id\":\"GMPR\",\n\"name\":\"GMP reductase\",\n\"metabolites\":{\n\"gmp_c\":-1.0,\n\"h_c\":-2.0,\n\"imp_c\":1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0,\n\"nh4_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"GmpR_AT1\",\n\"subsystem\":\"Nucleotides\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"GMPR\"\n]\n}\n},\n{\n\"id\":\"GMPS2\",\n\"name\":\"GMP synthase\",\n\"metabolites\":{\n\"amp_c\":1.0,\n\"atp_c\":-1.0,\n\"gln__L_c\":-1.0,\n\"glu__L_c\":1.0,\n\"gmp_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":2.0,\n\"ppi_c\":1.0,\n\"xmp_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Gmps_AT1\",\n\"subsystem\":\"Nucleotides\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"GMPS2\"\n]\n}\n},\n{\n\"id\":\"GND\",\n\"name\":\"Phosphogluconate dehydrogenase\",\n\"metabolites\":{\n\"6pgc_c\":-1.0,\n\"co2_c\":1.0,\n\"nadp_c\":-1.0,\n\"nadph_c\":1.0,\n\"ru5p__D_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Pgd_AT1\",\n\"subsystem\":\"Pentose Phosphate Pathway\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"GND\"\n]\n}\n},\n{\n\"id\":\"GPAM_hs_16_1\",\n\"name\":\"Glycerol-3-phosphate acyltransferase (C16:0)\",\n\"metabolites\":{\n\"alpa_hs_16_0_c\":1.0,\n\"coa_c\":1.0,\n\"glyc3p_c\":-1.0,\n\"pmtcoa_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Gpam_AT1\",\n\"subsystem\":\"Diacylglycerol Synthesis\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"GPAM_hs_16_0\"\n]\n}\n},\n{\n\"id\":\"GPAM_hs_18_3\",\n\"name\":\"Glycerol-3-phosphate acyltransferase (C18:1)\",\n\"metabolites\":{\n\"alpa_hs_18_1_c\":1.0,\n\"coa_c\":1.0,\n\"glyc3p_c\":-1.0,\n\"odecoa_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Gpam_AT1\",\n\"subsystem\":\"Diacylglycerol Synthesis\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"GPAM_hs_18_1\"\n]\n}\n},\n{\n\"id\":\"GPAM_hs_18_4\",\n\"name\":\"Glycerol-3-phosphate acyltransferase (C18:2)\",\n\"metabolites\":{\n\"alpa_hs_18_2_c\":1.0,\n\"coa_c\":1.0,\n\"glyc3p_c\":-1.0,\n\"lnlccoa_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Gpam_AT1\",\n\"subsystem\":\"Diacylglycerol Synthesis\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"GPAM_hs_18_2\"\n]\n}\n},\n{\n\"id\":\"GPDDA1\",\n\"name\":\"Glycerophosphodiester phosphodiesterase (Glycerophosphocholine)\",\n\"metabolites\":{\n\"chol_c\":1.0,\n\"g3pc_c\":-1.0,\n\"glyc3p_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"GPDDA1\"\n]\n}\n},\n{\n\"id\":\"GTHDH\",\n\"name\":\"Glutathione dehydrogenase (dehydroascorbate reductase)\",\n\"metabolites\":{\n\"ascb__L_c\":1.0,\n\"dhdascb_c\":-1.0,\n\"gthox_c\":1.0,\n\"gthrd_c\":-2.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Ascorbate and Aldarate Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"GTHDH\"\n]\n}\n},\n{\n\"id\":\"GTHOr\",\n\"name\":\"Glutathione oxidoreductase\",\n\"metabolites\":{\n\"gthox_c\":-1.0,\n\"gthrd_c\":2.0,\n\"h_c\":-1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Gsr_AT2\",\n\"subsystem\":\"Glutamate metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"GTHO\"\n]\n}\n},\n{\n\"id\":\"GTHOXti2\",\n\"name\":\"Oxidized glutathione irreversible active transport (rbc)\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"gthox_c\":-1.0,\n\"gthox_e\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"GTHOXti2\"\n]\n}\n},\n{\n\"id\":\"GTHPi\",\n\"name\":\"Glutathione peridoxase\",\n\"metabolites\":{\n\"gthox_c\":1.0,\n\"gthrd_c\":-2.0,\n\"h2o2_c\":-1.0,\n\"h2o_c\":2.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Prdx2_AT3 or Prdx1_AT1 or Prdx1_AT2 or Gpx1_AT2 or Prdx1_AT3 or Gpx1_AT1 or Gpx4_AT1 or Prdx2_AT1 or Prdx2_AT2\",\n\"subsystem\":\"Glutathione Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"GTHP\"\n]\n}\n},\n{\n\"id\":\"GTHS\",\n\"name\":\"Glutathione synthetase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"glucys_c\":-1.0,\n\"gly_c\":-1.0,\n\"gthrd_c\":1.0,\n\"h_c\":1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Gss_AT1\",\n\"subsystem\":\"Glutathione Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"GTHS\"\n]\n}\n},\n{\n\"id\":\"GUACYC\",\n\"name\":\"Guanylate cyclase\",\n\"metabolites\":{\n\"35cgmp_c\":1.0,\n\"gtp_c\":-1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Gucy2D_AT1 or Gucy1A2B3_AT1 or Gucy1A2B2_AT1 or Gucy1A3B2_AT1 or Gucy2F_AT1 or Npr2_AT1 or Gucy1A3B3_AT1 or Gucy2C_AT1 or Npr2_AT2 or Npr1_AT1\",\n\"subsystem\":\"Nucleotides\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"GUACYC\"\n]\n}\n},\n{\n\"id\":\"GUAPRT\",\n\"name\":\"Guanine phosphoribosyltransferase\",\n\"metabolites\":{\n\"gmp_c\":1.0,\n\"gua_c\":-1.0,\n\"ppi_c\":1.0,\n\"prpp_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"HprT1_AT1\",\n\"subsystem\":\"Salvage Pathway\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"GUAPRT\"\n]\n}\n},\n{\n\"id\":\"GULN3D\",\n\"name\":\"L-gulonate 3-dehydrogenase\",\n\"metabolites\":{\n\"3dhguln_c\":1.0,\n\"guln__L_c\":-1.0,\n\"h_c\":1.0,\n\"nad_c\":-1.0,\n\"nadh_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"51084\",\n\"subsystem\":\"Pentose and Glucuronate Interconversions\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"GULN3D\"\n]\n}\n},\n{\n\"id\":\"GULND\",\n\"name\":\"Gulonate dehydrogenase\",\n\"metabolites\":{\n\"glcur_c\":-1.0,\n\"guln__L_c\":1.0,\n\"h_c\":-1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Pentose and Glucuronate Interconversions\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"GULND\"\n]\n}\n},\n{\n\"id\":\"H2O2t\",\n\"name\":\"Hydrogen peroxide transport via diffusion\",\n\"metabolites\":{\n\"h2o2_c\":1.0,\n\"h2o2_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"H2O2t\"\n]\n}\n},\n{\n\"id\":\"H2Ot\",\n\"name\":\"H2O transport via diffusion\",\n\"metabolites\":{\n\"h2o_c\":1.0,\n\"h2o_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Slc5a1_1_e\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"H2Ot\"\n]\n}\n},\n{\n\"id\":\"HCO3E\",\n\"name\":\"HCO3 equilibration reaction\",\n\"metabolites\":{\n\"co2_c\":-1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"hco3_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Ca1_AT1 or Ca2_AT1 or Ca3_AT1\",\n\"subsystem\":\"Miscellaneous\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"HCO3E\"\n]\n}\n},\n{\n\"id\":\"HCO3_CLt\",\n\"name\":\"Bicarbonate transport (Cl-/HCO3- exchange)\",\n\"metabolites\":{\n\"cl_c\":-1.0,\n\"cl_e\":1.0,\n\"hco3_c\":1.0,\n\"hco3_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Slc4a1_1_e\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"HCO3_CLt\"\n]\n}\n},\n{\n\"id\":\"HCYSte\",\n\"name\":\"Homocysteine transport (extracellular)\",\n\"metabolites\":{\n\"hcys__L_c\":1.0,\n\"hcys__L_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"HCYSte\"\n]\n}\n},\n{\n\"id\":\"HDCAt\",\n\"name\":\"Hexadecanoate n C160 transport in via uniport\",\n\"metabolites\":{\n\"hdca_c\":1.0,\n\"hdca_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"HDCAtr\"\n]\n}\n},\n{\n\"id\":\"HEX1\",\n\"name\":\"Hexokinase (D-glucose:ATP)\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"g6p_c\":1.0,\n\"glc__D_c\":-1.0,\n\"h_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Hk2_AT1 or Hk1_AT3 or Hk1_AT1 or Hk1_AT2 or Hk3_AT1 or Flj22761_AT1 or Hk1_AT4 or Hk1_AT5\",\n\"subsystem\":\"Glycolysis/Gluconeogenesis\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"HEX1\"\n]\n}\n},\n{\n\"id\":\"HEX10\",\n\"name\":\"Hexokinase (D-glucosamine:ATP)\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"gam6p_c\":1.0,\n\"gam_c\":-1.0,\n\"h_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Hk1_AT3 or Hk1_AT2 or Hk1_AT5 or Flj22761_AT1 or Hk2_AT1 or Hk1_AT4 or Hk3_AT1 or Hk1_AT1\",\n\"subsystem\":\"Aminosugar Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"HEX10\"\n]\n}\n},\n{\n\"id\":\"HEX4\",\n\"name\":\"Hexokinase (D-mannose:ATP)\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"h_c\":1.0,\n\"man6p_c\":1.0,\n\"man_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Hk1_AT1 or Hk1_AT3 or Hk1_AT4 or Hk1_AT2 or Hk1_AT5 or Hk3_AT1 or Flj22761_AT1 or Hk2_AT1\",\n\"subsystem\":\"Fructose and Mannose Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"HEX4\"\n]\n}\n},\n{\n\"id\":\"HEX7\",\n\"name\":\"Hexokinase (D-fructose:ATP)\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"f6p_c\":1.0,\n\"fru_c\":-1.0,\n\"h_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Hk1_AT4 or Hk3_AT1 or Hk1_AT1 or Hk1_AT5 or Hk2_AT1 or Hk1_AT3 or Flj22761_AT1 or Hk1_AT2\",\n\"subsystem\":\"Fructose and Mannose Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"HEX7\"\n]\n}\n},\n{\n\"id\":\"HMBS\",\n\"name\":\"Hydroxymethylbilane synthase\",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"hmbil_c\":1.0,\n\"nh4_c\":4.0,\n\"ppbng_c\":-4.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Hmbs_AT1\",\n\"subsystem\":\"Heme Biosynthesis\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"HMBS\"\n]\n}\n},\n{\n\"id\":\"HOXG\",\n\"name\":\"Heme oxygenase 1\",\n\"metabolites\":{\n\"biliverd_c\":1.0,\n\"co_c\":1.0,\n\"fe2_c\":1.0,\n\"h2o_c\":3.0,\n\"h_c\":-5.0,\n\"nadp_c\":3.0,\n\"nadph_c\":-3.0,\n\"o2_c\":-3.0,\n\"pheme_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Hmox2_AT1 or Hmox1_AT1\",\n\"subsystem\":\"Heme Degradation\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"HOXG\"\n]\n}\n},\n{\n\"id\":\"HXPRT\",\n\"name\":\"Hypoxanthine phosphoribosyltransferase (Hypoxanthine)\",\n\"metabolites\":{\n\"hxan_c\":-1.0,\n\"imp_c\":1.0,\n\"ppi_c\":1.0,\n\"prpp_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"HprT1_AT1\",\n\"subsystem\":\"Salvage Pathway\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"HXPRT\"\n]\n}\n},\n{\n\"id\":\"HYXNt\",\n\"name\":\"Hypoxanthine transport\",\n\"metabolites\":{\n\"hxan_c\":1.0,\n\"hxan_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Slc29a2_1_e\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"HYXNt\"\n]\n}\n},\n{\n\"id\":\"Ht\",\n\"name\":\"Proton diffusion\",\n\"metabolites\":{\n\"h_c\":1.0,\n\"h_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Ht\"\n]\n}\n},\n{\n\"id\":\"ICDHyr\",\n\"name\":\"Isocitrate dehydrogenase (NADP)\",\n\"metabolites\":{\n\"akg_c\":1.0,\n\"co2_c\":1.0,\n\"icit_c\":-1.0,\n\"nadp_c\":-1.0,\n\"nadph_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Idh1_AT1\",\n\"subsystem\":\"Citric Acid Cycle\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"ICDHy\"\n]\n}\n},\n{\n\"id\":\"IMPD\",\n\"name\":\"IMP dehydrogenase\",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"imp_c\":-1.0,\n\"nad_c\":-1.0,\n\"nadh_c\":1.0,\n\"xmp_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"ImpDH1_AT1 or ImpDH2_AT1 or ImpDH1_AT2\",\n\"subsystem\":\"Nucleotides\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"IMPD\"\n]\n}\n},\n{\n\"id\":\"INSt\",\n\"name\":\"Inosine transport (diffusion)\",\n\"metabolites\":{\n\"ins_c\":1.0,\n\"ins_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Slc29a1_1_e\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"INSt\"\n]\n}\n},\n{\n\"id\":\"KCCt\",\n\"name\":\"K+-Cl- cotransport\",\n\"metabolites\":{\n\"cl_c\":1.0,\n\"cl_e\":-1.0,\n\"k_c\":1.0,\n\"k_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Slc12a7_1_e\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"KCCt\"\n]\n}\n},\n{\n\"id\":\"L_LACt2r\",\n\"name\":\"L lactate reversible transport via proton symport\",\n\"metabolites\":{\n\"h_c\":1.0,\n\"h_e\":-1.0,\n\"lac__L_c\":1.0,\n\"lac__L_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Slc16a1_AT1\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"L_DASH_LACt2r\"\n]\n}\n},\n{\n\"id\":\"LDH_L\",\n\"name\":\"L-lactate