diff --git a/cli/npm/managed/resolvers/local.rs b/cli/npm/managed/resolvers/local.rs
index 4051c9c319caff..84fd488f48fb68 100644
--- a/cli/npm/managed/resolvers/local.rs
+++ b/cli/npm/managed/resolvers/local.rs
@@ -388,10 +388,13 @@ async fn sync_resolution_with_fs(
       .join("node_modules");
     let mut dep_setup_cache = setup_cache.with_dep(&package_folder_name);
     for (name, dep_id) in &package.dependencies {
-      let dep_cache_folder_id = snapshot
-        .package_from_id(dep_id)
-        .unwrap()
-        .get_package_cache_folder_id();
+      let dep = snapshot.package_from_id(dep_id).unwrap();
+      if package.optional_dependencies.contains(name)
+        && !dep.system.matches_system(system_info)
+      {
+        continue; // this isn't a dependency for the current system
+      }
+      let dep_cache_folder_id = dep.get_package_cache_folder_id();
       let dep_folder_name =
         get_package_folder_id_folder_name(&dep_cache_folder_id);
       if dep_setup_cache.insert(name, &dep_folder_name) {
diff --git a/cli/tests/integration/npm_tests.rs b/cli/tests/integration/npm_tests.rs
index fe3e6cd0f8ac8b..9ac4efc4a6c173 100644
--- a/cli/tests/integration/npm_tests.rs
+++ b/cli/tests/integration/npm_tests.rs
@@ -2009,6 +2009,15 @@ fn binary_package_with_optional_dependencies() {
       assert!(!project_path
         .join("node_modules/.deno/@denotest+binary-package-mac@1.0.0")
         .exists());
+      assert!(project_path
+        .join("node_modules/.deno/@denotest+binary-package@1.0.0/node_modules/@denotest/binary-package-windows")
+        .exists());
+      assert!(!project_path
+        .join("node_modules/.deno/@denotest+binary-package@1.0.0/node_modules/@denotest/binary-package-linux")
+        .exists());
+      assert!(!project_path
+        .join("node_modules/.deno/@denotest+binary-package@1.0.0/node_modules/@denotest/binary-package-mac")
+        .exists());
     }
 
     #[cfg(target_os = "macos")]
@@ -2027,6 +2036,15 @@ fn binary_package_with_optional_dependencies() {
       assert!(project_path
         .join("node_modules/.deno/@denotest+binary-package-mac@1.0.0")
         .exists());
+      assert!(!project_path
+        .join("node_modules/.deno/@denotest+binary-package@1.0.0/node_modules/@denotest/binary-package-windows")
+        .exists());
+      assert!(!project_path
+        .join("node_modules/.deno/@denotest+binary-package@1.0.0/node_modules/@denotest/binary-package-linux")
+        .exists());
+      assert!(project_path
+        .join("node_modules/.deno/@denotest+binary-package@1.0.0/node_modules/@denotest/binary-package-mac")
+        .exists());
     }
 
     #[cfg(target_os = "linux")]
@@ -2044,6 +2062,15 @@ fn binary_package_with_optional_dependencies() {
       assert!(!project_path
         .join("node_modules/.deno/@denotest+binary-package-mac@1.0.0")
         .exists());
+      assert!(!project_path
+        .join("node_modules/.deno/@denotest+binary-package@1.0.0/node_modules/@denotest/binary-package-windows")
+        .exists());
+      assert!(project_path
+        .join("node_modules/.deno/@denotest+binary-package@1.0.0/node_modules/@denotest/binary-package-linux")
+        .exists());
+      assert!(!project_path
+        .join("node_modules/.deno/@denotest+binary-package@1.0.0/node_modules/@denotest/binary-package-mac")
+        .exists());
     }
   }
 }