Talk:Naproxen

Drug-drug interactions

The article states:

"Naproxen should not be taken with antidepressants... Naproxen is not contraindicated in the presence of SSRIs, though concomitant use of the medications should be done with caution".

"not contraindicated seems to contradict the other two statements. I'm not a medical professional, but all the definitions of "contraindicated" I dug up, including from the U.S. National Library of Medicine, include either the meaning "use with caution" or "should not use". So, either the article wording needs to be corrected (perhaps distinguishing between relative and absolute contraindication), or the text should reflect disagreement between two sources. — Preceding unsigned comment added by Atkinson 291 (talk • contribs) 21:47, 15 February 2018 (UTC)

@Atkinson 291: You are absolutely correct! The presence of a drug interaction often isn't a contraindication (a situation in which one should not use a medication; the opposite of an indication), though it sometimes can be. I have corrected the text to represent the source.―Biochemistry🙴❤ 00:37, 16 February 2018 (UTC)

Alcohol

NSAIDs have some warning about alcohol, and I remember this being mentioned to me in person. Should we include something about alcohol and naproxen in the article? -User:Ick) 06:36, 3 September 2007 (UTC)

Absolutely. I was treated in the emergency room last night and told to take Naproxen. They told me that drinking while on the medication is quite serious and extremely dangerous. Sorry that I do not have an article citation on this; but I could tell my ER doc was quite serious about this. 24.251.84.221 02:05, 18 October 2007 (UTC)

I'm not a health professional, but I don't believe there is a direct link between the pharmacology of Naproxen (and other NSAIDs) and ethanol. The advice to avoid alcohol is because both NSAIDs and ethanol can cause stomach irritation and gastric bleeding, so ethanol may increase the prevalence and severity of these side effects. —Preceding unsigned comment added by 80.176.142.11 (talk) 19:44, 6 February 2008 (UTC)

Also a non-expert, but I think I've heard that some NSAIDs (Tylenol) have an interaction with ethanol that might lead to liver damage, whereas the others have the (fairly) mild risk of gastric upset (or more serious damage with long term use). None of that is meant to be put in the article, just a suggestion for a direction in which it might be developed, using WP:RS's. DavidOaks (talk) 13:32, 25 August 2010 (UTC)

• • Autosign signbot's statement is false and easily verified to be so from multiple, professional sites. One is to avoid more than 3 alchoholic drinks per day if using ANY NSAID. This is for an "average" person, whatever that might mean, so clearly caution makes more sense. Reasons: 1. Serious gastric or intestinal bleeding. 2. Liver damage. 3. Kidney damage. There most certainly should be a statement about alcohol in the article.

Kenfo 0 (talk) 22:12, 26 April 2011 (UTC)

There are no known hazardous interactions between Naproxen & Alcohol. NHS Website Alphaceo (talk) 17:00, 23 May 2013 (UTC)

That is not a reliable source for assessing DDIs. Biochemistry&Love (talk) 02:33, 4 May 2017 (UTC)

Definitely a DDI worth mentioning! Thanks for the reminder. Cited a review on PubMed. Biochemistry&Love (talk) 02:32, 4 May 2017 (UTC)

Naprogesic

I added the trade name 'Naprogesic'. Naprogesic is a Naproxen Sodium variant sold in Australia. Not 100% sure if the trade name should be on that list, ob I don't have access to the others to rtfm. Thoughts? 220.240.227.91 09:11, 6 February 2006 (UTC)

Stomach Cancer

This article has an unsourced statement claiming that has been linked to stomach cancer. However, Cancer.org claims it -reduces- the incidence of stomach cancer. https://www.cancer.org/docroot/CRI/content/CRI_2_4_2X_Can_stomach_cancer_be_prevented_40.asp SailorAlea 12:06, Sep 13 2006

Citations

problem solved. --84.172.231.31 19:28, 4 March 2007 (UTC)

Naproxen Sodium tablet photograph

Naproxen tablet

CPO792 20:01, 15 May 2007 (UTC)CPO792

Thank you! I'll add this to the article. ―Biochemistry🙴❤ 21:16, 17 May 2017 (UTC)

Adverse Effects

i think it's known that naproxen sodium can cause stevens-johnson syndrome. https://en.wikipedia.org/wiki/Stevens-Johnson_syndrome —Preceding unsigned comment added by 195.112.144.194 (talk) 08:18, 22 November 2007 (UTC)