dehydrogenase\",\n\"metabolites\":{\n\"h_c\":1.0,\n\"lac__L_c\":-1.0,\n\"nad_c\":-1.0,\n\"nadh_c\":1.0,\n\"pyr_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Ldhb_AT1 or Ldha_AT1\",\n\"subsystem\":\"Glycolysis/Gluconeogenesis\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"LDH_L\"\n]\n}\n},\n{\n\"id\":\"LEUKTRA4t\",\n\"name\":\"Leukotriene A4 transmembrane (homo sapiens) transport\",\n\"metabolites\":{\n\"leuktrA4_c\":1.0,\n\"leuktrA4_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"LEUKTRA4t\"\n]\n}\n},\n{\n\"id\":\"LEUKTRB4t\",\n\"name\":\"Leukotriene B4 transmembrane (homo sapiens) transport\",\n\"metabolites\":{\n\"leuktrB4_c\":1.0,\n\"leuktrB4_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"LEUKTRB4t\"\n]\n}\n},\n{\n\"id\":\"LGTHL\",\n\"name\":\"Lactoylglutathione lyase\",\n\"metabolites\":{\n\"gthrd_c\":-1.0,\n\"lgt__S_c\":1.0,\n\"mthgxl_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Glo1_AT1\",\n\"subsystem\":\"Pyruvate Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"LGTHL\"\n]\n}\n},\n{\n\"id\":\"LNLCCPT1\",\n\"name\":\"Carnitine O-palmitoyltransferase\",\n\"metabolites\":{\n\"coa_c\":1.0,\n\"crn_c\":-1.0,\n\"lnlccoa_c\":-1.0,\n\"lnlccrn_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Cpt1a_AT1\",\n\"subsystem\":\"Carnitine shuttle\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"LNLCCPT1\"\n]\n}\n},\n{\n\"id\":\"LNLCCPT2rbc\",\n\"name\":\"Carnitine transferase\",\n\"metabolites\":{\n\"coa_c\":-1.0,\n\"crn_c\":1.0,\n\"lnlccoa_c\":1.0,\n\"lnlccrn_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Acsl1_AT1\",\n\"subsystem\":\"Fatty acid activation\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"LNLCCPT2rbc\"\n]\n}\n},\n{\n\"id\":\"LNLCt\",\n\"name\":\"Linoleic acid (n-C18:2) transport in via diffusion\",\n\"metabolites\":{\n\"lnlc_c\":1.0,\n\"lnlc_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"LNLCt\"\n]\n}\n},\n{\n\"id\":\"LPASE_16_0\",\n\"name\":\"Lysophospholipase (C16:0)\",\n\"metabolites\":{\n\"g3pc_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"hdca_c\":1.0,\n\"lpchol_hs_16_0_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"29124 or Pla2g4a_AT1 or Clc_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"LPASE_16_0\"\n]\n}\n},\n{\n\"id\":\"LPASE_18_1\",\n\"name\":\"Lysophospholipase (C18:1)\",\n\"metabolites\":{\n\"g3pc_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"lpchol_hs_18_1_c\":-1.0,\n\"ocdcea_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"29124 or Pla2g4a_AT1 or Clc_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"LPASE_18_1\"\n]\n}\n},\n{\n\"id\":\"LPASE_18_2\",\n\"name\":\"Lysophospholipase (C18:w)\",\n\"metabolites\":{\n\"g3pc_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"lnlc_c\":1.0,\n\"lpchol_hs_18_2_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"29124 or Pla2g4a_AT1 or Clc_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"LPASE_18_2\"\n]\n}\n},\n{\n\"id\":\"LTA4H\",\n\"name\":\"Leukotriene A-4 hydrolase\",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"leuktrA4_c\":-1.0,\n\"leuktrB4_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Lta4h_AT1\",\n\"subsystem\":\"Eicosanoid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"LTA4H\"\n]\n}\n},\n{\n\"id\":\"MALt\",\n\"name\":\"Malate exchange, diffusion\",\n\"metabolites\":{\n\"mal__L_c\":1.0,\n\"mal__L_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"MALt\"\n]\n}\n},\n{\n\"id\":\"MAN6PI\",\n\"name\":\"Mannose-6-phosphate isomerase\",\n\"metabolites\":{\n\"f6p_c\":1.0,\n\"man6p_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Mpi_AT1\",\n\"subsystem\":\"Fructose and Mannose Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"MAN6PI\"\n]\n}\n},\n{\n\"id\":\"MANt1r\",\n\"name\":\"Mannose transport (uniport)\",\n\"metabolites\":{\n\"man_c\":1.0,\n\"man_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Slc2a1_1_e or Slc2a3_1_e\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"MANt1r\"\n]\n}\n},\n{\n\"id\":\"MDH\",\n\"name\":\"Malate dehydrogenase\",\n\"metabolites\":{\n\"h_c\":1.0,\n\"mal__L_c\":-1.0,\n\"nad_c\":-1.0,\n\"nadh_c\":1.0,\n\"oaa_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Mdh1_AT1\",\n\"subsystem\":\"Citric Acid Cycle\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"MDH\"\n]\n}\n},\n{\n\"id\":\"MDRPD\",\n\"name\":\"5-Methylthio-5-deoxy-D-ribulose 1-phosphate dehydratase\",\n\"metabolites\":{\n\"5mdru1p_c\":-1.0,\n\"dkmpp_c\":1.0,\n\"h2o_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Methionine Salvage\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"MDRPD\"\n]\n}\n},\n{\n\"id\":\"ME2\",\n\"name\":\"Malic enzyme (NADP)\",\n\"metabolites\":{\n\"co2_c\":1.0,\n\"mal__L_c\":-1.0,\n\"nadp_c\":-1.0,\n\"nadph_c\":1.0,\n\"pyr_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Me1_AT1\",\n\"subsystem\":\"Pyruvate Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"ME2\"\n]\n}\n},\n{\n\"id\":\"MEPIVESSte\",\n\"name\":\"Metanephrine secretion via secretory vesicle (ATP driven)\",\n\"metabolites\":{\n\"adp_c\":2.0,\n\"atp_c\":-2.0,\n\"h2o_c\":-2.0,\n\"h_c\":2.0,\n\"mepi_c\":-3.0,\n\"mepi_e\":3.0,\n\"pi_c\":2.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"MEPIVESSte\"\n]\n}\n},\n{\n\"id\":\"METAT\",\n\"name\":\"Methionine adenosyltransferase\",\n\"metabolites\":{\n\"amet_c\":1.0,\n\"atp_c\":-1.0,\n\"h2o_c\":-1.0,\n\"met__L_c\":-1.0,\n\"pi_c\":1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Mat2ab1 or Mat1a_AT1 or Mat2ab2\",\n\"subsystem\":\"Methionine Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"METAT\"\n]\n}\n},\n{\n\"id\":\"METtec\",\n\"name\":\"L-methionine transport via diffusion (extracellular to cytosol)\",\n\"metabolites\":{\n\"met__L_c\":1.0,\n\"met__L_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Slc43a1_AT1 or Slc43a2_AT1\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"METtec\"\n]\n}\n},\n{\n\"id\":\"MGSA\",\n\"name\":\"Methylglyoxal synthase\",\n\"metabolites\":{\n\"dhap_c\":-1.0,\n\"mthgxl_c\":1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Pyruvate Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"MGSA\"\n]\n}\n},\n{\n\"id\":\"MI1345PP\",\n\"name\":\"D-myo-Inositol 1,3,4,5-tetrakisphosphate 5-phosphohydrolase\",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"mi1345p_c\":-1.0,\n\"mi134p_c\":1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Inpp5d_AT1 or Synj1_AT1 or Synj1_AT2\",\n\"subsystem\":\"Inositol Phosphate Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"MI1345PP\"\n]\n}\n},\n{\n\"id\":\"MI145PK\",\n\"name\":\"Inositol-1,4,5-trisphosphate 3-kinase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"h_c\":1.0,\n\"mi1345p_c\":1.0,\n\"mi145p_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Itpkb_AT1 or Itpka_AT1 or Itpkc_AT1\",\n\"subsystem\":\"Inositol Phosphate Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"MI145PK\"\n]\n}\n},\n{\n\"id\":\"MI145PP\",\n\"name\":\"D-myo-Inositol-1,4,5-trisphosphate 5-phosphohydrolase\",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"mi145p_c\":-1.0,\n\"mi14p_c\":1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Inpp5d_AT1 or Synj1_AT1 or Synj1_AT2\",\n\"subsystem\":\"Inositol Phosphate Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"MI145PP\"\n]\n}\n},\n{\n\"id\":\"MI1PP\",\n\"name\":\"Myo-inositol 1-phosphatase\",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"inost_c\":1.0,\n\"mi1p__D_c\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Impa1_AT1\",\n\"subsystem\":\"Inositol Phosphate Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"MI1PP\"\n]\n}\n},\n{\n\"id\":\"MI1PS\",\n\"name\":\"Myo Inositol 1 phosphate synthase\",\n\"metabolites\":{\n\"g6p_c\":-1.0,\n\"mi1p__D_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Isyna1_AT1\",\n\"subsystem\":\"Inositol Phosphate Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"MI1PS\"\n]\n}\n},\n{\n\"id\":\"MTAP\",\n\"name\":\"5 methylthioadenosine phosphorylase\",\n\"metabolites\":{\n\"5mdr1p_c\":1.0,\n\"5mta_c\":-1.0,\n\"ade_c\":1.0,\n\"pi_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Mtap_AT1\",\n\"subsystem\":\"Arginine and Proline Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"MTAP\"\n]\n}\n},\n{\n\"id\":\"MTRI\",\n\"name\":\"5-methylthioribose-1-phosphate isomerase\",\n\"metabolites\":{\n\"5mdr1p_c\":-1.0,\n\"5mdru1p_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Methionine Salvage\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"MTRI\"\n]\n}\n},\n{\n\"id\":\"NACt\",\n\"name\":\"Nicotinic acid transport\",\n\"metabolites\":{\n\"nac_c\":1.0,\n\"nac_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"NACt\"\n]\n}\n},\n{\n\"id\":\"NADK\",\n\"name\":\"NAD kinase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"h_c\":1.0,\n\"nad_c\":-1.0,\n\"nadp_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Nadk_AT1\",\n\"subsystem\":\"NAD Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"NADK\"\n]\n}\n},\n{\n\"id\":\"NADPN\",\n\"name\":\"NADP nucleosidase\",\n\"metabolites\":{\n\"adprbp_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"nadp_c\":-1.0,\n\"ncam_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"NAD Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"NADPN\"\n]\n}\n},\n{\n\"id\":\"NADS2\",\n\"name\":\"Nicotinate-mononucleotide adenylyltransferase\",\n\"metabolites\":{\n\"amp_c\":1.0,\n\"atp_c\":-1.0,\n\"dnad_c\":-1.0,\n\"gln__L_c\":-1.0,\n\"glu__L_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"nad_c\":1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Nadsyn1_AT1\",\n\"subsystem\":\"NAD Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"NADS2\"\n]\n}\n},\n{\n\"id\":\"NAt\",\n\"name\":\"Sodium transport (uniport)\",\n\"metabolites\":{\n\"na1_c\":1.0,\n\"na1_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Slc5a3_1_e or Slc5a1_1_e or Slc5a5_1_e\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"NAt\"\n]\n}\n},\n{\n\"id\":\"NCAMUP\",\n\"name\":\"Nicotinamide acid uptake\",\n\"metabolites\":{\n\"ncam_c\":1.0,\n\"ncam_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"NCAMt\"\n]\n}\n},\n{\n\"id\":\"NDPK1\",\n\"name\":\"Nucleoside-diphosphate kinase (ATP:GDP)\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"gdp_c\":-1.0,\n\"gtp_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"NME12_AT2 or NME12_AT1 or NME3_AT1 or NME7_AT2 or NME6_AT1 or NME7_AT1\",\n\"subsystem\":\"Nucleotides\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"NDPK1\"\n]\n}\n},\n{\n\"id\":\"NDPK2\",\n\"name\":\"Nucleoside-diphosphate kinase (ATP:UDP)\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"udp_c\":-1.0,\n\"utp_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"NME3_AT1 or NME6_AT1 or NME7_AT2 or NME7_AT1 or NME12_AT2 or NME12_AT1\",\n\"subsystem\":\"Nucleotides\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"NDPK2\"\n]\n}\n},\n{\n\"id\":\"NDPK3\",\n\"name\":\"Nucleoside-diphosphate kinase (ATP:CDP)\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"cdp_c\":-1.0,\n\"ctp_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"NME7_AT2 or NME7_AT1 or NME3_AT1 or NME12_AT2 or NME6_AT1 or NME12_AT1\",\n\"subsystem\":\"Nucleotides\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"NDPK3\"\n]\n}\n},\n{\n\"id\":\"NH4t3r\",\n\"name\":\"Ammonia transport via proton antiport\",\n\"metabolites\":{\n\"h_c\":1.0,\n\"h_e\":-1.0,\n\"nh4_c\":-1.0,\n\"nh4_e\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Rhbg_1_e or Rhag_1_e\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"NH4t3r\"\n]\n}\n},\n{\n\"id\":\"NICRNS\",\n\"name\":\"Nicotinate D-ribonucleotide synthase (ATP)\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"h_c\":1.0,\n\"nicrns_c\":-1.0,\n\"nicrnt_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"NAD Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"NICRNS\"\n]\n}\n},\n{\n\"id\":\"NMNAT\",\n\"name\":\"Nicotinamide-nucleotide adenylyltransferase\",\n\"metabolites\":{\n\"atp_c\":-1.0,\n\"h_c\":-1.0,\n\"nad_c\":1.0,\n\"nmn_c\":-1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Nmnat3_AT1\",\n\"subsystem\":\"NAD Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"NMNATr\"\n]\n}\n},\n{\n\"id\":\"NNATr\",\n\"name\":\"Nicotinate-nucleotide adenylyltransferase\",\n\"metabolites\":{\n\"atp_c\":-1.0,\n\"dnad_c\":1.0,\n\"h_c\":-1.0,\n\"nicrnt_c\":-1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Nmnat3_AT1\",\n\"subsystem\":\"NAD Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"NNATr\"\n]\n}\n},\n{\n\"id\":\"NORMETEVESSte\",\n\"name\":\"L-Normetanephrine seceretion via secretory vesicle (ATP driven)\",\n\"metabolites\":{\n\"adp_c\":2.0,\n\"atp_c\":-2.0,\n\"h2o_c\":-2.0,\n\"h_c\":2.0,\n\"normete__L_c\":-3.0,\n\"normete__L_e\":3.0,\n\"pi_c\":2.