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Chandipura vesiculovirus

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Chandipura vesiculovirus (CHPV) is a member of the Rhabdoviridae family that is associated with an encephalitic illness, Chandipura encephalitis or Chandipura viral encephalitis, in humans. It was first identified in 1965 after isolation from the blood of two patients from Chandipura village in Maharashtra state, India[2] and has been associated with a number of outbreaks of encephalitic illness in central India.

Chandipura vesiculovirus
Virus classification Edit this classification
(unranked): Virus
Realm: Riboviria
Kingdom: Orthornavirae
Phylum: Negarnaviricota
Class: Monjiviricetes
Order: Mononegavirales
Family: Rhabdoviridae
Genus: Vesiculovirus
Species:
Chandipura vesiculovirus
Synonyms[1]
  • Chandipura virus

In India and West Africa Chandipura vesiculovirus was isolated from sandflies which spread the virus.[3][4]

Etymology

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Chandipura virus was named after the village it was first identified in,Chandipura village in Maharashtra state, India during an outbreak of encephalitis in 1965.[5]

Virology

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Chandipura vesiculovirus is an enveloped RNA virus with an approximate genome length of ~11 kb. Viral genome codes for five polypeptides, namely, nucleocapsid protein N, phosphoprotein P, matrix protein M, glycoprotein G and large protein L in five monocistronic mRNAs. N protein encapsidates genome RNA into a nuclease-resistant form to protect in from cellular RNAse function. L and P protein together forms viral RNA dependent RNA polymerase; where catalytic functions for RNA polymerization, capping and poly-A polymerase resides within the L protein and P acts as a transcriptional activator. Matrix protein glues the encapsidated genome RNA, also known as nucleocapsid, with the outer membrane envelope. G protein spikes out of the membrane and acts as a major antigenic determinant.[6]

The viral life cycle is cytosolic. During transcription, viral polymerase synthesizes five discrete mRNAs and obeys to stop signals present at the gene boundaries. Accumulation of adequate amounts of viral proteins within infected cells through viral transcription and subsequent translation potentiate the onset of viral replicative cycle. In this phase, some L protein acts as a replicase and ignore the gene junctions to generate a polycistronic anti-genomic analogue that acts as a template for further rounds of replication to generate many more copies of the genome RNA. This progeny genome RNA upon packaging by viral proteins bud out as mature virus particles. As of 2007, the precise mechanism underlying the switch in polymerase function during viral replication remained unknown.[6]

Epidemiology

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Chandipura virus is transmitted by sandflies, mosquitoes, and ticks.[5] Experimentally CHPV has been transmitted in Phlebotomus papatasi sand flies and Aedes aegypti mosquitoes. The ultimate reservoir is unknown.[7] Human-to-human transmission is not known to occur, therefore travel or trade restrictions are not needed.[5]

Geographically, Chandipura virus human infections so far have been described only in central India; however WHO suspects it could be found in other Asian or African countries,[5] as CHPV has been isolated from wild sandflies in Africa. The presence of the virus in Africa indicates a wide distribution.[7]

Past outbreaks occurred during extremely high ambient temperatures of 36–49 °C.[7] The 2024 outbreak correlates with exceptional rains and 2024 India floods where pools of water are breeding grounds for the insect vector, and lack of sanitation, lack of waste management or open sewerage.[5]

Infection

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Chandipura virus infection
SpecialtyInfectious disease
Symptomshigh fever, convulsion, confusion, diarrhea, vomiting, headache, unconsciousness, coma
ComplicationsChandipura viral encephalitis
CausesChandipura vesiculovirus
TreatmentSupportive care
MedicationIncurable

Signs and symptoms

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Symptoms of Chandipura virus infection typically include fever, muscle aches and headache. A high seroprevalence of neutralising antibodies in the healthy population has been found. Therefore most infections must be subclinical or mild. The lowest seroprevalence in the healthy population was in children under five (44%), 76% in those over five, and 97% in adults.[7]