I´m taking naproxen for a operation i have about 10 days ago, i need it to cope wiht the pain and inflamation, but i don´t know when it is nessecity or is startin to become something else, my uestion is, does Naproxen can cause adiction, or who addictive is this drug? 19:22, 25 January 2008. —Preceding unsigned comment added by 201.140.75.250 (talk)

Naproxen isn't physically addictive, none of the NSAIDs are. You should watch out for any analgesic with an opiate content (codeine, dihydrocodeine, oxycodone, methadone, morphine etc) as these certainly can result in addiction. --80.176.142.11 (talk) 19:54, 6 February 2008 (UTC)

About "addiction": It's worth distinguishing between addiction and physical dependence.Opiates cause chemical dependency in all people who take them long term, but addiction is relatively rare in pain patients who are not already addicts. Addictive behavior includes obsessive thoughts about the drug, taking more of the drug than is needed to control pain--i.e., getting high--and an inability to function well in day to day life because of abusing the drug. Chronic pain patients may cope very well, not abuse the drug (get high), and even forget to take it (as opposed to thinking obsessively about it).Eperotao (talk) 17:24, 23 May 2008 (UTC)

I'm bothered by the following sentence:

The National Institutes of Health prematurely terminated a randomized clinical trial of naproxen and celecoxib for prevention of Alzheimer's disease, after preliminary data suggested an increased risk of major cardiovascular events, such as heart attack or stroke, in patients taking naproxen.

My understanding was that it was known if these cardiovascular events were "major" or quite minor, as the data were never released. That's what I just read here at the Washington Post: <https://www.washingtonpost.com/wp-dyn/articles/A52625-2005Jan31.html> Unless, more information has come up, I would delete the word "major." Eperotao (talk) 17:24, 23 May 2008 (UTC)

I was told by the pharmacist to always eat with my Naproxen (which I take to cure a pericarditis). A work colleague told me she completely forgot her neck pain due to stomach cramps for taking Naproxen without food. I see no mention of this in the article. Maybe it should be updated? But I can't really mention personal experience as a source for the article... CielProfond (talk) 16:45, 9 December 2008 (UTC)

Structure and details

Naproxen is an oblong White Pill with the medical imprint code "IP110" following parallel score on the back which is for the patient using the drug can half it.

I think that description should be removed (or ammended), because not all Naproxen tablets look like that, the ones I get are blue, don't have "IP110" nor a score on it. Kyprosサマ (talk) 05:47, 18 January 2009 (UTC)

Was the discoverer of Naproxen trying to find a cure for the common cold?

I removed the sentence, "Naproxen was designed...while...trying to discover a cure for the common cold" because it wasn't supported by the source cited. However, if the part of the statement excerpted above is actually true, then it should be re-added with proper sourcing. Bwrs (talk) 16:21, 21 February 2009 (UTC)

Aleve is available in Quebec

While this press release says Aleve isn't available over-the-counter in Quebec, I can assure you that it is available "behind the counter," having bought it here in Montreal several times since mid-July. There is evidently some confusion about the exact meaning of "over-the-counter" here. The article on OTC drugs discusses "restricted OTC substances", which are drugs available without a prescription but stored behind the pharmacy counter and dispensed by the pharmacist. I would say these are still considered OTC drugs, even if they're not on the general pharmacy shelves. "Over-the-counter" is a confusing term anyway.

Further complicating things is the Aleve website, which reads "Sorry, ALEVE® is not available in BC/NFLD at this time. Coupon not valid in Quebec." Does this mean Aleve isn't available at all in B.C. and Newfoundland-Labrador? Or is it available behind the pharmacy counter? I'll be sending an email to the Bayer representative listed in the press release to ask for clarification. Puck35 (talk) 19:06, 16 August 2009 (UTC)

Aleve *is* available OTC in NL. Perhaps they obtained permission to do so after the original press release referred to in this article. I can personally confirm but can find nothing official on Bayer.ca or aleve.ca other than the coupon is valid in NL. 174.116.18.211 (talk) 21:58, 16 January 2010 (UTC)

risk of heart attack and stroke

I deleted this section because its bullshit and someone put it back in. Go read the study in source 5. Theres no statistical significance. —Preceding unsigned comment added by 98.209.40.98 (talk) 17:20, 19 November 2009 (UTC)

