Edoxudine: Difference between revisions

Edoxudine
Clinical data
ATC code	D06BB09 (WHO) ;
Legal status
Legal status	In general: ℞ (Prescription only);
Identifiers
	IUPAC name 5-ethyl-1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione;
CAS Number	15176-29-1 ;
PubChem CID	66377;
ChemSpider	59752 ;
UNII	15ZQM81Y3R;
ChEMBL	ChEMBL318153 ;
CompTox Dashboard (EPA)	DTXSID4045890 ;
ECHA InfoCard	100.035.645
Chemical and physical data
Formula	C11H16N2O5
Molar mass	256.258 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C/1NC(=O)N(\C=C\1CC)[C@@H]2O[C@@H]([C@@H](O)C2)CO;
	InChI InChI=1S/C11H16N2O5/c1-2-6-4-13(11(17)12-10(6)16)9-3-7(15)8(5-14)18-9/h4,7-9,14-15H,2-3,5H2,1H3,(H,12,16,17)/t7-,8+,9+/m0/s1 ; Key:XACKNLSZYYIACO-DJLDLDEBSA-N ;
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Latest revision as of 04:45, 25 March 2024

Edoxudine (or edoxudin) is an antiviral drug. It is an analog of thymidine, a nucleoside.

It has shown effectiveness against herpes simplex virus.^[1]

References

^ Hamuy R, Berman B (December 1998). "Topical antiviral agents for herpes simplex virus infections". Drugs of Today. 34 (12): 1013–1025. doi:10.1358/dot.1998.34.12.487486. PMID 14743269.

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[1] Hamuy R, Berman B (December 1998). "Topical antiviral agents for herpes simplex virus infections". Drugs of Today. 34 (12): 1013–1025. doi:10.1358/dot.1998.34.12.487486. PMID 14743269.

[1]

@@ Line 1: / Line 1: @@
+{{Short description|Chemical compound}}
 {{Drugbox
 | Verifiedfields = changed
@@ Line 16: / Line 17: @@
 | legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C -->
 | legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
-| legal_status =
+| legal_status = Rx-only
 | routes_of_administration =
@@ Line 42: / Line 43: @@
 | ChemSpiderID = 59752
 |  smiles = O=C/1NC(=O)N(\C=C\1CC)[C@@H]2O[C@@H]([C@@H](O)C2)CO
-|  InChI = 1/C11H16N2O5/c1-2-6-4-13(11(17)12-10(6)16)9-3-7(15)8(5-14)18-9/h4,7-9,14-15H,2-3,5H2,1H3,(H,12,16,17)/t7-,8+,9+/m0/s1
-|  InChIKey = XACKNLSZYYIACO-DJLDLDEBBB
 |  StdInChI_Ref = {{stdinchicite|changed|chemspider}}
 | StdInChI = 1S/C11H16N2O5/c1-2-6-4-13(11(17)12-10(6)16)9-3-7(15)8(5-14)18-9/h4,7-9,14-15H,2-3,5H2,1H3,(H,12,16,17)/t7-,8+,9+/m0/s1
@@ Line 51: / Line 50: @@
 <!--Chemical data-->
 | C = 11 | H = 16 | N = 2 | O = 5
-| molecular_weight = 256.25514
 }}
-'''Edoxudine''' (or '''edoxudin''') is an [[Antiviral drug]]. It is an analog of [[thymidine]], a [[nucleoside]].
+'''Edoxudine''' (or '''edoxudin''') is an [[antiviral drug]]. It is an analog of [[thymidine]], a [[nucleoside]].
-It has shown effectiveness against [[herpes simplex virus]].<ref>{{cite journal | pmid = 14743269 | volume=34 | issue=12 | title=Topical antiviral agents for herpes simplex virus infections |date=December 1998 | journal=Drugs Today | pages=1013–25}}</ref>
+It has shown effectiveness against [[herpes simplex virus]].<ref>{{cite journal | vauthors = Hamuy R, Berman B | title = Topical antiviral agents for herpes simplex virus infections | journal = Drugs of Today | volume = 34 | issue = 12 | pages = 1013–1025 | date = December 1998 | pmid = 14743269 | doi = 10.1358/dot.1998.34.12.487486 }}</ref>
-==Synthesis==
+== References ==
-[[File:Edoxudine synthesis.png|500px]]
-{{Cite journal|doi=10.1021/ja00422a056|pmid=1249369|title=Synthesis of C-5 substituted pyrimidine nucleosides via organopalladium intermediates|year=1976|last1=Bergstrom|first1=Donald E.|last2=Ruth|first2=Jerry L.|journal=Journal of the American Chemical Society|volume=98|issue=6|pages=1587–9}}
-==References==
 {{reflist}}
@@ Line 69: / Line 62: @@
 [[Category:Pyrimidinediones]]
 {{antiinfective-drug-stub}}