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"NORMETEVESSte\"\n]\n}\n},\n{\n\"id\":\"NP1\",\n\"name\":\"Nucleotide phosphatase\",\n\"metabolites\":{\n\"h_c\":-1.0,\n\"nac_c\":-1.0,\n\"nicrns_c\":1.0,\n\"pi_c\":1.0,\n\"r1p_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Np_AT1\",\n\"subsystem\":\"NAD Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"NP1\"\n]\n}\n},\n{\n\"id\":\"NRPPHRtu\",\n\"name\":\"Norepinephrine uniport\",\n\"metabolites\":{\n\"nrpphr_c\":1.0,\n\"nrpphr_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Slc22a2_AT2 or Slc22a2_AT1 or Slc22a3_AT1\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"NRPPHRtu\"\n]\n}\n},\n{\n\"id\":\"NT5C\",\n\"name\":\"5'-nucleotidase\",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"nicrns_c\":1.0,\n\"nicrnt_c\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Nt5C2_AT1\",\n\"subsystem\":\"NAD Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"NT5C\"\n]\n}\n},\n{\n\"id\":\"NTD11\",\n\"name\":\"5'-nucleotidase (IMP)\",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"imp_c\":-1.0,\n\"ins_c\":1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Nt5C2_AT1\",\n\"subsystem\":\"Purine Catabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"NTD11\"\n]\n}\n},\n{\n\"id\":\"NTD2\",\n\"name\":\"5'-nucleotidase (UMP)\",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"pi_c\":1.0,\n\"ump_c\":-1.0,\n\"uri_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Nt5C3_AT1\",\n\"subsystem\":\"Pyrimidine Catabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"NTD2\"\n]\n}\n},\n{\n\"id\":\"NMNHYD\",\n\"name\":\"Nicotinamide ribonucleotide phosphohydrolase\",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"nmn_c\":-1.0,\n\"pi_c\":1.0,\n\"rnam_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Nt5C_AT1\",\n\"subsystem\":\"NAD Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"NTD5_a\"\n]\n}\n},\n{\n\"id\":\"NTD7\",\n\"name\":\"5'-nucleotidase (AMP)\",\n\"metabolites\":{\n\"adn_c\":1.0,\n\"amp_c\":-1.0,\n\"h2o_c\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Nt5C2_AT1\",\n\"subsystem\":\"Nucleotides\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"NTD7\"\n]\n}\n},\n{\n\"id\":\"NTD9\",\n\"name\":\"5'-nucleotidase (GMP)\",\n\"metabolites\":{\n\"gmp_c\":-1.0,\n\"gsn_c\":1.0,\n\"h2o_c\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Nt5C2_AT1\",\n\"subsystem\":\"Nucleotides\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"NTD9\"\n]\n}\n},\n{\n\"id\":\"NaKt\",\n\"name\":\"Na+/K+ exchanging ATPase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"k_c\":2.0,\n\"k_e\":-2.0,\n\"na1_c\":-3.0,\n\"na1_e\":3.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Atp1a1b1 or Atp1a1b2 or Atp1a1b3 or Atp1a1b4\",\n\"objective_coefficient\":1.0,\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"NaKt\"\n]\n}\n},\n{\n\"id\":\"O2t\",\n\"name\":\"O2 transport diffusion \",\n\"metabolites\":{\n\"o2_c\":1.0,\n\"o2_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"O2t\"\n]\n}\n},\n{\n\"id\":\"OCDCEAt\",\n\"name\":\"Octadecenoate n C181 transport in via uniport\",\n\"metabolites\":{\n\"ocdcea_c\":1.0,\n\"ocdcea_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"OCDCEAtr\"\n]\n}\n},\n{\n\"id\":\"OMPDC\",\n\"name\":\"Orotidine-5'-phosphate decarboxylase\",\n\"metabolites\":{\n\"co2_c\":1.0,\n\"h_c\":-1.0,\n\"orot5p_c\":-1.0,\n\"ump_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Umps_AT1\",\n\"subsystem\":\"Pyrimidine Biosynthesis\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"OMPDC\"\n]\n}\n},\n{\n\"id\":\"OPAH\",\n\"name\":\"5-Oxoproline amidohydrolase (ATP-hydrolysing) (ir)\",\n\"metabolites\":{\n\"5oxpro_c\":-1.0,\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"glu__L_c\":1.0,\n\"h2o_c\":-2.0,\n\"h_c\":1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Oplah_AT1\",\n\"subsystem\":\"Glutathione Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"OPAHir\"\n]\n}\n},\n{\n\"id\":\"ORNDC\",\n\"name\":\"Ornithine Decarboxylase\",\n\"metabolites\":{\n\"co2_c\":1.0,\n\"h_c\":-1.0,\n\"orn_c\":-1.0,\n\"ptrc_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Odc1_AT1\",\n\"subsystem\":\"Urea cycle/amino group metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"ORNDC\"\n]\n}\n},\n{\n\"id\":\"OROATP\",\n\"name\":\"Orotic acid transport inout via proton symporter\",\n\"metabolites\":{\n\"h_c\":1.0,\n\"h_e\":-1.0,\n\"orot_c\":1.0,\n\"orot_e\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"OROATP\"\n]\n}\n},\n{\n\"id\":\"ORPT\",\n\"name\":\"Orotate phosphoribosyltransferase\",\n\"metabolites\":{\n\"orot5p_c\":-1.0,\n\"orot_c\":1.0,\n\"ppi_c\":-1.0,\n\"prpp_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Umps_AT1\",\n\"subsystem\":\"Pyrimidine Biosynthesis\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"ORPT\"\n]\n}\n},\n{\n\"id\":\"PDE1\",\n\"name\":\"3',5'-cyclic-nucleotide phosphodiesterase\",\n\"metabolites\":{\n\"amp_c\":1.0,\n\"camp_c\":-1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Pde8a_AT5 or Pde8a_AT3 or Pde8a_AT2 or Pde7A_AT2 or Pde11A_AT1 or Pde8a_AT1 or Pde1C_AT1 or Pde4C_AT1 or Pde4B_AT1 or Pde2A_AT1 or Pde3A_AT1 or Pde3B_AT2 or Pde7A_AT1 or Pde8b_AT1 or Pde7B_AT1 or Pde4A_AT1 or Pde1A_AT2 or 10846 or Pde1B_AT1 or Pde4D_AT1 or Pde1A_AT1 or Pde8a_AT4 or Pde3B_AT1\",\n\"subsystem\":\"Nucleotides\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PDE1\"\n]\n}\n},\n{\n\"id\":\"PDX5POi\",\n\"name\":\"Pyridoxine 5'-phosphate oxidase\",\n\"metabolites\":{\n\"h2o2_c\":1.0,\n\"o2_c\":-1.0,\n\"pdx5p_c\":-1.0,\n\"pydx5p_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"PnpO_AT1\",\n\"subsystem\":\"Vitamin B6 Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PDX5PO\"\n]\n}\n},\n{\n\"id\":\"PDXPP\",\n\"name\":\"Pyridoxine 5-phosphate phosphatase\",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"pdx5p_c\":-1.0,\n\"pi_c\":1.0,\n\"pydxn_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"PdxP_AT1\",\n\"subsystem\":\"Vitamin B6 Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PDXPP\"\n]\n}\n},\n{\n\"id\":\"PETHCT\",\n\"name\":\"Phosphoethanolamine cytidyltransferase\",\n\"metabolites\":{\n\"cdpea_c\":1.0,\n\"ctp_c\":-1.0,\n\"ethamp_c\":-1.0,\n\"h_c\":-1.0,\n\"ppi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Pcyt2_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PETHCT\"\n]\n}\n},\n{\n\"id\":\"PFK\",\n\"name\":\"Phosphofructokinase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"f6p_c\":-1.0,\n\"fdp_c\":1.0,\n\"h_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Pfkl_AT2 or Pfkm_AT1 or Pfkl_AT1\",\n\"subsystem\":\"Glycolysis/Gluconeogenesis\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PFK\"\n]\n}\n},\n{\n\"id\":\"PFK26\",\n\"name\":\"6 phosphofructo 2 kinase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"f26bp_c\":1.0,\n\"f6p_c\":-1.0,\n\"h_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Pfkfb1_AT1 or Pfkfb4_AT1 or Pfkfb3_AT1 or Pfkfb2_AT1\",\n\"subsystem\":\"Fructose and Mannose Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PFK26\"\n]\n}\n},\n{\n\"id\":\"PGI\",\n\"name\":\"Glucose-6-phosphate isomerase\",\n\"metabolites\":{\n\"f6p_c\":1.0,\n\"g6p_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Gpi_AT1\",\n\"subsystem\":\"Glycolysis/Gluconeogenesis\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PGI\"\n]\n}\n},\n{\n\"id\":\"PGK\",\n\"name\":\"Phosphoglycerate kinase\",\n\"metabolites\":{\n\"13dpg_c\":1.0,\n\"3pg_c\":-1.0,\n\"adp_c\":1.0,\n\"atp_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Pgk1_AT1\",\n\"subsystem\":\"Glycolysis/Gluconeogenesis\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PGK\"\n]\n}\n},\n{\n\"id\":\"PGL\",\n\"name\":\"6-phosphogluconolactonase\",\n\"metabolites\":{\n\"6pgc_c\":1.0,\n\"6pgl_c\":-1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Pgls_AT1\",\n\"subsystem\":\"Pentose Phosphate Pathway\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PGL\"\n]\n}\n},\n{\n\"id\":\"PGM\",\n\"name\":\"Phosphoglycerate mutase\",\n\"metabolites\":{\n\"2pg_c\":-1.0,\n\"3pg_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Bpgm_AT1 or Bpgm_AT2\",\n\"subsystem\":\"Glycolysis/Gluconeogenesis\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PGM\"\n]\n}\n},\n{\n\"id\":\"PGMT\",\n\"name\":\"Phosphoglucomutase\",\n\"metabolites\":{\n\"g1p_c\":-1.0,\n\"g6p_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"55276\",\n\"subsystem\":\"Glycolysis/Gluconeogenesis\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PGMT\"\n]\n}\n},\n{\n\"id\":\"PHETA1\",\n\"name\":\"Phenylalanine transaminase\",\n\"metabolites\":{\n\"akg_c\":-1.0,\n\"glu__L_c\":1.0,\n\"phe__L_c\":-1.0,\n\"phpyr_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Got1_AT1\",\n\"subsystem\":\"Phenylalanine metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PHETA1\"\n]\n}\n},\n{\n\"id\":\"PHEtec\",\n\"name\":\"L-phenylalanine transport via diffusion (extracellular to cytosol)\",\n\"metabolites\":{\n\"phe__L_c\":1.0,\n\"phe__L_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Slc43a2_AT1\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PHEtec\"\n]\n}\n},\n{\n\"id\":\"PI45P5P_16_0_16_0\",\n\"name\":\"Phosphatidylinositol-4,5-bisphosphate 5-phosphatase (C16:0, C16:0)\",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"pail45p_hs_16_0_16_0_c\":-1.0,\n\"pail4p_hs_16_0_16_0_c\":1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Synj1_AT2 or Synj1_AT1\",\n\"subsystem\":\"Inositol Phosphate Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PI45P5P_16_0_16_0\"\n]\n}\n},\n{\n\"id\":\"PI45P5P_16_0_18_1\",\n\"name\":\"Phosphatidylinositol-4,5-bisphosphate 5-phosphatase (C16:0, C18:1)\",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"pail45p_hs_16_0_18_1_c\":-1.0,\n\"pail4p_hs_16_0_18_1_c\":1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Synj1_AT2 or Synj1_AT1\",\n\"subsystem\":\"Inositol Phosphate Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PI45P5P_16_0_18_1\"\n]\n}\n},\n{\n\"id\":\"PI45P5P_16_0_18_2\",\n\"name\":\"Phosphatidylinositol-4,5-bisphosphate 5-phosphatase (C16:0, C18:2)\",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"pail45p_hs_16_0_18_2_c\":-1.0,\n\"pail4p_hs_16_0_18_2_c\":1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Synj1_AT2 or Synj1_AT1\",\n\"subsystem\":\"Inositol Phosphate Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PI45P5P_16_0_18_2\"\n]\n}\n},\n{\n\"id\":\"PI45P5P_18_1_18_1\",\n\"name\":\"Phosphatidylinositol-4,5-bisphosphate 