HGF

HGF
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1BHT, 1GMN, 1GMO, 1GP9, 1NK1, 1SHY, 1SI5, 2HGF, 2QJ2, 3HMS, 3HMT, 3HN4, 3MKP, 3SP8, 4K3J, 4O3T, 4O3U, 5COE, 5CP9, 5CS1, 5CS3, 5CS5, 5CS9, 5CSQ, 5CT1, 5CT2, 5CT3, 4D3C
Dynodwyr
Cyfenwau	HGF, DFNB39, F-TCF, HGFB, HPTA, SF, hepatocyte growth factor
Dynodwyr allanol	OMIM: 142409 HomoloGene: 503 GeneCards: HGF
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0001948, GO:0016582 protein binding; • identical protein binding; • chemoattractant activity; • protein heterodimerization activity; • growth factor activity; • serine-type endopeptidase activity; • protein tyrosine kinase activity; • phosphatidylinositol-4,5-bisphosphate 3-kinase activity;
Cydrannau o'r gell	• bilen; • extracellular region; • platelet alpha granule lumen; • extracellular space;
Prosesau biolegol	• negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; • negative regulation of hydrogen peroxide-mediated programmed cell death; • positive regulation of neuron projection regeneration; • positive regulation of interleukin-10 production; • positive regulation of cell migration; • cellular response to hepatocyte growth factor stimulus; • negative regulation of release of cytochrome c from mitochondria; • negative regulation of interleukin-6 production; • platelet degranulation; • negative regulation of apoptotic process; • regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling; • positive regulation of angiogenesis; • positive regulation of myelination; • positive regulation of osteoblast differentiation; • myoblast proliferation; • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; • animal organ regeneration; • GO:0000767 cell morphogenesis; • positive regulation of cell population proliferation; • hyaluronan metabolic process; • positive regulation of DNA biosynthetic process; • negative regulation of peptidyl-serine phosphorylation; • epithelial to mesenchymal transition; • positive regulation of peptidyl-tyrosine phosphorylation; • cell chemotaxis; • liver development; • positive regulation of phosphatidylinositol 3-kinase signaling; • regulation of p38MAPK cascade; • cell population proliferation; • negative regulation of autophagy; • hepatocyte growth factor receptor signaling pathway; • negative regulation of inflammatory response; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • regulation of tau-protein kinase activity; • proteolysis; • positive chemotaxis; • MAPK cascade; • peptidyl-tyrosine phosphorylation; • phosphatidylinositol phosphate biosynthetic process; • GO:0007067 Mitosis; • regulation of signaling receptor activity; • positive regulation of protein kinase B signaling; • positive regulation of protein phosphorylation; • cytokine-mediated signaling pathway; • epithelial cell proliferation;
	Sources:Amigo / QuickGO
Orthologau
	3082
	n/a
	ENSG00000019991
	n/a
	P14210
	n/a
	NM_000601; NM_001010931; NM_001010932; NM_001010933; NM_001010934
	n/a
	NP_000592; NP_001010931; NP_001010932; NP_001010933; NP_001010934
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HGF yw HGF a elwir hefyd yn Hepatocyte growth factor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 7, band 7q21.11.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HGF.

SF
HGFB
HPTA
F-TCF
DFNB39

Llyfryddiaeth

"Hepatocyte growth factor is a prognostic marker in patients with colorectal cancer: a meta-analysis. ". Oncotarget. 2017. PMID 28423584.
"Plasma hepatocyte growth factor is a novel marker of AL cardiac amyloidosis. ". Amyloid. 2016. PMID 27809600.
"The effect of hepatocyte growth factor on secretory functions in human eosinophils. ". Cytokine. 2016. PMID 27552115.
"Rescuing Impaired Re-endothelialization of Drug-Eluting Stents Using the Hepatocyte Growth Factor. ". Ann Vasc Surg. 2016. PMID 27423724.
"Utility of Hepatocyte Growth Factor as a Biomarker for Early Diagnosis of Pulmonary Artery Hypertension.". Mol Diagn Ther. 2016. PMID 27342109.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] HGF - Cronfa NCBI

[1]

[2]