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ENZYME

ENZYME entry: EC 1.1.1.290

Accepted Name
4-phosphoerythronate dehydrogenase
Alternative Name(s)
4-O-phosphoerythronate dehydrogenase
4PE dehydrogenase
erythronate-4-phosphate dehydrogenase
Reaction catalysed
4-phospho-D-erythronate + NAD(+) = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + NADH + H(+)
Comment(s)
  • This enzyme catalyzes a step in a bacterial pathway for the biosynthesis of pyridoxal 5'-phosphate.
  • The enzyme contains a tightly-bound NAD(H) cofactor that is not re-oxidized by free NAD(+).
  • In order to re-oxidize the cofactor and restore enzyme activity, the enzyme catalyzes the reduction of a 2-oxo acid (such as 2-oxoglutarate, oxaloacetate, or pyruvate) to the respective (R)- hydroxy acid. cf. EC 1.1.1.399.
Cross-references
BRENDA1.1.1.290
EC2PDB1.1.1.290
ExplorEnz1.1.1.290
PRIAM enzyme-specific profiles1.1.1.290
KEGG Ligand Database for Enzyme Nomenclature1.1.1.290
IUBMB Enzyme Nomenclature1.1.1.290
IntEnz1.1.1.290
MEDLINEFind literature relating to 1.1.1.290
MetaCyc1.1.1.290
Rhea expert-curated reactions1.1.1.290
UniProtKB/Swiss-Prot
Q6F943, PDXB_ACIADB7GY62, PDXB_ACIB3B7I5Z2, PDXB_ACIB5
B2HX89, PDXB_ACIBCB0VT23, PDXB_ACIBSA3M810, PDXB_ACIBT
B0VDM7, PDXB_ACIBYA0KLP0, PDXB_AERHHA4SNU1, PDXB_AERS4
Q0VQC3, PDXB_ALCBSQ5E452, PDXB_ALIF1B5FFP0, PDXB_ALIFM
B6EIW3, PDXB_ALISLC1DM66, PDXB_AZOVDQ5LIR8, PDXB_BACFN
Q64ZV5, PDXB_BACFRQ8A2E4, PDXB_BACTNQ1LTA7, PDXB_BAUCH
Q7VRU9, PDXB_BLOFLQ492H2, PDXB_BLOPBB3PK14, PDXB_CELJU
Q1QXV7, PDXB_CHRSDA8ADQ9, PDXB_CITK8Q47XK1, PDXB_COLP3
A9KEY5, PDXB_COXBNA9NAQ7, PDXB_COXBRQ83AR8, PDXB_COXBU
A7MH63, PDXB_CROS8A7ZPD6, PDXB_ECO24B7UFX8, PDXB_ECO27
B7MG84, PDXB_ECO45B7LBH4, PDXB_ECO55Q8XCR0, PDXB_ECO57
B5YXW1, PDXB_ECO5EB7NP01, PDXB_ECO7IB7MXZ7, PDXB_ECO81
B7M6K1, PDXB_ECO8AC4ZVL3, PDXB_ECOBWB1X931, PDXB_ECODH
A8A2I9, PDXB_ECOHSA1ADG9, PDXB_ECOK1Q0TFC6, PDXB_ECOL5
Q8FFH2, PDXB_ECOL6B1IXM2, PDXB_ECOLCP05459, PDXB_ECOLI
B7N5T2, PDXB_ECOLUB6I4U8, PDXB_ECOSEB1LLS6, PDXB_ECOSM
