No bug - How to explain Salmon workflow simply ? (avoid mathematics-heavy explanation)

[deekshamisri]

NO BUG! I am presenting bulk RNA seq to non-bioinformaticians and wanted to go over how Salmon works in simple terms.

I tried understanding all the algorithms and models underlying the tool, but need help in explaining it more simply to a crowd of non-mathematicians. How would you explain the quasi mapping and quantification broadly and in simple terms? No need to get into deeper details. Just want an overview of a complicated mathematical pipeline.

Presentation is on Monday so would really appreciate a timely response.
Thanks!