Notes from Meeting 12/9/20

[shntnu]

(I'm using this as a scratchpad for now)

This is the data used in the first part of the analysis presented

Metadata_batch	Metadata_Plate	Metadata_clone_number	Metadata_model_split	Metadata_clone_type	n
2019_03_20_Batch2	207106_exposure320	CloneA	test	resistant	1
2020_07_02_Batch8	218361	CloneA	test	resistant	2
2019_02_15_Batch1_20X	HCT116bortezomib	CloneE	test	resistant	1
2019_03_20_Batch2	207106_exposure320	CloneE	test	resistant	1
2020_07_02_Batch8	218361	CloneE	test	resistant	1
2020_07_02_Batch8	218361	WT_parental	test	sensitive	3
2019_02_15_Batch1_20X	HCT116bortezomib	CloneA	training	resistant	3
2019_03_20_Batch2	207106_exposure320	CloneA	training	resistant	2
2020_07_02_Batch8	218361	CloneA	training	resistant	3
2019_02_15_Batch1_20X	HCT116bortezomib	CloneE	training	resistant	2
2019_03_20_Batch2	207106_exposure320	CloneE	training	resistant	2
2020_07_02_Batch8	218361	CloneE	training	resistant	4
2019_02_15_Batch1_20X	HCT116bortezomib	WT_parental	training	sensitive	3
2019_03_20_Batch2	207106_exposure320	WT_parental	training	sensitive	3
2020_07_02_Batch8	218361	WT_parental	training	sensitive	2
2020_07_02_Batch8	218360	CloneA	validation	resistant	5
2020_07_02_Batch8	218360	CloneE	validation	resistant	5
2020_07_02_Batch8	218360	WT_parental	validation	sensitive	5

Grouping further:

Metadata_model_split	Metadata_clone_type	Metadata_clone_number	n
test	resistant	CloneA	3
test	resistant	CloneE	3
test	sensitive	WT_parental	3
training	resistant	CloneA	8
training	resistant	CloneE	8
training	sensitive	WT_parental	8
validation	resistant	CloneA	5
validation	resistant	CloneE	5
validation	sensitive	WT_parental	5

Grouping even further:

Metadata_model_split	Metadata_clone_type	n
training	resistant	16
training	sensitive	8
test	resistant	6
test	sensitive	3
validation	resistant	10
validation	sensitive	5

We are building a binary classifier of sorts (via regression-based feature selection + singscore) on the training set which comprises n=16 and n=8 samples in the two classes (sensitive and resistant).