5-phosphatase (C18:1, C18:1)\",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"pail45p_hs_18_1_18_1_c\":-1.0,\n\"pail4p_hs_18_1_18_1_c\":1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Synj1_AT2 or Synj1_AT1\",\n\"subsystem\":\"Inositol Phosphate Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PI45P5P_18_1_18_1\"\n]\n}\n},\n{\n\"id\":\"PI45P5P_18_1_18_2\",\n\"name\":\"Phosphatidylinositol-4,5-bisphosphate 5-phosphatase (C18:1, C18:2)\",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"pail45p_hs_18_1_18_2_c\":-1.0,\n\"pail4p_hs_18_1_18_2_c\":1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Synj1_AT2 or Synj1_AT1\",\n\"subsystem\":\"Inositol Phosphate Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PI45P5P_18_1_18_2\"\n]\n}\n},\n{\n\"id\":\"PI45P5P_18_2_16_0\",\n\"name\":\"Phosphatidylinositol-4,5-bisphosphate 5-phosphatase (C18:2, C16:0)\",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"pail45p_hs_18_2_16_0_c\":-1.0,\n\"pail4p_hs_18_2_16_0_c\":1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Synj1_AT2 or Synj1_AT1\",\n\"subsystem\":\"Inositol Phosphate Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PI45P5P_18_2_16_0\"\n]\n}\n},\n{\n\"id\":\"PI45P5P_18_2_18_1\",\n\"name\":\"Phosphatidylinositol-4,5-bisphosphate 5-phosphatase (C18:2, C18:1)\",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"pail45p_hs_18_2_18_1_c\":-1.0,\n\"pail4p_hs_18_2_18_1_c\":1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Synj1_AT2 or Synj1_AT1\",\n\"subsystem\":\"Inositol Phosphate Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PI45P5P_18_2_18_1\"\n]\n}\n},\n{\n\"id\":\"PI45PLC_16_0_16_0\",\n\"name\":\"Phosphatidylinositol 4,5-bisphosphate phospholipase C (C16:0, C16:0)\",\n\"metabolites\":{\n\"dag_hs_16_0_16_0_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"mi145p_c\":1.0,\n\"pail45p_hs_16_0_16_0_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Plcb3_AT1\",\n\"subsystem\":\"Inositol Phosphate Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PI45PLC_16_0_16_0\"\n]\n}\n},\n{\n\"id\":\"PI45PLC_16_0_18_1\",\n\"name\":\"Phosphatidylinositol 4,5-bisphosphate phospholipase C (C16:0, C18:1)\",\n\"metabolites\":{\n\"dag_hs_16_0_18_1_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"mi145p_c\":1.0,\n\"pail45p_hs_16_0_18_1_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Plcb3_AT1\",\n\"subsystem\":\"Inositol Phosphate Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PI45PLC_16_0_18_1\"\n]\n}\n},\n{\n\"id\":\"PI45PLC_16_0_18_2\",\n\"name\":\"Phosphatidylinositol 4,5-bisphosphate phospholipase C (C16:0, C18:2)\",\n\"metabolites\":{\n\"dag_hs_16_0_18_2_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"mi145p_c\":1.0,\n\"pail45p_hs_16_0_18_2_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Plcb3_AT1\",\n\"subsystem\":\"Inositol Phosphate Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PI45PLC_16_0_18_2\"\n]\n}\n},\n{\n\"id\":\"PI45PLC_18_1_18_1\",\n\"name\":\"Phosphatidylinositol 4,5-bisphosphate phospholipase C (C18:1, C18:1)\",\n\"metabolites\":{\n\"dag_hs_18_1_18_1_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"mi145p_c\":1.0,\n\"pail45p_hs_18_1_18_1_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Plcb3_AT1\",\n\"subsystem\":\"Inositol Phosphate Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PI45PLC_18_1_18_1\"\n]\n}\n},\n{\n\"id\":\"PI45PLC_18_1_18_2\",\n\"name\":\"Phosphatidylinositol 4,5-bisphosphate phospholipase C (C18:1, C18:2)\",\n\"metabolites\":{\n\"dag_hs_18_1_18_2_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"mi145p_c\":1.0,\n\"pail45p_hs_18_1_18_2_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Plcb3_AT1\",\n\"subsystem\":\"Inositol Phosphate Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PI45PLC_18_1_18_2\"\n]\n}\n},\n{\n\"id\":\"PI45PLC_18_2_16_0\",\n\"name\":\"Phosphatidylinositol 4,5-bisphosphate phospholipase C (C18:2, C16:0)\",\n\"metabolites\":{\n\"dag_hs_18_2_16_0_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"mi145p_c\":1.0,\n\"pail45p_hs_18_2_16_0_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Plcb3_AT1\",\n\"subsystem\":\"Inositol Phosphate Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PI45PLC_18_2_16_0\"\n]\n}\n},\n{\n\"id\":\"PI45PLC_18_2_18_1\",\n\"name\":\"Phosphatidylinositol 4,5-bisphosphate phospholipase C (C18:2, C18:1)\",\n\"metabolites\":{\n\"dag_hs_18_2_18_1_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"mi145p_c\":1.0,\n\"pail45p_hs_18_2_18_1_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Plcb3_AT1\",\n\"subsystem\":\"Inositol Phosphate Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PI45PLC_18_2_18_1\"\n]\n}\n},\n{\n\"id\":\"PI4P5K_16_0_16_1\",\n\"name\":\"Phosphatidylinositol 4-phosphate 5-kinase (C16:0,C16:0)\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"h_c\":1.0,\n\"pail45p_hs_16_0_16_0_c\":1.0,\n\"pail4p_hs_16_0_16_0_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Pip5k1a_AT1 or Pip5k2c_AT1 or Pip5k3_AT1 or Pip5k1b_AT1 or Pip5k2b_AT2 or Pip5k1c_AT1 or Pip5k2a_AT1 or Pip5k3_AT2 or Pip5k3_AT3 or Pip5k2b_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PI4P5K_16_0_16_0\"\n]\n}\n},\n{\n\"id\":\"PI4P5K_16_0_18_3\",\n\"name\":\"Phosphatidylinositol 4-phosphate 5-kinase (C16:0,C18:1)\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"h_c\":1.0,\n\"pail45p_hs_16_0_18_1_c\":1.0,\n\"pail4p_hs_16_0_18_1_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Pip5k1a_AT1 or Pip5k2c_AT1 or Pip5k3_AT1 or Pip5k1b_AT1 or Pip5k2b_AT2 or Pip5k1c_AT1 or Pip5k2a_AT1 or Pip5k3_AT2 or Pip5k3_AT3 or Pip5k2b_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PI4P5K_16_0_18_1\"\n]\n}\n},\n{\n\"id\":\"PI4P5K_16_0_18_4\",\n\"name\":\"Phosphatidylinositol 4-phosphate 5-kinase (C16:0,C18:2)\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"h_c\":1.0,\n\"pail45p_hs_16_0_18_2_c\":1.0,\n\"pail4p_hs_16_0_18_2_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Pip5k1a_AT1 or Pip5k2c_AT1 or Pip5k3_AT1 or Pip5k1b_AT1 or Pip5k2b_AT2 or Pip5k1c_AT1 or Pip5k2a_AT1 or Pip5k3_AT2 or Pip5k3_AT3 or Pip5k2b_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PI4P5K_16_0_18_2\"\n]\n}\n},\n{\n\"id\":\"PI4P5K_18_1_18_3\",\n\"name\":\"Phosphatidylinositol 4-phosphate 5-kinase (C18:1,C18:1)\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"h_c\":1.0,\n\"pail45p_hs_18_1_18_1_c\":1.0,\n\"pail4p_hs_18_1_18_1_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Pip5k1a_AT1 or Pip5k2c_AT1 or Pip5k3_AT1 or Pip5k1b_AT1 or Pip5k2b_AT2 or Pip5k1c_AT1 or Pip5k2a_AT1 or Pip5k3_AT2 or Pip5k3_AT3 or Pip5k2b_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PI4P5K_18_1_18_1\"\n]\n}\n},\n{\n\"id\":\"PI4P5K_18_1_18_4\",\n\"name\":\"Phosphatidylinositol 4-phosphate 5-kinase (C18:1,C18:2)\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"h_c\":1.0,\n\"pail45p_hs_18_1_18_2_c\":1.0,\n\"pail4p_hs_18_1_18_2_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Pip5k1a_AT1 or Pip5k2c_AT1 or Pip5k3_AT1 or Pip5k1b_AT1 or Pip5k2b_AT2 or Pip5k1c_AT1 or Pip5k2a_AT1 or Pip5k3_AT2 or Pip5k3_AT3 or Pip5k2b_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PI4P5K_18_1_18_2\"\n]\n}\n},\n{\n\"id\":\"PI4P5K_18_2_16_0\",\n\"name\":\"Phosphatidylinositol 4-phosphate 5-kinase (C18:2,C16:0)\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"h_c\":1.0,\n\"pail45p_hs_18_2_16_0_c\":1.0,\n\"pail4p_hs_18_2_16_0_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Pip5k1a_AT1 or Pip5k2c_AT1 or Pip5k3_AT1 or Pip5k1b_AT1 or Pip5k2b_AT2 or Pip5k1c_AT1 or Pip5k2a_AT1 or Pip5k3_AT2 or Pip5k3_AT3 or Pip5k2b_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PI4P5K_18_2_16_0\"\n]\n}\n},\n{\n\"id\":\"PI4P5K_18_2_18_1\",\n\"name\":\"Phosphatidylinositol 4-phosphate 5-kinase (C18:2,C18:1)\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"h_c\":1.0,\n\"pail45p_hs_18_2_18_1_c\":1.0,\n\"pail4p_hs_18_2_18_1_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Pip5k1a_AT1 or Pip5k2c_AT1 or Pip5k3_AT1 or Pip5k1b_AT1 or Pip5k2b_AT2 or Pip5k1c_AT1 or Pip5k2a_AT1 or Pip5k3_AT2 or Pip5k3_AT3 or Pip5k2b_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PI4P5K_18_2_18_1\"\n]\n}\n},\n{\n\"id\":\"PI4PLC_16_0_16_0\",\n\"name\":\"Phosphatidylinositol 4-phosphate phospholipase C (C16:0,C16:0)\",\n\"metabolites\":{\n\"dag_hs_16_0_16_0_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"mi14p_c\":1.0,\n\"pail4p_hs_16_0_16_0_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Plcb3_AT1\",\n\"subsystem\":\"Inositol Phosphate Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PI4PLC_16_0_16_0\"\n]\n}\n},\n{\n\"id\":\"PI4PLC_16_0_18_1\",\n\"name\":\"Phosphatidylinositol 4-phosphate phospholipase C (C16:0,C18:1)\",\n\"metabolites\":{\n\"dag_hs_16_0_18_1_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"mi14p_c\":1.0,\n\"pail4p_hs_16_0_18_1_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Plcb3_AT1\",\n\"subsystem\":\"Inositol Phosphate Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PI4PLC_16_0_18_1\"\n]\n}\n},\n{\n\"id\":\"PI4PLC_16_0_18_2\",\n\"name\":\"Phosphatidylinositol 4-phosphate phospholipase C (C16:0,C18:2)\",\n\"metabolites\":{\n\"dag_hs_16_0_18_2_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"mi14p_c\":1.0,\n\"pail4p_hs_16_0_18_2_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Plcb3_AT1\",\n\"subsystem\":\"Inositol Phosphate Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PI4PLC_16_0_18_2\"\n]\n}\n},\n{\n\"id\":\"PI4PLC_18_1_18_1\",\n\"name\":\"Phosphatidylinositol 4-phosphate phospholipase C (C18:1,C18:1)\",\n\"metabolites\":{\n\"dag_hs_18_1_18_1_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"mi14p_c\":1.0,\n\"pail4p_hs_18_1_18_1_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Plcb3_AT1\",\n\"subsystem\":\"Inositol Phosphate Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PI4PLC_18_1_18_1\"\n]\n}\n},\n{\n\"id\":\"PI4PLC_18_1_18_2\",\n\"name\":\"Phosphatidylinositol 4-phosphate phospholipase C (C18:1,C18:2)\",\n\"metabolites\":{\n\"dag_hs_18_1_18_2_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"mi14p_c\":1.0,\n\"pail4p_hs_18_1_18_2_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Plcb3_AT1\",\n\"subsystem\":\"Inositol Phosphate Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PI4PLC_18_1_18_2\"\n]\n}\n},\n{\n\"id\":\"PI4PLC_18_2_16_0\",\n\"name\":\"Phosphatidylinositol 4-phosphate phospholipase C (C18:2,C16:0)\",\n\"metabolites\":{\n\"dag_hs_18_2_16_0_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"mi14p_c\":1.0,\n\"pail4p_hs_18_2_16_0_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Plcb3_AT1\",\n\"subsystem\":\"Inositol Phosphate Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PI4PLC_18_2_16_0\"\n]\n}\n},\n{\n\"id\":\"PI4PLC_18_2_18_1\",\n\"name\":\"Phosphatidylinositol 4-phosphate phospholipase C (C18:2,C18:1)\",\n\"metabolites\":{\n\"dag_hs_18_2_18_1_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"mi14p_c\":1.0,\n\"pail4p_hs_18_2_18_1_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Plcb3_AT1\",\n\"subsystem\":\"Inositol Phosphate Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PI4PLC_18_2_18_1\"\n]\n}\n},\n{\n\"id\":\"PI4PP_16_0_16_0\",\n\"name\":\"Phosphatidylinositol-4-phosphate 4-phosphatase (C16:0,C16:0)\",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"pail4p_hs_16_0_16_0_c\":-1.0,\n\"pail_hs_16_0_16_0_c\":1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Inositol Phosphate Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PI4PP_16_0_16_0\"\n]\n}\n},\n{\n\"id\":\"PI4PP_16_0_18_1\",\n\"name\":\"Phosphatidylinositol-4-phosphate 