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Pronethalol

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Pronethalol (Alderlin, Nethalide) was an early non-selective beta blocker clinical candidate. It was never used clinically due to carcinogenicity in mice, which was thought to result from formation of a carcinogenic naphthalene epoxide metabolite.[1]

Pronethalol
Clinical data
Routes of
administration		Oral
ATC code
  • none
Legal status
Legal status
  • In general: uncontrolled
Identifiers
  • 1-(naphthalen-2-yl)-2-(propan-2-ylamino)ethanol
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC15H19NO
Molar mass229.32 g/mol g·mol−1
3D model (JSmol)
  • CC(C)NCC(C1=CC2=CC=CC=C2C=C1)O

See also

References

  1. ^ Stapleton MP (1997). "Sir James Black and propranolol. The role of the basic sciences in the history of cardiovascular pharmacology". Tex Heart Inst J. 24 (4): 336–42. PMC 325477. PMID 9456487.


 

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