Q1R992, PDXB_ECOUTC5B8N0, PDXB_EDWI9A4WCV4, PDXB_ENT38
B7LLF0, PDXB_ESCF3Q2SJQ9, PDXB_HAHCHQ31IH6, PDXB_HYDCU
Q5QUE2, PDXB_IDILOB5XNR7, PDXB_KLEP3Q5X6I6, PDXB_LEGPA
Q5ZX15, PDXB_LEGPHQ5WXZ0, PDXB_LEGPLA6VXM3, PDXB_MARMS
A1U1I8, PDXB_MARN8Q6D2N5, PDXB_PECASC6DA76, PDXB_PECCP
Q7N2B2, PDXB_PHOLLQ6LNU2, PDXB_PHOPRQ7MV70, PDXB_PORGI
B4EZF9, PDXB_PROMHQ48KQ3, PDXB_PSE14Q15QG8, PDXB_PSEA6
A6V8H9, PDXB_PSEA7B7UVK4, PDXB_PSEA8Q02JM2, PDXB_PSEAB
Q9I3W9, PDXB_PSEAEQ1I7B3, PDXB_PSEE4Q4KFD1, PDXB_PSEF5
C3K5G7, PDXB_PSEFSA4XTK4, PDXB_PSEMYA5W6I8, PDXB_PSEP1
Q3K9D1, PDXB_PSEPFB0KGD9, PDXB_PSEPGQ88L20, PDXB_PSEPK
B1J5D7, PDXB_PSEPWQ884R9, PDXB_PSESMQ3IF36, PDXB_PSET1
Q4ZVE7, PDXB_PSEU2Q4FV16, PDXB_PSYA2Q1QE21, PDXB_PSYCK
A1SW94, PDXB_PSYINA5WHK7, PDXB_PSYWFA1AWW7, PDXB_RUTMC
Q21LK8, PDXB_SACD2B5EZQ4, PDXB_SALA4A9MJ55, PDXB_SALAR
Q57LY4, PDXB_SALCHB5FPL4, PDXB_SALDCB5R3Q1, PDXB_SALEP
B5RCJ5, PDXB_SALG2B4TBN9, PDXB_SALHSB4SZP2, PDXB_SALNS
Q5PCV8, PDXB_SALPAA9N474, PDXB_SALPBC0PZZ3, PDXB_SALPC
B5BCH6, PDXB_SALPKQ2S0U3, PDXB_SALRDB4TQA6, PDXB_SALSV
P60801, PDXB_SALTIP60802, PDXB_SALTYA8GH44, PDXB_SERP5
A1S7K2, PDXB_SHEAMB8EEB4, PDXB_SHEB2A3D669, PDXB_SHEB5
A6WQ07, PDXB_SHEB8A9KTV0, PDXB_SHEB9Q12P58, PDXB_SHEDO
Q084S1, PDXB_SHEFNB0TKZ7, PDXB_SHEHHA3QFC7, PDXB_SHELP
Q8ECR2, PDXB_SHEONA4Y882, PDXB_SHEPCA0KV91, PDXB_SHESA
A8FTT7, PDXB_SHESHQ0HKB6, PDXB_SHESMQ56731, PDXB_SHESP
Q0HWL8, PDXB_SHESRA1RIA7, PDXB_SHESWQ56733, PDXB_SHEVD
B1KKP1, PDXB_SHEWMB2TWA2, PDXB_SHIB3Q31YD8, PDXB_SHIBS
Q32DL6, PDXB_SHIDSQ0T2G5, PDXB_SHIF8Q83QR1, PDXB_SHIFL
Q3YZP1, PDXB_SHISSQ2NSH9, PDXB_SODGMA4VKJ1, PDXB_STUS1
C5BR49, PDXB_TERTTC4LF16, PDXB_TOLATA5CWD1, PDXB_VESOH
B7VL81, PDXB_VIBA3Q9KQ92, PDXB_VIBCHQ87MN8, PDXB_VIBPA
Q8DB36, PDXB_VIBVUQ7MIT6, PDXB_VIBVYQ8D2P6, PDXB_WIGBR
A1JL55, PDXB_YERE8A7FGL9, PDXB_YERP3Q1C676, PDXB_YERPA
B2K8H7, PDXB_YERPBQ8D0U3, PDXB_YERPEA9R7V0, PDXB_YERPG
Q1CHL8, PDXB_YERPNA4TM66, PDXB_YERPPQ668W7, PDXB_YERPS
B1JGI0, PDXB_YERPY

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-