4-phosphatase (C16:0,C18:1)\",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"pail4p_hs_16_0_18_1_c\":-1.0,\n\"pail_hs_16_0_18_1_c\":1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Inositol Phosphate Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PI4PP_16_0_18_1\"\n]\n}\n},\n{\n\"id\":\"PI4PP_16_0_18_2\",\n\"name\":\"Phosphatidylinositol-4-phosphate 4-phosphatase (C16:0,C18:2)\",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"pail4p_hs_16_0_18_2_c\":-1.0,\n\"pail_hs_16_0_18_2_c\":1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Inositol Phosphate Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PI4PP_16_0_18_2\"\n]\n}\n},\n{\n\"id\":\"PI4PP_18_1_18_1\",\n\"name\":\"Phosphatidylinositol-4-phosphate 4-phosphatase (C18:1,C18:1)\",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"pail4p_hs_18_1_18_1_c\":-1.0,\n\"pail_hs_18_1_18_1_c\":1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Inositol Phosphate Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PI4PP_18_1_18_1\"\n]\n}\n},\n{\n\"id\":\"PI4PP_18_1_18_2\",\n\"name\":\"Phosphatidylinositol-4-phosphate 4-phosphatase (C18:1,C18:2)\",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"pail4p_hs_18_1_18_2_c\":-1.0,\n\"pail_hs_18_1_18_2_c\":1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Inositol Phosphate Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PI4PP_18_1_18_2\"\n]\n}\n},\n{\n\"id\":\"PI4PP_18_2_16_0\",\n\"name\":\"Phosphatidylinositol-4-phosphate 4-phosphatase (C18:2,C16:0)\",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"pail4p_hs_18_2_16_0_c\":-1.0,\n\"pail_hs_18_2_16_0_c\":1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Inositol Phosphate Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PI4PP_18_2_16_0\"\n]\n}\n},\n{\n\"id\":\"PI4PP_18_2_18_1\",\n\"name\":\"Phosphatidylinositol-4-phosphate 4-phosphatase (C18:2,C18:1)\",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"pail4p_hs_18_2_18_1_c\":-1.0,\n\"pail_hs_18_2_18_1_c\":1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Inositol Phosphate Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PI4PP_18_2_18_1\"\n]\n}\n},\n{\n\"id\":\"PIK4_16_0_16_0\",\n\"name\":\"Phosphatidylinositol 4-kinase (C16:0,C16:0)\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"h_c\":1.0,\n\"pail4p_hs_16_0_16_0_c\":1.0,\n\"pail_hs_16_0_16_0_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Pik4ca_AT1 or Pik4cb_AT1 or Pi4kii_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PIK4_16_0_16_0\"\n]\n}\n},\n{\n\"id\":\"PIK4_16_0_18_1\",\n\"name\":\"Phosphatidylinositol 4-kinase (C16:0,C18:1)\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"h_c\":1.0,\n\"pail4p_hs_16_0_18_1_c\":1.0,\n\"pail_hs_16_0_18_1_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Pik4ca_AT1 or Pik4cb_AT1 or Pi4kii_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PIK4_16_0_18_1\"\n]\n}\n},\n{\n\"id\":\"PIK4_16_0_18_2\",\n\"name\":\"Phosphatidylinositol 4-kinase (C16:0,C18:2)\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"h_c\":1.0,\n\"pail4p_hs_16_0_18_2_c\":1.0,\n\"pail_hs_16_0_18_2_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Pik4ca_AT1 or Pik4cb_AT1 or Pi4kii_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PIK4_16_0_18_2\"\n]\n}\n},\n{\n\"id\":\"PIK4_18_1_18_1\",\n\"name\":\"Phosphatidylinositol 4-kinase (C18:1,C18:1)\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"h_c\":1.0,\n\"pail4p_hs_18_1_18_1_c\":1.0,\n\"pail_hs_18_1_18_1_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Pik4ca_AT1 or Pik4cb_AT1 or Pi4kii_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PIK4_18_1_18_1\"\n]\n}\n},\n{\n\"id\":\"PIK4_18_1_18_2\",\n\"name\":\"Phosphatidylinositol 4-kinase (C18:1,C18:2)\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"h_c\":1.0,\n\"pail4p_hs_18_1_18_2_c\":1.0,\n\"pail_hs_18_1_18_2_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Pik4ca_AT1 or Pik4cb_AT1 or Pi4kii_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PIK4_18_1_18_2\"\n]\n}\n},\n{\n\"id\":\"PIK4_18_2_16_0\",\n\"name\":\"Phosphatidylinositol 4-kinase (C18:2,C16:0)\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"h_c\":1.0,\n\"pail4p_hs_18_2_16_0_c\":1.0,\n\"pail_hs_18_2_16_0_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Pik4ca_AT1 or Pik4cb_AT1 or Pi4kii_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PIK4_18_2_16_0\"\n]\n}\n},\n{\n\"id\":\"PIK4_18_2_18_1\",\n\"name\":\"Phosphatidylinositol 4-kinase (C18:2,C18 1)\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"h_c\":1.0,\n\"pail4p_hs_18_2_18_1_c\":1.0,\n\"pail_hs_18_2_18_1_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Pik4ca_AT1 or Pik4cb_AT1 or Pi4kii_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PIK4_18_2_18_1\"\n]\n}\n},\n{\n\"id\":\"PIPLC_16_0_16_0\",\n\"name\":\"Phosphatidylinositol phospholipase C (C16:0,C16:0)\",\n\"metabolites\":{\n\"dag_hs_16_0_16_0_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"mi1p__D_c\":1.0,\n\"pail_hs_16_0_16_0_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Plcb3_AT1\",\n\"subsystem\":\"Inositol Phosphate Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PIPLC_16_0_16_0\"\n]\n}\n},\n{\n\"id\":\"PIPLC_16_0_18_1\",\n\"name\":\"Phosphatidylinositol phospholipase C (C16:0,C18:1)\",\n\"metabolites\":{\n\"dag_hs_16_0_18_1_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"mi1p__D_c\":1.0,\n\"pail_hs_16_0_18_1_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Plcb3_AT1\",\n\"subsystem\":\"Inositol Phosphate Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PIPLC_16_0_18_1\"\n]\n}\n},\n{\n\"id\":\"PIPLC_16_0_18_2\",\n\"name\":\"Phosphatidylinositol phospholipase C (C16:0,C18:2)\",\n\"metabolites\":{\n\"dag_hs_16_0_18_2_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"mi1p__D_c\":1.0,\n\"pail_hs_16_0_18_2_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Plcb3_AT1\",\n\"subsystem\":\"Inositol Phosphate Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PIPLC_16_0_18_2\"\n]\n}\n},\n{\n\"id\":\"PIPLC_18_1_18_1\",\n\"name\":\"Phosphatidylinositol phospholipase C (C18:1,C18:1)\",\n\"metabolites\":{\n\"dag_hs_18_1_18_1_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"mi1p__D_c\":1.0,\n\"pail_hs_18_1_18_1_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Plcb3_AT1\",\n\"subsystem\":\"Inositol Phosphate Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PIPLC_18_1_18_1\"\n]\n}\n},\n{\n\"id\":\"PIPLC_18_1_18_2\",\n\"name\":\"Phosphatidylinositol phospholipase C (C18:1,C18:2)\",\n\"metabolites\":{\n\"dag_hs_18_1_18_2_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"mi1p__D_c\":1.0,\n\"pail_hs_18_1_18_2_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Plcb3_AT1\",\n\"subsystem\":\"Inositol Phosphate Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PIPLC_18_1_18_2\"\n]\n}\n},\n{\n\"id\":\"PIPLC_18_2_16_0\",\n\"name\":\"Phosphatidylinositol phospholipase C (C18:2,C16:0)\",\n\"metabolites\":{\n\"dag_hs_18_2_16_0_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"mi1p__D_c\":1.0,\n\"pail_hs_18_2_16_0_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Plcb3_AT1\",\n\"subsystem\":\"Inositol Phosphate Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PIPLC_18_2_16_0\"\n]\n}\n},\n{\n\"id\":\"PIPLC_18_2_18_1\",\n\"name\":\"Phosphatidylinositol phospholipase C (C18:2,C18:1)\",\n\"metabolites\":{\n\"dag_hs_18_2_18_1_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"mi1p__D_c\":1.0,\n\"pail_hs_18_2_18_1_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Plcb3_AT1\",\n\"subsystem\":\"Inositol Phosphate Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PIPLC_18_2_18_1\"\n]\n}\n},\n{\n\"id\":\"PIt\",\n\"name\":\"Inorganic phosphate exchange, diffusion\",\n\"metabolites\":{\n\"pi_c\":-1.0,\n\"pi_e\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PIt\"\n]\n}\n},\n{\n\"id\":\"PLA2_2_16_0_16_0\",\n\"name\":\"Phospholipase A2 (C16:0,C16:0)\",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"hdca_c\":1.0,\n\"lpchol_hs_16_0_c\":1.0,\n\"pchol_hs_16_0_16_0_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Pla2g6_AT1 or Pla2g6_AT2 or Pla2g2a_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PLA2_2_16_0_16_0\"\n]\n}\n},\n{\n\"id\":\"PLA2_2_16_0_18_1\",\n\"name\":\"Phospholipase A2 (C16:0,C18:1)\",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"lpchol_hs_16_0_c\":1.0,\n\"ocdcea_c\":1.0,\n\"pchol_hs_16_0_18_1_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Pla2g6_AT1 or Pla2g6_AT2 or Pla2g2a_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PLA2_2_16_0_18_1\"\n]\n}\n},\n{\n\"id\":\"PLA2_2_16_0_18_2\",\n\"name\":\"Phospholipase A2 (C16:0,C18:2)\",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"lnlc_c\":1.0,\n\"lpchol_hs_16_0_c\":1.0,\n\"pchol_hs_16_0_18_2_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Pla2g6_AT1 or Pla2g6_AT2 or Pla2g2a_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PLA2_2_16_0_18_2\"\n]\n}\n},\n{\n\"id\":\"PLA2_2_18_1_18_1\",\n\"name\":\"Phospholipase A2 (C18:1,C18:1)\",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"lpchol_hs_18_1_c\":1.0,\n\"ocdcea_c\":1.0,\n\"pchol_hs_18_1_18_1_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Pla2g6_AT1 or Pla2g6_AT2 or Pla2g2a_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PLA2_2_18_1_18_1\"\n]\n}\n},\n{\n\"id\":\"PLA2_2_18_1_18_2\",\n\"name\":\"Phospholipase A2 (C18:1,C18:2)\",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"lnlc_c\":1.0,\n\"lpchol_hs_18_1_c\":1.0,\n\"pchol_hs_18_1_18_2_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Pla2g6_AT1 or Pla2g6_AT2 or Pla2g2a_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PLA2_2_18_1_18_2\"\n]\n}\n},\n{\n\"id\":\"PLA2_2_18_2_16_0\",\n\"name\":\"Phospholipase A2 (C18:2,C16:0)\",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"hdca_c\":1.0,\n\"lpchol_hs_18_2_c\":1.0,\n\"pchol_hs_18_2_16_0_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Pla2g6_AT1 or Pla2g6_AT2 or Pla2g2a_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PLA2_2_18_2_16_0\"\n]\n}\n},\n{\n\"id\":\"PLA2_2_18_2_18_1\",\n\"name\":\"Phospholipase A2 (C18:2,C18:1)\",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"lpchol_hs_18_2_c\":1.0,\n\"ocdcea_c\":1.0,\n\"pchol_hs_18_2_18_1_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Pla2g6_AT1 or Pla2g6_AT2 or Pla2g2a_AT1\",\n\"subsystem\":\"Glycerophospholipid Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PLA2_2_18_2_18_1\"\n]\n}\n},\n{\n\"id\":\"PMANM\",\n\"name\":\"Phosphomannomutase\",\n\"metabolites\":{\n\"man1p_c\":-1.0,\n\"man6p_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"55276 or Pmm2_AT1\",\n\"subsystem\":\"Fructose and Mannose Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PMANM\"\n]\n}\n},\n{\n\"id\":\"PNP\",\n\"name\":\"Purine nucleoside phosphorylase\",\n\"metabolites\":{\n\"h_c\":1.0,\n\"ncam_c\":1.0,\n\"pi_c\":-1.0,\n\"r1p_c\":1.0,\n\"rnam_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Np_AT1\",\n\"subsystem\":\"NAD Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PNP\"\n]\n}\n},\n{\n\"id\":\"PPA\",\n\"name\":\"Inorganic diphosphatase\",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"pi_c\":2.0,\n\"ppi_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Ppa2_AT1 or Ppa2_AT2 or Ppa2_AT3 or Ppa2_AT4\",\n\"subsystem\":\"Oxidative Phosphorylation\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PPA\"\n]\n}\n},\n{\n\"id\":\"PPAP_16_0_16_0\",\n\"name\":\"Phosphatidic acid phosphatase (C16:0, C16:0)\",\n\"metabolites\":{\n\"dag_hs_16_0_16_0_c\":1.0,\n\"h2o_c\":-1.0,\n\"pa_hs_16_0_16_0_c\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Ppap2c_AT1 