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{{Short description|Chemical compound}}
{{Drugbox
| IUPAC_name = 1-(naphthalen-2-yl)-2-(propan-2-ylamino)ethanol
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}}
 
'''Pronethalol''' (also known as '''Alderlinnethalide''' or '''compound 38,174'''; trade name '''NethalideAlderlin''') was an early non-selective [[beta blocker]] clinical candidate. It was neverthe usedfirst clinicallybeta dueblocker to be developed by [[carcinogenicityJames Black (pharmacologist)|James Black]] inand mice,associates whichat was[[Imperial thoughtChemical toIndustries]], resultand fromthe formationfirst ofto aenter carcinogenicclinical [[naphthaleneuse, epoxide]]in November metabolite1963.<ref name=Quirke>{{cite journal | vauthors =Quirke Stapleton MPV | title =Putting Sirtheory into practice: James Black, andreceptor propranolol.theory The role ofand the basicdevelopment sciences inof the historybeta-blockers ofat cardiovascularICI, pharmacology1958-1978 | journal =Med Texas Heart Institute JournalHist | volume = 2450 | issue = 41 | pages = 336–4269–92 | year date=January 19972006 | pmid = 945648716502872 | pmc=1369014 |doi= 325477 10.1017/s0025727300009455}}</ref>
 
However, it was never used widely due to [[carcinogenicity]] in mice, which was thought to result from formation of a carcinogenic [[naphthalene epoxide]] metabolite,<ref>{{cite journal | vauthors = Stapleton MP | title = Sir James Black and propranolol. The role of the basic sciences in the history of cardiovascular pharmacology | journal = Texas Heart Institute Journal | volume = 24 | issue = 4 | pages = 336–42 | year = 1997 | pmid = 9456487 | pmc = 325477 }}</ref> and was superseded by [[propranolol]] from 1965 onward.<ref name=Quirke/>
 
== See also ==
* [[Beta blocker]]
* [[Discovery and development of beta-blockers]]
 
== References ==
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[[Category:Beta blockers]]
[[Category:Naphthalenes2-Naphthyl compounds]]
[[Category:Secondary alcoholsPhenylethanolamines]]
 
{{antihypertensive-stub}}
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