The complicated course with brain infection includes convulsions, and unconsciousness, progressing rapidly to coma and in severe cases to death.[8] There has been a discussion in the scientific community as to whether the CNS infection should be termed encephalitis or febrile encephalopathy or vasculitis-associated cerebral infarction,[7] hence WHO uses the broader term "encephalitis syndrome".[5] In past outbreak studies cerebrospinal fluid analyses were normal. CNS imaging showed brain edema due to middle cerebral artery infarction or vasospasm,[7] with endothelial damage being the result of encephalitis. CNS imaging has also shown hypodense cortical areas in the frontal and temporal lobes.[9] The case-fatality rate of untreated encephalitis syndrome is 56–75%,[5] but early treatment of raised intracranial pressure reduces fatality rate. Of 27 children surviving encephalitis syndrome 24 completely recovered within 3 months, only two developed late onset refractory epilepsy and four continued to have hemiplegia after 8 months.[7]

Diagnosis

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Diagnosis of Chandipura virus infection is confirmed with immunoglobulin M enzyme-linked immunosorbent assay (IgM ELISA) or reverse transcription polymerase chain reaction (RT-PCR).[10]

Prevention and treatment

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No specific treatment or vaccine is available for Chandipura virus infection, so management focuses on supportive care and prevention measures such as mosquito control.[8]

Outbreaks

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Between June and August 2003, 329 children contracted the virus, and 183 died in Andhra Pradesh and Maharashtra states of India.[11] Further sporadic cases and deaths in children were observed in Gujarat state in 2004.[12] [13] In 2009, there were 52 positive cases, and 15 fatalities I n Maharashtra. In 2010, there were 50 positive cases and 16 fatalities in an outbreak in Gujarat in Kheda District, Vadodara District, and Panchmahal District. Between 2009 and 2011, there were 110 positive cases, and 3 fatalities. [14][15] Sandfly bites were blamed for the outbreak, as they inhabit cracks in walls or parts of homes made of sand or mud. Sporadic cases appeared in Gujarat in 2014 and 2016. In 2016, a girl from Ahmedabad succumbed to the virus. In 2019, another girl from Bhayli, Vadodara succumbed to the virus.[16]

In July 2024, the so far largest outbreak occurred, particularly affecting children in Sabarkantha district of Gujarat. The outbreak raised public health concerns due to the rapid spread and the severity of symptoms observed.[17][8][18] At the end of July, 38 deaths caused by the virus were confirmed,[19] and there remains a speculative death toll of 48.[20][21]

