Differential interaction

[wangjiawen2013]

Hi,
Does ncem support differential analysis between two conditions (healthy and disease samples)?

[wangjiawen2013]

Besides, can ncem be used to analyze both scRNA-seq and spatial transcriptome or only spatial transcriptome ?

[AnnaChristina]

Hi @wangjiawen2013,

thanks for your questions.

Does ncem support differential analysis between two conditions (healthy and disease samples)?

NCEM can be used separately on conditions by first identifying type couplings in the healthy samples and then in the diseased ones.

Besides, can ncem be used to analyze both scRNA-seq and spatial transcriptome or only spatial transcriptome ?

NCEM is designed for spatial transcriptomics data. It can, however, be used for imputed scRNA-seq data.

I hope this answers your questions. I am closing this issue, but please feel free to open it again in case of further comments. Thanks!