or Ppap2b_AT1 or Ppap2a_AT1 or Ppap2a_AT2\",\n\"subsystem\":\"Diacylglycerol Synthesis\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PPAP_16_0_16_0\"\n]\n}\n},\n{\n\"id\":\"PPAP_16_0_18_1\",\n\"name\":\"Phosphatidic acid phosphatase (C16:0, C18:1)\",\n\"metabolites\":{\n\"dag_hs_16_0_18_1_c\":1.0,\n\"h2o_c\":-1.0,\n\"pa_hs_16_0_18_1_c\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Ppap2c_AT1 or Ppap2b_AT1 or Ppap2a_AT1 or Ppap2a_AT2\",\n\"subsystem\":\"Diacylglycerol Synthesis\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PPAP_16_0_18_1\"\n]\n}\n},\n{\n\"id\":\"PPAP_16_0_18_2\",\n\"name\":\"Phosphatidic acid phosphatase (C16:0, C18:2)\",\n\"metabolites\":{\n\"dag_hs_16_0_18_2_c\":1.0,\n\"h2o_c\":-1.0,\n\"pa_hs_16_0_18_2_c\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Ppap2c_AT1 or Ppap2b_AT1 or Ppap2a_AT1 or Ppap2a_AT2\",\n\"subsystem\":\"Diacylglycerol Synthesis\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PPAP_16_0_18_2\"\n]\n}\n},\n{\n\"id\":\"PPAP_18_1_18_1\",\n\"name\":\"Phosphatidic acid phosphatase (C18:1,C18:1)\",\n\"metabolites\":{\n\"dag_hs_18_1_18_1_c\":1.0,\n\"h2o_c\":-1.0,\n\"pa_hs_18_1_18_1_c\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Ppap2c_AT1 or Ppap2b_AT1 or Ppap2a_AT1 or Ppap2a_AT2\",\n\"subsystem\":\"Diacylglycerol Synthesis\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PPAP_18_1_18_1\"\n]\n}\n},\n{\n\"id\":\"PPAP_18_1_18_2\",\n\"name\":\"Phosphatidic acid phosphatase (C18:1,C18:2)\",\n\"metabolites\":{\n\"dag_hs_18_1_18_2_c\":1.0,\n\"h2o_c\":-1.0,\n\"pa_hs_18_1_18_2_c\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Ppap2c_AT1 or Ppap2b_AT1 or Ppap2a_AT1 or Ppap2a_AT2\",\n\"subsystem\":\"Diacylglycerol Synthesis\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PPAP_18_1_18_2\"\n]\n}\n},\n{\n\"id\":\"PPAP_18_2_16_0\",\n\"name\":\"Phosphatidic acid phosphatase (C18:2, C16:0)\",\n\"metabolites\":{\n\"dag_hs_18_2_16_0_c\":1.0,\n\"h2o_c\":-1.0,\n\"pa_hs_18_2_16_0_c\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Ppap2c_AT1 or Ppap2b_AT1 or Ppap2a_AT1 or Ppap2a_AT2\",\n\"subsystem\":\"Diacylglycerol Synthesis\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PPAP_18_2_16_0\"\n]\n}\n},\n{\n\"id\":\"PPAP_18_2_18_1\",\n\"name\":\"Phosphatidic acid phosphatase (C18:2, C18:1)\",\n\"metabolites\":{\n\"dag_hs_18_2_18_1_c\":1.0,\n\"h2o_c\":-1.0,\n\"pa_hs_18_2_18_1_c\":-1.0,\n\"pi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Ppap2c_AT1 or Ppap2b_AT1 or Ppap2a_AT1 or Ppap2a_AT2\",\n\"subsystem\":\"Diacylglycerol Synthesis\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PPAP_18_2_18_1\"\n]\n}\n},\n{\n\"id\":\"PPBNGS\",\n\"name\":\"Porphobilinogen synthase\",\n\"metabolites\":{\n\"5aop_c\":-2.0,\n\"h2o_c\":2.0,\n\"h_c\":1.0,\n\"ppbng_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Alad_AT1 or Alad_AT2\",\n\"subsystem\":\"Heme Biosynthesis\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PPBNGS\"\n]\n}\n},\n{\n\"id\":\"PPM\",\n\"name\":\"Phosphopentomutase\",\n\"metabolites\":{\n\"r1p_c\":-1.0,\n\"r5p_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Pgm1_AT1\",\n\"subsystem\":\"Pentose Phosphate Pathway\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PPM\"\n]\n}\n},\n{\n\"id\":\"PPPGO\",\n\"name\":\"Protoporphyrinogen oxidase (aerobic)\",\n\"metabolites\":{\n\"h2o_c\":3.0,\n\"o2_c\":-1.5,\n\"ppp9_c\":1.0,\n\"pppg9_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Heme Biosynthesis\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PPPGO\"\n]\n}\n},\n{\n\"id\":\"PRPPS\",\n\"name\":\"Phosphoribosylpyrophosphate synthetase\",\n\"metabolites\":{\n\"amp_c\":1.0,\n\"atp_c\":-1.0,\n\"h_c\":1.0,\n\"prpp_c\":1.0,\n\"r5p_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Prps1l1_AT1 or Prps1l1_AT2 or Prps1_AT1\",\n\"subsystem\":\"Pentose Phosphate Pathway\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PRPPS\"\n]\n}\n},\n{\n\"id\":\"PTRCtex2\",\n\"name\":\"Putrescine excretion cytosol to extracellular \",\n\"metabolites\":{\n\"ptrc_c\":-1.0,\n\"ptrc_e\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PTRCt\"\n]\n}\n},\n{\n\"id\":\"PUNP1\",\n\"name\":\"Purine-nucleoside phosphorylase (Adenosine)\",\n\"metabolites\":{\n\"ade_c\":1.0,\n\"adn_c\":-1.0,\n\"pi_c\":-1.0,\n\"r1p_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Np_AT1\",\n\"subsystem\":\"Nucleotides\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PUNP1\"\n]\n}\n},\n{\n\"id\":\"PUNP3\",\n\"name\":\"Purine-nucleoside phosphorylase (Guanosine)\",\n\"metabolites\":{\n\"gsn_c\":-1.0,\n\"gua_c\":1.0,\n\"pi_c\":-1.0,\n\"r1p_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Np_AT1\",\n\"subsystem\":\"Purine Catabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PUNP3\"\n]\n}\n},\n{\n\"id\":\"PUNP5\",\n\"name\":\"Purine-nucleoside phosphorylase (Inosine)\",\n\"metabolites\":{\n\"hxan_c\":1.0,\n\"ins_c\":-1.0,\n\"pi_c\":-1.0,\n\"r1p_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Np_AT1\",\n\"subsystem\":\"Purine Catabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PUNP5\"\n]\n}\n},\n{\n\"id\":\"PYAM5PO\",\n\"name\":\"Pyridoxamine 5'-phosphate oxidase\",\n\"metabolites\":{\n\"h2o2_c\":1.0,\n\"h2o_c\":-1.0,\n\"nh4_c\":1.0,\n\"o2_c\":-1.0,\n\"pyam5p_c\":-1.0,\n\"pydx5p_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"PnpO_AT1\",\n\"subsystem\":\"Vitamin B6 Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PYAM5PO\"\n]\n}\n},\n{\n\"id\":\"PYDAMK\",\n\"name\":\"Pyridoxamine kinase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"h_c\":1.0,\n\"pyam5p_c\":1.0,\n\"pydam_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"PdxK_AT1\",\n\"subsystem\":\"Vitamin B6 Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PYDAMK\"\n]\n}\n},\n{\n\"id\":\"PYDAMtr\",\n\"name\":\"Pyridoxamine transport via diffusion\",\n\"metabolites\":{\n\"pydam_c\":1.0,\n\"pydam_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PYDAMtr\"\n]\n}\n},\n{\n\"id\":\"PYDXDH\",\n\"name\":\"Pyridoxal dehydrogenase\",\n\"metabolites\":{\n\"4pyrdx_c\":1.0,\n\"h2o2_c\":1.0,\n\"h2o_c\":-1.0,\n\"o2_c\":-1.0,\n\"pydx_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Aox1_AT1\",\n\"subsystem\":\"Vitamin B6 Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PYDXDH\"\n]\n}\n},\n{\n\"id\":\"PYDXK\",\n\"name\":\"Pyridoxal kinase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"h_c\":1.0,\n\"pydx5p_c\":1.0,\n\"pydx_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"PdxK_AT1\",\n\"subsystem\":\"Vitamin B6 Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PYDXK\"\n]\n}\n},\n{\n\"id\":\"PYDXNK\",\n\"name\":\"Pyridoxine kinase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"h_c\":1.0,\n\"pdx5p_c\":1.0,\n\"pydxn_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"PdxK_AT1\",\n\"subsystem\":\"Vitamin B6 Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PYDXNK\"\n]\n}\n},\n{\n\"id\":\"PYDXNtr\",\n\"name\":\"Pyridoxine transport via diffusion\",\n\"metabolites\":{\n\"pydxn_c\":1.0,\n\"pydxn_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PYDXNtr\"\n]\n}\n},\n{\n\"id\":\"PYDXPP\",\n\"name\":\"Pyridoxal 5-phosphate phosphatase\",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"pi_c\":1.0,\n\"pydx5p_c\":-1.0,\n\"pydx_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"PdxP_AT1\",\n\"subsystem\":\"Vitamin B6 Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PYDXPP\"\n]\n}\n},\n{\n\"id\":\"PYDXtr\",\n\"name\":\"Pyridoxal transport via diffusion\",\n\"metabolites\":{\n\"pydx_c\":1.0,\n\"pydx_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PYDXtr\"\n]\n}\n},\n{\n\"id\":\"PYK\",\n\"name\":\"Pyruvate kinase\",\n\"metabolites\":{\n\"adp_c\":-1.0,\n\"atp_c\":1.0,\n\"h_c\":-1.0,\n\"pep_c\":-1.0,\n\"pyr_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Pkm2_AT1 or Pklr_AT2 or Pklr_AT1 or Pkm2_AT3 or Pkm2_AT2\",\n\"subsystem\":\"Glycolysis/Gluconeogenesis\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PYK\"\n]\n}\n},\n{\n\"id\":\"PYRt2\",\n\"name\":\"Pyruvate transport in via proton symport\",\n\"metabolites\":{\n\"h_c\":1.0,\n\"h_e\":-1.0,\n\"pyr_c\":1.0,\n\"pyr_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Slc16a1_AT1\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"PYRt2r\"\n]\n}\n},\n{\n\"id\":\"RBFK\",\n\"name\":\"Riboflavin kinase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"fmn_c\":1.0,\n\"h_c\":1.0,\n\"ribflv_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Rfk_AT1\",\n\"subsystem\":\"Riboflavin Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"RBFK\"\n]\n}\n},\n{\n\"id\":\"RIBFLVt3\",\n\"name\":\"Riboflavin transport (ATP dependent)\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"pi_c\":1.0,\n\"ribflv_c\":1.0,\n\"ribflv_e\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"RIBFLVt3\"\n]\n}\n},\n{\n\"id\":\"RIBFLVt3o\",\n\"name\":\"Riboflavin transport out (ATP dependent)\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"pi_c\":1.0,\n\"ribflv_c\":-1.0,\n\"ribflv_e\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"9429\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"RIBFLVt3o\"\n]\n}\n},\n{\n\"id\":\"RNMK\",\n\"name\":\"Ribosylnicotinamide kinase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"h_c\":1.0,\n\"nmn_c\":1.0,\n\"rnam_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Nrk1_AT1\",\n\"subsystem\":\"NAD Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"RNMK\"\n]\n}\n},\n{\n\"id\":\"RPE\",\n\"name\":\"Ribulose 5-phosphate 3-epimerase\",\n\"metabolites\":{\n\"ru5p__D_c\":-1.0,\n\"xu5p__D_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Rpe_AT2 or Rpe_AT1\",\n\"subsystem\":\"Pentose Phosphate Pathway\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"RPE\"\n]\n}\n},\n{\n\"id\":\"RPI\",\n\"name\":\"Ribose-5-phosphate isomerase\",\n\"metabolites\":{\n\"r5p_c\":-1.0,\n\"ru5p__D_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Rpia_AT1\",\n\"subsystem\":\"Pentose Phosphate Pathway\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"RPI\"\n]\n}\n},\n{\n\"id\":\"SALMCOM\",\n\"name\":\"S-Adenosyl-L-methionine:catechol O-methyltransferase\",\n\"metabolites\":{\n\"ahcys_c\":1.0,\n\"amet_c\":-1.0,\n\"h_c\":1.0,\n\"normete__L_c\":1.0,\n\"nrpphr_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Comt_AT2 or Comt_AT1\",\n\"subsystem\":\"Tyrosine metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"SALMCOM\"\n]\n}\n},\n{\n\"id\":\"SALMCOM2\",\n\"name\":\"S-Adenosyl-L-methionine:catechol O-methyltransferase\",\n\"metabolites\":{\n\"adrnl_c\":-1.0,\n\"ahcys_c\":1.0,\n\"amet_c\":-1.0,\n\"h_c\":1.0,\n\"mepi_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Comtd1_AT1\",\n\"subsystem\":\"Tyrosine metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"SALMCOM2\"\n]\n}\n},\n{\n\"id\":\"SBTD_D2\",\n\"name\":\"D sorbitol dehydrogenase D fructose producing \",\n\"metabolites\":{\n\"fru_c\":1.0,\n\"h_c\":1.0,\n\"nad_c\":-1.0,\n\"nadh_c\":1.0,\n\"sbt__D_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Sord_AT1\",\n\"subsystem\":\"Fructose and Mannose Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"SBTD_D2\"\n]\n}\n},\n{\n\"id\":\"SBTR\",\n\"name\":\"D sorbitol reductase\",\n\"metabolites\":{\n\"glc__D_c\":-1.0,\n\"h_c\":-1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0,\n\"sbt__D_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Akr7a2_AT1 or Akr1a1_AT1 or Akr1a1_AT2 or Akr1b1_AT1\",\n\"subsystem\":\"Fructose and Mannose Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"SBTR\"\n]\n}\n},\n{\n\"id\":\"SPMDtex2\",\n\"name\":\"Spermidine