EP 1692176 A4 20081112 - ANTI-IGF-I RECEPTOR ANTIBODY
Title (en)
ANTI-IGF-I RECEPTOR ANTIBODY
Title (de)
ANTI-IGF-I-REZEPTOR-ANTIKÖRPER
Title (fr)
ANTICORPS DU RECEPTEUR ANTI-IGF-I
Publication
Application
Priority
- US 2004038230 W 20041207
- US 72944103 A 20031208
Abstract (en)
[origin: CA2548065A1] Antibodies, humanized antibodies, resurfaced antibodies antibody fragments, derivatized antibodies, and conjugates of same with cytotoxic agents, which specifically bind to, and inhibit, insulin-like growth factor-I receptor, antagonize the effects of IGF-I, IGF-II and serum on the growth and survival of tumor cells, and which are substantially devoid of agonist activity. The antibodies and fragments thereof may be used, optionally in conjunction with other therapeutic agents, in the treatment of tumors that express elevated levels of IGF-I receptor, such as breast cancer, colon cancer, lung cancer, ovarian carcinoma, synovial sarcoma, prostate cancer and pancreatic cancer a nd the derivatized antibodies may be used in the diagnosis and imaging of tumor s that express elevated levels of IGF-I receptor.
IPC 8 full level
C07K 16/00 (2006.01); A61K 39/395 (2006.01); C07H 21/04 (2006.01); C07K 16/28 (2006.01); C12N 15/00 (2006.01)
CPC (source: EP KR)
A61K 39/39541 (2013.01 - EP); C07K 16/18 (2013.01 - KR); C07K 16/28 (2013.01 - KR); C07K 16/2863 (2013.01 - EP); A61K 2039/505 (2013.01 - EP); C07K 2317/24 (2013.01 - EP); C07K 2317/55 (2013.01 - EP); C07K 2317/56 (2013.01 - EP); C07K 2317/565 (2013.01 - EP); C07K 2317/76 (2013.01 - EP)
C-Set (source: EP)
Citation (search report)
- [X] WO 02053596 A2 20020711 - PFIZER [US], et al
- [PX] WO 03106621 A2 20031224 - IMMUNOGEN INC [US]
- [PX] WO 2004071529 A2 20040826 - PFIZER PROD INC [US], et al
- [A] SURMACZ E: "Growth factor receptors as therapeutic targets: Strategies to inhibit the insulin-like growth factor I receptor", ONCOGENE, NATURE PUBLISHING GROUP, GB BASINGSTOKE, HANTS, vol. 22, no. 42, 29 September 2003 (2003-09-29), pages 6589 - 6597, XP002392351, ISSN: 0950-9232
- See references of WO 2005061541A1
Citation (examination)
RUDIKOFF S ET AL: "Single amino acid substitution altering antigen-binding specificity", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC; US, vol. 79, 1 March 1982 (1982-03-01), pages 1979 - 1983, XP007901436, ISSN: 0027-8424, DOI: 10.1073/PNAS.79.6.1979
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA HR LV MK YU
DOCDB simple family (publication)
AU 2004303792 A1 20050707; BR PI0417406 A 20070403; CA 2548065 A1 20050707; CN 1886424 A 20061227; CR 8426 A 20071204; EA 009807 B1 20080428; EA 200600931 A1 20061027; EC SP066595 A 20061017; EP 1692176 A1 20060823; EP 1692176 A4 20081112; IL 174770 A0 20060820; JP 2008502589 A 20080131; KR 20070001883 A 20070104; MX PA06005540 A 20060817; NO 20063155 L 20060811
DOCDB simple family (application)
AU 2004303792 A 20041207; BR PI0417406 A 20041207; CA 2548065 A 20041207; CN 200480034889 A 20041207; CR 8426 A 20060601; EA 200600931 A 20041207; EC SP066595 A 20060531; EP 04811082 A 20041207; IL 17477006 A 20060404; JP 2006543832 A 20041207; KR 20067010010 A 20060523; MX PA06005540 A 20041207; NO 20063155 A 200607