References

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  1. ^ Walker P (15 June 2015). "Implementation of taxon-wide non-Latinized binomial species names in the family Rhabdoviridae" (PDF). International Committee on Taxonomy of Viruses (ICTV). p. 7. Archived (PDF) from the original on 15 February 2023. Retrieved 6 February 2019.
  2. ^ Bhatt PN, Rodrigues FM (December 1967). "Chandipura: a new Arbovirus isolated in India from patients with febrile illness". The Indian Journal of Medical Research. 55 (12): 1295–1305. PMID 4970067.
  3. ^ Fontenille D, Traore-Lamizana M, Trouillet J, Leclerc A, Mondo M, Ba Y, et al. (May 1994). "First isolations of arboviruses from phlebotomine sand flies in West Africa". The American Journal of Tropical Medicine and Hygiene. 50 (5): 570–574. doi:10.4269/ajtmh.1994.50.570. PMID 8203705.
  4. ^ Mani RS, Ravi V, Desai A, Madhusudana SN (2012-03-01). "Emerging Viral Infections in India". Proceedings of the National Academy of Sciences, India Section B. 82 (1): 5–21. Bibcode:2012PINSB..82....5M. doi:10.1007/s40011-011-0001-1. PMC 7100311. PMID 32226201.
  5. ^ a b c d e f g Devi S (September 7, 2024). "India facing largest Chandipura virus outbreak in 20 years". The Lancet. 404 (10456): 919. doi:10.1016/S0140-6736(24)01861-0.
  6. ^ a b Basak S, Mondal A, Polley S, Mukhopadhyay S, Chattopadhyay D (October 2007). "Reviewing Chandipura: a vesiculovirus in human epidemics". Bioscience Reports. 27 (4–5): 275–298. doi:10.1007/s10540-007-9054-z. PMC 7087735. PMID 17610154.
  7. ^ a b c d e f g Shepherd JG, Davis C, Streicker DG, Thomson EC (June 2023). "Emerging Rhabdoviruses and Human Infection". Biology. 12 (6): 878. doi:10.3390/biology12060878. PMC 10294888. PMID 37372162.
  8. ^ a b c Oommen N (2024-07-15). "Chandipura virus outbreak reported in Gujarat. What we know". Hindustan Times. Archived from the original on 2024-07-15. Retrieved 2024-07-16.
  9. ^ Mishra A (December 2004). "Chandipura virus, encephalitis, and epidemic brain attack in India". The Lancet. 364 (9452): 2175–2176. doi:10.1016/S0140-6736(04)17580-6.
  10. ^ "Acute encephalitis syndrome due to Chandipura virus – India". www.who.int. 23 August 2024. Retrieved 2024-09-06.
  11. ^ Rao BL, Basu A, Wairagkar NS, Gore MM, Arankalle VA, Thakare JP, et al. (2004). "A large outbreak of acute encephalitis with high fatality rate in children in Andhra Pradesh, India, in 2003, associated with Chandipura virus". Lancet. 364 (9437): 869–874. doi:10.1016/S0140-6736(04)16982-1. PMC 7137741. PMID 15351194.
  12. ^ Chadha MS, Arankalle VA, Jadi RS, Joshi MV, Thakare JP, Mahadev PV, et al. (September 2005). "An outbreak of Chandipura virus encephalitis in the eastern districts of Gujarat state, India". The American Journal of Tropical Medicine and Hygiene. 73 (3): 566–570. doi:10.4269/ajtmh.2005.73.566. PMID 16172482.
  13. ^ "Four children die in Gujarat from suspected Chandipura virus infection". Gujarat Samachar. Archived from the original on 2024-07-14. Retrieved 2024-07-14.
  14. ^ "Chandipura virus killed three, infected 11 in Maharashtra last year". The Times of India. 2012-06-11. ISSN 0971-8257. Archived from the original on 2024-07-14. Retrieved 2024-07-14.
  15. ^ "Chandipura Virus Kills 17 in Gujarat". DNA—Daily News & Analysis. Gandhinagar. 2010-08-05. Archived from the original on 2012-02-24. Retrieved 2012-02-24.
  16. ^ "5-year-old girl dies of Chandipura virus in Gujarat". India Today. Press Trust of India. 17 July 2019. Archived from the original on 26 July 2019. Retrieved 26 July 2019.
  17. ^ "Chandipura Virus claims twenty lives in Gujarat: Symptoms, precautions, treatments, how it spreads and all you need to know". The Economic Times. 2024-07-16. ISSN 0013-0389. Archived from the original on 2024-07-16. Retrieved 2024-07-16.
  18. ^ "'12 suspected cases of Chandipura viral encephalitis reported in Gujarat'". The Times of India. 2024-07-16. ISSN 0971-8257. Archived from the original on 2024-07-16. Retrieved 2024-07-16.
  19. ^ Mohammed M (2024-07-29). "India is suffering its largest Chandipura virus outbreak in 20 years – what you need to know". The Conversation. Archived from the original on 2024-07-30. Retrieved 2024-07-30.
  20. ^ DHNS. "NIV confirms first death due to Chandipura virus in Gujarat; suspected death toll rises to 14". Deccan Herald. Archived from the original on 2024-07-17. Retrieved 2024-07-18.
  21. ^ HT Correspondent (27 July 2024). "Gujarat records 48 AES deaths, 39 confirmed cases of Chandipura virus". Hindustan Times.
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