New data 2014 = "NAPROXEN LINKED TO HEART ATTACK RISK FOR OLDER WOMEN. Futurity (7/15) reports that a new study found that regular use of the painkiller naproxen may increase the risk of stroke, heart attack, and even death in postmenopausal women. The researchers analyzed data from more than 160,000 postmenopausal women who were surveyed as part of the Women’s Health Initiative—a 15-year research study funded by the National Institutes of Health." https://www.futurity.org/naproxen-heart-attack-women-731052/ — Preceding unsigned comment added by 128.231.237.7 (talk) 18:21, 15 July 2014 (UTC)

premature?

The article currently concludes with "The National Institutes of Health prematurely terminated a randomized clinical trial[5] of naproxen and celecoxib for prevention of Alzheimer's disease, after preliminary data suggested similar effects to Vioxx, such as heart attack or stroke, in patients taking naproxen." However, the cited source actually states "For celecoxib, ADAPT data do not show the same level of risk as those of the APC trial. The data for naproxen, although not definitive, are suggestive of increased cardiovascular and cerebrovascular risk." [emphasis added]. It seems that the WP article is over stating the case for naproxen--at least the wp claim doesn't seem to follow from the cited source. Ann arbor street (talk) 20:33, 9 January 2010 (UTC)

In combination

I am currently taking brand name Vimovo, 500mg/20mg combination of naproxen and esomeprazole. It was prescribed to me for shoulder tendinitis. I thought I might find more information about it here on Wikipedia, but it seems to be new to you. The NSAID-PPI combination drug is apparently supposed to reduce the chance of NSAID-related ulcers. It appears that Axorid is a similar brand, with different ingredients. I'd edit this article or the other, but this type of combination drug seems to warrant its own page. I'll leave it to others to decide what, if anything, to do with this. 24.57.210.141 (talk) 02:08, 30 June 2012 (UTC)

Why Sodium?

Why is it called Naproxen Sodium? The chemical formula states that there isn't actually any sodium in it. 2601:8:8900:436:8006:E424:8DA8:635D (talk) 19:30, 23 February 2014 (UTC)

This article is not about Aleve, Naprosyn etc which are Naproxen Sodium, a different drug from Naprpoxen which is not water soluable and may not be medically useful. The article is probably wrong that "Naproxen _and_ naproxen sodium are marketed under various brand names ...". Certainly the m.w. and other chemical info is wrong about the drug people actually get. 73.81.150.65 (talk) 07:56, 3 February 2017 (UTC)

Picture Authenticity

250 mg tablet of naproxen

I can't find this pill in Drugs.com and Lexi-Comp. Does anyone have proof that this is naproxen? Doc James, maybe you have something? ―Biochemistry🙴❤ 21:27, 17 May 2017 (UTC)

I can get another picture next time I am at work. As a generic there will be 100s if not 1000s of examples. Doc James (talk · contribs · email) 00:12, 20 May 2017 (UTC)

Thanks! (: ―Biochemistry🙴❤ 13:35, 20 May 2017 (UTC)

EC

Teva Naproxen EC 500 (Enteric coating), EC are easier for stomac.

Teva Naproxen EC 500 mg, back and front / Canada

Thanks!―Biochemistry🙴❤ 02:15, 25 January 2018 (UTC)

Naproxen vs Naproxen Sodium

This article does not explain the difference between Naproxen and Naproxen Sodium. In "Sodium Chloride," Sodium and Chlorine are elements. Sodium is metal and with chlorine the sodium chloride salt is produced. But the name "Naproxen Sodium," is not an analogous name. I have run across on several site the statement that "220 mg of Naproxen sodium 'has' 200 mg of Naproxen." I would like this article to explain what that means. Also I would like to know why this drug is sold in 220 mg pills, exclusively over the counter I think; yet it may be prescribed in 500 mg pills. 220 mg does not match with recommended dosages (neither does 440 or 660 mg.)(PeacePeace (talk) 00:39, 7 September 2019 (UTC))

