rust-sasa-python is a Python library for computing SASA (Solvent Accessible Surface Area) far faster than biopython and other packages. See RustSasa for more info.

• 🦀 Backend written in Pure Rust
• ⚡️ 3X Faster than Biopython and ~120% faster than Freesasa
• 🐍 Quick drop-in replacement for Biopython

You can now utilize RustSasa within Python to speed up your scripts! Take a look at rust-sasa-python!

Installation:

pip install rust-sasa-python

Example:

from rust_sasa_python import calculate_sasa_at_residue_level
residue_sasa_values = calculate_sasa_at_residue_level("path_to_pdb_file.pdb") # Also supports mmCIF files!

See full docs here

Benchmarks were performed on an M2 Apple Mac with 8GB of RAM and 8 Cores with the protein AF-A0A2K5XT84-F1 (AlphaFold).

• Biopython: ~150ms

• Freesasa: ~90ms

• RustSASA: ~40ms