excretion cytosol to extracellular \",\n\"metabolites\":{\n\"spmd_c\":-1.0,\n\"spmd_e\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"SPMDt\"\n]\n}\n},\n{\n\"id\":\"SPMS\",\n\"name\":\"Spermidine synthase\",\n\"metabolites\":{\n\"5mta_c\":1.0,\n\"ametam_c\":-1.0,\n\"h_c\":1.0,\n\"ptrc_c\":-1.0,\n\"spmd_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Srm_AT1\",\n\"subsystem\":\"Urea cycle/amino group metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"SPMS\"\n]\n}\n},\n{\n\"id\":\"SPRMS\",\n\"name\":\"Spermine synthase\",\n\"metabolites\":{\n\"5mta_c\":1.0,\n\"ametam_c\":-1.0,\n\"h_c\":1.0,\n\"spmd_c\":-1.0,\n\"sprm_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Sms_AT1\",\n\"subsystem\":\"Urea cycle/amino group metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"SPRMS\"\n]\n}\n},\n{\n\"id\":\"SPRMt2i\",\n\"name\":\"Spermine transport via proton antiport irreversible\",\n\"metabolites\":{\n\"h_c\":-1.0,\n\"h_e\":1.0,\n\"sprm_c\":1.0,\n\"sprm_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"SPRMt2r\"\n]\n}\n},\n{\n\"id\":\"TALA\",\n\"name\":\"Transaldolase\",\n\"metabolites\":{\n\"e4p_c\":1.0,\n\"f6p_c\":1.0,\n\"g3p_c\":-1.0,\n\"s7p_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Taldo1_AT1\",\n\"subsystem\":\"Pentose Phosphate Pathway\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"TALA\"\n]\n}\n},\n{\n\"id\":\"TDP\",\n\"name\":\"Thiamin pyrophosphatase\",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"pi_c\":1.0,\n\"thmmp_c\":1.0,\n\"thmpp_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Thiamine Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"TDP\"\n]\n}\n},\n{\n\"id\":\"THMMPtrbc\",\n\"name\":\"Thiamine monophosphate transport (passive - red blood cell)\",\n\"metabolites\":{\n\"thmmp_c\":1.0,\n\"thmmp_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"THMMPtrbc\"\n]\n}\n},\n{\n\"id\":\"THMTP\",\n\"name\":\"Thiamine-triphosphatase\",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"pi_c\":1.0,\n\"thmpp_c\":1.0,\n\"thmtp_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"ThmtP_AT1\",\n\"subsystem\":\"Thiamine Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"THMTP\"\n]\n}\n},\n{\n\"id\":\"THMtrbc\",\n\"name\":\"Thiamine transprot (passive - red blood cell)\",\n\"metabolites\":{\n\"thm_c\":1.0,\n\"thm_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"THMtrbc\"\n]\n}\n},\n{\n\"id\":\"TKT1\",\n\"name\":\"Transketolase\",\n\"metabolites\":{\n\"g3p_c\":1.0,\n\"r5p_c\":-1.0,\n\"s7p_c\":1.0,\n\"xu5p__D_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Tkt_AT1\",\n\"subsystem\":\"Pentose Phosphate Pathway\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"TKT1\"\n]\n}\n},\n{\n\"id\":\"TKT2\",\n\"name\":\"Transketolase\",\n\"metabolites\":{\n\"e4p_c\":-1.0,\n\"f6p_c\":1.0,\n\"g3p_c\":1.0,\n\"xu5p__D_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Tkt_AT1\",\n\"subsystem\":\"Pentose Phosphate Pathway\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"TKT2\"\n]\n}\n},\n{\n\"id\":\"TMDPK\",\n\"name\":\"Thiamine diphosphokinase\",\n\"metabolites\":{\n\"amp_c\":1.0,\n\"atp_c\":-1.0,\n\"h_c\":1.0,\n\"thm_c\":-1.0,\n\"thmpp_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Tpk1_AT1\",\n\"subsystem\":\"Thiamine Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"TMDPK\"\n]\n}\n},\n{\n\"id\":\"TMDPPK\",\n\"name\":\"Thiamine diphosphate kinase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"thmpp_c\":-1.0,\n\"thmtp_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Thiamine Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"TMDPPK\"\n]\n}\n},\n{\n\"id\":\"TPI\",\n\"name\":\"Triose-phosphate isomerase\",\n\"metabolites\":{\n\"dhap_c\":-1.0,\n\"g3p_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Tpi1_AT1\",\n\"subsystem\":\"Glycolysis/Gluconeogenesis\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"TPI\"\n]\n}\n},\n{\n\"id\":\"UDPG4E\",\n\"name\":\"UDPglucose 4-epimerase\",\n\"metabolites\":{\n\"udpg_c\":-1.0,\n\"udpgal_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Gale_AT2 or Gale_AT1\",\n\"subsystem\":\"Galactose metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"UDPG4E\"\n]\n}\n},\n{\n\"id\":\"UDPGD\",\n\"name\":\"UDPglucose 6-dehydrogenase\",\n\"metabolites\":{\n\"h2o_c\":-1.0,\n\"h_c\":3.0,\n\"nad_c\":-2.0,\n\"nadh_c\":2.0,\n\"udpg_c\":-1.0,\n\"udpglcur_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Ugdh_AT1\",\n\"subsystem\":\"Starch and Sucrose Metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"UDPGD\"\n]\n}\n},\n{\n\"id\":\"UDPGNP\",\n\"name\":\"UDP-glucuronate glucuronohydrolase\",\n\"metabolites\":{\n\"glcur_c\":1.0,\n\"h2o_c\":-1.0,\n\"h_c\":1.0,\n\"udp_c\":1.0,\n\"udpglcur_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Pentose and Glucuronate Interconversions\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"UDPGNP\"\n]\n}\n},\n{\n\"id\":\"UGLT\",\n\"name\":\"UDPglucose--hexose-1-phosphate uridylyltransferase\",\n\"metabolites\":{\n\"g1p_c\":1.0,\n\"gal1p_c\":-1.0,\n\"udpg_c\":-1.0,\n\"udpgal_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Galt_AT1 or Galt_AT2 or Galt_AT3\",\n\"subsystem\":\"Galactose metabolism\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"UGLT\"\n]\n}\n},\n{\n\"id\":\"UMPK\",\n\"name\":\"UMP kinase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"udp_c\":1.0,\n\"ump_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"UmpK_AT1\",\n\"subsystem\":\"Nucleotides\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"UMPK\"\n]\n}\n},\n{\n\"id\":\"UPP3S\",\n\"name\":\"Uroporphyrinogen-III synthase\",\n\"metabolites\":{\n\"h2o_c\":1.0,\n\"hmbil_c\":-1.0,\n\"uppg3_c\":1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Uros_AT1\",\n\"subsystem\":\"Heme Biosynthesis\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"UPP3S\"\n]\n}\n},\n{\n\"id\":\"UPPDC1\",\n\"name\":\"Uroporphyrinogen decarboxylase (uroporphyrinogen III)\",\n\"metabolites\":{\n\"co2_c\":4.0,\n\"cpppg3_c\":1.0,\n\"h_c\":-4.0,\n\"uppg3_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Urod_AT1\",\n\"subsystem\":\"Heme Biosynthesis\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"UPPDC1\"\n]\n}\n},\n{\n\"id\":\"UREAt\",\n\"name\":\"Urea transport via facilitate diffusion\",\n\"metabolites\":{\n\"urea_c\":1.0,\n\"urea_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Slc14a1_1_e\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"UREAt\"\n]\n}\n},\n{\n\"id\":\"URIt\",\n\"name\":\"Uridine facilated transport in cytosol\",\n\"metabolites\":{\n\"uri_c\":1.0,\n\"uri_e\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Slc29a1_1_e\",\n\"subsystem\":\"Transport, Extracellular\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"URIt\"\n]\n}\n},\n{\n\"id\":\"XYLK\",\n\"name\":\"Xylulokinase\",\n\"metabolites\":{\n\"adp_c\":1.0,\n\"atp_c\":-1.0,\n\"h_c\":1.0,\n\"xu5p__D_c\":1.0,\n\"xylu__D_c\":-1.0\n},\n\"lower_bound\":0.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Xylb_AT1\",\n\"subsystem\":\"Pentose and Glucuronate Interconversions\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"XYLK\"\n]\n}\n},\n{\n\"id\":\"XYLTD_D\",\n\"name\":\"Xylitol dehydrogenase D xyulose forming \",\n\"metabolites\":{\n\"h_c\":1.0,\n\"nad_c\":-1.0,\n\"nadh_c\":1.0,\n\"xylt_c\":-1.0,\n\"xylu__D_c\":1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"\",\n\"subsystem\":\"Pentose and Glucuronate Interconversions\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"XYLTD_Dr\"\n]\n}\n},\n{\n\"id\":\"XYLUR\",\n\"name\":\"Xylulose reductase\",\n\"metabolites\":{\n\"h_c\":-1.0,\n\"nadp_c\":1.0,\n\"nadph_c\":-1.0,\n\"xylt_c\":1.0,\n\"xylu__L_c\":-1.0\n},\n\"lower_bound\":-1000.0,\n\"upper_bound\":1000.0,\n\"gene_reaction_rule\":\"Dcxr_AT1\",\n\"subsystem\":\"Pentose and Glucuronate 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me\":\"CMPK1\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"UmpK.1\"\n]\n}\n},\n{\n\"id\":\"Slc16a1_AT1\",\n\"name\":\"SLC16A1\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Slc16a1.1\"\n]\n}\n},\n{\n\"id\":\"Dgkd_AT2\",\n\"name\":\"DGKD\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Dgkd.2\"\n]\n}\n},\n{\n\"id\":\"Dgkz_AT3\",\n\"name\":\"DGKZ\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Dgkz.3\"\n]\n}\n},\n{\n\"id\":\"Dgkz_AT2\",\n\"name\":\"DGKZ\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Dgkz.2\"\n]\n}\n},\n{\n\"id\":\"Dgkb_AT1\",\n\"name\":\"DGKB\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Dgkb.1\"\n]\n}\n},\n{\n\"id\":\"Dgkd_AT1\",\n\"name\":\"DGKD\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Dgkd.1\"\n]\n}\n},\n{\n\"id\":\"Dgkz_AT1\",\n\"name\":\"DGKZ\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Dgkz.1\"\n]\n}\n},\n{\n\"id\":\"Dgka_AT1\",\n\"name\":\"DGKA\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Dgka.1\"\n]\n}\n},\n{\n\"id\":\"Dgki_AT1\",\n\"name\":\"DGKI\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Dgki.1\"\n]\n}\n},\n{\n\"id\":\"Dgkq_AT1\",\n\"name\":\"DGKQ\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Dgkq.1\"\n]\n}\n},\n{\n\"id\":\"Dgkb_AT2\",\n\"name\":\"DGKB\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Dgkb.2\"\n]\n}\n},\n{\n\"id\":\"Dgkh_AT1\",\n\"name\":\"DGKH\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Dgkh.1\"\n]\n}\n},\n{\n\"id\":\"Dgkg_AT1\",\n\"name\":\"DGKG\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Dgkg.1\"\n]\n}\n},\n{\n\"id\":\"Dgke_AT1\",\n\"name\":\"DGKE\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Dgke.1\"\n]\n}\n},\n{\n\"id\":\"Dgkh_AT2\",\n\"name\":\"DGKH\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Dgkh.2\"\n]\n}\n},\n{\n\"id\":\"Slc2a1_1_e\",\n\"name\":\"\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Slc2a1.1-e\"\n]\n}\n},\n{\n\"id\":\"Comt_AT2\",\n\"name\":\"COMT\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Comt.2\"\n]\n}\n},\n{\n\"id\":\"Comt_AT1\",\n\"name\":\"COMT\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Comt.1\"\n]\n}\n},\n{\n\"id\":\"Slc22a2_AT1\",\n\"name\":\"SLC22A2\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Slc22a2.1\"\n]\n}\n},\n{\n\"id\":\"Slc22a2_AT2\",\n\"name\":\"SLC22A2\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Slc22a2.2\"\n]\n}\n},\n{\n\"id\":\"Slc22a3_AT1\",\n\"name\":\"SLC22A3\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Slc22a3.1\"\n]\n}\n},\n{\n\"id\":\"Bpgm_AT1\",\n\"name\":\"BPGM\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Bpgm.1\"\n]\n}\n},\n{\n\"id\":\"Bpgm_AT2\",\n\"name\":\"BPGM\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Bpgm.2\"\n]\n}\n},\n{\n\"id\":\"Eno1_AT1\",\n\"name\":\"ENO1\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Eno1.1\"\n]\n}\n},\n{\n\"id\":\"Acsl1_AT1\",\n\"name\":\"ACSL1\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Acsl1.1\"\n]\n}\n},\n{\n\"id\":\"EnpP1_AT1\",\n\"name\":\"ENPP1\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"EnpP1.1\"\n]\n}\n},\n{\n\"id\":\"Aldoa_AT1\",\n\"name\":\"ALDOA\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Aldoa.1\"\n]\n}\n},\n{\n\"id\":\"Aldoc_AT1\",\n\"name\":\"ALDOC\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Aldoc.1\"\n]\n}\n},\n{\n\"id\":\"Aldoa_AT3\",\n\"name\":\"ALDOA\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Aldoa.3\"\n]\n}\n},\n{\n\"id\":\"Aldoa_AT2\",\n\"name\":\"ALDOA\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Aldoa.2\"\n]\n}\n},\n{\n\"id\":\"Pfkfb3_AT1\",\n\"name\":\"PFKFB3\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Pfkfb3.1\"\n]\n}\n},\n{\n\"id\":\"Pfkfb4_AT1\",\n\"name\":\"PFKFB4\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