EP 2139461 A2 20100106 - AMINO DERIVATIVES TO PREVENT NEPHROTOXICITY AND CANCER
Title (en)
AMINO DERIVATIVES TO PREVENT NEPHROTOXICITY AND CANCER
Title (de)
AMINO-DERIVATE ZUR VERHINDERUNG VON NEPHROTOXIZITÄT UND KREBS
Title (fr)
PRÉVENTION DE LA NÉPHROTOXICITÉ III
Publication
Application
Priority
- DK 2008050070 W 20080319
- DK PA200700424 A 20070320
- DK PA200700958 A 20070629
Abstract (en)
[origin: WO2008113364A2] The present invention relates to the use of compounds for the manufacture of a medicament for the prophylaxis and/or treatment of induced cell toxicity, such as nephrotoxicity and ototoxicity, in particular where the cell toxicity is induced by a medical treatment. In an embodiment, the compounds have at least two nitrogen atoms, more preferably at least two amino groups. The compounds according to the invention are capable of blocking binding of cell toxic compounds to the megalin receptor, and thereby inhibiting uptake of the cell toxic compounds into cells. The invention further relates to novel compounds for use in said treatment, as well as a method for reducing the cell toxicity of cell toxic compounds.
IPC 8 full level
A61K 31/132 (2006.01); A61K 31/133 (2006.01); A61K 31/136 (2006.01); A61K 31/14 (2006.01); A61K 31/155 (2006.01); A61K 31/166 (2006.01); A61K 31/18 (2006.01); A61K 31/195 (2006.01); A61K 31/198 (2006.01); A61K 31/381 (2006.01); A61K 31/4035 (2006.01); A61K 31/4045 (2006.01); A61K 31/4164 (2006.01); A61K 31/417 (2006.01); A61K 31/4412 (2006.01)
CPC (source: EP)
A61K 31/132 (2013.01); A61K 31/133 (2013.01); A61K 31/136 (2013.01); A61K 31/14 (2013.01); A61K 31/155 (2013.01); A61K 31/166 (2013.01); A61K 31/18 (2013.01); A61K 31/195 (2013.01); A61K 31/198 (2013.01); A61K 31/381 (2013.01); A61K 31/4035 (2013.01); A61K 31/4045 (2013.01); A61K 31/4164 (2013.01); A61K 31/417 (2013.01); A61K 31/4412 (2013.01); A61K 31/4418 (2013.01); A61K 31/454 (2013.01); A61K 31/4545 (2013.01); A61K 31/473 (2013.01); A61K 31/495 (2013.01); A61K 31/498 (2013.01); A61K 31/505 (2013.01); A61K 31/506 (2013.01); A61K 31/517 (2013.01); A61K 31/5375 (2013.01); A61K 31/5513 (2013.01); Y02A 50/30 (2017.12)
Citation (search report)
See references of WO 2008113364A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2008113364 A2 20080925; WO 2008113364 A3 20090416; EP 213946