EP 2164830 B1 20130529 - PROCESS FOR THE PREPARATION OF DIBENZO [B,D]AZEPIN-6-ONE DERIVATIVE
Title (en)
PROCESS FOR THE PREPARATION OF DIBENZO [B,D]AZEPIN-6-ONE DERIVATIVE
Title (de)
VERFAHREN ZUR HERSTELLUNG VON DIBENZO-[B,D]-AZEPIN-6-ON-DERIVATEN
Title (fr)
PROCÉDÉ DE PRÉPARATION D'UN DÉRIVÉ DE DIBENZO [B,D]AZÉPIN-6-ONE
Publication
Application
Priority
- EP 2008055937 W 20080515
- EP 07108904 A 20070525
- EP 08759612 A 20080515
Abstract (en)
[origin: US2008293933A1] The invention relates to a process for the optical resolution of a dibenzo[b,d]azepinone derivative of formula II, wherein R1 is hydrogen or halogen and R2 is either C1-4-alkyl optionally substituted with C3-7-cycloalkyl or benzyl which is optionally substituted with C1-4-alkoxy, to obtain a (S)-7-amino-5H,7H-dibenzo[b,d]azepin-6-one of formula I, wherein R1 is as in the compound of formula II. The (S)-7-amino-5H,7H-dibenzo[b,d]azepin-6-one of formula I can be used as a chiral building block for the preparation of malonamide derivatives which have the potential to act as gamma-secretase inhibitors and therefore may be useful in the treatment of Alzheimer's disease and cancer.
IPC 8 full level
C07D 225/08 (2006.01)
CPC (source: EP KR US)
A61P 43/00 (2017.12 - EP); C07D 223/18 (2013.01 - KR); C07D 225/08 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR
DOCDB simple family (publication)
US 2008293933 A1 20081127; US 7579464 B2 20090825; AU 2008257734 A1 20081204; AU 2008257734 B2 20121206; BR PI0812161 A2 20141216; CA 2686645 A1 20081204; CA 2686645 C 20150505; CN 101679278 A 20100324; CN 101679278 B 20130814; EP 2164830 A2 20100324; EP 2164830 B1 20130529; ES 2422602 T3 20130912; IL 202016 A0 20100616; IL 202016 A 20141130; JP 2010527955 A 20100819; JP 2014037431 A 20140227; JP 5745841 B2 20150708; KR 101494918 B1 20150223; KR 20100016476 A 20100212; MX 2009012277 A 20091125; WO 2008145525 A2 20081204; WO 2008145525 A3 20090813
DOCDB simple family (application)
US 11037208 A 20080428; AU 2008257734 A 20080515; BR PI0812161 A 20080515; CA 2686645 A 20080515; CN 200880016696 A 20080515; EP 08759612 A 20080515; EP 2008055937 W 20080515; ES 08759612 T 20080515; IL 20201609 A 20091109; JP 2010508802 A 20080515; JP 2013222376 A 20131025; KR 20097023604 A 20080515; MX 2009012277 A 20080515