It actually does seem to be pretty analogous, in the sense that Naproxen Sodium is the sodium salt form of the drug. Per drugs.com "Naproxen comes in two forms - either as the base naproxen or as the salt form naproxen sodium. Both the base and salt forms work the same way to relieve pain. There is one difference -- naproxen base on a milligram-per-milligram basis is slightly stronger than naproxen sodium. Here’s how it works out -- 220, 275, or 550 mg of naproxen sodium equals 200, 250, and 500 mg of naproxen, respectively. However, you don’t need to worry about any conversion as these slight differences are already taken into account when doses are determined." And from Dailymed "The sodium salt of naproxen has been developed as a more rapidly absorbed formulation of naproxen for use as an analgesic.... The different dosage forms of naproxen are bioequivalent in terms of extent of absorption (AUC) and peak concentration (Cmax); however, the products do differ in their pattern of absorption.... After administration of naproxen tablets, peak plasma levels are attained in 2 to 4 hours. After oral administration of naproxen sodium, peak plasma levels are attained in 1 to 2 hours. The difference in rates between the two products is due to the increased aqueous solubility of the sodium salt of naproxen used in naproxen sodium." I'm not sure in regards to the status of drugs.com or dailymed are in regards to being WP:MEDRS but even if they aren't I'm sure the same info could be attained from sources that meet the MEDRS criteria and added, doesn't seem to be particularly contentious or anything. AmbivalentUnequivocality (talk) 09:21, 8 September 2019 (UTC)

On second look some of this info (about the differing rates of absorption) is already present in the article. AmbivalentUnequivocality (talk) 09:24, 8 September 2019 (UTC)

This text

"where it is only available over the counter for period pain"

User:Artemgy I do not see how the source supports this? Doc James (talk · contribs · email) 02:02, 12 March 2020 (UTC)

Doc James In the first section "1. About naproxen", after listing all the uses, and prescription details, the text "You can buy it without a prescription from a pharmacy for period pain". The British English 'without a prescription' translates to 'over the counter'. This said, you could perhaps go on to argue the word 'only' in that edit that you have removed. However this article is produced by the UK government health department (assume authoritative) and goes on to say

• "If you get naproxen on prescription, the dose depends on the reason why you're taking it [snip] If you buy naproxen from a pharmacy for painful menstrual periods:"
• "Naproxen is also called by the brand names Naprosyn or Stirlescent" i.e. pharmaceutical names "Naproxen tablets you buy to treat period pain are called Feminax Ultra, Period Pain Reliever and Boots Period Pain Relief." i.e. consumer names

So I think there is good reason to infer the `only` from this slant towards buying OTC = period pain. Artemgy (talk) 18:29, 12 March 2020 (UTC)

Sure you can get it over the counter for period pains. No reason you cannot get it for other stuff. I see no ability to refer only. Would need a source that says only. Doc James (talk · contribs · email) 17:24, 26 March 2020 (UTC)

User:Doc James If your dispute is the word `only`, then what is your reason for removing the other text that clearly was validated by the source? I'm afraid I could not understand the reason from your edit summary nor your response above. — Preceding unsigned comment added by Artemgy (talk • contribs) 14:37, 28 March 2020 (UTC)

EOx redirect removal request

EOx redirects to this page but is not referenced in the article at all. EOx is also used for electrochemical oxidation. The current redirect should be removed since it is not exclusive or expected IMO. Whether it should point to electrochemical oxidation is open to debate but it seems stronger to me than Naproxen. — Preceding unsigned comment added by 2601:19B:200:D340:94E3:6F16:1AE9:484F (talk) 02:16, 12 April 2023 (UTC)

References

Naproxen

The article repeatedly describes Naproxen sodium as anti-inflammatory but the drug’s manufacturer Bayer’s website Aleve.com maintains that it is not, and they should know. My experience agrees with Bayer. Also, in my experience it takes far longer than 1 hour to take effect. Yesterday it was more than 2 hours and today it was 4 hours. I attribute that to its inability to reduce the inflammation that is causing the pain. I wish the article had not misled me. I would have stayed with ibuprofen. Please adjust the article. 2601:19C:4A09:302E:149C:AD9:E2D9:95F8 (talk) 19:16, 28 July 2024 (UTC)

In my experience it acts quicker than ibuprofen. And now with fever it removes it faster than any drug I’ve tried in the past. 188.93.221.40 (talk) 17:19, 17 October 2024 (UTC)