Global Patent Index - EP 3270940 A4

EP 3270940 A4 20180829 - VIROTHERAPY WITH AN ANTIBODY COMBINATION

Title (en)

VIROTHERAPY WITH AN ANTIBODY COMBINATION

Title (de)

VIROTHERAPIE MIT EINER ANTIKÖRPERKOMBINATION

Title (fr)

VIROTHÉRAPIE BASÉE SUR UNE COMBINAISON D'ANTICORPS

Publication

EP 3270940 A4 20180829 (EN)

Application

EP 16765795 A 20160317

Priority

  • US 201562135096 P 20150318
  • US 2016022978 W 20160317

Abstract (en)

[origin: WO2016149559A1] Disclosed herein are viruses that can be used in methods of treatment for cancer. More specifically, the viruses express two or more antibodies which induce an effective anti-tumor immune response. The viruses also can be used in diagnostic methods.

IPC 8 full level

A61K 35/768 (2015.01); A61K 35/13 (2015.01); A61K 39/00 (2006.01); A61P 35/00 (2006.01); C07K 16/22 (2006.01); C07K 16/28 (2006.01); C12N 7/01 (2006.01); C12N 7/04 (2006.01); C12N 15/09 (2006.01)

CPC (source: EP KR US)

A61K 9/0019 (2013.01 - US); A61K 35/768 (2013.01 - EP KR US); A61K 39/395 (2013.01 - KR); A61K 45/06 (2013.01 - KR); A61P 35/00 (2017.12 - EP US); C07K 16/22 (2013.01 - EP KR US); C07K 16/2863 (2013.01 - EP KR US); C07K 16/30 (2013.01 - EP KR US); C07K 16/40 (2013.01 - EP KR US); C12N 15/8636 (2013.01 - US); A61K 2039/505 (2013.01 - EP KR US); A61K 2039/507 (2013.01 - EP KR US); C07K 2317/22 (2013.01 - EP KR US); C07K 2317/24 (2013.01 - EP KR US); C07K 2317/569 (2013.01 - EP US); C07K 2317/73 (2013.01 - EP US); C07K 2317/76 (2013.01 - EP US); C12N 2710/24132 (2013.01 - EP US); C12N 2710/24143 (2013.01 - EP US)

Citation (search report)

  • [XY] US 2008206201 A1 20080828 - BEIER RUDOLF [DE], et al
  • [XY] US 2013273007 A1 20131017 - SZALAY ALADAR A [US], et al
  • [XY] WO 2012142529 A2 20121018 - GENELUX CORP [US], et al
  • [X] HUANG, TING ET AL: "Vaccinia Virus-mediated Therapy of Solid Tumor Xenografts: Intra-tumoral Delivery of Therapeutic Antibodies", 12 February 2014 (2014-02-12), XP055312660, Retrieved from the Internet <URL:https://opus.uni-wuerzburg.de/opus4-wuerzburg/frontdoor/deliver/index/docId/9132/file/Diss_Huang_Ting.pdf> [retrieved on 20161020]
  • [XY] SANDEEP S. PATIL ET AL: "Virotherapy of Canine Tumors with Oncolytic Vaccinia Virus GLV-1h109 Expressing an Anti-VEGF Single-Chain Antibody", PLOS ONE, vol. 7, no. 10, 16 October 2012 (2012-10-16), pages e47472, XP055312664, DOI: 10.1371/journal.pone.0047472
  • [XY] ALEXA FRENTZEN ET AL: "Anti-VEGF single-chain antibody GLAF-1 encoded by oncolytic vaccinia virus significantly enhances antitumor therapy", vol. 106, no. 31, 19 June 2012 (2012-06-19), pages 12915 - 20090804, XP002678052, ISSN: 0027-8424, Retrieved from the Internet <URL:https://www.pnas.org/content/106/31/12915> [retrieved on 20090715], DOI: 10.1073/PNAS.0900660106
  • [XDY] LISA BUCKEL ET AL: "Combination of fractionated irradiation with anti-VEGF expressing vaccinia virus therapy enhances tumor control by simultaneous radiosensitization of tumor associated endothelium : Oncolytic Viral Therapy", INTERNATIONAL JOURNAL OF CANCER, 1 June 2013 (2013-06-01), US, pages n/a - n/a, XP055487904, ISSN: 0020-7136, DOI: 10.1002/ijc.28296
  • [Y] HESKAMP S ET AL: "Bevacizumab reduces tumor targeting of antiepidermal growth factor and anti-insulin-like growth factor 1 receptor antibodies", INTERNATIONAL JOURNAL OF CANCER, JOHN WILEY & SONS, INC, US, vol. 133, no. 2, 15 July 2013 (2013-07-15), pages 307 - 314, XP002760089, ISSN: 0020-7136, [retrieved on 20130215], DOI: 10.1002/IJC.28046
  • [Y] QING-YANG FENG ET AL: "Anti-EGFR and anti-VEGF agents: Important targeted therapies of colorectal liver metastases", WORLD JOURNAL OF GASTROENTEROLOGY, vol. 20, no. 15, 21 April 2014 (2014-04-21), CN, pages 4263 - 4275, XP055487935, ISSN: 1007-9327, DOI: 10.3748/wjg.v20.i15.4263
  • [XP] TING HUANG ET AL: "Expression of anti-VEGF antibody together with anti-EGFR or anti-FAP enhances tumor regression as a result of vaccinia virotherapy", MOLECULAR THERAPY - ONCOLYTICS, vol. 2, 18 March 2015 (2015-03-18), pages 15003, XP055487690, ISSN: 2372-7705, DOI: 10.1038/mto.2015.3
  • See references of WO 2016149559A1

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DOCDB simple family (publication)

WO 2016149559 A1 20160922; AU 2016232863 A1 20171109; CN 107530384 A 20180102; EA 201792058 A1 20180330; EP 3270940 A1 20180124; EP 3270940 A4 20180829; JP 2018510158 A 20180412; KR 20170139020 A 20171218; MX 2017011991 A 20180528; US 2018092951 A1 20180405

DOCDB simple family (application)

US 2016022978 W 20160317; AU 2016232863 A 20160317; CN 201680028921 A 20160317; EA 201792058 A 20160317; EP 16765795 A 20160317; JP 2017549196 A 20160317; KR 20177029793 A 20160317;