Pfkfb4.1\"\n]\n}\n},\n{\n\"id\":\"Fbp2_AT1\",\n\"name\":\"FBP2\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Fbp2.1\"\n]\n}\n},\n{\n\"id\":\"Pfkfb1_AT1\",\n\"name\":\"PFKFB1\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Pfkfb1.1\"\n]\n}\n},\n{\n\"id\":\"Pfkfb2_AT1\",\n\"name\":\"PFKFB2\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Pfkfb2.1\"\n]\n}\n},\n{\n\"id\":\"Fbp1_AT1\",\n\"name\":\"FBP1\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Fbp1.1\"\n]\n}\n},\n{\n\"id\":\"Fech_AT1\",\n\"name\":\"FECH\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Fech.1\"\n]\n}\n},\n{\n\"id\":\"Fech_AT2\",\n\"name\":\"FECH\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Fech.2\"\n]\n}\n},\n{\n\"id\":\"FadS_AT1\",\n\"name\":\"FLAD1\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"FadS.1\"\n]\n}\n},\n{\n\"id\":\"FadS_AT2\",\n\"name\":\"FLAD1\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"FadS.2\"\n]\n}\n},\n{\n\"id\":\"Slc2a5_1_e\",\n\"name\":\"\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Slc2a5.1-e\"\n]\n}\n},\n{\n\"id\":\"Slc2a8_1_e\",\n\"name\":\"\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Slc2a8.1-e\"\n]\n}\n},\n{\n\"id\":\"Slc2a11_1_e\",\n\"name\":\"\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Slc2a11.1-e\"\n]\n}\n},\n{\n\"id\":\"Slc2a7_1_e\",\n\"name\":\"\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Slc2a7.1-e\"\n]\n}\n},\n{\n\"id\":\"Slc2a2_1_e\",\n\"name\":\"\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Slc2a2.1-e\"\n]\n}\n},\n{\n\"id\":\"Fh_AT1\",\n\"name\":\"FH\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Fh.1\"\n]\n}\n},\n{\n\"id\":\"Gnpda1_AT1\",\n\"name\":\"GNPDA1\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Gnpda1.1\"\n]\n}\n},\n{\n\"id\":\"G6pd_AT1\",\n\"name\":\"G6PD\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"G6pd.1\"\n]\n}\n},\n{\n\"id\":\"Galk1_AT1\",\n\"name\":\"GALK1\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Galk1.1\"\n]\n}\n},\n{\n\"id\":\"Akr1a1_AT2\",\n\"name\":\"AKR1A1\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Akr1a1.2\"\n]\n}\n},\n{\n\"id\":\"Akr1a1_AT1\",\n\"name\":\"AKR1A1\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Akr1a1.1\"\n]\n}\n},\n{\n\"id\":\"Akr1b1_AT1\",\n\"name\":\"AKR1B1\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Akr1b1.1\"\n]\n}\n},\n{\n\"id\":\"Galt_AT3\",\n\"name\":\"GALT\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Galt.3\"\n]\n}\n},\n{\n\"id\":\"Galt_AT1\",\n\"name\":\"GALT\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Galt.1\"\n]\n}\n},\n{\n\"id\":\"Galt_AT2\",\n\"name\":\"GALT\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Galt.2\"\n]\n}\n},\n{\n\"id\":\"Ugp2_AT2\",\n\"name\":\"UGP2\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Ugp2.2\"\n]\n}\n},\n{\n\"id\":\"Ugp2_AT1\",\n\"name\":\"UGP2\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Ugp2.1\"\n]\n}\n},\n{\n\"id\":\"Slc2a3_1_e\",\n\"name\":\"\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Slc2a3.1-e\"\n]\n}\n},\n{\n\"id\":\"Slc2a4_1_e\",\n\"name\":\"\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Slc2a4.1-e\"\n]\n}\n},\n{\n\"id\":\"Gapdh_AT1\",\n\"name\":\"GAPDH\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Gapdh.1\"\n]\n}\n},\n{\n\"id\":\"Gctg_AT1\",\n\"name\":\"GGCT\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Gctg.1\"\n]\n}\n},\n{\n\"id\":\"Guk1_AT1\",\n\"name\":\"GUK1\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Guk1.1\"\n]\n}\n},\n{\n\"id\":\"Glul_AT1\",\n\"name\":\"GLUL\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Glul.1\"\n]\n}\n},\n{\n\"id\":\"Gclc_AT1\",\n\"name\":\"GCLC\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Gclc.1\"\n]\n}\n},\n{\n\"id\":\"Gclm_AT1\",\n\"name\":\"GCLM\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Gclm.1\"\n]\n}\n},\n{\n\"id\":\"Gk2_AT1\",\n\"name\":\"GK2\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Gk2.1\"\n]\n}\n},\n{\n\"id\":\"Gk_AT1\",\n\"name\":\"GK\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Gk.1\"\n]\n}\n},\n{\n\"id\":\"Gkp3_AT1\",\n\"name\":\"\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Gkp3.1\"\n]\n}\n},\n{\n\"id\":\"Gk_AT2\",\n\"name\":\"GK\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Gk.2\"\n]\n}\n},\n{\n\"id\":\"Hagh_AT1\",\n\"name\":\"HAGH\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Hagh.1\"\n]\n}\n},\n{\n\"id\":\"Slc6a9_AT2\",\n\"name\":\"SLC6A9\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Slc6a9.2\"\n]\n}\n},\n{\n\"id\":\"Slc6a9_AT1\",\n\"name\":\"SLC6A9\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Slc6a9.1\"\n]\n}\n},\n{\n\"id\":\"GmpR_AT1\",\n\"name\":\"GMPR\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"GmpR.1\"\n]\n}\n},\n{\n\"id\":\"Gmps_AT1\",\n\"name\":\"GMPS\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Gmps.1\"\n]\n}\n},\n{\n\"id\":\"Pgd_AT1\",\n\"name\":\"PGD\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Pgd.1\"\n]\n}\n},\n{\n\"id\":\"Gpam_AT1\",\n\"name\":\"GPAM\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Gpam.1\"\n]\n}\n},\n{\n\"id\":\"Gsr_AT2\",\n\"name\":\"GSR\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Gsr.2\"\n]\n}\n},\n{\n\"id\":\"Prdx2_AT3\",\n\"name\":\"PRDX2\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Prdx2.3\"\n]\n}\n},\n{\n\"id\":\"Gpx1_AT1\",\n\"name\":\"GPX1\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Gpx1.1\"\n]\n}\n},\n{\n\"id\":\"Gpx1_AT2\",\n\"name\":\"GPX1\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Gpx1.2\"\n]\n}\n},\n{\n\"id\":\"Prdx2_AT1\",\n\"name\":\"PRDX2\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Prdx2.1\"\n]\n}\n},\n{\n\"id\":\"Gpx4_AT1\",\n\"name\":\"GPX4\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Gpx4.1\"\n]\n}\n},\n{\n\"id\":\"Prdx1_AT3\",\n\"name\":\"PRDX1\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Prdx1.3\"\n]\n}\n},\n{\n\"id\":\"Prdx2_AT2\",\n\"name\":\"PRDX2\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Prdx2.2\"\n]\n}\n},\n{\n\"id\":\"Prdx1_AT2\",\n\"name\":\"PRDX1\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Prdx1.2\"\n]\n}\n},\n{\n\"id\":\"Prdx1_AT1\",\n\"name\":\"PRDX1\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Prdx1.1\"\n]\n}\n},\n{\n\"id\":\"Gss_AT1\",\n\"name\":\"GSS\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Gss.1\"\n]\n}\n},\n{\n\"id\":\"Gucy2F_AT1\",\n\"name\":\"GUCY2F\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Gucy2F.1\"\n]\n}\n},\n{\n\"id\":\"Gucy1A3B2_AT1\",\n\"name\":\"\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Gucy1A3B2.1\"\n]\n}\n},\n{\n\"id\":\"Gucy1A2B3_AT1\",\n\"name\":\"\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Gucy1A2B3.1\"\n]\n}\n},\n{\n\"id\":\"Gucy2C_AT1\",\n\"name\":\"GUCY2C\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Gucy2C.1\"\n]\n}\n},\n{\n\"id\":\"Gucy2D_AT1\",\n\"name\":\"GUCY2D\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Gucy2D.1\"\n]\n}\n},\n{\n\"id\":\"Npr2_AT2\",\n\"name\":\"NPR2\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Npr2.2\"\n]\n}\n},\n{\n\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}\n},\n{\n\"id\":\"Rpe_AT1\",\n\"name\":\"RPE\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Rpe.1\"\n]\n}\n},\n{\n\"id\":\"Rpia_AT1\",\n\"name\":\"RPIA\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Rpia.1\"\n]\n}\n},\n{\n\"id\":\"Comtd1_AT1\",\n\"name\":\"COMTD1\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Comtd1.1\"\n]\n}\n},\n{\n\"id\":\"Sord_AT1\",\n\"name\":\"SORD\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Sord.1\"\n]\n}\n},\n{\n\"id\":\"Akr7a2_AT1\",\n\"name\":\"AKR7A2\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Akr7a2.1\"\n]\n}\n},\n{\n\"id\":\"Srm_AT1\",\n\"name\":\"SRM\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Srm.1\"\n]\n}\n},\n{\n\"id\":\"Sms_AT1\",\n\"name\":\"SMS\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Sms.1\"\n]\n}\n},\n{\n\"id\":\"Taldo1_AT1\",\n\"name\":\"TALDO1\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Taldo1.1\"\n]\n}\n},\n{\n\"id\":\"ThmtP_AT1\",\n\"name\":\"\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"ThmtP.1\"\n]\n}\n},\n{\n\"id\":\"Tkt_AT1\",\n\"name\":\"TKT\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Tkt.1\"\n]\n}\n},\n{\n\"id\":\"Tpk1_AT1\",\n\"name\":\"TPK1\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Tpk1.1\"\n]\n}\n},\n{\n\"id\":\"Tpi1_AT1\",\n\"name\":\"TPI1\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Tpi1.1\"\n]\n}\n},\n{\n\"id\":\"Gale_AT1\",\n\"name\":\"GALE\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Gale.1\"\n]\n}\n},\n{\n\"id\":\"Gale_AT2\",\n\"name\":\"GALE\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Gale.2\"\n]\n}\n},\n{\n\"id\":\"Ugdh_AT1\",\n\"name\":\"UGDH\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Ugdh.1\"\n]\n}\n},\n{\n\"id\":\"Uros_AT1\",\n\"name\":\"UROS\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Uros.1\"\n]\n}\n},\n{\n\"id\":\"Urod_AT1\",\n\"name\":\"UROD\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Urod.1\"\n]\n}\n},\n{\n\"id\":\"Slc14a1_1_e\",\n\"name\":\"\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Slc14a1.1-e\"\n]\n}\n},\n{\n\"id\":\"Xylb_AT1\",\n\"name\":\"XYLB\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Xylb.1\"\n]\n}\n},\n{\n\"id\":\"Dcxr_AT1\",\n\"name\":\"DCXR\",\n\"notes\":{\n\"original_bigg_ids\":[\n\"Dcxr.1\"\n]\n}\n}\n],\n\"id\":\"iAB_RBC_283\",\n\"compartments\":{\n\"c\":\"cytosol\",\n\"e\":\"extracellular space\"\n},\n\"version\":\"1\"\n}", @@ -10783,7 +10783,7 @@ }, "b9f76460f6374d19a2c182ad8d03da1b": { "model_module": "escher", - "model_module_version": "1.7.0-beta.19", + "model_module_version": "1.7.1", "model_name": "EscherMapModel", "state": { "_loaded_map_json": "[{\"map_name\": \"e_coli_core.Core metabolism\", \"map_id\": \"0df3827fde8464e80f455a773a52c274\", \"map_description\": \"E. coli core metabolic network\\nLast Modified Fri Dec 05 2014 16:39:44 GMT-0800 (PST)\", \"homepage\": \"https://escher.github.io\", \"schema\": \"https://escher.github.io/escher/jsonschema/1-0-0#\"}, {\"reactions\": {\"1577514\": {\"name\": \"Formate transport in via proton symport\", \"bigg_id\": \"FORt2\", \"segments\": {\"11\": {\"to_node_id\": \"1577044\", \"from_node_id\": \"1576666\", \"b2\": {\"y\": 4749.209372712298, \"x\": 1360.0}, \"b1\": {\"y\": 4827.353507999329, \"x\": 1360.0}}, \"10\": {\"to_node_id\": \"1577046\", \"from_node_id\": \"1577045\", \"b2\": null, \"b1\": null}, \"13\": {\"to_node_id\": \"1576590\", \"from_node_id\": \"1577046\", \"b2\": {\"y\": 4275.94781629675, \"x\": 1360.0}, \"b1\": {\"y\": 4411.784344889025, \"x\": 1360.0}}, \"12\": {\"to_node_id\": \"1577044\", \"from_node_id\": \"1576833\", \"b2\": {\"y\": 4744.773286702694, \"x\": 1360.0}, \"b1\": {\"y\": 4779.244289008981, \"x\": 1360.0}}, \"14\": {\"to_node_id\": \"1576811\", \"from_node_id\": \"1577046\", \"b2\": {\"y\": 4422.5658350974745, \"x\": 1360.0}, \"b1\": {\"y\": 4455.769750529243, \"x\": 1360.0}}, \"9\": {\"to_node_id\": \"1577045\", \"from_node_id\": \"1577044\", \"b2\": null, \"b1\": null}}, \"genes\": [{\"bigg_id\": \"b2492\", \"name\": \"focB\"}, {\"bigg_id\": \"b0904\", \"name\": \"focA\"}], \"reversibility\": false, \"metabolites\": [{\"coefficient\": -1.0, \"bigg_id\": \"for_e\"}, {\"coefficient\": 1.0, \"bigg_id\": \"h_c\"}, {\"coefficient\": 1.0, \"bigg_id\": \"for_c\"}, {\"coefficient\": -1.0, \"bigg_id\": \"h_e\"}], \"label_x\": 1255.7530517578125, \"label_y\": 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