diff --git a/CHANGELOG.rst b/CHANGELOG.rst
index c9229b8..f2aaeb9 100644
--- a/CHANGELOG.rst
+++ b/CHANGELOG.rst
@@ -8,6 +8,7 @@ Changelog
 * Add new submodule ``pychip``.
 * Add new method :meth:`common.reverse_complement`.
 * Fix bug in :meth:`common.extract_sequence` where a long DNA sequence output was truncated.
+* :issue:`68`: Refresh the variant consequences database from Ensembl VEP. The database's latest update was on May 31, 2021.
 
 0.36.0 (2022-08-12)
 -------------------
diff --git a/fuc/api/pymaf.py b/fuc/api/pymaf.py
index 2d956ee..45f1f1d 100644
--- a/fuc/api/pymaf.py
+++ b/fuc/api/pymaf.py
@@ -97,7 +97,7 @@
 
 # Below is the list of calculated variant consequences from Ensembl VEP:
 # https://m.ensembl.org/info/genome/variation/prediction/predicted_data.html
-# (accessed on 2021-05-31)
+# (accessed on 2023-09-03)
 #
 # Note that both frameshift_variant and protein_altering_variant require
 # additional information to find their correct Variant_Classification.
@@ -139,6 +139,11 @@
     'regulatory_region_variant':          'IGR',
     'feature_truncation':                 'Targeted_Region',
     'intergenic_variant':                 'IGR',
+    'splice_donor_5th_base_variant':       'AMBIGUOUS',
+    'splice_donor_region_variant':         'AMBIGUOUS',
+    'splice_polypyrimidine_tract_variant': 'AMBIGUOUS',
+    'coding_transcript_variant':           'AMBIGUOUS',
+    'sequence_variant':                    'AMBIGUOUS',
 }
 
 VARCLS_LIST = [