TLN1

TLN1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1SYQ, 2MWN, 4DJ9
Dynodwyr
Cyfenwau	TLN1, ILWEQ, TLN, talin 1, talin-1
Dynodwyr allanol	OMIM: 186745 HomoloGene: 21267 GeneCards: TLN1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • structural constituent of cytoskeleton • actin filament binding • LIM domain binding • integrin binding • GO:0001948, GO:0016582 protein binding • vinculin binding • GO:0032403 protein-containing complex binding • actin binding • cadherin binding • phosphatidylserine binding • phosphatidylinositol binding Cydrannau o'r gell • Cytosgerbwd • cell projection • ruffle membrane • ruffle • cytosol • extracellular exosome • bilen • cell surface • cell-cell junction • cell junction • focal adhesion • extracellular region • cytoplasm • Cellbilen Prosesau biolegol • cell-substrate junction assembly • IRE1-mediated unfolded protein response • muscle contraction • platelet degranulation • platelet aggregation • cell-cell junction assembly • GO:0033109 cortical actin cytoskeleton organization • cell adhesion • GO:0022415 viral process • integrin-mediated signaling pathway • integrin activation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7094	n/a
Ensembl	ENSG00000137076	n/a
UniProt	Q9Y490	n/a
RefSeq (mRNA)	NM_006289	n/a
RefSeq (protein)	NP_006280	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TLN1 yw TLN1 a elwir hefyd yn Talin 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 9, band 9p13.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TLN1.

• TLN
• ILWEQ
• talin-1

Llyfryddiaeth

• "Talin-1 interaction network promotes hepatocellular carcinoma progression. ". Oncotarget. 2017. PMID 28099903.
• "Talin-1 and Non-invasive Fibrosis Models in the Assessment of Patients with Hepatocellular Carcinoma. ". Asian Pac J Cancer Prev. 2016. PMID 27644664.
• "Multiplexing molecular tension sensors reveals piconewton force gradient across talin-1. ". Nat Methods. 2017. PMID 28945706.
• "Downregulation of Talin1 promotes hepatocellular carcinoma progression through activation of the ERK1/2 pathway. ". Cancer Sci. 2017. PMID 28375585.
• "Serum soluble Talin-1 levels are elevated in patients with multiple sclerosis, reflecting its disease activity.". J Neuroimmunol. 2017. PMID 28284333.